Abstract:
BACKGROUND:There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM:To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary disease (COPD), pneumonia, chronic kidney disease, rheumatoid arthritis, cognitive impairment, obesity, metabolic syndrome and cancer, and to document headline discussions of the state of each field. Periodontal associations with diabetes, cardiovascular disease and adverse pregnancy outcomes were not discussed by working group 4. RESULTS:Working group 4 recognized that the studies performed to date were largely cross-sectional or case-control with few prospective cohort studies and no randomized clinical trials. The best current evidence suggests that periodontitis is characterized by both infection and pro-inflammatory events, which variously manifest within the systemic diseases and disorders discussed. Diseases with at least minimal evidence of an association with periodontitis include COPD, pneumonia, chronic kidney disease, rheumatoid arthritis, cognitive impairment, obesity, metabolic syndrome and cancer. The working group agreed that there is insufficient evidence to date to infer causal relationships with the exception that organisms originating in the oral microbiome can cause lung infections. CONCLUSIONS:The group was unanimous in their opinion that the reported associations do not imply causality, and establishment of causality will require new studies that fulfil the Bradford Hill or equivalent criteria. Precise and community-agreed case definitions of periodontal disease states must be implemented systematically to enable consistent and clearer interpretations of studies of the relationship to systemic diseases. The members of the working group were unanimous in their opinion that to develop data that best inform clinicians, investigators and the public, studies should focus on robust disease outcomes and avoid surrogate endpoints. It was concluded that because of the relative immaturity of the body of evidence for each of the purported relationships, the field is wide open and the gaps in knowledge are large.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Linden GJ,Herzberg MC,working group 4 of the joint EFP\/AAP workshop.doi
10.1902/jop.2013.1340020subject
Has Abstractpub_date
2013-04-01 00:00:00pages
S20-3issue
4 Suppleissn
0022-3492issn
1943-3670journal_volume
84pub_type
杂志文章abstract:BACKGROUND:In early case studies, use of a collagen barrier as a guided tissue regeneration (GTR) material has shown particular promise in procedures aimed at root coverage. The similarities between collagen membrane and subepithelial connective tissue graft (SCTG) have made collagen membrane an attractive and a possib...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2001.72.10.1301
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Various surgical techniques have been proposed for treating gingival recession. This randomized clinical trial compared the coronally positioned flap (CPF) alone or in conjunction with a subepithelial connective tissue graft (SCTG) in the treatment of gingival recession. METHODS:Eleven non-smoking subjects ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2004.75.3.413
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Platelet-derived growth factor (PDGF-BB) has been shown to enhance periodontal regeneration. Principles of guided tissue regeneration dictate that one of the goals of therapy is to modulate the wound healing processes to favor repopulation of the wound with cells derived from the periodontal ligament rather ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.3.331
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Aspartate aminotransferase (AST) is an enzyme normally confined to the cytoplasm of cells, but released to the exracellular environment upon cell death. Its levels are associated with the severity of experimental gingivitis and the loss of periodontal attachement. The aim of the present study was to investig...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.7.1151
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Non-surgical and surgical periodontal treatment may cause volumetric changes in the gingival contour. Many techniques have been suggested to minimize soft tissue shrinkage; however, there is a lack of three-dimensional (3D) quantitative data comparing different treatment approaches. The aim of the present st...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080288
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Collagen membranes cross-linked by glycation (GLYM) for guided bone regeneration (GBR) and guided tissue regeneration (GTR) are used extensively with proven safety and efficacy. Complete GLYM ossification, when placed in contact with bone, was described in a canine jaw model, suggesting that GLYM may serve a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070421
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The purpose of this clinical study was to evaluate the possible influence of testosterone hormone on common clinical measurements of periodontal disease in men with hypergonadotropic hypogonadism. METHODS:Twenty-four hypergonadotropic hypogonadal men (H) and 24 systemically healthy men (S) were divided into...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050286
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090741
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Volumetric alterations in gingival crevicular fluid (GCF) are widely accepted to be associated with periodontal health/disease. The volume/flow of GCF was shown to be affected by an array of methodological factors. However, relatively limited information is available on whether GCF is subject to circadian rh...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130367
更新日期:2014-03-01 00:00:00
abstract::A rotation flap for covering denuded single root surfaces with attached gingiva has been described and illustrated. This was performed utilizing a closed wound technique. The single flap provided attached gingiva coverage for a moderate area while a double flap provided coverage for a larger area. Although more attach...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.1.41
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Proper formation of cementum, a mineralized tissue lining the tooth root surface, is required for development of a functional periodontal ligament. Further, the presence of healthy cementum is considered to be an important criterion for predictable restoration of periodontal tissues lost as a consequence of ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.1.63
更新日期:2000-01-01 00:00:00
abstract::The placement of hydroxyapatite-coated dental implants in fresh extraction sockets was compared to placement in adjacent healed sites in 14 patients. Systematic sequential documentation was obtained regarding periodontal health, radiographic bone levels, and implant stability at the time of implant placement, at uncov...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.7.468
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Gingiva is composed of attached and marginal (free) gingiva and interdental papilla. Increasing esthetic demands in dentistry have created a need to restore all parts of the gingiva. However, the interdental papilla has limited regeneration potential compared to other parts of the gingiva. It also is more su...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060165
更新日期:2007-02-01 00:00:00
abstract::Interleukin-1 beta (IL-1 beta) is the predominant form of IL-1 produced by macrophages. IL-1 beta possesses numerous and diverse biological activities. Several of these activities, including fibroblast proliferation, potentiation of the immune response, and stimulation of bone resorption may be of relevance to the pat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.1.36
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The minimum inhibitory concentration (MIC) does not provide information on the efficacy of antimicrobial agents against infections involving biofilms, which are many times more resistant than planktonic forms of bacteria. This report is on the design and initial trial of a device for growing standard biofilm...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1443
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:There is a large amount of data on surgical root coverage procedures for the treatment of gingival recessions but no controlled clinical trials on the behavior of marginal gingiva following non-surgical therapy. The aim of our study was to compare in terms of root coverage two different modalities of root su...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.2.256
更新日期:2005-02-01 00:00:00
abstract::Sensory innervation of gingival tissue can cause neurogenic inflammation that depends on the extent of the branching area of the peripheral nerve fibers. We designed the present study to determine whether single trigeminal axons branch to both the buccal and palatal gingiva of maxillary molars of adult rats. Accumulat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.9.817
更新日期:1995-09-01 00:00:00
abstract::Partial-mouth scores are often used in epidemiologic studies to estimate the prevalence and severity of periodontal disease. Such estimates systematically underestimate the prevalence of disease, but the bias can be in either direction for disease severity. Three large data sets containing full-mouth examinations (mes...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.11.707
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Periopathogens and cariogenic species survive more than 48 hours on toothbrushes even under dry storage. This study examined a decontamination of toothbrushes by means of the bactericidal effect of different toothpastes or a special coating of the tufts. METHODS:Eight untreated periodontitis patients were p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.3.312
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:The present study was planned to investigate the therapeutic actions of 1-tetradecanol complex (1-TDC), a novel monounsaturated fatty acid mixture, in established periodontitis in rabbits. METHODS:Periodontitis was initiated in 18 New Zealand White rabbits using ligatures around mandibular second premolars,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090002
更新日期:2009-07-01 00:00:00
abstract::The prevalence and features of 3 types of exostoses commonly encountered during periodontal surgery were studied in a sample of 328 modern American skulls drawn from the collection at the American Museum of Natural History. Measurements were made of the height, width, and breadth of exostoses. The relationship to teet...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.3.329
更新日期:1999-03-01 00:00:00
abstract::Smoker's melanosis is a benign pigmentation of the oral mucosa, predominantly observed on the attached anterior mandibular gingiva and interdental papillae. These macular lesions are independent of genetic factors, therapeutic medication usage, and various systemic disorders. As a group they are often seen after the t...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1991.62.8.524
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Recent studies showed the clinical benefits of a one stage full-mouth disinfection, when compared to the worldwide standard treatment strategy of consecutive root planings per quadrant without proper disinfection of the remaining intraoral niches. The purpose of this study was to investigate the microbiologi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1999.70.6.646
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Periodontists have found the gingival autograft to be an effective and predictable technique to increase the amount of attached gingiva around teeth, but this technique requires the surgeon to harvest donor tissue from a remote surgical site. The present study seeks to evaluate the safety and effectiveness o...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.6.867
更新日期:2005-06-01 00:00:00
abstract::The morphotypes of the subgingival microflora from 85 12 to 18-year-old Finnish adolescents with insulin-dependent diabetes mellitus (IDDM) were studied in Gram- and Rhodes-stained smears. A comparison was made with subgingival plaque samples from paired age- and sex-matched healthy controls. Significant differences w...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.9.526
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Guided bone regeneration (GBR) has been widely utilized for the promotion of bone augmentation in bone loss areas. However, little information has been available regarding chronological changes in newly formed bone and alterations in the nature of newly formed bone after removal of a barrier membrane. The pr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.3.341
更新日期:2000-03-01 00:00:00
abstract::There are few studies that provide information on the natural history of calculus formation. The purpose of this study is to evaluate the relationship between pre-scaling baseline calculus scores, the time since the last prophylaxis before baseline, and scores 8 weeks after scaling in a group of presumed heavy calculu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.8.750
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Sex hormones are linked to inflammation and bone turnover. The goal of this study is to explore the association between sex hormone levels and periodontitis in men using data from the third National Health and Nutrition Examination Survey (NHANES III). METHODS:Data from 755 men (aged ≥ 30 years), including ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.140530
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Crestal bone thickness is a critical determinant of peri-implant tissue stability. This retrospective observational study sought to quantify the buccal bone thickness achieved adjacent to virtual dental implants following guided bone regeneration (GBR) surgery and evaluate the influence of patient- and proce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0304
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:In this study, we compare the effectiveness of enamel matrix derivative (EMD) associated with a simplified papilla preservation flap (SPPF) technique to SPPF alone when surgically treating supra-alveolar-type defects. METHODS:Fifty patients, from 54 initially selected, presenting horizontal bone loss around...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.120075
更新日期:2013-08-01 00:00:00