Alanine aminopeptidase and dipeptidyl peptidase IV in saliva of chronic periodontitis patients.

Abstract:

BACKGROUND:Alanine aminopeptidase (ALAP) and dipeptidyl peptidase IV (DPPIV) are ectopeptidases that play a role in collagen degradation and are thought to be involved in the destruction of periodontal tissue. This study compared the activities of salivary ALAP and DPPIV in patients with periodontitis and periodontally healthy subjects. The correlations of enzyme activities with clinical variables and the presence of Porphyromonas gingivalis were also evaluated. METHODS:Whole saliva was collected from 30 periodontally healthy subjects, 30 localized chronic periodontitis (LCP) patients, and 30 generalized chronic periodontitis (GCP) patients to determine the activities of ALAP and DPPIV. The presence of P. gingivalis in subgingival plaque was detected by polymerase chain reaction. Periodontal clinical assessments included probing depth, clinical attachment level, and bleeding on probing. RESULTS:The activities of DPPIV in the LCP and GCP groups were not significantly different from one another, but both groups had significantly higher enzyme activities than the periodontally healthy group (P = 0.001). DPPIV activity was positively correlated with all clinical parameters and the prevalence of P. gingivalis. The ALAP activities were not significantly different among the three study groups. There was no significant correlation of ALAP activity with any of the clinical and bacterial parameters. CONCLUSION:DPPIV, but not ALAP, activity is associated with periodontitis and the presence of P. gingivalis.

journal_name

J Periodontol

authors

Aemaimanan P,Sattayasai N,Wara-aswapati N,Pitiphat W,Suwannarong W,Prajaneh S,Taweechaisupapong S

doi

10.1902/jop.2009.090233

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

1809-14

issue

11

eissn

0022-3492

issn

1943-3670

journal_volume

80

pub_type

杂志文章
  • Platelet-Rich Fibrin With 1.2% Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.

    abstract:BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2016.160015

    authors: Pradeep AR,Garg V,Kanoriya D,Singhal S

    更新日期:2016-12-01 00:00:00

  • A method to assess the clinical outcome of ridge augmentation procedures.

    abstract:BACKGROUND:Alveolar ridge augmentation procedures are often needed prior to implant placement or prosthetic rehabilitation. The purpose of this study was to develop a quantitative method to assess the clinical outcome of such procedures. METHODS:Two volumetric methods, based on the volume difference between the pre- a...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2002.73.3.302

    authors: Proussaefs PT,Valencia G,Lozada J,Tatakis DN

    更新日期:2002-03-01 00:00:00

  • Clinical and volumetric analysis of three-wall intrabony defects following open flap debridement.

    abstract::Fourteen defects were treated with flap debridement procedures using the Prichard principle of epithelial exclusion. Six defects were considered to be medium in width (3-4 mm), seven defects were wide (greater than 4 mm), and one defect was narrow (1-2 mm). The parameters studied were changes in gingival and plaque sc...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1986.57.5.277

    authors: Becker W,Becker BE,Berg L,Samsam C

    更新日期:1986-05-01 00:00:00

  • Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.

    abstract:BACKGROUND:There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM:To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary disease (COPD), pneum...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.1340020

    authors: Linden GJ,Herzberg MC,working group 4 of the joint EFP\/AAP workshop.

    更新日期:2013-04-01 00:00:00

  • Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration. A review.

    abstract::The use of antibiotics in periodontal therapy has received increasing attention in recent years. Although generally safe, certain antibiotics, including tetracycline and ampicillin, have been shown to interact indirectly with oral contraceptives, with a resultant decrease in oral contraceptive efficacy. This paper rev...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1985.56.1.18

    authors: Barnett ML

    更新日期:1985-01-01 00:00:00

  • Demystifying the mist: Sources of microbial bioload in dental aerosols.

    abstract::The risk of transmitting airborne pathogens is an important consideration in dentistry and has acquired special significance in the context of recent respiratory disease epidemics. The purpose of this review, therefore, is to examine (1) what is currently known regarding the physics of aerosol creation, (2) the types ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1002/JPER.20-0395

    authors: Kumar PS,Subramanian K

    更新日期:2020-09-01 00:00:00

  • Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III.

    abstract:BACKGROUND:Sex hormones are linked to inflammation and bone turnover. The goal of this study is to explore the association between sex hormone levels and periodontitis in men using data from the third National Health and Nutrition Examination Survey (NHANES III). METHODS:Data from 755 men (aged ≥ 30 years), including ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.140530

    authors: Steffens JP,Wang X,Starr JR,Spolidorio LC,Van Dyke TE,Kantarci A

    更新日期:2015-10-01 00:00:00

  • Creeping attachment after free gingival grafts.

    abstract::Free gingival grafts were placed in the lower anterior vestibular region of 30 patients each of whom had a gingival recession. According to the width of the recession and to the surgical procedure, the patients were divided into four groups. Group 1 showed a "narrow" (less than 3 mm) type of recession, while Group 2 h...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1976.47.10.574

    authors: Matter J,Cimasoni G

    更新日期:1976-10-01 00:00:00

  • Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria: a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores.

    abstract:BACKGROUND:To validate the concept of early implant placement for use in the esthetically sensitive anterior maxilla, clinical trials should ideally include objective esthetic criteria when assessing outcome parameters. METHODS:In this cross-sectional, retrospective 2- to 4-year study involving 45 patients treated wit...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.080435

    authors: Belser UC,Grütter L,Vailati F,Bornstein MM,Weber HP,Buser D

    更新日期:2009-01-01 00:00:00

  • Volatile components of cigarette smoke: effect of acrolein and acetaldehyde on human gingival fibroblasts in vitro.

    abstract:BACKGROUND:Tobacco and some of its volatile and non-volatile components have been found to affect many types of cells including gingival fibroblasts. Since normal gingival fibroblast functioning is fundamental to the maintenance of the periodontal connective tissue, as well as to wound healing, we examined the effect o...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.3.425

    authors: Cattaneo V,Cetta G,Rota C,Vezzoni F,Rota MT,Gallanti A,Boratto R,Poggi P

    更新日期:2000-03-01 00:00:00

  • A short-term study of the effects of SBHAN, a novel compound, on gingival inflammation in the beagle dog.

    abstract::Unique hydroxyl ion-modulating compounds based on the amino acid glycine have been developed that possess both antimicrobial and pro-healing properties. The purpose of the present study was to determine the effects of one of these compounds, 8.5% (w/v) sodium N, N-bis-2 (hydroxylethyl) aminoacetate (SBHA) with 0.3% (w...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1997.68.5.448

    authors: Cutler CW,Ghaffar KA

    更新日期:1997-05-01 00:00:00

  • Cyclosporine A upregulates platelet-derived growth factor B chain in hyperplastic human gingiva.

    abstract::Cyclosporine A (CSA) is a widely used immunosuppressant for transplant patients and is also used for the treatment of a wide variety of systemic diseases with immunologic components. A prominent side effect of CSA administration is gingival overgrowth (hyperplasia). It has been postulated that CSA alters fibroblast ac...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.3.271

    authors: Nares S,Ng MC,Dill RE,Park B,Cutler CW,Iacopino AM

    更新日期:1996-03-01 00:00:00

  • A Major Human Oral Lysophosphatidic Acid Species, LPA 18:1, Regulates Novel Genes in Human Gingival Fibroblasts.

    abstract:BACKGROUND:The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both normal physiology and inflammation in many systems. However, its actions are just beginning to be defined in oral biology and pathophysiology. METHODS:Microarray analysis was used to test the hypothesis that human gingival fi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.140592

    authors: Cerutis DR,Weston MD,Alnouti Y,Bathena SP,Nunn ME,Ogunleye AO,McVaney TP,Headen KV,Miyamoto T

    更新日期:2015-05-01 00:00:00

  • Topographic classification of deformities of the alveolar process.

    abstract::A system of nomenclature for deformities of the alveolar process is presented. Descriptive, familiar topographic terms are used (crater, trench, moat, ramp and plane), and specific criteria are given for each term. Two hundred randomly selected osseous deformities in dry skulls were classified by two examiners at inde...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.6.336

    authors: Karn KW,Shockett HP,Moffitt WC,Gray JL

    更新日期:1984-06-01 00:00:00

  • The effect of periodontal bone loss on bite force discrimination.

    abstract::This study compared bite force discrimination between 14 treated periodontal patients with significant bone resorption and 14 control subjects who were free of periodontal disease. Bite force was measured using a strain gauge scale which permitted subjects to visually monitor when their bite force equaled a preset res...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.4.236

    authors: Williams WN,Low SB,Cooper WR,Cornell CE

    更新日期:1987-04-01 00:00:00

  • Commentary: A Translational Medicine Approach to Tooth Transplantation.

    abstract::The autogenous tooth transplantation approach to replace missing teeth has been in use for a long time. Different surgical techniques have been developed to improve prognosis and longevity of transplanted teeth with complete root formation. Many factors reportedly affected short- and long-term success of the procedure...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2017.160820

    authors: Prato GP,Zuccati G,Clauser C

    更新日期:2017-06-01 00:00:00

  • Generalized juvenile periodontitis: report of a familial case followed for 5 years.

    abstract::The case of a family, followed for 5 years and showing an exceptionally high prevalence of Generalized Juvenile Periodontitis (GJP), is presented. Two siblings were affected by a severe form of GJP meanwhile the dycorial twin of one was periodontally healthy. Both the affected siblings showed infection by Actinobacill...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1990.61.9.590

    authors: Sbordone L,Ramaglia L,Bucci E

    更新日期:1990-09-01 00:00:00

  • Coronally advanced flap procedure for root coverage. Treatment of root surface: root planning versus polishing.

    abstract::This clinical study was designed to determine if mechanical instrumentation (root planing) of the exposed root is useful in treating gingival recession caused by traumatic toothbrushing following a coronally advanced flap (CAF). Ten patients with high levels of oral hygiene (full-mouth plaque score <20%), from 25 to 5...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1999.70.9.1064

    authors: Pini-Prato G,Baldi C,Pagliaro U,Nieri M,Saletta D,Rotundo R,Cortellini P

    更新日期:1999-09-01 00:00:00

  • Detection of eight periodontal microorganisms and distribution of Porphyromonas gingivalis fimA genotypes in Chinese patients with aggressive periodontitis.

    abstract:BACKGROUND:The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP. METHODS:...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.120677

    authors: Feng X,Zhang L,Xu L,Meng H,Lu R,Chen Z,Shi D,Wang X

    更新日期:2014-01-01 00:00:00

  • Investigating the Effects of Systemically Administered Strontium Ranelate on Alveolar Bone Loss Histomorphometrically and Histopathologically on Experimental Periodontitis in Rats.

    abstract:BACKGROUND:The aim of this study is to investigate effects of strontium ranelate (SR) on alveolar bone loss (ABL) in rats with experimental periodontitis. METHODS:Forty Wistar rats were randomly divided into five groups: 1) control (n = 8); 2) ligated (n = 8); 3) 300 mg/kg SR (SR300, n = 8); 4) 625 mg/kg SR (SR625, n ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.160227

    authors: Karakan NC,Akpınar A,Göze F,Poyraz Ö

    更新日期:2017-02-01 00:00:00

  • The interaction between serum amyloid A and Toll-like receptor 2 pathway regulates inflammatory cytokine secretion in human gingival fibroblasts.

    abstract:BACKGROUND:Serum amyloid A (SAA) has been identified to trigger inflammation response, and play a crucial role in chronic inflammatory diseases. However, the regulatory mechanism of SAA still remains unclear during the development of periodontitis METHODS: SAA mRNA and protein expression were detected in healthy and in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.19-0050

    authors: Song LT,Lai W,Li JS,Mu YZ,Li CY,Jiang SY

    更新日期:2020-01-01 00:00:00

  • Histologic and histomorphometric findings from retrieved, immediately occlusally loaded implants in humans.

    abstract:BACKGROUND:The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reco...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.11.1823

    authors: Romanos GE,Testori T,Degidi M,Piattelli A

    更新日期:2005-11-01 00:00:00

  • Guided tissue regeneration: comparison of bioabsorbable and non-bioabsorbable membranes. Histologic and histometric study in dogs.

    abstract::This study examined histologic and histometric responses to 2 bioabsorbable membranes made from a synthetic copolymer of glycolide and lactide. They were tested for their biocompatibility, resorption characteristics, and ability to support periodontal regeneration. Expanded polytetrafluoroethylene (ePTFE) was used as ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1994.65.6.583

    authors: Caffesse RG,Nasjleti CE,Morrison EC,Sanchez R

    更新日期:1994-06-01 00:00:00

  • Reexamining the association between smoking and periodontitis in the dunedin study with an enhanced analytical approach.

    abstract:BACKGROUND:Smoking is a major risk factor for periodontal disease. Conventional oral epidemiology approaches have found strong, consistent associations between chronic smoking and periodontal attachment loss (AL) through ages 26, 32, and 38 years, but those statistical methods disregarded the data's hierarchical struct...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.130577

    authors: Zeng J,Williams SM,Fletcher DJ,Cameron CM,Broadbent JM,Shearer DM,Thomson WM

    更新日期:2014-10-01 00:00:00

  • Paradental cyst: report of two cases.

    abstract:BACKGROUND:The paradental cyst is an odontogenic lesion of inflammatory origin that has few clinical signs and symptoms apart from recurring acute episodes. A well-defined radiolucency associated with the roots or distal to the crown may be seen radiographically. The purpose of this article is to report on different as...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050380

    authors: Kanno CM,Gulinelli JL,Nagata MJ,Soubhia AM,Crivelini MM

    更新日期:2006-09-01 00:00:00

  • Alveolar ridge and sinus augmentation utilizing platelet-rich plasma in combination with freeze-dried bone allograft: case series.

    abstract:BACKGROUND:Alveolar bone regeneration is frequently necessary prior to placement of implants. Efforts to improve wound healing have focused on factors that may enhance bone formation following guided bone regeneration (GBR) techniques alone or in combination with bone replacement graft materials. Recent reports suggest...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.10.1654

    authors: Kassolis JD,Rosen PS,Reynolds MA

    更新日期:2000-10-01 00:00:00

  • Bacterial invasion in experimental gingivitis in man.

    abstract::Gingival biopsies of the mesial papilla area of the first molar were obtained from each patient at 0-, 14- and 21-day intervals during plaque formation. The biopsies were fixed, serially sectioned, and Gram-stained. The incidence and distribution of the bacteria-like structures were studied by microscopy. In all the s...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.12.837

    authors: Saglie FR,Pertuiset JH,Rezende MT,Sabet MS,Raoufi D,Carranza FA Jr

    更新日期:1987-12-01 00:00:00

  • Validation of antibiotic efficacy on in vitro subgingival biofilms.

    abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.130167

    authors: Belibasakis GN,Thurnheer T

    更新日期:2014-02-01 00:00:00

  • Association between periodontitis and gestational diabetes mellitus: a case-control study.

    abstract:BACKGROUND:Some studies have reported an association between gestational diabetes mellitus (GDM) and periodontitis. The aim of the present study is to analyze this potential association and the influence of risk variables associated with GDM. METHODS:This case-control study includes 360 women, 90 with GDM and 270 cont...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.120350

    authors: Esteves Lima RP,Miranda Cota LO,Costa FO

    更新日期:2013-09-01 00:00:00

  • Guided tissue regeneration with dentin biomodification.

    abstract::This study was undertaken to provide histologic observations on the effectiveness of citric acid and tetracycline HCl root surface demineralization when used in conjunction with guided tissue regeneration (GTR) procedures. Eight beagle dogs with naturally-occurring periodontitis were initially treated with scaling and...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1993.64.11.1052

    authors: Dyer BL,Caffesse RG,Nasjleti CE,Morrison EC

    更新日期:1993-11-01 00:00:00