Abstract:
:On the basis of our reported experience with colchicine for recurrent pericarditis, we administered colchicine to two patients with large pericardial effusions complicating idiopathic pericarditis. The first was a 26-year-old male who showed clinical deterioration following emergency pericardiocentesis and aspirin (3 g/day) for 10 days; the second was a 2-year-old girl who was unsuccessfully treated with aspirin (100 mg/kg/day) for 2 weeks, followed by corticosteroids for 7 months. Administration of colchicine (1 mg/day) instead of aspirin in the first case, and with a rapid tapering-off of the corticosteroids in the second case, led to complete regression of the pericardial effusion on echocardiography within 1 week and 1 month, respectively. Colchicine was discontinued after 1 month in the first patient and was continued for 6 months in the child. Neither has had a recurrence at 24 and 6 months of follow-up, respectively. No side effects of colchicine were observed. We conclude that colchicine may be effective in the treatment of large pericardial effusion when therapy with nonsteroidal anti-inflammatory drugs and/or corticosteroids fails.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Adler Y,Guindo J,Finkelstein Y,Khouri A,Assali A,Bayes-Genis A,Bayes de Luna Adoi
10.1002/clc.4960210220subject
Has Abstractpub_date
1998-02-01 00:00:00pages
143-4issue
2eissn
0160-9289issn
1932-8737journal_volume
21pub_type
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