Abstract:
BACKGROUND:We previously reported that an index of afterload-related left ventricular diastolic function, operant diastolic elastance (Ed)/effective arterial elastance (Ea) = E/e'/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensive women. We aimed to determine sex-related differences in the E/e'-related indices for left ventricular diastolic function and their related factors during admission in patients with heart failure with preserved ejection fraction (HFpEF). HYPOTHESIS:Elderly HFpEF women exhibit severe left ventricular diastolic dysfunction associated with different left atrioventricular volume ratio. METHODS:We divided 267 patients with HFpEF (men/women, 116/151) into two groups by age (≥75 years, n = 212; <75 years, n = 55). We examined the alterations of E/e', E/e'/stroke volume index = Ed, and Ed/Ea, and cardiac structure during admission. RESULTS:Ed and Ea were significantly higher in women than in men, at admission, especially in patients ≥75 years. Before discharge, not only Ed and Ea but also Ed/Ea was significantly higher in women than in men, especially in patients ≥75 years. Elderly female patients had larger left atrial than left ventricular volume. CONCLUSIONS:Higher afterload-related left ventricular diastolic elastance, Ed/Ea, in association with higher arterial elastance, Ea, accompanied by left atrioventricular volume mismatch was observed in elderly HFpEF women.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Hoshida S,Watanabe T,Shinoda Y,Ikeoka K,Minamisaka T,Fukuoka H,Inui H,Ueno K,Suna S,Nakatani D,Hikoso S,Yamada T,Yasumura Y,Fuji H,Sakata Y,PURSUIT HFpEF Investigators.doi
10.1002/clc.23073subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1529-1536issue
12eissn
0160-9289issn
1932-8737journal_volume
41pub_type
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