Abstract:
BACKGROUND:The present study was planned to investigate the therapeutic actions of 1-tetradecanol complex (1-TDC), a novel monounsaturated fatty acid mixture, in established periodontitis in rabbits. METHODS:Periodontitis was initiated in 18 New Zealand White rabbits using ligatures around mandibular second premolars, followed by topical Porphyromonas gingivalis application (10(9) colony forming units). After 6 weeks of disease induction (phase 1), three animals were sacrificed to assess the established periodontitis level. P. gingivalis application was discontinued, and the remaining 15 animals continued with topical treatment of 1-TDC (100 mg/ml; n = 5) or placebo (n = 5) or no treatment (n = 5) for an additional 6 weeks (phase 2). Mandibular block sections obtained after euthanasia were decalcified and embedded in paraffin. In addition to the macroscopic analyses, hematoxylin and eosin-stained sections were used to study cellular inflammatory infiltrate and quantitative histomorphometry. Tartrate-resistant acid phosphatase and osteocalcin were used to identify osteoclastic and osteoblastic activity, respectively. RESULTS:P. gingivalis application resulted in periodontal disease with gingival inflammation and bone loss (30% compared to baseline) at 6 weeks. Treatment with 1-TDC stopped the progression of the disease and resulted in a significant reduction in the macroscopic periodontal inflammation, attachment, and bone loss (10.1% +/- 1.8%), whereas periodontal disease progressed in the untreated and placebo groups (P <0.05). Histologic assessment and histomorphometric measurements demonstrated that 1-TDC inhibited inflammatory cell infiltration and osteoclastic activity (P <0.05). CONCLUSION:The findings suggest that topical application of cetylated monounsaturated fatty acid complex (1-TDC) is a potential therapeutic approach in controlling the progression of chronic periodontal disease.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Hasturk H,Goguet-Surmenian E,Blackwood A,Andry C,Kantarci Adoi
10.1902/jop.2009.090002subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1103-13issue
7eissn
0022-3492issn
1943-3670journal_volume
80pub_type
杂志文章abstract::The capacity of epithelial cells to migrate and grow from gingival explants cultured on mineralized and partially demineralized root surfaces in an in vitro system was assessed. Explants of attached gingiva were obtained from mongrel dogs, cut into rectangular pieces (1 x 2 mm) and cultured either on mineralized or pa...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.8.531
更新日期:1988-08-01 00:00:00
abstract::In order to increase our understanding of the immunologic aspects of periodontal disease, three groups of extracted human teeth were evaluated for the presence of antibody on the cementum surface. Antibody was demonstrated by direct immunofluorescence using monospecific antibody with human alpha , gamma and upsilon ch...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.168
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Previous studies have shown an association between a specific genotype for the inflammatory cytokine interleukin (IL)-1 and the severity of periodontal disease. The purpose of this study was to evaluate the effect of the IL-1 genotype on the outcomes of periodontal surgical regenerative treatment with bone r...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.10.1335
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:In the treatment of periodontal intrabony defects, the benefits of adding platelet-rich plasma (PRP) to a bone replacement grafting material have not been tested. The purpose of this study was to compare the clinical outcomes obtained by the combination of PRP and a bovine derived xenograft (BDX) to those ob...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2004.75.12.1668
更新日期:2004-12-01 00:00:00
abstract::The purpose of this study was to identify factors which might affect the healing response in intrabony defects treated with guided tissue regeneration. Selected sites presented with deep periodontal lesions with 1, 2, and 3 wall combination intrabony component of 6.1 +/- 2.5 mm. The significance of patient, tooth, and...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.10.934
更新日期:1993-10-01 00:00:00
abstract::A randomized, double-blind, clinical study was done to assess the microbiological and clinical effects of metronidazole plus amoxicillin (M+A) as the only therapy in 46 patients with moderate to advanced progressive adult periodontitis. Patients were included in the study after at least 2 sites showed > or =2 mm clini...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1998.69.11.1291
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Placement of endosseous dental implants in edentulous areas of the anterior maxilla poses a unique challenge due to variations in the amount of residual alveolar bone. Implant position becomes crucial in cases demanding high esthetic results but possessing minimal ridge width or in cases requiring augmentati...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.10.1202
更新日期:2002-10-01 00:00:00
abstract::Immunoglobulins in sera and in supernatant fluids of explant cultures of diseased gingival tissues from 20 rapidly progressive and 20 adult periodontitis sites were tested by an ELISA assay for reactivity with typed strains of Eubacterium alactolyticum, E. brachy, E. limosum and E. nodatum. Immunoglobulins present in ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.1.32
更新日期:1988-01-01 00:00:00
abstract::This cross-sectional study examined the gingivitis occurring at puberty in a population of insulin-dependent juvenile diabetics. Seventy-seven children between the ages of 6 and 15 years were examined for gingivitis levels, stages of pubertal maturation and blood levels of glucose and glycosylated hemoglobin. Bacteria...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.12.714
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Recently, brain-derived neurotrophic factor (BDNF)/high molecular weight hyaluronic acid (HMW-HA) complex with flap surgery has been shown to promote periodontal tissue regeneration. The objective of this study was to evaluate the effects of local subgingival application of BDNF/HMW-HA complex adjunctive to ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0070
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy of deproteinized bovine bone mineral with 10% collagen (DBBM-C) soaked with hyaluronic acid (HA) for ridge preservation in compromised extraction sockets. METHODS:Bilateral third, fourth premolars and first molar were hemisected, distal roots were extracted...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0832
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:The crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the correlation and accuracy of ultrasound in measuring periodontal dimensions, compared to ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0342
更新日期:2020-07-01 00:00:00
abstract::A system of nomenclature for deformities of the alveolar process is presented. Descriptive, familiar topographic terms are used (crater, trench, moat, ramp and plane), and specific criteria are given for each term. Two hundred randomly selected osseous deformities in dry skulls were classified by two examiners at inde...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.6.336
更新日期:1984-06-01 00:00:00
abstract::The purpose of this study was to determine the levels of calprotectin and lactoferrin, 2 microbiostatic proteins, in the gingival crevicular fluid (GCF) of normal children. The children represented a population, primarily underprivileged, seeking care at a regional dental health care center. GCF was collected from Ram...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.8.879
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Previous findings of an association between 25-hydroxyvitamin D [25(OH)D] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin D. To the best of the authors' knowledge, no study has investigated the association between 25(OH)D and pathogenic oral bacter...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130518
更新日期:2014-07-01 00:00:00
abstract::Nineteen young adult Caucasian males had an average Gingival Index Score of 0.47. Each was asked to demonstrate his present method of toothbrushing: thirteen used the scrub method, and six combined the scrub and roll methods. Control gingival tissue specimens were taken from the mandibular left first bicuspid or first...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.4.163
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including ...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究
doi:10.1902/jop.2014.140425
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Susceptibility to periodontal infections may, in part, be genetically determined. Porphyromonas gingivalis is a major periodontopathogen, and the immune response to this organism requires T-cell help. The aim of the present study was to examine the specific T-cell cytokine responses to P. gingivalis outer me...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.6.591
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia (previously T. forsythensis), which are regarded as the principal periodontopathogenic bacteria, exist as a consortium in subgingival biofilms. We aimed to examine quantitative relationships between P. gingivalis, T. denticola, and T. fo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070398
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:This study compared 6-month and 3-year outcomes for root coverage (RC) by coronally advanced flap (CAF) procedures in localized gingival recessions. METHODS:Two centers, that had participated in a 6-month multinational multicenter randomized clinical trial (RCT), followed up 18 patients with 36 Miller Class...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2017.160767
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:In a previous study, recombinant human transforming growth factor-beta1 (rhTGF-β1 ) in a calcium carbonate carrier was implanted into critical-size, supraalveolar periodontal defects under conditions for guided tissue regeneration (GTR) to study whether rhTGF-β1 would enhance or accelerate periodontal regene...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060336
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study is to determine whether sex dimorphism exists in the expression of inflammatory and apoptotic mediators in gingiva obtained from normal and diseased sites of periodontal disease. METHODS:Gingival papillae were obtained from individuals (56 males and 62 females) who required extract...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130718
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Pigmentations of the oral cavity are commonly noted in clinical practice and may have physiologic, non-physiologic, or pathologic etiologies. The most common non-physiologic localized pigmentation is the amalgam tattoo; another, less common, non-physiologic pigmentation is the graphite tattoo. Graphite tatto...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1572
更新日期:2005-09-01 00:00:00
abstract::There are only a few long-term investigations on root-resected teeth in the literature. This article is a 10-year review of 28 root-resection cases, which mainly had been used as bridge abutments. The periodontal, prosthetic, and endodontic problems were evaluated. After 10 years a total failure rate of 32% was observ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.12.805
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Full-mouth scaling (FMS) is claimed by some researchers to be superior to standard scaling and root planing (SRP). The aim of the present study was to evaluate clinical outcomes of two modalities of non-surgical periodontal therapy for patients with chronic periodontitis. METHODS:In a prospective, randomize...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2007.070010
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:The habit of chewing areca quid (AQ) has been implicated in oral pathogenesis, including periodontal disease. Little is understood about the roles of AQ in the cytokine secretion by immune cells. The study examined the effects of areca nut, the major ingredient of AQ, on the production of interleukin (IL)-6 ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060039
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:A disintegrin and metalloproteinase 28 (ADAM28) is considered to be the possible virulence gene for congenital hypoplasia of tooth root. Periodontal ligament stem cells (PDLSCs) are regarded as playing crucial roles in the developing process of the periodontium and are generally used in dental regenerative m...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090703
更新日期:2010-06-01 00:00:00
abstract::This tribute was written by Dr. E. Brady Hancock, who was a student of and who succeeded Dr. Timothy J. O'Leary as chair of the Department of Periodontics at Indiana University. Dr. O'Leary served as co-editor of the Journal of Periodontologyfrom 1970 until 1988. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.9.1175
更新日期:2004-09-01 00:00:00
abstract::There are few studies that provide information on the natural history of calculus formation. The purpose of this study is to evaluate the relationship between pre-scaling baseline calculus scores, the time since the last prophylaxis before baseline, and scores 8 weeks after scaling in a group of presumed heavy calculu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.8.750
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The need for keratinized mucosa (KM) or immobile keratinized mucosa (i.e., attached mucosa [AM]) for the maintenance of osseointegrated endosseous dental implants has been controversial. The purpose of this study was to investigate the significance of KM in the maintenance of root-form dental implants with d...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050393
更新日期:2006-08-01 00:00:00