Abstract：
BACKGROUND:Low-calorie diets are commonplace for reducing body weight. However, no information is available on the effects of a reduced-calorie diet on periodontal inflammation and disease. The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an animal model of periodontitis. METHODS:Periodontitis was induced in 55 young, healthy, adult rhesus monkeys (Macaca mulatta) by tying 2.0 silk ligatures at the gingival margins of maxillary premolar/molar teeth. Animals on a CR diet (30% CR; N = 23) were compared to ad libitum diet controls (N = 32). Clinical measures, including the plaque index (PI), probing depth (PD), clinical attachment level (CAL), modified gingival index (GI), and bleeding on probing (BOP) were recorded at baseline and 1, 2, and 3 months after ligature placement. RESULTS:Significant effects of CR were observed on the development of inflammation and the progression of periodontal destruction in this model. Compared to controls, CR resulted in a significant reduction in ligature-induced GI (P <0.0001), BOP (P <0.0015), PD (P <0.0016), and CAL (P <0.0038). Periodontal destruction, as measured by CAL, progressed significantly more slowly in the CR animals than in the controls (P <0.001). CONCLUSIONS:These clinical findings are consistent with available evidence that CR has anti-inflammatory effects. Moreover, these experimental findings are the first observations, to the best of our knowledge, that CR dampens the inflammatory response and reduces active periodontal breakdown associated with an acute microbial challenge.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Branch-Mays GL,Dawson DR,Gunsolley JC,Reynolds MA,Ebersole JL,Novak KF,Mattison JA,Ingram DK,Novak MJdoi
10.1902/jop.2008.070629subject
Has Abstractpub_date
2008-07-01 00:00:00pages
1184-91issue
7eissn
0022-3492issn
1943-3670journal_volume
79pub_type
杂志文章abstract：BACKGROUND:Aspartate aminotransferase (AST) is an enzyme normally confined to the cytoplasm of cells, but released to the exracellular environment upon cell death. Its levels are associated with the severity of experimental gingivitis and the loss of periodontal attachement. The aim of the present study was to investig...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2000.71.7.1151
更新日期：2000-07-01 00:00:00
abstract：:Serial histological sections of gingiva obtained from each of six advanced adult periodontitis, two localized juvenile periodontitis and two periodontally healthy patients were used for specific identification of bacteria within the oral epithelium and adjacent connective tissue. Healthy gingival biopsies served as co...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1986.57.8.492
更新日期：1986-08-01 00:00:00
abstract：:The Orbison ultrasonic instrument and the Cavitron ultrasonic dental unit were compared for the smoothness of the root surfaces they produced. Twenty teeth were analyzed with the scanning electron microscope and classified as to rough or smooth. Both instruments produced similar degrees of smoothness on the root surfa...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1975.46.2.119
更新日期：1975-02-01 00:00:00
abstract：:Classification by origin and structure of the many different coatings which occur on the surfaces of teeth and artificial surfaces exposed to the oral environment necessitate a revision of the terminology used to describe these coatings. Numerous gaps still exist in our understanding of the origin, morphological struc...
journal_title：Journal of periodontology
pub_type： 杂志文章,评审
doi：10.1902/jop.1976.47.3.139
更新日期：1976-03-01 00:00:00
abstract：BACKGROUND:Recently, a genetic marker (IL-1 genotype) that identifies individuals at higher risk for developing severe periodontal disease was discovered. A subgroup of the population reported on earlier was evaluated to determine if knowledge of the patient's IL-1 genotype would improve accuracy in assignment of progn...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1999.70.1.49
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Recent research indicated that periodontal infection may worsen systemic diseases, including pulmonary disease. Respiratory infections, such as pneumonia and the exacerbation of chronic obstructive pulmonary disease, involve the aspiration of bacteria from the oropharynx into the lower respiratory tract. ME...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2011.100582
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Pentraxins are acute-phase proteins that belong to a family of evolutionarily conserved proteins, and they are considered markers of inflammation. Pentraxin-3 (PTX3) is a prototype of the long pentraxin group. It is suggested to play an important role in innate resistance against pathogens, regulation of inf...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2013.120718
更新日期：2014-02-01 00:00:00
abstract：:The purpose of this investigation was to evaluate calcium hydroxide and potassium nitrate individually as densensitizing agents for hypersensitive root surfaces. The apparatus used in the experiment to measure hypersensitivity was (a) a thermo-electric stimulating device to measure hot and cold stimulation quantitativ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1977.48.10.667
更新日期：1977-10-01 00:00:00
abstract：BACKGROUND:One endpoint of periodontal therapy is to regenerate the structure lost due to periodontal disease. In the periodontium, gingival epithelium is regenerated by oral epithelium. Underlying connective tissue, periodontal ligament, bone, and cementum are derived from connective tissue. Primitive connective tissu...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2005.76.12.2194
更新日期：2005-12-01 00:00:00
abstract：:Computer-based thermal imaging techniques were used to compare the rewarming rates of normal and inflamed human gingiva following cooling. A Modified Gingival Index (MGI) score, gingival crevicular fluid (GCF) measurement, and clinical photograph were obtained from a maxillary or mandibular anterior facial region in 2...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1989.60.11.628
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:The aim of the present study is to assess the osteogenic differentiation of rat bone marrow stromal cells (RBMCs) in β-tricalcium phosphate (β-TCP) blocks containing extracellular matrix (ECM) produced by human alveolar bone periosteal cells (HABPCs). METHODS:HABPCs were cultured in β-TCP blocks for 1 week ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2012.120490
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Guided bone regeneration (GBR) has been widely utilized for the promotion of bone augmentation in bone loss areas. However, little information has been available regarding chronological changes in newly formed bone and alterations in the nature of newly formed bone after removal of a barrier membrane. The pr...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2000.71.3.341
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:An experimental periodontal sensor probe (SP) equipped with an optical fiber for recording function was developed. The aim was to test the intraexaminer reproducibility of probing using the SP and to assess the consistency with the manual probe (MP). METHODS:The SP was assembled with an external sheath cove...
journal_title：Journal of periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1902/jop.2011.110047
更新日期：2012-02-01 00:00:00
abstract：:1. The subjective separation of the normal and the diseased periodontium for splinting purposes is artificial. With the exception of cases of secondary trauma from occlusion, the diseased periodontium should be treated in the same manner as the normal periodontium with regards to splinting. 2. Retionales for stabiliza...
journal_title：Journal of periodontology
pub_type： 杂志文章,评审
doi：10.1902/jop.1976.47.7.405
更新日期：1976-07-01 00:00:00
abstract：:Three block sections of treated human intraosseous lesions within one individual are presented. These lesions were debrided, filled with autogenous grafts and at two sites the root was treated with citric acid. The treated sites were lightly root planed once a month and the blocks were removed 6 months after surgery. ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1983.54.2.67
更新日期：1983-02-01 00:00:00
abstract：:Several different types of interactions are possible between a chemical, a mixture of chemicals, and associated extrinsic factors (i.e., mechanical irritation) in the oral mucosa. These interactions can be broadly classified as irritative or allergenic in nature. In each case, the pathology usually includes mucosal in...
journal_title：Journal of periodontology
pub_type： 杂志文章,评审
doi：10.1902/jop.1998.69.6.620
更新日期：1998-06-01 00:00:00
abstract：:The clinical efficacy of minocycline in a subgingival local delivery system was evaluated alone (M) or as an adjunct to scaling and root planing (M + SRP), in comparison to scaling and root planing (SRP) or to no subgingival treatment (NoTx) in adult periodontitis. Fifty-one adult patients with > or = 7 mm periodontal...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1902/jop.1994.65.11.1058
更新日期：1994-11-01 00:00:00
abstract：:A surgical and suturing method is described for the subgingival placement of Gore-tex periodontal material during new attachment procedures. The periodontal material isolates the root surface from epithelium and gingival connective tissue. Three cases were treated. Clinical new attachment was evident from clinical pro...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1987.58.12.819
更新日期：1987-12-01 00:00:00
abstract：:Ceramic grafting material was used to treat a vertical osseous defect associated with a maxillary left lateral incisor tooth. The area was monitored at maintenance appointments. Root resorption was detected radiographically 12 months after grafting. At 18 months, resorption was evident clinically in the presence of mo...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1985.56.7.419
更新日期：1985-07-01 00:00:00
abstract：BACKGROUND:Immediate functional loading is a new surgical-prosthetic technique that can be used extensively in implant placement. Because of a lack of experimental reports regarding edentulous maxilla, we decided to evaluate the survival rate of immediately loaded dental implants in this area. METHODS:Forty-three pati...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2005.76.6.1016
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Chronic inflammation has been implicated in the pathogenesis of gestational diabetes mellitus (GDM). Periodontal disease is associated with increased levels of inflammatory mediators and may be a risk factor for GDM. The authors aimed to examine the association between periodontitis and GDM among non-smoking...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2012.120344
更新日期：2013-07-01 00:00:00
abstract：:Intraoral transmission radiographs have been the primary diagnostic method for the assessment of bone support as well as for the detection and measurement of osseous changes due to periodontitis. The purpose of the present paper is three-fold. The first is to review radiographic techniques for the assessment of period...
journal_title：Journal of periodontology
pub_type： 杂志文章,评审
doi：10.1902/jop.1992.63.4s.367
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:The protease-induced cytotoxicity of P. gingivalis may partly result from alteration of the extracellular matrix and/or surface receptors that mediate interaction between the host cells and their matrix. While P. gingivalis-induced degradation of E-cadherin has been documented, there is no information on the...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2001.72.5.641
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:This case report describes a 22-year-old female who was referred with a radiolucent lesion between her mandibular right molars. The original radiographic image suggested an odontogenic cyst. METHODS:The surgical enucleation and osteotomy of the residual cavity were performed with a piezoelectric knife. Hist...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2007.060417
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to evaluate the adjunctive effect of the local application of a hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis. METHODS:Twelve patients with chronic periodontitis were recruited to participate in a study with a split-mouth design and pro...
journal_title：Journal of periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1902/jop.2009.090128
更新日期：2009-09-01 00:00:00
abstract：:The purpose of this study was to evaluate interexaminer and intraexaminer probing force variations in various regions of the mouth and adjacent to different tooth surfaces. Fifty-eight dental clinicians composed of 13 periodontists, 15 general dentists, 15 hygienists and 15 senior dental students probed the facial sur...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1983.54.8.488
更新日期：1983-08-01 00:00:00
abstract：BACKGROUND:Cyclosporin A (CsA) induces gingival overgrowth (GO) in patients who seem to be prone to this disorder. It is still impossible to determine which patients will develop GO. Patients treated with the new immunosuppressive drug tacrolimus seem not to have GO. The aims of this study were to investigate transform...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2006.050086
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Systemic bone loss has been proposed as a risk factor for periodontal disease; however, the relationship between these two diseases is still not clear. The objective of this study was to assess the relationship between systemic bone mineral density and periodontal disease, controlling for known confounders. ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2000.71.9.1492
更新日期：2000-09-01 00:00:00
abstract：:The feasibility of a new combined collagen gel-autolysed antigen-extracted allogeneic bone implant was tested. Its effect on gaining new attachment in surgically created defects in four dogs was evaluated over 24 weeks. As controls, sites receiving implants of the bone implant alone, nonimplanted and untreated defects...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1986.57.2.84
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:Sarcoidosis is an inflammatory granulomatous systemic disease that rarely affects the oral cavity. Gingival involvement has been reported in only a very limited number of cases, occasionally as the first manifestation of the disease. This article reports a case of sarcoidosis affecting the gingiva and alveol...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2008.070139
更新日期：2008-03-01 00:00:00
