Abstract:
BACKGROUND:Sex hormones are linked to inflammation and bone turnover. The goal of this study is to explore the association between sex hormone levels and periodontitis in men using data from the third National Health and Nutrition Examination Survey (NHANES III). METHODS:Data from 755 men (aged ≥ 30 years), including serum levels of testosterone, estradiol, sex hormone binding globulin, and androstenediol glucuronide, were analyzed. Calculated bioavailable testosterone (CBT) and estradiol-to-testosterone ratio were calculated. Periodontitis was defined using the latest classification of extent and severity of periodontitis for NHANES data (≥ 2 interproximal sites with ≥ 3 mm attachment loss, ≥ 2 interproximal sites with probing depth [PD] ≥ 4 mm not on the same tooth, or one site with PD ≥ 5 mm). Sex hormones were evaluated as categorized and continuous variables. Correlations between the presence and severity of periodontitis and levels of sex hormones were determined and expressed as odds ratios (ORs). RESULTS:When adjusted for confounding factors, high total testosterone (TT) and CBT levels correlated with both the prevalence (OR [95% confidence interval (CI)], 2.1 [1 to 4.5] and 3.9 [1 to 14.8], respectively) and severity (OR [95% CI], 2.1 [1 to 4.3] and 3.4 [1.2 to 9.8]) of periodontitis. When continuous variables were used, the ORs (95% CIs) for presence and severity of periodontitis were 1.4 (0.6 to 3.3) and 1.5 (0.6 to 3.6) for TT and 1.3 (0.9 to 1.9) and 1.3 (0.9 to 1.8) for CBT, respectively. CONCLUSIONS:These findings are consistent with the existence of an association of periodontitis with sex hormone levels, especially testosterone, in men.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Steffens JP,Wang X,Starr JR,Spolidorio LC,Van Dyke TE,Kantarci Adoi
10.1902/jop.2015.140530subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1116-25issue
10eissn
0022-3492issn
1943-3670journal_volume
86pub_type
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journal_title:Journal of periodontology
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journal_title:Journal of periodontology
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更新日期:2019-12-18 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1997.68.1.39
更新日期:1997-01-01 00:00:00
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doi:10.1902/jop.1996.67.8.803
更新日期:1996-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2004-07-01 00:00:00