Abstract:
BACKGROUND:Titanium (Ti) dental implants have been widely used for prosthetic reconstruction of dentition. Unfortunately, peri-implantitis can result in failure of dental implant osseointegration. Lipopolysaccharide (LPS) acts as a chronic inflammatory stimulus and maintains peri-implant inflammation, worsening the prognosis for implant osseointegration. The purpose of this study is to determine the effects of 10 M NaOH-modified Ti surface with nanonetwork structure on the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMMSCs) in the context of Porphyromonas gingivalis LPS exposure. METHODS:Titanium disks treated with 10 M NaOH solution and control were incubated with BMMSCs and exposed to P. gingivalis LPS (0, 0.1, or 1 μg/mL). The effects of the modified nanonetwork structure on osteogenic differentiation of rat BMMSCs were evaluated in the context of different concentrations of P. gingivalis LPS exposure. RESULTS:Rat BMMSCs on the 10 M NaOH-modified Ti surface with nanonetwork structure had higher levels of osteogenesis-related gene expression and significantly greater cell proliferation, alkaline phosphatase activity, and extracellular matrix deposition and mineralization than cells on the untreated Ti surfaces, in all the groups with different doses of P. gingivalis LPS exposure. CONCLUSION:The 10 M NaOH-modified Ti surface with nanonetwork structure has better endotoxin tolerance under P. gingivalis LPS exposure than the non-modified surface.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Xing H,Taguchi Y,Komasa S,Yamawaki I,Sekino T,Umeda M,Okazaki Jdoi
10.1902/jop.2014.140386subject
Has Abstractpub_date
2015-03-01 00:00:00pages
448-55issue
3eissn
0022-3492issn
1943-3670journal_volume
86pub_type
杂志文章abstract::The purposes of this study were to determine if: 1) an association exists between cigarette smoking and signs of periodontal disease after controlling for the confounding variables of age, sex, plaque, and calculus; 2) the prevalence of 5 bacteria commonly associated with periodontal disease differs between smokers an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.12.1225
更新日期:1993-12-01 00:00:00
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journal_title:Journal of periodontology
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.3.249
更新日期:1997-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160140
更新日期:2017-01-01 00:00:00
abstract::This study was conducted to determine the possible influence of diabetes on the pathogenesis of periodontal disease. A total of 148 patients, 120 females and 28 males, were surveyed. Their ages ranged between 9 and 50 years, with an average age of 30. The experimental group consisted of 83 diabetics and there was a co...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.9.445
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Successful periodontal treatment requires a commitment to regular lifelong maintenance and may be perceived by patients to be costly. This study calculates the total lifetime cost of periodontal treatment in the setting of a specialist periodontal practice and investigates the cost implications of choosing n...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110689
更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2015.140612
更新日期:2015-06-01 00:00:00
abstract::In an earlier report, we examined the relationship of patient-derived clinical and epidemiological variables to the risk for future clinical attachment loss (CAL) in chronic adult periodontitis. We determined that the extent of the patient's existing periodontal disease as measured by mean attachment loss (MAL) and th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.4.262
更新日期:1992-04-01 00:00:00
abstract::Primary socket closure in immediate implantation may be difficult, due to the opening left by the extracted tooth. The absolute need for bone augmentation and primary flap closure for implants placed into fresh extraction sites has never been proven. The hypothesis of the present study was that immediate implants can ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.7.743
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.11s.81
更新日期:1985-11-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
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更新日期:2008-08-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.8.879
更新日期:1998-08-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-05-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.9.1175
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Data are limited on the potential effect of intensive oral hygiene regimens and periodontal therapy during pregnancy on periodontal health, gingival crevicular fluid (GCF) and serum cytokines, and pregnancy outcomes. METHODS:A clinical trial was conducted on 120 community-dwelling, 16- to 35-year-old pregna...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.11.699
更新日期:1985-11-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.7.402
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:In sinus augmentation, when remaining bone height is ≤5 mm, a lateral window approach is often the preferred choice; nonetheless, patients prefer to have a less invasive approach such as crestal sinus augmentation (CSA). Prior case reports have described the use of various staged approaches of a CSA techniqu...
journal_title:Journal of periodontology
pub_type:
doi:10.1002/JPER.18-0632
更新日期:2020-02-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.10.567
更新日期:1984-10-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.5.311
更新日期:1988-05-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2014.140198
更新日期:2014-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1976.47.7.419
更新日期:1976-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
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更新日期:2009-09-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.10.667
更新日期:1977-10-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.8.492
更新日期:1985-08-01 00:00:00