Abstract:
BACKGROUND:Human leukocyte antigens (HLAs) are a basic precondition to induce the immune response to pathogens. Therefore, this study evaluates associations among periodontitis, five key periodontopathic bacteria, and HLAs to test their impact together with additional risk factors in multivariate analyses. METHODS:Eighty-five patients with generalized aggressive periodontitis (GAgP) and 71 patients with generalized chronic periodontitis (CP) were compared to 88 periodontitis-free controls. HLA Class I and II typing was performed by polymerase chain reaction (PCR) with sequence-specific primers. Subgingival plaque specimens were detected by PCR with sequence-specific oligonucleotides. Risk-factor analyses were performed with respect to the cofactors age, sex, smoking, and plaque level by logistic regression. RESULTS:In the total patient group (GAgP + CP), the adjusted odds ratio (OR) of periodontitis was decreased in cases who were carriers of HLA-B*57 (OR = 0.259, 95% confidence interval [CI] = 0.086 to 0.782), HLA-DQB1*08 (OR = 0.404, 95% CI = 0.187 to 0.871), or the combination HLA-DRB1*04;DRB4*;DQB1*0302 (OR = 0.407, 95% CI = 0.185 to 0.895). Moreover, individuals who expressed HLA-DRB1*04 (OR = 0.36, 95% CI = 0.148 to 0.886) or HLA-DRB1*04;DRB4*;DQB1*0302 (OR = 0.29, 95% CI = 0.092 to 0.884) had a decreased colonization risk with Aggregatibacter actinomycetemcomitans. CONCLUSIONS:Certain HLA markers were negatively associated to the manifestation of a generalized periodontitis and/or the individual colonization of A. actinomycetemcomitans. The underlying mechanisms have to be investigated in future studies.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Reichert S,Altermann W,Stein JM,Schaller HG,Machulla HK,Schulz Sdoi
10.1902/jop.2012.110545subject
Has Abstractpub_date
2013-01-01 00:00:00pages
100-9issue
1eissn
0022-3492issn
1943-3670journal_volume
84pub_type
杂志文章abstract:BACKGROUND:Neopterin, a marker of cellular immune activation, is produced by human macrophages after induction by interferon gamma that is secreted by T lymphocytes. Neopterin concentrations in diverse body fluids have been reported to increase in parallel with bacteria in the clinical course of infections. Therefore, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.7.720
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Evidence is accumulating to support poor oral health as a risk factor for systemic conditions, including cardiovascular diseases, diabetes control, adverse pregnancy outcomes, and pneumonia. Prohibitive costs for clinical assessment of periodontal disease limit information to assess the prevalence and trends...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060481
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Our purpose was to compare the risk of tooth loss caused by periodontal disease between diabetic and nondiabetic individuals and to estimate the relative risk of tooth loss according to the severity and control of diabetes. METHODS:We selected 10,215 individuals who were diagnosed as diabetics in the Korean...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0480
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Caspases are key mediators of apoptosis. Caspase-8 mediates extrinsic, and caspase-9 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase-independent process. Because apoptosis is involved in periodontal disease,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.17-0716
更新日期:2019-03-01 00:00:00
abstract::This study tested the effects of using a Gore-Tex periodontal material on new connective tissue attachment in beagle dogs with natural periodontitis. Seven female beagle dogs with advanced periodontitis were selected and given thorough root debridement. Under general anesthesia four weeks later, mucoperiosteal flaps w...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.9.589
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:The diagnosis and treatment of early-onset forms of periodontitis (EOP) represent a major challenge to periodontists. In this case report, we describe a multidisciplinary approach for the treatment of a patient with severe generalized juvenile periodontitis (GJP). Our approach incorporates clinical laborator...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.1.96
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including ...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究
doi:10.1902/jop.2014.140425
更新日期:2015-02-01 00:00:00
abstract::Ceramic grafting material was used to treat a vertical osseous defect associated with a maxillary left lateral incisor tooth. The area was monitored at maintenance appointments. Root resorption was detected radiographically 12 months after grafting. At 18 months, resorption was evident clinically in the presence of mo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.7.419
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:Cannabis sativa (marijuana) can interfere with bone physiopathology because of its effect on osteoblast and osteoclast activity. However, its impact on periodontal tissues is still controversial. The present study evaluates whether marijuana smoke affects bone loss (BL) on ligature-induced periodontitis in r...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100362
更新日期:2011-11-01 00:00:00
abstract::Probing pain threshold (PPT) assessments were conducted in the facial and oral sulci of maxillary central incisors and first molars of 10 periodontally healthy adults. All subjects were systemically healthy, free of pain, and reported no current medication usage. A computer-linked electronic probe, modified to deliver...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.7.812
更新日期:1998-07-01 00:00:00
abstract::Basement membranes in human gingiva are found in dento-epithelial junction, epithelial-connective tissue junction and endothelium-connective-tissue junction where they have important attachment and filtering functions. The ability of plaque and gingiva-derived proteinases to degrade Type IV collagen, the major protein...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.12.740
更新日期:1983-12-01 00:00:00
abstract::Temporary splints to immobilize periodontally diseased teeth were made by fiber glass bonded and attached to the teeth with acid-etch technique with BIS-GMA resin. Twenty-one splints were made. Observation time ranged from 4 to 14 months. During the observation only one splint fractured and was repaired while the othe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.4.193
更新日期:1979-04-01 00:00:00
abstract::The aims of this paper are to briefly describe laser physics, the types of lasers currently available for use on soft tissues focusing primarily on CO2 and Nd:YAG laser energies, the histological effects of lasers on oral tissues, laser safety, the clinical applications of lasers on oral soft tissues, and future direc...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1993.64.7.589
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Sex hormones are linked to inflammation and bone turnover. The goal of this study is to explore the association between sex hormone levels and periodontitis in men using data from the third National Health and Nutrition Examination Survey (NHANES III). METHODS:Data from 755 men (aged ≥ 30 years), including ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.140530
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Clinical manifestations of sarcoidosis affecting the periodontium could mimic aggressive periodontitis. This case report documents the occurrence of sarcoidosis affecting the periodontium, including its clinical features, diagnosis, treatment, and 6-year follow-up. METHODS:An individual with a history of pu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070117
更新日期:2007-11-01 00:00:00
abstract::This study was undertaken to provide histologic observations on the effectiveness of citric acid and tetracycline HCl root surface demineralization when used in conjunction with guided tissue regeneration (GTR) procedures. Eight beagle dogs with naturally-occurring periodontitis were initially treated with scaling and...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.11.1052
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:The aim of this study is to make a longitudinal evaluation of the incidence and severity of gingival overgrowth (GO) induced by immunosuppressive agents, such as tacrolimus (Tcr) and cyclosporin A (CsA), in the absence of calcium channel blockers in patients undergoing renal transplantation (RT). METHODS:Th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100368
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:This cross-sectional study aimed to evaluate the association between body mass index (BMI) and body fat with gingivitis in 613 adults of Porto Alegre, Brazil. METHODS:Individuals with at least four teeth were included in this study. They were identified through a multi-stage probability sampling, considerin...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.17-0292
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:T and B lymphocytes play important roles in periodontitis. Smoking is considered a risk factor for periodontitis and may exert its negative effects through leukocytes. Taking smoking into consideration, the aim of this study was to analyze numbers of circulating T (CD3+) cells and their CD4+ and CD8+ subpopu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.4.557
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:The purpose of this experimental study was to evaluate the collagen fiber distribution histologically after phenytoin, cyclosporin, or nifedipine therapy and to correlate it with collagen I and matrix metalloproteinase (MMP)-1 and -2 gene expression levels. METHODS:Gingival samples from the canine area were...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070267
更新日期:2008-01-01 00:00:00
abstract::During the past few years, improvements in detecting longitudinal changes in clinical attachment or alveolar bone density have been introduced. For example, constant-force electronic probes and computer-assisted subtraction analysis of longitudinal radiographs have been reported to be more sensitive and reproducible i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.10.831
更新日期:1992-10-01 00:00:00
abstract::The purpose of this investigation was to determine the prevalence of the palato-gingival groove in maxillary incisor teeth and the health status of the lingual periodontal tissues adjacent to maxillary incisor teeth with and without the grooves. A total of 531 individuals aged 17 to 35 years were examined for the pres...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.1.41
更新日期:1981-01-01 00:00:00
abstract::A bacterial concentration fluorescence immunoassay (BCFIA) was developed to rapidly detect periodontopathic bacteria in human plaque samples. The BCFIA utilized fluorescent-tagged monoclonal antibodies (MAbs) directed against the lipopolysaccharide of selected Gram-negative bacteria. Microorganisms identified in plaqu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.12s.1093
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:The purpose of these clinical guidelines, commissioned by the Italian Society of Periodontology and compiled with the tools and instructions of the Appraisal of Guidelines for Research and Evaluation (AGREE) collaboration, was to determine, in terms of efficacy, complications, and patient opinions, the most ...
journal_title:Journal of periodontology
pub_type: 杂志文章,实务指引
doi:10.1902/jop.2008.080266
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:As patient demand increases for more natural restorations in the esthetic zone, clinicians must have the highest level of skill and knowledge to maintain or reform the interdental papilla between teeth, between implants and teeth, and between adjacent implants. To date, there are no reports that have measure...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.12.1785
更新日期:2003-12-01 00:00:00
abstract::This report describes the case of a 21-year-old female who presented with localized gingival ulceration that over a period of 4 weeks became generalized, affecting all the buccal gingiva as well as the lower lip. A detailed medical history suggested that the patient was generating the lesions herself. She was monitore...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.5.442
更新日期:1994-05-01 00:00:00
abstract::The sensitivity to tetracycline of 345 bacterial isolates from periodontal lesions was determined. Most species of bacteria, including those thought to be involved in the initiation and progress of destructive periodontal disease, were inhibited in vitro by tetracycline concentrations of 4 to 8 micrograms/ml. This con...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.10.613
更新日期:1981-10-01 00:00:00
abstract::Histiocytosis X, a reticuloendothelial disorder, includes the three clinical syndromes: Letterer-Siwe and Hand-Schuller-Christian diseases and eosinophilic granuloma of the bone. Twenty-eight cases of adult onset of histiocytosis X involving the head and neck region were found in the literature during the past 20 year...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1989.60.1.57
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The need for keratinized mucosa (KM) or immobile keratinized mucosa (i.e., attached mucosa [AM]) for the maintenance of osseointegrated endosseous dental implants has been controversial. The purpose of this study was to investigate the significance of KM in the maintenance of root-form dental implants with d...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050393
更新日期:2006-08-01 00:00:00
abstract::The purpose of this study was to provide additional evidence that in the lesions of acute necrotizing ulcerative gingivitis (ANUG), spirochetes and other microorganisms are capable of invading the nonnecrotic lamina propria of affected gingivae. Biopsies from eight patients with pathognomonic signs of ANUG were obtain...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.11.671
更新日期:1983-11-01 00:00:00