Irritant contact stomatitis: a review of the condition.


:Several different types of interactions are possible between a chemical, a mixture of chemicals, and associated extrinsic factors (i.e., mechanical irritation) in the oral mucosa. These interactions can be broadly classified as irritative or allergenic in nature. In each case, the pathology usually includes mucosal inflammation. The information compiled and reviewed in this article suggests that, given the broad definition of surface lesions/mucosal abnormalities, there may be a continuum of irritation that can be termed "irritant contact stomatitis." This may be due to the fact that the mouth is lined with highly vascular mucosa that turns over rapidly compared to the skin, and may or may not be covered by keratin. Some regions in the mouth are uniquely sensitive to irritants because they can penetrate through the tissue easily. Key factors involved in the potential development of irritation are: inherent irritation potential of the agent, amount of exposure (concentration, duration, and frequency), ability to penetrate the tissue, and inherent reactivity of the subject as well as other extrinsic factors. Irritation leading to oral mucosal alterations is a common occurrence caused by a wide variety of exposures and insults to the oral cavity. Various irritants such as foods, chemicals, friction, thermal/mechanical injury, metals, spices, and oral care products have been documented to cause irritant reactions in susceptible individuals, particularly if used under exaggerated exposure conditions. It is important to note that most irritation in the oral cavity tends to reverse quickly when the causative agent is removed. Oral irritation is a commonly occurring phenomenon. Thus, it is important that the clinician be aware of the clinical manifestations and etiology of the condition.


J Periodontol


Davis CC,Squier CA,Lilly GE




Has Abstract


1998-06-01 00:00:00












  • Acceptance Program Guidelines. Products designed to regenerate periodontal tissues. Council on Scientific Affairs. American Dental Association.

    abstract:SCOPE:These Guidelines apply to products used to promote the regeneration of periodontal tissues lost due to periodontal diseases or other causes. Periodontal regeneration is defined histologically as regeneration of the tooth's supporting tissues, including alveolar bone, periodontal ligament, and cementum over a prev...

    journal_title:Journal of periodontology

    pub_type: 杂志文章



    更新日期:1998-09-01 00:00:00

  • Enhancement of bone formation by bone morphogenetic protein-2 during alveolar distraction: an experimental study in sheep.

    abstract:BACKGROUND:The purpose of this study was to perform alveolar ridge augmentation by distraction osteogenesis (DO) and to enhance bone regeneration through the use of recombinant human bone morphogenetic protein-2 (rhBMP-2), followed by implant placement. METHODS:Alveolar segmental osteotomy was performed in the mandibl...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Rachmiel A,Aizenbud D,Peled M

    更新日期:2004-11-01 00:00:00

  • Treatment of dehiscence-type defects with collagen matrix and/or enamel matrix derivative: Histomorphometric study in minipigs.

    abstract:BACKGROUND:This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehiscence-type recession defects in minipigs. METHODS:Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated. Bilateral dehiscence-type...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: França-Grohmann IL,Sangiorgio JPM,Bueno MR,Casarin RCV,Silvério Ruiz KG,Nociti FH Jr,Casati MZ,Sallum EA

    更新日期:2020-07-01 00:00:00

  • Hepatitis. A review of the disease and its significance to dentistry.

    abstract::The report is a review of the literature related to hepatitis B and its implications for dental practitioners. Hepatitis B represents a serious health risk among dentists and simple preventive measures can greatly reduce the risk of transmission or contraction of the disease. Certain positive findings in a healthy his...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审


    authors: Withers JA

    更新日期:1980-03-01 00:00:00

  • Analysis of daytime variations in gingival crevicular fluid: a circadian periodicity?

    abstract:BACKGROUND:Volumetric alterations in gingival crevicular fluid (GCF) are widely accepted to be associated with periodontal health/disease. The volume/flow of GCF was shown to be affected by an array of methodological factors. However, relatively limited information is available on whether GCF is subject to circadian rh...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Günday S,Topcu AO,Ercan E,Yamalik N

    更新日期:2014-03-01 00:00:00

  • Mast cell subpopulations in gingival overgrowth induced by immunosuppressive and nifedipine medication.

    abstract:BACKGROUND:An immunohistochemical study was conducted to compare distributions of mast cell subpopulations in normal human gingiva and in gingival overgrowth induced by nifedipine and immunosuppressive medication. METHODS:Gingival samples were collected from 12 triple-medicated organ transplant recipients (immunosuppr...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Nurmenniemi PK,Pernu HE,Knuuttila ML

    更新日期:2004-07-01 00:00:00

  • Dental infections and cardiovascular diseases: a review.

    abstract::Accumulating evidence suggests that chronic infections, such as periodontitis, are associated with increased risk for cardiovascular diseases (CVD). The mechanisms behind the association are not known. Like herpes viruses and Chlamydia pneumoniae, periodontal pathogens cause atherosclerosis in experimental animals and...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审


    authors: Mattila KJ,Pussinen PJ,Paju S

    更新日期:2005-11-01 00:00:00

  • The effect of risk communication on periodontal treatment outcomes: A randomized controlled trial.

    abstract:BACKGROUND:This study determines the effects of a routine assessment (Treatment as Usual, TAU) versus a risk communication intervention (Risk) versus a Goal-Setting, Planning and Self-Monitoring (GPS) intervention on periodontal disease patients' clinical and psychological outcomes. METHODS:In a three-arm randomized c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Asimakopoulou K,Nolan M,McCarthy C,Newton JT

    更新日期:2019-09-01 00:00:00

  • Efficacy of preprocedural mouth rinsing in reducing aerosol contamination produced by ultrasonic scaler: a pilot study.

    abstract:BACKGROUND:The aerosol generated by an ultrasonic scaler contains microorganisms that can penetrate into the body through the respiratory system of dental surgeons and patients. The aim of this pilot study is to evaluate and compare the efficacy of commercially available preprocedural mouthrinses containing 0.2% chlorh...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Gupta G,Mitra D,Ashok KP,Gupta A,Soni S,Ahmed S,Arya A

    更新日期:2014-04-01 00:00:00

  • Laterally moved, coronally advanced flap: a modified surgical approach for isolated recession-type defects.

    abstract:BACKGROUND:Various modifications of the laterally sliding flap have been proposed to reduce the risk of gingival recession at the donor tooth site, but the reported root coverage predictability was quite low. The goal of the present study was to evaluate the effectiveness with respect to root coverage of a modified sur...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Zucchelli G,Cesari C,Amore C,Montebugnoli L,De Sanctis M

    更新日期:2004-12-01 00:00:00

  • Estimation of pentraxin-3 levels in the gingival tissues of chronic and aggressive periodontitis participants: an in vivo study.

    abstract:BACKGROUND:Pentraxins are acute-phase proteins that belong to a family of evolutionarily conserved proteins, and they are considered markers of inflammation. Pentraxin-3 (PTX3) is a prototype of the long pentraxin group. It is suggested to play an important role in innate resistance against pathogens, regulation of inf...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Lakshmanan R,Jayakumar ND,Sankari M,Padmalatha O,Varghese S

    更新日期:2014-02-01 00:00:00

  • Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation.

    abstract::Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. The rationale for use of DFDBA includes the fact that proteins capable of inducing new bone; i.e., bone morphogenetic proteins, can be isolated from bone grafts. Commercial bone banks have provided DFDBA to the dental p...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Schwartz Z,Mellonig JT,Carnes DL Jr,de la Fontaine J,Cochran DL,Dean DD,Boyan BD

    更新日期:1996-09-01 00:00:00

  • Cytokines and bone-related factors in systemically healthy patients with chronic periodontitis and patients with type 2 diabetes and chronic periodontitis.

    abstract:BACKGROUND:This study compares the levels of cytokines and bone-related factors in the gingival crevicular fluid (GCF) of systemically healthy patients with chronic periodontitis (CP); and better-controlled, and poorly controlled patients with type 2 diabetes and CP. METHODS:Thirty-seven patients with type 2 diabetes ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Ribeiro FV,de Mendonça AC,Santos VR,Bastos MF,Figueiredo LC,Duarte PM

    更新日期:2011-08-01 00:00:00

  • Clinical and microbiological effects of controlled-release locally delivered minocycline in periodontitis.

    abstract::The clinical efficacy of minocycline in a subgingival local delivery system was evaluated alone (M) or as an adjunct to scaling and root planing (M + SRP), in comparison to scaling and root planing (SRP) or to no subgingival treatment (NoTx) in adult periodontitis. Fifty-one adult patients with > or = 7 mm periodontal...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones AA,Kornman KS,Newbold DA,Manwell MA

    更新日期:1994-11-01 00:00:00

  • Epidermolysis bullosa acquisita: clinical manifestations, microscopic findings, and surgical periodontal therapy. A case report.

    abstract:BACKGROUND:Epidermolysis bullosa acquisita (EBA) is an uncommon, acquired, chronic subepidermal bullous disease. This report describes a case of EBA with gingival involvement. A 43-year-old woman with EBA was referred to our clinic for periodontal therapy because of gingival tenderness and bleeding. She has been on cyc...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Hakki SS,Celenligil-Nazliel H,Karaduman A,Usubütün A,Ertoy D,Ayhan A,Ruacan S

    更新日期:2001-04-01 00:00:00

  • Effect of Fluoxetine on Periodontal Status in Patients With Depression: A Cross-Sectional Observational Study.

    abstract:BACKGROUND:Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to reduce periodontal disease severity in a rat ligature-induced periodontitis model. The objective of the present study is to investigate the influence of fluoxetine intake on periodontal parameters in patients with periodontitis with c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Bhatia A,Sharma RK,Tewari S,Khurana H,Narula SC

    更新日期:2015-08-01 00:00:00

  • Longitudinal observation of cementum regeneration through multiple fluorescent labeling.

    abstract::The assessment of new attachment after periodontal treatment has been the focus of continuous research. An approach to longitudinally examine the deposition of cementum was devised by using fluorescence microscopy (FL), contact microradiography (CMR), and toluidine blue staining (TBS) after the injection of three labe...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Ogura N,Mera T,Sato F,Ishikawa I

    更新日期:1991-04-01 00:00:00

  • A multi-center study comparing dual acid-etched and machined-surfaced implants in various bone qualities.

    abstract:BACKGROUND:A major reason for the success of modern dental implant systems has been the development of implant designs that enhance direct bone-implant interface. Surface roughness has been a factor in this success and different systems have utilized very different implant surface roughness. The major purpose of this s...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Khang W,Feldman S,Hawley CE,Gunsolley J

    更新日期:2001-10-01 00:00:00

  • Inter-implant bone height changes in anterior maxillary immediate and non-immediate adjacent dental implants.

    abstract:BACKGROUND:The purpose of this study was to evaluate inter-implant bone crest height changes between immediate and non-immediate dental implants placed in the anterior maxillary region. METHODS:A retrospective study was conducted on consecutively treated patients requiring at least two adjacent implants in the anterio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Kupershmidt I,Levin L,Schwartz-Arad D

    更新日期:2007-06-01 00:00:00

  • The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

    abstract::A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximate...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章


    authors: Vogel RI,Lamster IB,Wechsler SA,Macedo B,Hartley LJ,Macedo JA

    更新日期:1986-08-01 00:00:00

  • Movements of healthy and periodontally involved teeth measured with laser reflection technique.

    abstract::The laser reflection method of remote measurement was used to register small tooth movements of upper central incisors from a group of subjects with healthy teeth and another group with periodontally involved teeth. The mobility of the healthy maxillary incisors over a period of 24 hours was well within normal limits....

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Rydén H,Bjelkhagen H,Söder PO

    更新日期:1982-07-01 00:00:00

  • Clinical evaluation of calcium sulfate in combination with demineralized freeze-dried bone allograft for the treatment of human intraosseous defects.

    abstract:BACKGROUND:Medical-grade calcium sulfate (CS) is a biocompatible, bioabsorbable, and clinically versatile ceramic for use in bone repair. This study compared the clinical efficacy of a combination of calcium sulfate dihydrate, as a binder and barrier, and demineralized freeze-dried bone allograft (DFDBA) to polytetrafl...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Aichelmann-Reidy ME,Heath CD,Reynolds MA

    更新日期:2004-03-01 00:00:00

  • A Major Human Oral Lysophosphatidic Acid Species, LPA 18:1, Regulates Novel Genes in Human Gingival Fibroblasts.

    abstract:BACKGROUND:The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both normal physiology and inflammation in many systems. However, its actions are just beginning to be defined in oral biology and pathophysiology. METHODS:Microarray analysis was used to test the hypothesis that human gingival fi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Cerutis DR,Weston MD,Alnouti Y,Bathena SP,Nunn ME,Ogunleye AO,McVaney TP,Headen KV,Miyamoto T

    更新日期:2015-05-01 00:00:00

  • Prevalence of human herpesviruses in patients with aggressive periodontitis.

    abstract:BACKGROUND:Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV) and Epstein-Barr virus type-1 (EBV-1), seem to play a part in the pathogenesis of human periodontitis. The aim of this investigation was to evaluate the subgingival presence of HCMV and EBV in patients with aggress...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Yapar M,Saygun I,Ozdemir A,Kubar A,Sahin S

    更新日期:2003-11-01 00:00:00

  • Histochemical and immunocytochemical localization of dipeptidyl peptidases II and IV in human gingiva.

    abstract::Dipeptidyl peptidase (DPP) II and IV activities were demonstrated in unfixed cryostat sections of gingival tissue from chronic periodontitis patients using histochemistry with 2-methoxy-4-naphthylamine (MNA) substrates. In the case of DPP IV, enzyme localization was confirmed by immunocytochemistry with mouse monoclon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Kennett CN,Cox SW,Eley BM

    更新日期:1996-09-01 00:00:00

  • Optimizing autologous bone contribution to implant osseointegration.

    abstract:BACKGROUND:Autologous bone can be harvested from the flutes of a conventional drill or from a bone scraper; here we compared whether autologous bone chips generated by a new slow-speed instrument were more osteogenic than the bone chips generated by conventional drills or bone scrapers. Additionally, we tested whether ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Coyac BR,Sun Q,Leahy B,Salvi G,Yuan X,Brunski JB,Helms JA

    更新日期:2020-12-01 00:00:00

  • Validity of partial protocols to assess the prevalence of periodontal outcomes and associated sociodemographic and behavior factors in adolescents and young adults.

    abstract:BACKGROUND:Most studies comparing prevalence of periodontal disease and risk factors by using partial protocols were performed in adult populations, with several studies being conducted in clinical settings. The aim of this study is to assess the accuracy of partial protocols in estimating the prevalence of periodontal...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Peres MA,Peres KG,Cascaes AM,Correa MB,Demarco FF,Hallal PC,Horta BL,Gigante DP,Menezes AB

    更新日期:2012-03-01 00:00:00

  • Evaluation of the safety and efficacy of periodontal applications of a living tissue-engineered human fibroblast-derived dermal substitute. I. Comparison to the gingival autograft: a randomized controlled pilot study.

    abstract:BACKGROUND:Periodontists have found the gingival autograft to be an effective and predictable technique to increase the amount of attached gingiva around teeth, but this technique requires the surgeon to harvest donor tissue from a remote surgical site. The present study seeks to evaluate the safety and effectiveness o...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McGuire MK,Nunn ME

    更新日期:2005-06-01 00:00:00

  • Surgical or non-surgical periodontal treatment: factors affecting patient decision making.

    abstract:BACKGROUND:This study explored which factors affected patients' decisions to pursue either surgical or non-surgical periodontal treatment. METHODS:Data were collected from 74 patients at a regularly scheduled periodontal appointment, at which each patient was told that periodontal treatment was needed, and 2 weeks fol...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Patel AM,Richards PS,Wang HL,Inglehart MR

    更新日期:2006-04-01 00:00:00

  • Comparison of two differently processed acellular dermal matrix products for root coverage procedures: a prospective, randomized multicenter study.

    abstract:BACKGROUND:The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession defects. METHODS:Eig...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wang HL,Romanos GE,Geurs NC,Sullivan A,Suárez-López Del Amo F,Eber RM

    更新日期:2014-12-01 00:00:00