Abstract:
BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal improvements. Platelet analogs such as platelet-rich fibrin (PRF), being rich sources of growth factors, have also come into widespread periodontal regenerative use. The aim of this study is to evaluate and compare efficacy of open flap debridement (OFD) with or without PRF or PRF + 1.2% RSV gel in treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP). METHODS:Ninety individuals with a total of 90 IBDs were randomly assigned to one of three treatment groups: 1) OFD alone; 2) OFD + PRF; and 3) OFD + PRF + 1.2% RSV gel placement. Measurements recorded at baseline and 9 months after surgery were: 1) plaque index (PI); 2) modified sulcus bleeding index (mSBI); 3) probing depth (PD); 4) clinical attachment level (CAL); and 5) IBD depth. RESULTS:Significant PI and mSBI reductions were observed in all three groups. PRF placement significantly enhanced improvements in periodontal parameters compared with OFD alone. Addition of 1.2% RSV gel to PRF resulted in significantly greater CAL gain and PD and IBD depth reductions over 9 months compared with other groups. CONCLUSION:OFD with RSV (1.2%) and PRF results in significantly greater periodontal benefits compared with OFD alone or with PRF.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Pradeep AR,Garg V,Kanoriya D,Singhal Sdoi
10.1902/jop.2016.160015subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1468-1473issue
12eissn
0022-3492issn
1943-3670journal_volume
87pub_type
杂志文章,随机对照试验abstract::The interpretation of dental radiographs for the diagnosis of periodontal disease conditions poses several difficulties. These include the inability to adequately reproduce the projection geometry and optical density of the exposures. In order to improve the ability to extract accurate quantitative information from a ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.7.435
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Gingiva is composed of attached and marginal (free) gingiva and interdental papilla. Increasing esthetic demands in dentistry have created a need to restore all parts of the gingiva. However, the interdental papilla has limited regeneration potential compared to other parts of the gingiva. It also is more su...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060165
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. In the present study, we investigated whether a mouse cementoblast cell line, OCCM-30 cells,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060257
更新日期:2007-01-01 00:00:00
abstract::An investigation into periodontal disease in the Syrian Golden hamster was conducted over a period of six months. With the periodontitis-producing Diet 2000 only mild destruction of the periodontium was observed. The interproximal area between M1 and M2 may be a better area for analysis of early periodontal disease in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.6.368
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:Platelet-rich fibrin (PRF) is an autologous preparation that has encouraging effects in healing and regeneration. The aim of this trial is to evaluate the effectiveness of coronally advanced flap (CAF) + connective tissue graft (CTG) + PRF in Miller Class I and II recession treatment compared to CAF + CTG. ...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2015.150015
更新日期:2015-11-01 00:00:00
abstract::One hundred mandibles of South African Negroes were examined for the presence of intrabony defects, and the distance between the cemento-enamel junction and alveolar bone crest was measured along the buccal and lingual surface of roots associated with interdental craters. Two-hundred thirty-one intrabony defects were ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.3.149
更新日期:1984-03-01 00:00:00
abstract::A total of 305 dry human skull specimens were examined for the presence of furcation involvements. Of a total of 188 furcation involvements, 142 (75%) were related to the close proximity of the furcation to the cemento enamel junction of the tooth. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.10.608
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:It was hypothesized that periodontal diseases may increase the risk of preeclampsia. To test this hypothesis, this study was conducted to determine the association between periodontal parameters and preeclampsia among women in the north of Jordan. METHODS:A case-control study was conducted among women who g...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050463
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Titanium (Ti) dental implants have been widely used for prosthetic reconstruction of dentition. Unfortunately, peri-implantitis can result in failure of dental implant osseointegration. Lipopolysaccharide (LPS) acts as a chronic inflammatory stimulus and maintains peri-implant inflammation, worsening the pro...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140386
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools. METHODS:Gingival biopsy samples collected from 14 subjects during a 28-day stent-induce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080645
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:There has been speculation as to whether hormonal changes during pregnancy or pre-existing conditions of general, oral, and dental health and socio-cultural background have a greater impact on the development of periodontal disease during pregnancy. METHODS:This study evaluates the periodontal status of 130...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.7.779
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:A major reason for the success of modern dental implant systems has been the development of implant designs that enhance direct bone-implant interface. Surface roughness has been a factor in this success and different systems have utilized very different implant surface roughness. The major purpose of this s...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2001.72.10.1384
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Previous studies demonstrated significant variability in the histologic biologic width in periodontal health and mild periodontitis. The purpose of this study was to determine whether the previously established dimensions of the biologic width applied to subjects with severe, generalized, chronic periodontit...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080066
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the adjunctive effect of the local application of a hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis. METHODS:Twelve patients with chronic periodontitis were recruited to participate in a study with a split-mouth design and pro...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2009.090128
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Non-surgical and surgical periodontal treatment may cause volumetric changes in the gingival contour. Many techniques have been suggested to minimize soft tissue shrinkage; however, there is a lack of three-dimensional (3D) quantitative data comparing different treatment approaches. The aim of the present st...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080288
更新日期:2009-01-01 00:00:00
abstract::Gingival biopsies of the mesial papilla area of the first molar were obtained from each patient at 0-, 14- and 21-day intervals during plaque formation. The biopsies were fixed, serially sectioned, and Gram-stained. The incidence and distribution of the bacteria-like structures were studied by microscopy. In all the s...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.12.837
更新日期:1987-12-01 00:00:00
abstract::Temporary splints to immobilize periodontally diseased teeth were made by fiber glass bonded and attached to the teeth with acid-etch technique with BIS-GMA resin. Twenty-one splints were made. Observation time ranged from 4 to 14 months. During the observation only one splint fractured and was repaired while the othe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.4.193
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Titanium implants are widely used in dentistry to replace lost teeth. Various surface modifications have been used to improve implant retention and osseointegration. This study is designed to compare the ability of three titanium surfaces to promote cell attachment and cell motility of cells relevant to peri...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100733
更新日期:2012-01-01 00:00:00
abstract::This study showed histopathological findings of the extracellular matrix in healthy, inflamed, and hyperplastic human gingiva with immunohistochemical techniques. The distribution of collagen types V and VI, as well as of glycoprotein fibronectin, shows that they are extracellular matrix structural components which di...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.2.110
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP. METHODS:...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.120677
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:This cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. METHODS:Samples from 97 implants/teeth (58 implants [19 hea...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160751
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Despite previous studies addressing the link between preterm or low birth weight infants and maternal periodontitis, extreme preterm births have received far less attention. This study is designed to address the possible association between maternal periodontal disease and preterm or extreme preterm birth. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090527
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Hypertension and periodontal disease are common conditions among postmenopausal women. Periodontal disease has been found associated with hypertension in previous studies, but data in postmenopausal women is limited. METHODS:We assessed the cross-sectional associations of clinically measured periodontal dis...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.17-0562
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II Type 1 (AT1) receptor axis. It is known that periodontal pathogens elici...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160354
更新日期:2017-01-01 00:00:00
abstract::Cystatins are physiological inhibitors of cysteine proteinases and widely distributed in human tissues and fluids including saliva. Cystatins S, SA, SN, and D are only found in glandular saliva and tear fluid whereas cystatin C has been detected in all tested biological fluids. Previous studies demonstrated that total...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.3.205
更新日期:1996-03-01 00:00:00
abstract::There are only a few long-term investigations on root-resected teeth in the literature. This article is a 10-year review of 28 root-resection cases, which mainly had been used as bridge abutments. The periodontal, prosthetic, and endodontic problems were evaluated. After 10 years a total failure rate of 32% was observ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.12.805
更新日期:1988-12-01 00:00:00
abstract::Dipeptidyl peptidase (DPP) II and IV activities were demonstrated in unfixed cryostat sections of gingival tissue from chronic periodontitis patients using histochemistry with 2-methoxy-4-naphthylamine (MNA) substrates. In the case of DPP IV, enzyme localization was confirmed by immunocytochemistry with mouse monoclon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.9.846
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:This cross-sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll-like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy. METHODS:Whole saliva and plasma samples were obtained and full-mouth c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100467
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140077
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the results after guided tissue regeneration (GTR) using a bioabsorbable membrane in Class II furcation defects in mandibular molars over a 24-month period. METHODS:Nine patients with 2 comparable Class II furcation defects were included. The defects in each patient...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2003.74.1.3
更新日期:2003-01-01 00:00:00