Abstract:
BACKGROUND:In a previous study, recombinant human transforming growth factor-beta1 (rhTGF-β1 ) in a calcium carbonate carrier was implanted into critical-size, supraalveolar periodontal defects under conditions for guided tissue regeneration (GTR) to study whether rhTGF-β1 would enhance or accelerate periodontal regeneration. The results showed minimal benefits of rhTGF-β1 , and a clear account for this could not be offered. One potential cause may be that the rhTGF-β1 formulation was biologically inactive. Several growth or differentiation factors have been suggested to accelerate degradation of biomaterials used as carriers. The objective of this study was to evaluate possible activity of rhTGF-β1 on biodegradation of the calcium carbonate carrier. METHODS:rhTGF-β1 in a putty-formulated particulate calcium carbonate carrier was implanted into critical-size, supraalveolar periodontal defects under conditions for GTR in five beagle dogs. Contralateral defects received the calcium carbonate carrier combined with GTR without rhTGF-β1 (control). The animals were euthanized at week 4 post-surgery and block biopsies of the defect sites were collected for histologic and histometric analysis. Radiographs were obtained at defect creation and weeks 2 and 4 after defect creation. RESULTS:No statistically significant differences were observed in new bone formation (bone height and area) among the treatments. However, total residual carrier was significantly reduced in sites receiving rhTGF-β1 compared to control (P = 0.04). Similarly, carrier density was considerably reduced in sites receiving rhTGF-β1 compared to control; the difference was borderline statistically significant (P = 0.06). CONCLUSION:Within the limitations of the study, it may be concluded that rhTGF-β1 accelerates biodegradation of a particulate calcium carbonate biomaterial, indicating a biologic activity of the rhTGF-β1 formulation apparently not encompassing enhanced or accelerated periodontal regeneration.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Koo KT,Susin C,Wikesjö UME,Choi SH,Kim CKdoi
10.1902/jop.2007.060336subject
Has Abstractpub_date
2007-04-01 00:00:00pages
723-729issue
4eissn
0022-3492issn
1943-3670journal_volume
78pub_type
杂志文章abstract::The purpose of this study was to determine the levels of calprotectin and lactoferrin, 2 microbiostatic proteins, in the gingival crevicular fluid (GCF) of normal children. The children represented a population, primarily underprivileged, seeking care at a regional dental health care center. GCF was collected from Ram...
journal_title:Journal of periodontology
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doi:10.1902/jop.1998.69.8.879
更新日期:1998-08-01 00:00:00
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2013.120701
更新日期:2013-12-01 00:00:00
abstract::The oral hygiene, the gingival condition, pocket depth, and the incidence of caries on crowned teeth were studied during a period of 5 years in a group of patients (114) who had been treated with fixed dental prostheses. Prior to the prosthetic treatment, the patients received periodontal treatment. During the study, ...
journal_title:Journal of periodontology
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doi:10.1902/jop.1977.48.4.221
更新日期:1977-04-01 00:00:00
abstract::To quantify patient perceptions of periodontal therapy, we administered a self-report questionnaire employing a visual analog scale (VAS) to 162 patients following surgical and non-surgical treatments. The questionnaire tested for variables of pain, sensitivity, swelling, function, altered appearance, comparison of po...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.10.990
更新日期:1993-10-01 00:00:00
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doi:10.1902/jop.2008.070621
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-07-01 00:00:00
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doi:10.1902/jop.1999.70.2.205
更新日期:1999-02-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1977.48.9.570
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journal_title:Journal of periodontology
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doi:10.1902/jop.2011.110480
更新日期:2012-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.4.267
更新日期:1995-04-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070117
更新日期:2007-11-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.1.45
更新日期:2002-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1976.47.3.139
更新日期:1976-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.1.41
更新日期:1981-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,评审
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更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2000.71.10.1654
更新日期:2000-10-01 00:00:00
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更新日期:2019-02-19 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1999.70.11.1361
更新日期:1999-11-01 00:00:00
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journal_title:Journal of periodontology
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doi:10.1902/jop.2011.100638
更新日期:2011-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1457
更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2014.130595
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The great variability of periodontal and systemic responses to experimental periodontitis reflects the inherent pathogenic complexity of mice models and could limit the resulting interpretations and their extension to human diseases. This study compared the effect of Porphyromonas gingivalis (Pg) infection a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110540
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2003.74.7.982
更新日期:2003-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.6.781
更新日期:2004-06-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2009.090086
更新日期:2009-08-01 00:00:00