Axonal transport of fluorescent carbocyanine dyes allows mapping of peripheral nerve territories in gingiva.

Abstract:

:Sensory innervation of gingival tissue can cause neurogenic inflammation that depends on the extent of the branching area of the peripheral nerve fibers. We designed the present study to determine whether single trigeminal axons branch to both the buccal and palatal gingiva of maxillary molars of adult rats. Accumulation via retrograde transport of DiI (red) or DiA (green) fluorescent carbocyanine dyes in neurons of trigeminal ganglia was evaluated 7 days after applying one dye to the buccal sulcus and the other to the palatal sulcus. Both dyes were absorbed through the junctional epithelium, and the two sites each labeled similar numbers and sizes of neurons in the lateral zone of the maxillary division (44% from buccal and 46% from palatal gingiva). Double-labeled neurons had the same size (32.5 +/- 6.70 microns, mean circumference +/- S.D.) and location as single-labeled neurons, and they were 9% of the total. This study shows that exogenous dyes can diffuse into mucosa and thereby allow in vivo mapping of sensory nerve branching patterns to several intact tissues per animal. We found that 9% of the labeled cells extended to both the buccal and palatal gingiva. Thus, inflammation that spreads from one gingival region to the other could have a neurogenic mechanism involving trigeminal sensory neurons that extend their peripheral branches to innervate both buccal and palatal gingiva of adult rat molars.

journal_name

J Periodontol

authors

Sugaya A,Chudler EH,Byers MR

doi

10.1902/jop.1995.66.9.817

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

817-21

issue

9

eissn

0022-3492

issn

1943-3670

journal_volume

66

pub_type

杂志文章
  • Experimental gingivitis in ODU plaque-susceptible rats. V. On the vascular permeability factor of dental plaque.

    abstract::Plaque-induced inflammation has been documented from various aspects, but is still not well understood. In an effort to clarify the physicochemical properties of dental plaque and to isolate the active factor which give rise to inflammation, we studied a factor in plaque which may be a direct and local cause of gingiv...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1980.51.7.400

    authors: Matsuda K,Yamanaka Y,Shen CT,Mori M

    更新日期:1980-07-01 00:00:00

  • Effects of marrow penetration on bone augmentation within a titanium cap in rabbit calvarium.

    abstract:BACKGROUND:Some studies have advocated marrow penetration in guided bone augmentation (GBA), whereas others have shown that bone can be generated without marrow penetration. This study examined the effect of marrow penetration and the optimal rate of penetration. METHODS:In 10 rabbits, the calvarium was exposed, and c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.070086

    authors: Min S,Sato S,Murai M,Okuno K,Fujisaki Y,Yamada Y,Ito K

    更新日期:2007-10-01 00:00:00

  • Levels of pentraxin-3 in gingival crevicular fluid and plasma in periodontal health and disease.

    abstract:BACKGROUND:Pentraxins are classic mediators of inflammation and markers of acute-phase reactions. Pentraxin-3 (PTX3) is the first-identified long pentraxin and is believed to be a true independent indicator of disease activity. Although a classic pentraxin, C-reactive protein, and its association with various systemic ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100526

    authors: Pradeep AR,Kathariya R,Raghavendra NM,Sharma A

    更新日期:2011-05-01 00:00:00

  • Changes of subgingival total colony forming units and black pigmented bacteroides after a single irrigation of periodontal pockets with 1.64% SnF2.

    abstract::Periodontal pockets of 11 subjects were irrigated once with either 1.64% SnF2 or saline applied by syringe. Changes on the total anaerobic colony forming units (CFU) and black pigmented bacteroides (BPBs) of the irrigated pockets were assessed for 31 days. The results showed little change of the CFUs by either single ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.6.330

    authors: Schmid E,Kornman KS,Tinanoff N

    更新日期:1985-06-01 00:00:00

  • Effect of Fluoxetine on Periodontal Status in Patients With Depression: A Cross-Sectional Observational Study.

    abstract:BACKGROUND:Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to reduce periodontal disease severity in a rat ligature-induced periodontitis model. The objective of the present study is to investigate the influence of fluoxetine intake on periodontal parameters in patients with periodontitis with c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.140706

    authors: Bhatia A,Sharma RK,Tewari S,Khurana H,Narula SC

    更新日期:2015-08-01 00:00:00

  • Number of teeth is related to atherosclerotic plaque in the carotid arteries in an elderly population.

    abstract:BACKGROUND:Periodontal disease has been associated with cardiovascular disorders with an atherosclerotic background, and number of teeth (NT) has been suggested as a possible risk indicator for cardiovascular disease. The objective of this study is to investigate whether NT was related to the intima-media thickness (IM...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.110100

    authors: Holmlund A,Lind L

    更新日期:2012-03-01 00:00:00

  • Radiographic and digital imaging in periodontal practice.

    abstract::This review defines terms such as accuracy, validity, and reliability, which are used to describe the quality of methods for taking x-rays and for analyzing digital images. Values for these parameters are described for techniques of taking standardized x-rays such as ear-rod fixation and fixation by use of teeth with ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2000.71.3.497

    authors: Hausmann E

    更新日期:2000-03-01 00:00:00

  • A comparison of porous and non-porous teflon membranes plus demineralized freeze-dried bone allograft in the treatment of class II buccal/lingual furcation defects: a clinical reentry study.

    abstract:BACKGROUND:The aim of this 9-month reentry study was to compare the regenerative healing using porous (P) and non-porous (NP) teflon barrier membranes plus demineralized freeze dried bone allografts (DFDBA) in Class II buccal/lingual furcation defects. METHODS:Twenty-four patients, 13 males and 11 females, ages 38 to ...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2001.72.11.1580

    authors: Lamb JW 3rd,Greenwell H,Drisko C,Henderson RD,Scheetz JP,Rebitski G

    更新日期:2001-11-01 00:00:00

  • Transforming Growth Factor-β1 Accelerates Resorption of a Calcium Carbonate Biomaterial in Periodontal Defects.

    abstract:BACKGROUND:In a previous study, recombinant human transforming growth factor-beta1 (rhTGF-β1 ) in a calcium carbonate carrier was implanted into critical-size, supraalveolar periodontal defects under conditions for guided tissue regeneration (GTR) to study whether rhTGF-β1 would enhance or accelerate periodontal regene...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060336

    authors: Koo KT,Susin C,Wikesjö UME,Choi SH,Kim CK

    更新日期:2007-04-01 00:00:00

  • Coping with stress: its influence on periodontal disease.

    abstract:BACKGROUND:Various forms of stress behavior were documented and in patients with periodontitis their relationship with periodontal disease was investigated. METHODS:Eighty-nine patients with different forms of chronic periodontitis were included in this retrospective case-control study. They were all undergoing period...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2002.73.11.1343

    authors: Wimmer G,Janda M,Wieselmann-Penkner K,Jakse N,Polansky R,Pertl C

    更新日期:2002-11-01 00:00:00

  • Risk indicators for tooth loss due to periodontal disease.

    abstract:BACKGROUND:Several risk indicators for periodontal disease severity have been identified. The association of these factors with tooth loss for periodontal reasons was investigated in this cross-sectional comparative study. METHODS:All extractions performed in 21 general dental practice clinics (25% of such clinics in ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究

    doi:10.1902/jop.2005.76.11.1910

    authors: Al-Shammari KF,Al-Khabbaz AK,Al-Ansari JM,Neiva R,Wang HL

    更新日期:2005-11-01 00:00:00

  • Periodontal microcirculatory abnormalities in patients with systemic sclerosis.

    abstract:BACKGROUND:The aim of this study was to observe the differences in periodontal microcirculation between healthy patients and patients with systemic sclerosis (SSc). METHODS:Fifteen healthy patients and 15 patients with SSc were examined. Periodontal capillaroscopy was used to investigate the characteristics of microci...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.11.1991

    authors: Scardina GA,Pizzigatti ME,Messina P

    更新日期:2005-11-01 00:00:00

  • Histologic comparison of healing following tooth extraction with ridge preservation using two different xenograft protocols.

    abstract:BACKGROUND:The objectives of this study are to compare differences in histologic and clinical healing following tooth extraction and ridge preservation using two different xenograft treatment protocols. METHODS:Forty-four patients with a non-molar tooth that required extraction and planned implant placement were rando...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2012.120219

    authors: Cook DC,Mealey BL

    更新日期:2013-05-01 00:00:00

  • The distribution of plasma cells in naturally occurring periodontitis lesions in rats. A light and electron microscopic study.

    abstract::Plasma cells are widely distributed in inflamed periodontal tissues, the adjacent periodontal ligament and nearby alveolar bone spaces, of old rats (20 and 27 months) raised on a conventional diet in a normal laboratory environment. Electron microscopy revealed three morphologic types (or perhaps stages) of these cell...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1983.54.4.227

    authors: Garant PR,Paik KS,Cho MI

    更新日期:1983-04-01 00:00:00

  • Relationship among clinical periodontal, microbiologic parameters and lung function in participants with chronic obstructive pulmonary disease.

    abstract:BACKGROUND:The aim of this study was to evaluate the relationship among clinical periodontal, microbiologic parameters and lung function in participants with chronic obstructive pulmonary disease (COPD). METHODS:A total of 160 participants were recruited, including 80 participants with COPD (COPD group) and 80 partici...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.17-0705

    authors: Tan L,Tang X,Pan C,Wang H,Pan Y

    更新日期:2019-02-01 00:00:00

  • Exposure to occupational noise and periodontitis in Korean workers.

    abstract:BACKGROUND:Chronic exposure to occupational noise is reported to cause a wide range of health problems. But, there are no reports on studies investigating the association between noise exposure and periodontitis. The purpose of this study was to examine the relationship between occupational noise exposure and periodont...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.17-0484

    authors: Shim SH,Han DH

    更新日期:2018-04-01 00:00:00

  • Total antioxidant capacity and antioxidant enzymes in serum, saliva, and gingival crevicular fluid of preeclamptic women with and without periodontal disease.

    abstract:BACKGROUND:The aim of this study was to investigate the total antioxidant capacity, superoxide dismutase and glutathione peroxidase activities, and malondialdehyde levels in serum, saliva, and gingival crevicular fluid (GCF) in preeclamptic and normotensive pregnant women with and without periodontal disease. METHODS:...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060469

    authors: Canakci V,Yildirim A,Canakci CF,Eltas A,Cicek Y,Canakci H

    更新日期:2007-08-01 00:00:00

  • Preprosthetic periodontal surgery in the interproximal area with modification of the COL area: anatomic and histologic study in dogs.

    abstract:BACKGROUND:Due to its concave morphology, a COL creates difficulties for proper oral hygiene. When this characteristic is accentuated by tooth position or caries and when restorations are necessary, they should be corrected by preprosthetic surgery. However, there are no data proving the efficacy of the procedures. The...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.12.1734

    authors: Novaes AB Jr,Novaes AB,De Oliveira PT

    更新日期:2001-12-01 00:00:00

  • Growth and migration of gingival epithelial cells on mineralized and partially demineralized root surfaces in an in vitro system.

    abstract::The capacity of epithelial cells to migrate and grow from gingival explants cultured on mineralized and partially demineralized root surfaces in an in vitro system was assessed. Explants of attached gingiva were obtained from mongrel dogs, cut into rectangular pieces (1 x 2 mm) and cultured either on mineralized or pa...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.8.531

    authors: Pitaru S,Hekmati M,Soldinger M,Savion N

    更新日期:1988-08-01 00:00:00

  • Effects of occlusal overload on peri-implant tissue health: a systematic review of animal-model studies.

    abstract:BACKGROUND:This study systematically evaluates the effect of occlusal overload (OV) on peri-implant tissue health in animal studies. METHODS:MEDLINE, EMBASE, and LILACS databases were searched for articles published up to and including January 2010. Studies that reported outcomes of non-splinted titanium dental implan...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2010.100176

    authors: Chambrone L,Chambrone LA,Lima LA

    更新日期:2010-10-01 00:00:00

  • Detection of eight periodontal microorganisms and distribution of Porphyromonas gingivalis fimA genotypes in Chinese patients with aggressive periodontitis.

    abstract:BACKGROUND:The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP. METHODS:...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.120677

    authors: Feng X,Zhang L,Xu L,Meng H,Lu R,Chen Z,Shi D,Wang X

    更新日期:2014-01-01 00:00:00

  • Partial regeneration of periodontal tissues using collagen barriers. Initial observations in the canine.

    abstract::The capacity of collagen membranes to support guided regeneration of periodontal tissues in the dog was assessed. The mesiolabial, labial and distolabial aspects of the mesial root of the second and third mandibular premolar were surgically exposed in three beagle dogs. Collagen membranes, 0.5 to 0.7 mm thick, prepare...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.6.380

    authors: Pitaru S,Tal H,Soldinger M,Grosskopf A,Noff M

    更新日期:1988-06-01 00:00:00

  • Histologic and histomorphometric findings from retrieved, immediately occlusally loaded implants in humans.

    abstract:BACKGROUND:The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reco...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.11.1823

    authors: Romanos GE,Testori T,Degidi M,Piattelli A

    更新日期:2005-11-01 00:00:00

  • The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis.

    abstract::The purpose of this study was to evaluate the safety and clinical efficacy of controlled-release tetracycline-containing fibers in patients with refractory periodontitis versus the preceding classical treatment. One hundred twenty-one sites in 20 patients were followed from baseline to 6 months after fiber insertion. ...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1997.68.4.353

    authors: Vandekerckhove BN,Quirynen M,van Steenberghe D

    更新日期:1997-04-01 00:00:00

  • Analysis of Subgingival Plaque Ability to Stimulate Toll-Like Receptor 2 and 4.

    abstract:BACKGROUND:It has been shown that toll-like receptor (TLR) 2- and TLR4-stimulating abilities of supragingival plaque (SPP) are associated with periodontal conditions. It is hypothesized that SPP might affect the periodontium through its influence on subgingival plaque (SBP). This study investigates relationships betwee...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.150573

    authors: Ziauddin SM,Montenegro Raudales JL,Sato K,Yoshioka H,Ozaki Y,Kaneko T,Yoshimura A,Hara Y

    更新日期:2016-09-01 00:00:00

  • Sinus floor augmentation with simultaneous implant placement in the severely atrophic maxilla.

    abstract::Dental implant placement associated with augmentation of the sinus floor in the severely atrophic maxilla can be performed in 1- or 2-surgical stages, depending on the height of the residual alveolar bone. A minimum of 4 to 5 mm of residual alveolar bone height is recommended for a 1-stage surgical procedure. The pres...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1998.69.12.1397

    authors: Peleg M,Mazor Z,Chaushu G,Garg AK

    更新日期:1998-12-01 00:00:00

  • Bacterial invasion in experimental gingivitis in man.

    abstract::Gingival biopsies of the mesial papilla area of the first molar were obtained from each patient at 0-, 14- and 21-day intervals during plaque formation. The biopsies were fixed, serially sectioned, and Gram-stained. The incidence and distribution of the bacteria-like structures were studied by microscopy. In all the s...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.12.837

    authors: Saglie FR,Pertuiset JH,Rezende MT,Sabet MS,Raoufi D,Carranza FA Jr

    更新日期:1987-12-01 00:00:00

  • Levels of immunoglobulins IgG, IgA, and IgM in the human inflamed gingiva.

    abstract::Resected inflamed gingival tissue obtained from 16 periodontal patients and a pooled sample of noninflamed gingiva from five edentulous patients were assayed for immunoglobulins IgG, IgA, and IgM using low-level immunodiffusion plates. Findings based on the gingival assays include:(1) IgA and IgG are present in both i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1975.46.7.387

    authors: Byers CW,Toto PD,Gargiulo AW

    更新日期:1975-07-01 00:00:00

  • Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils.

    abstract:BACKGROUND:Areca quid chewers have a higher prevalence of periodontal disease than non-chewers. Little is known about the influence of areca quid on the immune system. This study was to determine the possible effects of the areca nut on phagocytic activity of human neutrophils. METHODS:Aqueous extracts of ripe areca n...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.3.373

    authors: Hung SL,Cheng YY,Peng JL,Chang LY,Liu TY,Chen YT

    更新日期:2005-03-01 00:00:00

  • Tissue interactions with dentin specimens after demineralization using tetracycline.

    abstract::Greater cell attachment to demineralized dentin has been associated with subsequent development of a fiber attachment system. The purpose of this study was to evaluate tissue interactions to dentin demineralized with different concentrations of tetracycline solution. Dentin specimens were obtained from beneath root su...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.11.714

    authors: Frantz B,Polson A

    更新日期:1988-11-01 00:00:00