Functional role of the cytoplasmic tail domain of the major envelope fusion protein of group II baculoviruses.

abstract：:Three tegument proteins of human cytomegalovirus (HCMV), ppUL82 (pp71), pUL69, and ppUL83 (pp65), were examined for the ability to stimulate the production of infectious virus from human diploid fibroblasts transfected with viral DNA. Although viral DNA alone had a low intrinsic infectivity of 3 to 8 plaques/microg of...

journal_title：Journal of virology

authors： Baldick CJ Jr,Marchini A,Patterson CE,Shenk T

更新日期：1997-06-01 00:00:00

abstract：:Chromatography of RNA polymerase purified from vaccinia virions and from vaccinia virus-infected HeLa cells resulted in the separation of populations active for early and late transcription. An RNA polymerase population immunodepleted for the vaccinia virus H4 gene peptide could support late transcription. ...

journal_title：Journal of virology

authors： Wright CF,Coroneos AM

更新日期：1995-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) protein pUL38 has been shown to prevent premature cell death by antagonizing cellular stress responses; however, the underlying mechanism remains unknown. In this study, we identified the host protein ubiquitin-specific protease 24 (USP24) as an interaction partner of pUL38. Mutagenesis an...

journal_title：Journal of virology

authors： Sun Y,Bao Q,Xuan B,Xu W,Pan D,Li Q,Qian Z

更新日期：2018-06-13 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) mutants with codon insertions and deletions in IE-0, the gene encoding ICP0, were constructed. The HSV-1 deletion mutant dl1403 (N. D. Stow and E. C. Stow, J. Gen. Virol. 67:2571-2585, 1986) and an IE-0:lacZ transplacement vector isolated in this study were used to facilitate the co...

journal_title：Journal of virology

authors： Chen J,Silverstein S

更新日期：1992-05-01 00:00:00

abstract：UNLABELLED:HIV-1-specific CD8 T cells can influence HIV-1 disease progression during untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 T cells in individuals treated with suppressive antiretroviral therapy remain less well understood. Here we show that a subgroup of HIV-1-spe...

journal_title：Journal of virology

authors： Vigano S,Negron J,Ouyang Z,Rosenberg ES,Walker BD,Lichterfeld M,Yu XG

更新日期：2015-08-01 00:00:00

abstract：:The 5' untranslated region (UTR) of hepatitis C virus (HCV), which is composed of four domains (I, II, III, and IV) and a pseudoknot, is essential for translation and viral replication. Equine nonprimate hepacivirus (EHcV) harbors a 5' UTR consisting of a large 5'-terminal domain (I); three additional domains (I', II,...

journal_title：Journal of virology

authors： Tanaka T,Otoguro T,Yamashita A,Kasai H,Fukuhara T,Matsuura Y,Moriishi K

更新日期：2018-03-14 00:00:00

abstract：:Early sensing of viral components or infection-induced tissue damage is a prerequisite for the successful control of pathogenic viruses by the host innate immune system. Recent results from our laboratory show how immune cells use the DNA-sensing machinery to detect intracellular damage generated early during infectio...

journal_title：Journal of virology

authors： Aguirre S,Fernandez-Sesma A

更新日期：2017-06-26 00:00:00

abstract：:The hemagglutinin of fowl plague virus has been expressed in Spodoptera frugiperda (Sf9) cells and in Estigmene acrea cells by using a baculovirus vector. Structural analysis revealed that the endo-H-resistant N-glycans of HA from Sf9 cells were predominantly trimannosyl core oligosaccharides, whereas in E. acrea cell...

journal_title：Journal of virology

authors： Wagner R,Geyer H,Geyer R,Klenk HD

更新日期：1996-06-01 00:00:00

abstract：:Ribonucleic acid extracted from influenza virus was labeled at the 3' termini with (3)H and analyzed by polyacrylamide gel electrophoresis. Influenza virus was found to contain a minimum of seven and possibly as many as 10 polynucleotide chains, most of which appear to terminate at the 3' end in uridine. ...

journal_title：Journal of virology

authors： Lewandowski LJ,Content J,Leppla SH

更新日期：1971-11-01 00:00:00

abstract：:A cell model of primary macrophages isolated from the peritoneal cavity of flavivirus-susceptible and congenic resistant mice has been used to study the extent and kinetics of antiviral effects against West Nile virus upon priming with alpha/beta interferon (IFN-alpha/beta) or poly(I-C) (pIC). The pattern of flaviviru...

journal_title：Journal of virology

authors： Pantelic L,Sivakumaran H,Urosevic N

更新日期：2005-02-01 00:00:00

abstract：:Growth of bacteriophage T7 is inhibited by the antibiotic coumermycin A1, an inhibitor of the Escherichia coli DNA gyrase. Since growth of the phage is insensitive to the antibiotic in strains containing a coumermycin-resistant DNA gyrase, this enzyme appears to be required for phage growth. We have investigated the e...

journal_title：Journal of virology

authors： De Wyngaert M,Hinkle DC

更新日期：1979-02-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV-68) is a naturally occurring rodent pathogen with significant homology to human pathogens Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. T cells are essential for primary clearance of MHV-68 and survival of mice following intranasal infection. Previous reports have sugg...

journal_title：Journal of virology

authors： Giannoni F,Lyon AB,Wareing MD,Dias PB,Sarawar SR

更新日期：2005-06-01 00:00:00

abstract：:The E7 proteins of human papillomaviruses (HPVs) promote S-phase reentry in differentiated keratinocytes of the squamous epithelia to support viral DNA amplification. In this study, we showed that nuclear p130 was present in the differentiated strata of several native squamous epithelia susceptible to HPV infection. I...

journal_title：Journal of virology

authors： Genovese NJ,Banerjee NS,Broker TR,Chow LT

更新日期：2008-05-01 00:00:00

abstract：:Originally identified as the gamma interferon-inducing factor, interleukin-18 (IL-18) was rediscovered as a proinflammatory cytokine related to the IL-1 family of cytokines that plays an important role in both innate and adaptive immune responses against viruses and intracellular pathogens. Despite its importance in i...

journal_title：Journal of virology

authors： Ahmad R,Sindhu ST,Toma E,Morisset R,Ahmad A

更新日期：2002-12-01 00:00:00

abstract：:In cytomegalovirus-infected cells, the rate of protein synthesis was detected as two peaks. One occurred during the early phase of infection, 0 to 36 h postinfection, and the other occurred during the late phase, after the initiation of viral DNA synthesis. Double-isotopic-label difference analysis demonstrated that h...

journal_title：Journal of virology

authors： Stinski MF

更新日期：1977-09-01 00:00:00

abstract：:Cowpox virus, in contrast to vaccinia virus, can multiply in Chinese hamster ovary cells. To study the genetic basis for this difference in host range, recombinants between vaccinia and cowpox viruses were isolated and their DNA restriction patterns were examined. The ability to multiply in Chinese hamster ovary cells...

journal_title：Journal of virology

authors： Spehner D,Gillard S,Drillien R,Kirn A

更新日期：1988-04-01 00:00:00

abstract：:Hepatitis delta virus (HDV) contains two types of hepatitis delta antigens (HDAg) in the virion. The small form (S-HDAg) is required for HDV RNA replication, whereas the large form (L-HDAg) potently inhibits it by a dominant-negative inhibitory mechanism. The sequential appearance of these two forms in the infected ce...

journal_title：Journal of virology

authors： Modahl LE,Lai MM

更新日期：2000-08-01 00:00:00

abstract：:The gene encoding the precursor polypeptide of the Marek's disease herpesvirus (MDHV) secretory glycoprotein gp57-65 (formerly identified as A antigen) has been sequenced. Previous results had localized the gene to a 4.6-kilobase (kb) segment of the BamHI B fragment in the unique long region of the MDHV genome. S1 nuc...

journal_title：Journal of virology

authors： Coussens PM,Velicer LF

更新日期：1988-07-01 00:00:00

abstract：:The retroviral Gag precursor plays an important role in the assembly of virion particles. The capsid (CA) protein of the Gag molecule makes a major contribution to this process. In the crystal structure of the free CA protein of the human immunodeficiency virus type 1 (HIV-1), 11 residues of the C terminus were found ...

journal_title：Journal of virology

authors： Melamed D,Mark-Danieli M,Kenan-Eichler M,Kraus O,Castiel A,Laham N,Pupko T,Glaser F,Ben-Tal N,Bacharach E

更新日期：2004-09-01 00:00:00

abstract：:Previous work on the strict late (gamma) UL38 promoter of herpes simplex virus type 1 identified three cis-acting elements required for wild-type levels of transcription: a TATA box at -31, a consensus mammalian initiator element at the transcription start site, and a downstream activation sequence (DAS) at +20 to +33...

journal_title：Journal of virology

authors： Petroski MD,Wagner EK

更新日期：1998-10-01 00:00:00

abstract：:The entire varicella-zoster virus (VZV) genome appears to be present in latently infected human ganglia, but the extent of virus DNA transcription is unknown. Conventional methods to study virus gene transcripts by Northern (RNA) blotting are not feasible, since ganglia are small and VZV DNA is not abundant. To circum...

journal_title：Journal of virology

authors： Cohrs RJ,Srock K,Barbour MB,Owens G,Mahalingam R,Devlin ME,Wellish M,Gilden DH

更新日期：1994-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) requires that its genome be reverse transcribed into double-stranded DNA for productive infection of cells. This process requires not only reverse transcriptase but also the nucleocapsid protein (NC), which functions as a nucleic acid chaperone. Reverse transcription general...

journal_title：Journal of virology

authors： Thomas JA,Bosche WJ,Shatzer TL,Johnson DG,Gorelick RJ

更新日期：2008-10-01 00:00:00

abstract：:Radioimmunoassays were developed for the 19,000, 15,000, and 12,000 molecular weight polypeptides of avian myeloblastosis virus and for the 19,000 and 12,000 polypeptides of RAV-0, a subgroup E avian tumor virus. Each polypeptide was shown to possess both group- and type-specific antigenic determinants, in contrast to...

journal_title：Journal of virology

authors： Stephenson JR,Smith EJ,Crittenden LB,Aaronson SA

更新日期：1975-07-01 00:00:00

abstract：:The genome of the simian virus 40 (SV40) temperature-sensitive (ts) mutant tsD202 rescued by passage on transformed permissive monkey lines (see accompanying paper [Y. Gluzman et al., J. Virol. 24:534-540, 1977]) was analyzed by restriction endonuclease cleavage mapping to obtain biochemical evidence that the rescue o...

journal_title：Journal of virology

authors： Vogel T,Gluzman Y,Winocour E

更新日期：1977-11-01 00:00:00

abstract：:Dengue virus (DENV) is an important human pathogen, especially in the tropical and subtropical parts of the world, causing considerable morbidity and mortality. DENV replication occurs in the cytoplasm; however, a high proportion of nonstructural protein 5 (NS5), containing methyltransferase (MTase) and RNA-dependent ...

journal_title：Journal of virology

authors： Kumar A,Bühler S,Selisko B,Davidson A,Mulder K,Canard B,Miller S,Bartenschlager R

更新日期：2013-04-01 00:00:00

abstract：:We previously observed that when human immunodeficiency virus (HIV)-infected T lymphocytes are added to epithelial cells, they adhere, polarize, and secrete virions unidirectionally onto the epithelium. Epithelial cells subsequently take up virus and become productively infected. We report here that colchicine treatme...

journal_title：Journal of virology

authors： Pearce-Pratt R,Malamud D,Phillips DM

更新日期：1994-05-01 00:00:00

abstract：UNLABELLED:Japanese encephalitis (JE) is an arthropod-borne disease associated with the majority of viral encephalitis cases in the Asia-Pacific region. The causative agent, Japanese encephalitis virus (JEV), has been phylogenetically divided into five genotypes. Recent surveillance data indicate that genotype I (GI) i...

journal_title：Journal of virology

authors： Han N,Adams J,Chen P,Guo ZY,Zhong XF,Fang W,Li N,Wen L,Tao XY,Yuan ZM,Rayner S

更新日期：2014-10-01 00:00:00

abstract：:Herein we demonstrate that chronic simian immunodeficiency virus (SIV) infection induces significant upregulation of the gut-homing marker alpha4beta7 on macaque NK cells, coupled with downregulation of the lymph node-trafficking marker, CCR7. Interestingly, in naïve animals, alpha4beta7 expression was associated with...

journal_title：Journal of virology

authors： Reeves RK,Evans TI,Gillis J,Johnson RP

更新日期：2010-09-01 00:00:00

abstract：:Herpes simplex virus establishes latent infections in the nuclei of sensory neurons. These infections are characterized by the abundant expression of a series of 5' coterminal transcripts termed the latency-associated transcripts (LATs). Available evidence indicates that LAT expression is specifically regulated in lat...

journal_title：Journal of virology

authors： Frazier DP,Cox D,Godshalk EM,Schaffer PA

更新日期：1996-11-01 00:00:00

abstract：:In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional...

journal_title：Journal of virology

authors： Bello NF,Wu F,Sette P,Dussupt V,Hirsch VM,Bouamr F

更新日期：2011-11-01 00:00:00