Abstract:
BACKGROUND:Pentraxins are acute-phase proteins that belong to a family of evolutionarily conserved proteins, and they are considered markers of inflammation. Pentraxin-3 (PTX3) is a prototype of the long pentraxin group. It is suggested to play an important role in innate resistance against pathogens, regulation of inflammation, and clearance of apoptotic cells. The aim of this study is to estimate the level of PTX3 in gingival tissues of individuals with chronic (CP) and aggressive (AgP) periodontitis and control participants and further correlate the level of PTX3 with clinical parameters. METHODS:The study population consisted of 50 participants ranging in age from 20 to 55 years and attending the outpatient section of Department of Periodontics, Saveetha Dental College and Hospital, Chennai, India. The study groups included the following: 1) group A, patients with generalized CP (n = 20); 2) group B (n = 20), patients with generalized AgP (GAgP); and 3) group C (n = 10), healthy controls. Tissue samples from participants were assayed for PTX3 levels using enzyme-linked immunosorbent assay. RESULTS:Gingival tissues from patients with GAgP (8.349 ± 5.076 ng/mL) had a higher mean concentration of PTX3 than tissues from patients with generalized CP (5.068 ± 3.274 ng/mL) and controls (0.251 ± 0.277). The PTX3 levels in the gingival tissues correlated positively with clinical parameters in all the groups. Among the parameters, probing depth was the most significant predictor variable associated with PTX3 in cases with periodontitis. CONCLUSIONS:PTX3 concentration in gingival tissues of patients with GAgP was higher than in tissues from patients with CP, and the levels correlated positively with clinical parameters. Hence, tissue PTX3 level can be considered a marker of inflammation in periodontal disease.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Lakshmanan R,Jayakumar ND,Sankari M,Padmalatha O,Varghese Sdoi
10.1902/jop.2013.120718subject
Has Abstractpub_date
2014-02-01 00:00:00pages
290-7issue
2eissn
0022-3492issn
1943-3670journal_volume
85pub_type
杂志文章abstract::Linear IgA disease (LAD) is a chronic, subepithelial blistering disease that is associated with the presence of linear deposits of IgA along the basement membrane zone. Etiopathogenic aspects of LAD are only partially known. LAD is clinically characterized by vesiculobullous skin and mucous lesions. Although more than...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.6.879
更新日期:2003-06-01 00:00:00
abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon blood stem cell disorder. The acquired defect is in the cell membrane of the precursor of the affected clone, which renders erythrocytes, platelets and granulocytes unusually sensitive to the hemolytic effects of complement. It is characterized by chronic hemoly...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.2.115
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:A subcategory of chronic neutropenia is chronic benign neutropenia, which is characterized by a prolonged non-cyclic neutropenia as the sole abnormality, with no underlying disease to which the neutropenia can be attributed. Chronic neutropenia is defined as a low absolute neutrophil count for >6 months. In ...
journal_title:Journal of periodontology
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doi:10.1902/jop.2006.060076
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Patients with juvenile idiopathic arthritis (JIA) have been shown to have incipient attachment loss (AL) more frequently than systemically healthy individuals. This study investigated neutrophil activity and proinflammatory cytokines in these patients and aged-matched controls. METHODS:Elastase activity, me...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.1.75
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the effect of strict supragingival plaque control on the subgingival microbiota in smokers and never-smokers. Research into the impact of supragingival plaque control on the number of subgingival bacteria has resulted in contradictory findings. Real-time polymeras...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2008.070558
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:This cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. METHODS:Samples from 97 implants/teeth (58 implants [19 hea...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160751
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Today, implants are placed using both non-submerged and submerged approaches, and in 1- and 2-piece configurations. Previous work has demonstrated that peri-implant crestal bone reactions differ radiographically under such conditions and are dependent on a rough/smooth implant border in 1-piece implants and ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.9.1412
更新日期:2000-09-01 00:00:00
abstract::This study was conducted to determine the possible influence of diabetes on the pathogenesis of periodontal disease. A total of 148 patients, 120 females and 28 males, were surveyed. Their ages ranged between 9 and 50 years, with an average age of 30. The experimental group consisted of 83 diabetics and there was a co...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.9.445
更新日期:1978-09-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0364
更新日期:2019-12-18 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.9.1081
更新日期:1998-09-01 00:00:00
abstract::Treatment of endodontically and periodontally involved teeth requires accurate diagnosis to determine the primary cause. The case presented involves a deep periodontal pocket associated with a necrotic tooth. The cause was diagnosed as being primarily endodontic and regeneration of the attachment apparatus occurred af...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.7.469
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Alveolar ridge augmentation procedures are often needed prior to implant placement or prosthetic rehabilitation. The purpose of this study was to develop a quantitative method to assess the clinical outcome of such procedures. METHODS:Two volumetric methods, based on the volume difference between the pre- a...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.3.302
更新日期:2002-03-01 00:00:00
abstract::A technique designed to utilize the autogenous free gingival graft without the use of sutures was demonstrated. Necessary objectives were maintained but achieved without unnecessarily piercing the graft, and in less time. The only variance in results would be due to the underlying physical properties of the recipient ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.2.75
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:This study explored which factors affected patients' decisions to pursue either surgical or non-surgical periodontal treatment. METHODS:Data were collected from 74 patients at a regularly scheduled periodontal appointment, at which each patient was told that periodontal treatment was needed, and 2 weeks fol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050206
更新日期:2006-04-01 00:00:00
abstract::Bacterial invasion of the pocket epithelium and underlying connective tissue was found in seven cases of advanced human periodontitis. Four cases showed invasion of the epithelium as well as the connective tissue while in the other three cases bacterial invasion was limited to the pocket epithelium. The microorganisms...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.10.567
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Only a few studies have examined the association between periodontitis and glycated hemoglobin (HbA1c) levels in individuals without diabetes. The aim of this study is to compare HbA1c levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130661
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate inter-implant bone crest height changes between immediate and non-immediate dental implants placed in the anterior maxillary region. METHODS:A retrospective study was conducted on consecutively treated patients requiring at least two adjacent implants in the anterio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060443
更新日期:2007-06-01 00:00:00
abstract::Studies of the inductive properties of human dentin and cementum have yielded differing results. Comparisons are difficult to draw because of variations in time, donor tissue, host immunologic status, implant site, decalcifying agents and degree of decalcification. Analysis of the many experiments intimates that the a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.11.699
更新日期:1985-11-01 00:00:00
abstract::von Willebrand's disease (vWD) is one of the most common hereditary hemorrhagic disorders. A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding. In this case report, the periodontal treatment of a patient with vWD is described. A 45-year-old woman with...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.5.548
更新日期:1999-05-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.12.1785
更新日期:2003-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2009.080400
更新日期:2009-02-01 00:00:00
abstract::Increasingly, patients referred to periodontists have undergone some form of non-surgical periodontal treatment prior to their referral. As a result of this, there is an increased need to treat isolated, rather than generalized, periodontal defects. A surgical technique that utilizes small incisions and a limited acce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1547
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Various modifications of the laterally sliding flap have been proposed to reduce the risk of gingival recession at the donor tooth site, but the reported root coverage predictability was quite low. The goal of the present study was to evaluate the effectiveness with respect to root coverage of a modified sur...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.12.1734
更新日期:2004-12-01 00:00:00
abstract::This study tested the hypothesis that severe periodontitis in persons with non-insulin-dependent diabetes mellitus (NIDDM) increases the risk of poor glycemic control. Data from the longitudinal study of residents of the Gila River Indian Community were analyzed for dentate subjects aged 18 to 67, comprising all those...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.10s.1085
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Little information is available about the effects of the cessation of cigarette smoking on oral health, although cigarette smoking has been shown to be associated with a variety of oral diseases. The aim of this study was to compare periodontal status, salivary proteolytic activity, especially collagenase-2 ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.11.1361
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:The minimum inhibitory concentration (MIC) does not provide information on the efficacy of antimicrobial agents against infections involving biofilms, which are many times more resistant than planktonic forms of bacteria. This report is on the design and initial trial of a device for growing standard biofilm...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1443
更新日期:2005-09-01 00:00:00
abstract::This study examined the effect of oral food consumption on the prevalence and levels of subgingival bacteria and yeasts in 20 gastrostomy tube-fed children and 24 healthy controls. Microbial identification was carried out using anaerobic culture and 16S rRNA-based PCR identification methods. Streptococcal and Actinomy...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.12.1163
更新日期:1997-12-01 00:00:00
abstract::A National Survey of the Oral Health of U.S. children aged 5 to 17 was conducted by the National Institute of Dental Research during the 1986-87 school year. Eleven thousand and seven adolescents aged 14 to 17 years received a periodontal assessment. Their patterns of loss of periodontal attachment as assessed by prob...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.10.608
更新日期:1991-10-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080510
更新日期:2009-03-01 00:00:00
abstract::Localized juvenile periodontitis (LJP) is an aggressive periodontal disease of familial nature. Neutrophils from a majority of patients with this disease exhibit decreased Chemotaxis with increased adherence, oxidative burst, and degranulation in response to opsonized bacteria. It is proposed that the biological basis...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.3s.337
更新日期:1996-03-01 00:00:00