Platelet-Rich Fibrin With 1.2% Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.

Abstract:

BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal improvements. Platelet analogs such as platelet-rich fibrin (PRF), being rich sources of growth factors, have also come into widespread periodontal regenerative use. The aim of this study is to evaluate and compare efficacy of open flap debridement (OFD) with or without PRF or PRF + 1.2% RSV gel in treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP). METHODS:Ninety individuals with a total of 90 IBDs were randomly assigned to one of three treatment groups: 1) OFD alone; 2) OFD + PRF; and 3) OFD + PRF + 1.2% RSV gel placement. Measurements recorded at baseline and 9 months after surgery were: 1) plaque index (PI); 2) modified sulcus bleeding index (mSBI); 3) probing depth (PD); 4) clinical attachment level (CAL); and 5) IBD depth. RESULTS:Significant PI and mSBI reductions were observed in all three groups. PRF placement significantly enhanced improvements in periodontal parameters compared with OFD alone. Addition of 1.2% RSV gel to PRF resulted in significantly greater CAL gain and PD and IBD depth reductions over 9 months compared with other groups. CONCLUSION:OFD with RSV (1.2%) and PRF results in significantly greater periodontal benefits compared with OFD alone or with PRF.

journal_name

J Periodontol

authors

Pradeep AR,Garg V,Kanoriya D,Singhal S

doi

10.1902/jop.2016.160015

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1468-1473

issue

12

eissn

0022-3492

issn

1943-3670

journal_volume

87

pub_type

杂志文章,随机对照试验
  • A method for the geometric and densitometric standardization of intraoral radiographs.

    abstract::The interpretation of dental radiographs for the diagnosis of periodontal disease conditions poses several difficulties. These include the inability to adequately reproduce the projection geometry and optical density of the exposures. In order to improve the ability to extract accurate quantitative information from a ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1983.54.7.435

    authors: Duckworth JE,Judy PF,Goodson JM,Socransky SS

    更新日期:1983-07-01 00:00:00

  • Distinctive molecular composition of human gingival interdental papilla.

    abstract:BACKGROUND:Gingiva is composed of attached and marginal (free) gingiva and interdental papilla. Increasing esthetic demands in dentistry have created a need to restore all parts of the gingiva. However, the interdental papilla has limited regeneration potential compared to other parts of the gingiva. It also is more su...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060165

    authors: Csiszar A,Wiebe C,Larjava H,Häkkinen L

    更新日期:2007-02-01 00:00:00

  • Cyclooxygenase-2-dependent prostaglandin E(2) upregulates interleukin (IL)-1alpha-induced IL-6 generation in mouse cementoblasts.

    abstract:BACKGROUND:Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. In the present study, we investigated whether a mouse cementoblast cell line, OCCM-30 cells,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060257

    authors: Noguchi K,Miyauchi M,Oka H,Komaki M,Somerman MJ,Takata T

    更新日期:2007-01-01 00:00:00

  • Early periodontal disease in the Syrian hamster.

    abstract::An investigation into periodontal disease in the Syrian Golden hamster was conducted over a period of six months. With the periodontitis-producing Diet 2000 only mild destruction of the periodontium was observed. The interproximal area between M1 and M2 may be a better area for analysis of early periodontal disease in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1975.46.6.368

    authors: Miller WA,Ripley JF

    更新日期:1975-06-01 00:00:00

  • The Adjunctive Effect of Platelet-Rich Fibrin to Connective Tissue Graft in the Treatment of Buccal Recession Defects: Results of a Randomized, Parallel-Group Controlled Trial.

    abstract:BACKGROUND:Platelet-rich fibrin (PRF) is an autologous preparation that has encouraging effects in healing and regeneration. The aim of this trial is to evaluate the effectiveness of coronally advanced flap (CAF) + connective tissue graft (CTG) + PRF in Miller Class I and II recession treatment compared to CAF + CTG. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2015.150015

    authors: Keceli HG,Kamak G,Erdemir EO,Evginer MS,Dolgun A

    更新日期:2015-11-01 00:00:00

  • The prevalence and distribution of intrabony defects in dry mandibles.

    abstract::One hundred mandibles of South African Negroes were examined for the presence of intrabony defects, and the distance between the cemento-enamel junction and alveolar bone crest was measured along the buccal and lingual surface of roots associated with interdental craters. Two-hundred thirty-one intrabony defects were ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.3.149

    authors: Tal H

    更新日期:1984-03-01 00:00:00

  • Some anatomical factors related to furcation involvements.

    abstract::A total of 305 dry human skull specimens were examined for the presence of furcation involvements. Of a total of 188 furcation involvements, 142 (75%) were related to the close proximity of the furcation to the cemento enamel junction of the tooth. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1975.46.10.608

    authors: Larato DC

    更新日期:1975-10-01 00:00:00

  • Lack of association between periodontal parameters and preeclampsia.

    abstract:BACKGROUND:It was hypothesized that periodontal diseases may increase the risk of preeclampsia. To test this hypothesis, this study was conducted to determine the association between periodontal parameters and preeclampsia among women in the north of Jordan. METHODS:A case-control study was conducted among women who g...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050463

    authors: Khader YS,Jibreal M,Al-Omiri M,Amarin Z

    更新日期:2006-10-01 00:00:00

  • Effect of Porphyromonas gingivalis lipopolysaccharide on bone marrow mesenchymal stem cell osteogenesis on a titanium nanosurface.

    abstract:BACKGROUND:Titanium (Ti) dental implants have been widely used for prosthetic reconstruction of dentition. Unfortunately, peri-implantitis can result in failure of dental implant osseointegration. Lipopolysaccharide (LPS) acts as a chronic inflammatory stimulus and maintains peri-implant inflammation, worsening the pro...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.140386

    authors: Xing H,Taguchi Y,Komasa S,Yamawaki I,Sekino T,Umeda M,Okazaki J

    更新日期:2015-03-01 00:00:00

  • Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans.

    abstract:BACKGROUND:To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools. METHODS:Gingival biopsy samples collected from 14 subjects during a 28-day stent-induce...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.080645

    authors: Offenbacher S,Barros SP,Paquette DW,Winston JL,Biesbrock AR,Thomason RG,Gibb RD,Fulmer AW,Tiesman JP,Juhlin KD,Wang SL,Reichling TD,Chen KS,Ho B

    更新日期:2009-12-01 00:00:00

  • The influence of general health and socio-cultural variables on the periodontal condition of pregnant women.

    abstract:BACKGROUND:There has been speculation as to whether hormonal changes during pregnancy or pre-existing conditions of general, oral, and dental health and socio-cultural background have a greater impact on the development of periodontal disease during pregnancy. METHODS:This study evaluates the periodontal status of 130...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.7.779

    authors: Machuca G,Khoshfeiz O,Lacalle JR,Machuca C,Bullón P

    更新日期:1999-07-01 00:00:00

  • A multi-center study comparing dual acid-etched and machined-surfaced implants in various bone qualities.

    abstract:BACKGROUND:A major reason for the success of modern dental implant systems has been the development of implant designs that enhance direct bone-implant interface. Surface roughness has been a factor in this success and different systems have utilized very different implant surface roughness. The major purpose of this s...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1902/jop.2001.72.10.1384

    authors: Khang W,Feldman S,Hawley CE,Gunsolley J

    更新日期:2001-10-01 00:00:00

  • Redefining the biologic width in severe, generalized, chronic periodontitis: implications for therapy.

    abstract:BACKGROUND:Previous studies demonstrated significant variability in the histologic biologic width in periodontal health and mild periodontitis. The purpose of this study was to determine whether the previously established dimensions of the biologic width applied to subjects with severe, generalized, chronic periodontit...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.080066

    authors: Novak MJ,Albather HM,Close JM

    更新日期:2008-10-01 00:00:00

  • Local delivery of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis.

    abstract:BACKGROUND:The aim of the present study was to evaluate the adjunctive effect of the local application of a hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis. METHODS:Twelve patients with chronic periodontitis were recruited to participate in a study with a split-mouth design and pro...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2009.090128

    authors: Johannsen A,Tellefsen M,Wikesjö U,Johannsen G

    更新日期:2009-09-01 00:00:00

  • In vivo validation of a three-dimensional optical method to document volumetric soft tissue changes of the interdental papilla.

    abstract:BACKGROUND:Non-surgical and surgical periodontal treatment may cause volumetric changes in the gingival contour. Many techniques have been suggested to minimize soft tissue shrinkage; however, there is a lack of three-dimensional (3D) quantitative data comparing different treatment approaches. The aim of the present st...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.080288

    authors: Strebel J,Ender A,Paqué F,Krähenmann M,Attin T,Schmidlin PR

    更新日期:2009-01-01 00:00:00

  • Bacterial invasion in experimental gingivitis in man.

    abstract::Gingival biopsies of the mesial papilla area of the first molar were obtained from each patient at 0-, 14- and 21-day intervals during plaque formation. The biopsies were fixed, serially sectioned, and Gram-stained. The incidence and distribution of the bacteria-like structures were studied by microscopy. In all the s...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.12.837

    authors: Saglie FR,Pertuiset JH,Rezende MT,Sabet MS,Raoufi D,Carranza FA Jr

    更新日期:1987-12-01 00:00:00

  • Fiber glass splints.

    abstract::Temporary splints to immobilize periodontally diseased teeth were made by fiber glass bonded and attached to the teeth with acid-etch technique with BIS-GMA resin. Twenty-one splints were made. Observation time ranged from 4 to 14 months. During the observation only one splint fractured and was repaired while the othe...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1979.50.4.193

    authors: Friskopp J,Blomlöf L,Söder PO

    更新日期:1979-04-01 00:00:00

  • Altered cell motility and attachment with titanium surface modifications.

    abstract:BACKGROUND:Titanium implants are widely used in dentistry to replace lost teeth. Various surface modifications have been used to improve implant retention and osseointegration. This study is designed to compare the ability of three titanium surfaces to promote cell attachment and cell motility of cells relevant to peri...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100733

    authors: Palaiologou A,Stoute D,Fan Y,Lallier TE

    更新日期:2012-01-01 00:00:00

  • Immunohistochemical distribution of extracellular matrix proteins as a diagnostic parameter in healthy and diseased gingiva.

    abstract::This study showed histopathological findings of the extracellular matrix in healthy, inflamed, and hyperplastic human gingiva with immunohistochemical techniques. The distribution of collagen types V and VI, as well as of glycoprotein fibronectin, shows that they are extracellular matrix structural components which di...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1993.64.2.110

    authors: Romanos GE,Strub JR,Bernimoulin JP

    更新日期:1993-02-01 00:00:00

  • Detection of eight periodontal microorganisms and distribution of Porphyromonas gingivalis fimA genotypes in Chinese patients with aggressive periodontitis.

    abstract:BACKGROUND:The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP. METHODS:...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.120677

    authors: Feng X,Zhang L,Xu L,Meng H,Lu R,Chen Z,Shi D,Wang X

    更新日期:2014-01-01 00:00:00

  • Biomarkers and Bacteria Around Implants and Natural Teeth in the Same Individuals.

    abstract:BACKGROUND:This cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. METHODS:Samples from 97 implants/teeth (58 implants [19 hea...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2017.160751

    authors: Gürlek Ö,Gümüş P,Nile CJ,Lappin DF,Buduneli N

    更新日期:2017-08-01 00:00:00

  • Maternal periodontal disease and preterm or extreme preterm birth: an ordinal logistic regression analysis.

    abstract:BACKGROUND:Despite previous studies addressing the link between preterm or low birth weight infants and maternal periodontitis, extreme preterm births have received far less attention. This study is designed to address the possible association between maternal periodontal disease and preterm or extreme preterm birth. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.090527

    authors: Guimarães AN,Silva-Mato A,Miranda Cota LO,Siqueira FM,Costa FO

    更新日期:2010-03-01 00:00:00

  • Association of clinical measures of periodontal disease with blood pressure and hypertension among postmenopausal women.

    abstract:BACKGROUND:Hypertension and periodontal disease are common conditions among postmenopausal women. Periodontal disease has been found associated with hypertension in previous studies, but data in postmenopausal women is limited. METHODS:We assessed the cross-sectional associations of clinically measured periodontal dis...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.17-0562

    authors: Gordon JH,LaMonte MJ,Genco RJ,Zhao J,Cimato TR,Hovey KM,Wactawski-Wende J

    更新日期:2018-10-01 00:00:00

  • Angiotensin II Type 1 Receptor Knockdown Impairs Interleukin-1β-Induced Cytokines in Human Periodontal Fibroblasts.

    abstract:BACKGROUND:The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II Type 1 (AT1) receptor axis. It is known that periodontal pathogens elici...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.160354

    authors: Gabriele LG,Morandini AC,Dionísio TJ,Santos CF

    更新日期:2017-01-01 00:00:00

  • Effect of periodontal treatment on the protein composition of whole and parotid saliva.

    abstract::Cystatins are physiological inhibitors of cysteine proteinases and widely distributed in human tissues and fluids including saliva. Cystatins S, SA, SN, and D are only found in glandular saliva and tear fluid whereas cystatin C has been detected in all tested biological fluids. Previous studies demonstrated that total...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.3.205

    authors: Henskens YM,van der Weijden FA,van den Keijbus PA,Veerman EC,Timmerman MF,van der Velden U,Amerongen AV

    更新日期:1996-03-01 00:00:00

  • Evaluation of root-resected teeth. Results after 10 years.

    abstract::There are only a few long-term investigations on root-resected teeth in the literature. This article is a 10-year review of 28 root-resection cases, which mainly had been used as bridge abutments. The periodontal, prosthetic, and endodontic problems were evaluated. After 10 years a total failure rate of 32% was observ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.12.805

    authors: Bühler H

    更新日期:1988-12-01 00:00:00

  • Histochemical and immunocytochemical localization of dipeptidyl peptidases II and IV in human gingiva.

    abstract::Dipeptidyl peptidase (DPP) II and IV activities were demonstrated in unfixed cryostat sections of gingival tissue from chronic periodontitis patients using histochemistry with 2-methoxy-4-naphthylamine (MNA) substrates. In the case of DPP IV, enzyme localization was confirmed by immunocytochemistry with mouse monoclon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.9.846

    authors: Kennett CN,Cox SW,Eley BM

    更新日期:1996-09-01 00:00:00

  • Salivary and plasma levels of Toll-like receptor 2 and Toll-like receptor 4 in chronic periodontitis.

    abstract:BACKGROUND:This cross-sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll-like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy. METHODS:Whole saliva and plasma samples were obtained and full-mouth c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100467

    authors: Buduneli N,Özçaka Ö,Nalbantsoy A

    更新日期:2011-06-01 00:00:00

  • Alveolar bone resorption induced by CD4+CD45RB high-density T-cell transfer in immunocompromised mice.

    abstract:BACKGROUND:The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.140077

    authors: Park JC,Kim BK,Jung IH,Choi E,Kim CS

    更新日期:2014-09-01 00:00:00

  • Long-term results of guided tissue regeneration therapy in the treatment of class II furcation defects: a randomized clinical trial.

    abstract:BACKGROUND:The purpose of this study was to evaluate the results after guided tissue regeneration (GTR) using a bioabsorbable membrane in Class II furcation defects in mandibular molars over a 24-month period. METHODS:Nine patients with 2 comparable Class II furcation defects were included. The defects in each patient...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2003.74.1.3

    authors: Cury PR,Sallum EA,Nociti FH Jr,Sallum AW,Jeffcoatt MK

    更新日期:2003-01-01 00:00:00