Abstract:
BACKGROUND:Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. In the present study, we investigated whether a mouse cementoblast cell line, OCCM-30 cells, that was stimulated with interleukin (IL)-1alpha produced COX-2-dependent PGE(2) and whether the produced PGE(2) affected IL-1alpha-induced IL-6 production. METHODS:OCCM-30 cells were stimulated with vehicle or IL-1alpha in the presence or absence of indomethacin (a COX-1/COX-2 inhibitor), NS-398 (a specific COX-2 inhibitor), PGE(2), and EP receptor agonists. PGE(2) and IL-6 levels were assayed by enzyme linked immunosorbent assay. RESULTS:IL-1alpha induced PGE(2) production in a time-dependent fashion. Indomethacin and NS-398 completely inhibited IL-1alpha-induced PGE(2) production. 17-phenyl-omega-trinor PGE(2) (an EP(1) agonist) and an EP(4) agonist mimicked PGE(2) enhancement of IL-1alpha-induced IL-6 production in OCCM-30 cells. CONCLUSIONS:From these data, we suggest that IL-1alpha induced PGE(2) production in a COX-2-dependent manner in OCCM-30 cells and that the COX-2-derived PGE(2) upregulates IL-1alpha-elicited IL-6 production via EP(1) and/or EP(4) receptors. PGE(2) and IL-6 produced by cementoblasts may be involved in the pathogenesis of periodontal disease.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Noguchi K,Miyauchi M,Oka H,Komaki M,Somerman MJ,Takata Tdoi
10.1902/jop.2007.060257subject
Has Abstractpub_date
2007-01-01 00:00:00pages
135-40issue
1eissn
0022-3492issn
1943-3670journal_volume
78pub_type
杂志文章abstract:BACKGROUND:Resorption of grafted bone and delayed osseointegration of implants are main problems associated with alveolar bone augmentation in dental implantology, especially for patients with osteoporosis. The aim of this study is to investigate the early healing response of implants to systemic treatment of zoledroni...
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abstract::THE MORBIDITY and incidence of bacteremia in periodontal surgery with or without cephalexin prophylaxis were assessed in adults on the basis of clinical evaluations and blood cultures. Cephalexin reduced the incidence of polymicrobic bacteremias. There was no correlation between objective signs of tissue healing and a...
journal_title:Journal of periodontology
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doi:10.1902/jop.1982.53.5.319
更新日期:1982-05-01 00:00:00
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doi:10.1902/jop.2013.130167
更新日期:2014-02-01 00:00:00
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.6.1016
更新日期:2005-06-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.3.149
更新日期:1984-03-01 00:00:00
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journal_title:Journal of periodontology
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journal_title:Journal of periodontology
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更新日期:2009-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1902/jop.1996.67.2.78
更新日期:1996-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2009.080288
更新日期:2009-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析
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更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:The aim of the present study is to assess the osteogenic differentiation of rat bone marrow stromal cells (RBMCs) in β-tricalcium phosphate (β-TCP) blocks containing extracellular matrix (ECM) produced by human alveolar bone periosteal cells (HABPCs). METHODS:HABPCs were cultured in β-TCP blocks for 1 week ...
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doi:10.1902/jop.2012.120490
更新日期:2013-10-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.10s.1085
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.10.608
更新日期:1975-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1983.54.12.740
更新日期:1983-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.7.422
更新日期:1986-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.3.249
更新日期:1997-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050159
更新日期:2006-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060336
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060398
更新日期:2007-06-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.12.1397
更新日期:1998-12-01 00:00:00