Abstract:
:Resected inflamed gingival tissue obtained from 16 periodontal patients and a pooled sample of noninflamed gingiva from five edentulous patients were assayed for immunoglobulins IgG, IgA, and IgM using low-level immunodiffusion plates. Findings based on the gingival assays include:(1) IgA and IgG are present in both inflamed and normal gingiva and although their levels are substanitally higher in the inflamed gingiva, their ratio, one to another, remains the same; (2) IgM can not be consistently demonstrated in inflamed gingiva with the assay technique employed: (3) local immune response exists in the inflamed gingiva of humans with chronic periodontal disease; and (4) there is an unknown homeostatic mechanism which regulates the globulin levels in states of health and inflammation. Further study is needed to correlate clinical impressions with histological and quantitative measure of immunoglobulin levels in the inflamed gingiva and to investigate the role of delayed hypersensitivity in the disease process. Work must also be directed toward the detection of specific antigens responsible for elicting the immune response in the gingival tissue of the periodontal patient.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Byers CW,Toto PD,Gargiulo AWdoi
10.1902/jop.1975.46.7.387subject
Has Abstractpub_date
1975-07-01 00:00:00pages
387-90issue
7eissn
0022-3492issn
1943-3670journal_volume
46pub_type
杂志文章abstract:BACKGROUND:Infection and inflammation induce epigenetic changes that alter gene expression. In periodontal disease, inflammation, and microbial dysbiosis occur, which can lead to compromised barrier function of the gingival epithelia. Here, we tested the hypotheses that infection of cultured human gingival epithelial (...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0262
更新日期:2020-10-01 00:00:00
abstract::Bacterial invasion of the pocket epithelium and underlying connective tissue was found in seven cases of advanced human periodontitis. Four cases showed invasion of the epithelium as well as the connective tissue while in the other three cases bacterial invasion was limited to the pocket epithelium. The microorganisms...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.10.567
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:A 5-year-old Japanese boy presented with persistent gingival inflammation and severe mobility of the right lower primary incisors. Due to severe alveolar bone loss and a deep periodontal pocket (5 mm), the incisors were extracted at the second visit. METHODS:Clinical, radiographic, histological, and microbi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.7.1060
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reco...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.11.1823
更新日期:2005-11-01 00:00:00
abstract::The purpose of this investigation was to evaluate calcium hydroxide and potassium nitrate individually as densensitizing agents for hypersensitive root surfaces. The apparatus used in the experiment to measure hypersensitivity was (a) a thermo-electric stimulating device to measure hot and cold stimulation quantitativ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.10.667
更新日期:1977-10-01 00:00:00
abstract::The greatest challenge in treatment planning is to assign an accurate prognosis and develop a predictable protocol. In the era of evidence-based dentistry, outcome studies have forced us to reexamine our treatment approaches and decide if superior treatment options should be pursued. As endosseous dental implants gain...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070551
更新日期:2008-06-01 00:00:00
abstract::During the acute phase of periodontal disease, as many as 60% of the cells of the junctional epithelium may be accounted for by polymorphonuclear cells (PMNs). It is generally accepted that these cells play a dominant role in the destruction of connective tissue by virtue of the proteinases they release and the free o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.7.422
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130167
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Gingival augmentation procedures are indicated primarily to increase an insufficient amount of gingiva and sometimes to halt the progression of gingival recession. The aim of this retrospective long-term study was to evaluate changes in the amount of keratinized tissue (KT) and in the position of the gingiva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070414
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Some studies have advocated marrow penetration in guided bone augmentation (GBA), whereas others have shown that bone can be generated without marrow penetration. This study examined the effect of marrow penetration and the optimal rate of penetration. METHODS:In 10 rabbits, the calvarium was exposed, and c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070086
更新日期:2007-10-01 00:00:00
abstract::Few scientific investigations have addressed the ability of mouthrinses to reduce oral malodor for periods longer than 3 hours. In the present report, we have employed simple, recently described techniques to assess the day-long reduction in oral malodor of a novel 2-phase oil:water mouthrinse (TPM), as compared to a ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1992.63.1.39
更新日期:1992-01-01 00:00:00
abstract::Demineralized bone matrix (DBM) is widely used in the repair of pathologies associated with skeletal defects and periodontal diseases. The present study was directed at establishing in vivo and in vitro models for a quantitative assessment of the osteoinductivity of DBM before clinical use. Athymic mice were used in a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.11.1076
更新日期:1997-11-01 00:00:00
abstract::A review of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Disease) is presented. Special emphasis is placed on the oral manifestations which include hemorrhagic vesicles, nodules, papules and ulcers that involve the gingiva and other areas of the mucosa. Two cases are included which were seen in a periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.163
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both normal physiology and inflammation in many systems. However, its actions are just beginning to be defined in oral biology and pathophysiology. METHODS:Microarray analysis was used to test the hypothesis that human gingival fi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.140592
更新日期:2015-05-01 00:00:00
abstract::The purpose of this study was to clinically evaluate the effectiveness of polytetrafluoroethylene membranes in the healing of interproximal Class II furcation defects in maxillary molars using a surgical treatment technique based on the principles of guided tissue regeneration. Eight subjects with similar bilateral Cl...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1998.69.9.1020
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:The purpose of this experimental study was to evaluate the collagen fiber distribution histologically after phenytoin, cyclosporin, or nifedipine therapy and to correlate it with collagen I and matrix metalloproteinase (MMP)-1 and -2 gene expression levels. METHODS:Gingival samples from the canine area were...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070267
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Periopathogens and cariogenic species survive more than 48 hours on toothbrushes even under dry storage. This study examined a decontamination of toothbrushes by means of the bactericidal effect of different toothpastes or a special coating of the tufts. METHODS:Eight untreated periodontitis patients were p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.3.312
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Patients with juvenile idiopathic arthritis (JIA) have been shown to have incipient attachment loss (AL) more frequently than systemically healthy individuals. This study investigated neutrophil activity and proinflammatory cytokines in these patients and aged-matched controls. METHODS:Elastase activity, me...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.1.75
更新日期:2005-01-01 00:00:00
abstract::The modification of a methacrylic gel for use as a periodontal dressing was attempted. The increased adhesion and rigidity of the resultant material appeared consistent with the clinical findings. Satisfactory retention of the dressing was found in 85% of those placed on a group of patients attending for periodontal s...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.8.465
更新日期:1975-08-01 00:00:00
abstract::Recent evidence suggests that dental plaque is not a homogeneous bacterial mass but, on the contrary, specific bacterial morphotypes and species may be preferentially located within certain microenvironments. The aim of the present study was to develop combined gold immunolabeling and scanning electron microscopic (SE...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.5.249
更新日期:1990-05-01 00:00:00
abstract::The report is a review of the literature related to hepatitis B and its implications for dental practitioners. Hepatitis B represents a serious health risk among dentists and simple preventive measures can greatly reduce the risk of transmission or contraction of the disease. Certain positive findings in a healthy his...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1980.51.3.162
更新日期:1980-03-01 00:00:00
abstract::This tribute was written by Dr. E. Brady Hancock, who was a student of and who succeeded Dr. Timothy J. O'Leary as chair of the Department of Periodontics at Indiana University. Dr. O'Leary served as co-editor of the Journal of Periodontologyfrom 1970 until 1988. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.9.1175
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Previous studies showed that host modulation therapy (HMT) or topical antimicrobial therapy (TAT) provided significant adjunctive benefits to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). The purpose of this study was to evaluate a combination therapy involving SRP, HMT, and ...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2008.070237
更新日期:2008-01-01 00:00:00
abstract::The sensitivity to tetracycline of 345 bacterial isolates from periodontal lesions was determined. Most species of bacteria, including those thought to be involved in the initiation and progress of destructive periodontal disease, were inhibited in vitro by tetracycline concentrations of 4 to 8 micrograms/ml. This con...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.10.613
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:The adjunctive use of enamel matrix derivative (EMD) in the surgical therapy of intrabony defects results in improved outcomes compared to surgical debridement alone. However, the role of EDTA root conditioning in EMD therapy has not been investigated. The purpose of this study was to compare the 12-month ou...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.77.1.103
更新日期:2006-01-01 00:00:00
abstract::The distance from cemento-enamel junction to alveolar crest was studied in relation to periodontal treatment need, socioeconomic factors and dental health. The subjects (315) of the study were employees of a paper mill in Finland. Alveolar crest height was measured from orthopantomograms, periodontal treatment need wa...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.2.99
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:The aim of this in vivo study was to evaluate the effects of plaque control on the patency of dentinal tubules using vital teeth of beagle dogs. METHODS:Class V cavities were prepared on the cervical areas of the mandibular and maxillary molars in each dog with a diamond point. To simulate the state of dent...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050159
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Bacterial constituents, such as Gram-negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host-derived inflammatory cytokines. The aim of this study was to establish a model of aggressive inflammatory alveolar bone loss in rats using LPS derived from the periodo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060321
更新日期:2007-03-01 00:00:00
abstract::Chlorhexidine in an alcohol vehicle with flavoring agents has been used as a mouthrinse to reduce plaque accumulation in periodontal surgery patients. The purpose of this study was to evaluate the effects of a chlorhexidine-containing mouthrinse on the early tensile wound strength of healing surgical wounds in the rat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.8.719
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Most research efforts in periodontal epidemiology have focused on middle-aged or older people, giving a picture of disease occurrence at a relatively late stage in the natural history of the condition. There is a paucity of comprehensive descriptive data from younger age groups. Understanding the epidemiolog...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.12.1840
更新日期:2000-12-01 00:00:00