Abstract:
BACKGROUND:Alveolar bone regeneration is frequently necessary prior to placement of implants. Efforts to improve wound healing have focused on factors that may enhance bone formation following guided bone regeneration (GBR) techniques alone or in combination with bone replacement graft materials. Recent reports suggest that platelet-rich plasma (PRP), presumably high in levels of peptide growth factors, may enhance the formation of new bone when used in combination with autogenous graft material. METHODS:In this report, the clinical and radiographic results are presented on 15 consecutively treated patients using autologous PRP in combination with freeze-dried bone allograft (FDBA) for sinus elevation and/or ridge augmentation. FDBA and PRP (0.5 g/2cc PRP) were mixed and placed as a composite graft material. A gel formed by mixing autologous thrombin-rich plasma with PRP (1:4 ratio) was used to cover the graft material. Core biopsies of grafted areas were obtained in several patients as part of implant site preparation and were evaluated histologically to determine site maturation. RESULTS:Of 36 implant fixtures, 32 (89%) were considered clinically successful demonstrating complete bone coverage of the implant, no mobility, and a normal radiographic appearance at the time of re-entry and 12 months post-implant exposure. Four implants were removed due to mobility at the time of surgical exposure. Histologic evaluation of biopsy specimens revealed numerous areas of osteoid and bone formation around FDBA particles, with no evidence of inflammatory cell infiltrate. CONCLUSIONS:These clinical and histological findings suggest that ridge augmentation and sinus grafting with FDBA in combination with PRP provide a viable therapeutic alternative for implant placements. Future studies are necessary to determine whether PRP enhances new bone formation or maturation with bone replacement allografts.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Kassolis JD,Rosen PS,Reynolds MAdoi
10.1902/jop.2000.71.10.1654subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1654-61issue
10eissn
0022-3492issn
1943-3670journal_volume
71pub_type
杂志文章abstract:BACKGROUND:Platelet-rich plasma (PRP) harbors growth factors identified in bone. It has been suggested that these factors enhance osteogenesis. The objective of this study was to conduct a radiographic evaluation on local bone formation following surgical implantation of a PRP preparation using a critical-size rat calv...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.8.1287
更新日期:2005-08-01 00:00:00
abstract::Subtraction radiography requires radiographs made with identical projection geometry. Recently a new radiographic aiming device and an x-ray beam manipulator made it possible to repeat radiographic exposures in vivo with small angular errors and to measure the angular errors occurring. The purpose of the present inves...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.4.278
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Smoking is a major risk factor for periodontal disease. Conventional oral epidemiology approaches have found strong, consistent associations between chronic smoking and periodontal attachment loss (AL) through ages 26, 32, and 38 years, but those statistical methods disregarded the data's hierarchical struct...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130577
更新日期:2014-10-01 00:00:00
abstract::A small laser doppler probe with an outside diameter comparable to a conventional periodontal probe (0.5 mm) was developed. The objectives of this investigation were to determine if intrasulcular laser doppler readings (LDR): 1) are reproducible; 2) can detect vascular changes associated with trauma from probe placeme...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1995.66.3.171
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:The number of immunocompromised patients is increasing as a consequence of successful organ transplantation. Placing dental implants in these patients has been questioned because of their increased risk for infections. The 10-year follow-up data of a 71-year-old liver transplant recipient with long-term immu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.6.909
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Although nitric oxide (NO) synthesis is increased in periodontal disease (PD), little is known about the possible sources of production by gingival tissues. In fact, gingival tissues from patients with periodontitis demonstrate greater levels of inducible nitric oxide (iNOS) expression than healthy tissue. M...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.4.392
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Epidemiologic and randomized controlled studies have shown that periodontal diseases may be associated with preterm labor and delivery of infants with low birth weights. The purpose of the present study was to determine the presence of microbial invasion of the amniotic cavity by periodontopathic bacteria in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060368
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:The purpose of this case series study was to evaluate posterior single-tooth implant survival and the long-term conditions of the adjacent teeth. METHODS:A retrospective evaluation of 1,162 consecutive patients with a single missing posterior tooth treated with 1,377 external hex implants supporting 1,365 r...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究
doi:10.1902/jop.2008.080188
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Pentraxins are acute-phase proteins that belong to a family of evolutionarily conserved proteins, and they are considered markers of inflammation. Pentraxin-3 (PTX3) is a prototype of the long pentraxin group. It is suggested to play an important role in innate resistance against pathogens, regulation of inf...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.120718
更新日期:2014-02-01 00:00:00
abstract::A study was conducted to evaluate the effects of repeated hand instrumentation on the marginal portion of a cast gold crown. Seven extracted periodontally diseased premolars were used. The finishing line of the preparation was placed on the root surface and then the crown was cast and cemented in the usual manner. One...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.1.41
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:β-glucuronidase (βG) is one of the enzymes involved in the destruction of non-collagenous components of the extracellular matrix. It is also considered an indicator or predictor of periodontal disease activity. The present study was conducted to determine the presence and the levels of βG activity in gingiva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.4.618
更新日期:2000-04-01 00:00:00
abstract::The case of a family, followed for 5 years and showing an exceptionally high prevalence of Generalized Juvenile Periodontitis (GJP), is presented. Two siblings were affected by a severe form of GJP meanwhile the dycorial twin of one was periodontally healthy. Both the affected siblings showed infection by Actinobacill...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.9.590
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Periodontitis is a multifactorial and infectious disease that may result in significant debilitation. The aim of this study is to exploit two optical coherence tomography (OCT) systems operating in the Fourier domain at different wavelengths, 930 and 1,325 nm, for structural analysis of periodontal tissue in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.150047
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Gingival augmentation procedures are indicated primarily to increase an insufficient amount of gingiva and sometimes to halt the progression of gingival recession. The aim of this retrospective long-term study was to evaluate changes in the amount of keratinized tissue (KT) and in the position of the gingiva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070414
更新日期:2008-04-01 00:00:00
abstract:SCOPE:These Guidelines apply to products used to promote the regeneration of periodontal tissues lost due to periodontal diseases or other causes. Periodontal regeneration is defined histologically as regeneration of the tooth's supporting tissues, including alveolar bone, periodontal ligament, and cementum over a prev...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.9.1081
更新日期:1998-09-01 00:00:00
abstract::Classification by origin and structure of the many different coatings which occur on the surfaces of teeth and artificial surfaces exposed to the oral environment necessitate a revision of the terminology used to describe these coatings. Numerous gaps still exist in our understanding of the origin, morphological struc...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1976.47.3.139
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Enamel matrix derivative (EMD) has been shown to promote several aspects of periodontal regeneration in vitro and in vivo. Recently, a bioengineered tissue (DG) was developed to promote wound healing of chronic skin ulcers. This pilot study sought to assess the effects of EMD and DG, alone or in combination,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.030264
更新日期:2006-05-01 00:00:00
abstract::Strict control of dental plaque accumulation remains the cornerstone of successful maintenance of the treated patient. However, some recurrences of periodontitis appear to take place despite good oral hygiene habits. A proportion of these are likely due to qualitative features of the periodontal microbiota rather than...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1988.59.7.439
更新日期:1988-07-01 00:00:00
abstract::1. The grafted material appears extremely compatible with the animals tested for the observed time periods. 2. The procedures used led to the obliteration of surgically created one-wall infrabony periodontal pockets with fibrous connective tissue and/or bone. 3. The ready access, ease of placement and flexibility of t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.8.453
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Heme oxygenase (HO)-1 is a stress-inducible protein that confers cytoprotection, but its role in gingiva during cyclosporin A (CsA) therapy is unknown. We used in vivo and in vitro models to investigate the expression of mRNA and protein for HO-1 in gingiva upon CsA treatment. METHODS:Twenty-six male Spragu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080160
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:A disintegrin and metalloproteinase 28 (ADAM28) is considered to be the possible virulence gene for congenital hypoplasia of tooth root. Periodontal ligament stem cells (PDLSCs) are regarded as playing crucial roles in the developing process of the periodontium and are generally used in dental regenerative m...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090703
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Periodontal disease is one of the major oral problems encountered in patients with diabetes mellitus (DM). Vascular changes, neutrophil dysfunction, altered collagen synthesis, and genetic predisposition observed in DM may contribute to periodontitis; and the vascular alterations observed in such patients ma...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.1.91
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:There is limited information regarding marginal bone-level changes around immediately loaded implants placed with the osteotome technique. The aim of this case series is to prospectively evaluate the clinical and radiographic outcome of immediately loaded implants placed with the osteotome technique over a 1...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2011.100751
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Some studies have advocated marrow penetration in guided bone augmentation (GBA), whereas others have shown that bone can be generated without marrow penetration. This study examined the effect of marrow penetration and the optimal rate of penetration. METHODS:In 10 rabbits, the calvarium was exposed, and c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070086
更新日期:2007-10-01 00:00:00
abstract::In previous studies Fusobacterium nucleatum has been shown to induce either stimulatory or inhibitory effects on human mononuclear cells. We examined the interaction of human mononuclear cells with human and cynomolgus monkey strains of F. nucleatum. Peripheral blood mononuclear cells (PBMCs) isolated from normal dono...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.1.39
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Earlier publications from our laboratory described the use of guided bone regeneration to fill large bone voids in the mandible created through en bloc resection in primates. The present report describes placement of implants into the regenerated bone with subsequent prostheses construction and loading. MET...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.6.703
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:A 5-year-old Japanese boy presented with persistent gingival inflammation and severe mobility of the right lower primary incisors. Due to severe alveolar bone loss and a deep periodontal pocket (5 mm), the incisors were extracted at the second visit. METHODS:Clinical, radiographic, histological, and microbi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.7.1060
更新日期:2003-07-01 00:00:00
abstract::Eleven cases are presented which demonstrated severe periodontal bone loss especially in the posterior segments of the mouth in a group of young men, ages 22 to 32, unexplained by other local etiologic factors. The only common denominator in all cases was severe emotional stress associated with active duty in Viet Nam...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.2.67
更新日期:1976-02-01 00:00:00
abstract::The clinical, histopathologic and functional consequences of the genetic deficiency of leukocyte Mac-1, LFA-1 and p150,95 were assessed among three affected patients, heterozygotes and unaffected individuals among two generations of a single kindred. Longitudinal assessments of this family afforded the unique opportun...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.6.400
更新日期:1987-06-01 00:00:00
abstract::Cyclosporine A (CsA) and verapamil are two agents used in renal transplantation, both of which are suspected of inducing gingival overgrowth. This study was conducted to investigate the effect of verapamil on the severity and prevalence of CsA-induced gingival overgrowth. Fifty-one (51) renal transplant recipients (to...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.11.1201
更新日期:1996-11-01 00:00:00