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Increased Interleukin-1β Concentration in Gingival Crevicular Fluid as a Characteristic of Periodontitis.

Abstract：

BACKGROUND:The levels of interleukin-1β (IL-1β) have been reported to be higher in sites with periodontitis than in healthy controls. This may be the result of a more severe inflammation and/or constitutional differences in IL-1β production. Our aim was to test the hypothesis that the level of IL-1β in gingival crevicular fluid (GCF) is a characteristic trait of periodontitis, regardless of the degree of tissue destruction. As a secondary aim, we investigated the correlation between IL-1β and neutrophil elastase. An untreated population was used. METHODS:GCF samples from inflamed sites in 13 patients with gingivitis (GG), and from inflamed sites with shallow (GP) and deep (PP) pockets in 18 patients with periodontitis were collected. Interleukin-1β, elastase-α-1-antitrypsin complex (E-A1AT), α-1-antitrypsin (A1AT), and α-2-macroglobulin (A2MG) were measured with ELISA. Elastase activity was measured with a specific substrate. RESULTS:The concentration of IL-1β was significantly higher in PP than in GG, but no significant differences were detected between PP and GP. A weak positive correlation between the elastase activity and IL-1β was also observed. The elastase activity had a tendency to be higher in PP, although no significant difference was found among the 3 groups. The concentrations of E-A1AT, A1AT, and A2MG were similar in the 3 types of sites. CONCLUSIONS:The levels of IL-1β in GCF were increased in samples from periodontitis patients, regardless of the severity of disease at the sampled site, suggesting that the levels of IL-1β are typical of a given patient. J Periodontol 1999;70:1457-1463.

journal_name

J Periodontol

journal_title

Journal of periodontology

authors

Figueredo CMS,Ribeiro MSM,Fischer RG,Gustafsson A

doi

10.1902/jop.1999.70.12.1457

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1457-1463

issue

12

eissn

0022-3492

issn

1943-3670

journal_volume

70

pub_type

杂志文章

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