Abstract：
:Our objective was to investigate whether hemorrhage control can be achieved faster when high-intensity focused ultrasound (HIFU) is applied in the presence of ultrasound contrast agents (UCA) as compared to HIFU only application. Incisions (3 cm long and 0.5 cm deep) were produced in the livers of anesthetized rabbits. UCA Optison (0.18 ml/kg) was injected into the mesenteric vein. A HIFU applicator (5.5 MHz, 6800 W/cm2 in situ) was scanned at a rate of 1-2 mm/s in one direction over the incision (with multiple passes if needed), until hemostasis was achieved. Hemostasis times were 59+/-23 s (n=21) in the presence of Optison and 70+/-23 s (n=29) without Optison. The presence of Optison produced on average 37% reduction in hemostasis times normalized to initial bleeding rates (p<0.05), as well as 60% faster formation of the coagulum seal over the incision (p<0.05). Gross and histological observations showed similar appearance of HIFU lesions produced in the presence of Optison and HIFU lesions produced without Optison. Our results suggest potential utility of UCA for increasing efficiency of HIFU-induced hemostasis of solid organ injuries.
journal_name
Ultrasonicsjournal_title
Ultrasonicsauthors
Zderic V,Brayman AA,Sharar SR,Crum LA,Vaezy Sdoi
10.1016/j.ultras.2006.07.018subject
Has Abstractpub_date
2006-12-01 00:00:00pages
113-20issue
1-4eissn
0041-624Xissn
1874-9968pii
S0041-624X(06)00342-8journal_volume
45pub_type
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