Abstract:
BACKGROUND:The purpose of this study is to evaluate whether β-tricalcium phosphate (β-TCP) could be a promising modality to help augment alveolar bone in periodontal tissue regeneration by bone marrow mesenchymal stem cells (BMMSCs). METHODS:Expanded BMMSCs and atelocollagen (Col) were mixed together (MSC/Col). A combination of β-TCP with MSC/Col was also prepared (MSC/Col/TCP). MSC/Col/TCP or MSC/Col was transplanted into experimental periodontal Class III furcation defects that had been exposed to inflammation in beagle dogs. Periodontal tissue regeneration was evaluated by histologic and morphometric analyses at 4 and 8 weeks after transplantation. RESULTS:MSC/Col and MSC/Col/TCP enhanced periodontal tissue regeneration compared to Col and TCP/Col according to hematoxylin and eosin staining. The percentage of new cementum length in the MSC/Col/TCP group was not significantly different from that in the MSC/Col group at 4 and 8 weeks. On the other hand, the percentage of new bone area in the MSC/Col/TCP group was much higher than that in the MSC/TCP group at 4 weeks. However, at 8 weeks, no significant difference in new bone area was found between the two groups. In the MSC/Col/TCP group, β-TCP was surrounded by newly formed bone. Multinucleated cells, which were positive for osteopontin and tartrate-resistant acid phosphatase, were present in the interconnected macropores of β-TCP. CONCLUSION:These findings suggest that β-TCP is applicable as a scaffold for BMMSCs transplantation and helps augment alveolar bone without impairing regeneration of cementum.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Nagahara T,Yoshimatsu S,Shiba H,Kawaguchi H,Takeda K,Iwata T,Mizuno N,Fujita T,Kurihara Hdoi
10.1902/jop.2014.140384subject
Has Abstractpub_date
2015-03-01 00:00:00pages
456-64issue
3eissn
0022-3492issn
1943-3670journal_volume
86pub_type
杂志文章abstract:BACKGROUND:The diagnosis and treatment of early-onset forms of periodontitis (EOP) represent a major challenge to periodontists. In this case report, we describe a multidisciplinary approach for the treatment of a patient with severe generalized juvenile periodontitis (GJP). Our approach incorporates clinical laborator...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.1.96
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Little is known regarding the interaction of dental implant surface nanotubes and oral soft and hard tissues. The purpose of this study was to evaluate both histologically and radiographically the qualitative and quantitative effects of dental implant surface nanotubes on hard and soft tissue in a canine mod...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0205
更新日期:2020-04-01 00:00:00
abstract::A previous multi-center study examining patients diagnosed as having at least four periodontally diseased teeth showed that when BANA (N-Benzoyl-DL-Arginine-Naphthylamide) hydrolysis by periodontal pathogens such as Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus was evaluated versus clinical ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.9.848
更新日期:1993-09-01 00:00:00
abstract::Histiocytosis X, a reticuloendothelial disorder, includes the three clinical syndromes: Letterer-Siwe and Hand-Schuller-Christian diseases and eosinophilic granuloma of the bone. Twenty-eight cases of adult onset of histiocytosis X involving the head and neck region were found in the literature during the past 20 year...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1989.60.1.57
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Unsupervised clustering is a method used to identify heterogeneity among groups and homogeneity within a group of patients. Without a prespecified outcome entry, the resulting model deciphers patterns that may not be disclosed using traditional methods. This is the first time such clustering analysis is appl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0489
更新日期:2020-12-14 00:00:00
abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon blood stem cell disorder. The acquired defect is in the cell membrane of the precursor of the affected clone, which renders erythrocytes, platelets and granulocytes unusually sensitive to the hemolytic effects of complement. It is characterized by chronic hemoly...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.2.115
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:This report describes the surgical treatment of a gingival recession in a hemophiliac HIV-infected patient. To our knowledge, mucogingival surgery has not been described previously in these patients. METHODS:Under the supervision of the patient's hematologist, a subepithelial connective tissue graft procedu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.10.1413
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Surface modifications to dental implants have been used in an attempt to accelerate the osseointegration process. The objective of this study was to biomechanically/histomorphometrically evaluate a bioceramic grit-blasted and acid-etched surface (BGB/AA; test) versus a dual acid-etched implant surface (contr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080106
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:This study evaluates the influence of platelet-rich plasma derived from bone marrow aspirate (PRP-BMA) on the healing of periodontal fenestration defects in rats. METHODS:Periodontal fenestration defects were surgically created in the mandibles of 40 rats. The animals were randomly divided into two groups, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140083
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:One of the success factors in periodontal plastic surgery is the synergistic relationship between involved tissues and vascular supply. Gingiva as a functional unit is unique with a specific vascular configuration and contains the supracrestal portion naturally created to survive over avascular root surfaces...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.110685
更新日期:2013-01-01 00:00:00
abstract::The aim of this investigation was to induce alveolar bone defects experimentally in dogs and to study the effects of mechanical tooth cleaning on their subsequent development. Thirty premolars from four beagle dogs were used. Bone defects were created by surgically exposing the adjacent alveolar bone and applying stee...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.3.135
更新日期:1978-03-01 00:00:00
abstract::A 1% carrageenan solution was injected into the palatal mucosa of male guinea pigs between the two first molars. Biopsy specimens were taken 1, 3, 6, 12 and 24 hours after the injection. Control specimens with healthy mucosa and tyrode injected mucosa were used in order to evaluate the carrageenan-induced inflammation...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.3.114
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Distraction of the periosteum results in the formation of new bone in the gap between the periosteum and the original bone. We postulate that the use of a barrier membrane would be beneficial for new bone formation in periosteal distraction. METHODS:To selectively influence the contribution of the periosteu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110418
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:The clinical use of an enamel matrix derivative (EMD) has been shown to promote formation of new cementum, periodontal ligament (PDL), and bone and to significantly enhance the clinical outcomes after regenerative periodontal surgery. It is currently unknown to what extent the bleeding during periodontal sur...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110404
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The specific advantage of administering systemic antibiotics during initial, non-surgical therapy or in the context of periodontal surgery is unclear. This study assesses the differential outcomes of periodontal therapy supplemented with amoxicillin-metronidazole during either the non-surgical or the surgica...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2014.140478
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The detailed mechanism of osseointegration, the most appropriate implant-bone interface, remains unclear in jaw tissues at the ultrastructural level in contrast to the many reports using long bones. The present study reports on tissue response to titanium-implantation on an animal model using rat maxilla. M...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.2.287
更新日期:2000-02-01 00:00:00
abstract::The case of a family, followed for 5 years and showing an exceptionally high prevalence of Generalized Juvenile Periodontitis (GJP), is presented. Two siblings were affected by a severe form of GJP meanwhile the dycorial twin of one was periodontally healthy. Both the affected siblings showed infection by Actinobacill...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.9.590
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:The purpose of this case series study was to evaluate posterior single-tooth implant survival and the long-term conditions of the adjacent teeth. METHODS:A retrospective evaluation of 1,162 consecutive patients with a single missing posterior tooth treated with 1,377 external hex implants supporting 1,365 r...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究
doi:10.1902/jop.2008.080188
更新日期:2008-12-01 00:00:00
abstract::Eleven cases are presented which demonstrated severe periodontal bone loss especially in the posterior segments of the mouth in a group of young men, ages 22 to 32, unexplained by other local etiologic factors. The only common denominator in all cases was severe emotional stress associated with active duty in Viet Nam...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.2.67
更新日期:1976-02-01 00:00:00
abstract::Bacterial invasion of the pocket epithelium and underlying connective tissue was found in seven cases of advanced human periodontitis. Four cases showed invasion of the epithelium as well as the connective tissue while in the other three cases bacterial invasion was limited to the pocket epithelium. The microorganisms...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.10.567
更新日期:1984-10-01 00:00:00
abstract::Patient plaque removal is a major component of periodontal therapy and should be continuously monitored during and following treatment. There do not appear to be studies which address plaque score changes achieved primarily by patient performance from the time of initial presentation to, during, and following active t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.6.343
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:The interproximal dental papilla is considered an essential component of the anterior and posterior regions of the maxilla and mandible. The absence of this structure has esthetic and phonetical consequences and lateral food impaction problems occur with the implant-supported prosthesis. The aims of the pres...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.9.1242
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Little attention has been given to understanding the variation in biomechanical behavior of oral soft tissues, and this represents an obstacle for the development of biomaterials that perform with appropriate biomechanical characteristics. With this as our motivation, a uniaxial mechanical analysis was perfo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100573
更新日期:2011-08-01 00:00:00
abstract::A great deal of controversy has existed in the periodontal literature as to whether the site or the subject should be the unit of analysis. Using the site as the unit of analysis assumes that observations of sites within the same subject are independent and ignores between subject variation. The purpose of this report...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.6.507
更新日期:1992-06-01 00:00:00
abstract::Resected inflamed gingival tissue obtained from 16 periodontal patients and a pooled sample of noninflamed gingiva from five edentulous patients were assayed for immunoglobulins IgG, IgA, and IgM using low-level immunodiffusion plates. Findings based on the gingival assays include:(1) IgA and IgG are present in both i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.7.387
更新日期:1975-07-01 00:00:00
abstract::This investigation studied the changes in probing depths and subgingival microbial flora of clinically healthy and diseased sites before and after scaling and root planing. Thirty-six sites in 18 individuals were studied in two groups of patients, Group I (9 patients) had received no periodontal surgery, while group I...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.7.391
更新日期:1984-07-01 00:00:00
abstract::Interleukin-1 beta (IL-1 beta) is the predominant form of IL-1 produced by macrophages. IL-1 beta possesses numerous and diverse biological activities. Several of these activities, including fibroblast proliferation, potentiation of the immune response, and stimulation of bone resorption may be of relevance to the pat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.1.36
更新日期:1991-01-01 00:00:00
abstract::The clinical periodontal status of 44 insulin-dependent diabetic children and adolescents and 20 healthy control subjects was compared for a period of approximately 5 years. Fasting blood glucose, fructosamine, and glycosylated hemoglobin (HbA1) values were determined at baseline and 5 years later. The differences in ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.2.136
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Bad breath is often caused by periodontitis and/or tongue coating. This study followed the impact of initial periodontal therapy on several halitosis-related outcome variables over a 6-month period. Organoleptic ratings are often uncomfortable for the patient and have several disadvantages. They are, for ins...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.5.705
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:It has been suggested that cyclosporine A (CsA) induces gingival enlargement by promoting an increase in the gingival extracellular matrix (ECM). Nonetheless, the variable occurrence of CsA-induced gingival enlargement in patients receiving this medication indicates a multifactorial pathogenesis. Clinical ob...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120224
更新日期:2013-05-01 00:00:00