Abstract:
:Cyclosporine A (CsA) and verapamil are two agents used in renal transplantation, both of which are suspected of inducing gingival overgrowth. This study was conducted to investigate the effect of verapamil on the severity and prevalence of CsA-induced gingival overgrowth. Fifty-one (51) renal transplant recipients (total group) of whom 22 were using only CsA (Group A) and 29 of whom were prescribed CsA + verapamil (Group B) were evaluated for various periodontal and pharmacological parameters. No statistically significant differences were found in age, sex, plaque index, gingival index, calculus index, probing depth, CsA oral dose, CsA whole blood level, duration of CsA therapy, azathioprine dose, and prednisolone dose. Although the prevalence of the gingival overgrowth was more pronounced in CsA + verapamil group compared to CsA group (51.72% vs. 40.91%), the difference was not statistically significant. Similarly, the severity of gingival overgrowth, although more manifest in CsA + verapamil group than CsA patients (34.24% vs. 28.91%), was not significantly different. Gingival overgrowth scores in the main group, CsA, and CsA + verapamil groups were found to be positively correlated to periodontal probing depths (r = 0.60, r = 0.70, r = 0.52, respectively) and the gingival index (r = 0.60, r = 0.70, r = 0.54, respectively). CsA oral dose, whole blood level, and duration of CsA therapy were not found to be correlated with the gingival overgrowth in either group. Likewise, the dose of verapamil and the duration of verapamil therapy were not correlated with the gingival overgrowth in Group B. This study indicates that verapamil, when prescribed as the calcium channel blocker in renal transplant patients, has no augmenting effect on the severity and the prevalence of CsA-induced gingival overgrowth.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Cebeci I,Kantarci A,Firatli E,Carin M,Tuncer Odoi
10.1902/jop.1996.67.11.1201subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1201-5issue
11eissn
0022-3492issn
1943-3670journal_volume
67pub_type
杂志文章abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130167
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:In an attempt to evaluate the influence of cyclosporin A (CsA) on fibroblast metabolism, the phospholipase C beta1, (PLC beta1) nuclear expression was evaluated in fibroblasts from heart transplantation patients treated with CsA who exhibited gingival overgrowth (GO) and from controls. METHODS:PLC beta1 was...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.11.1722
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:It is unknown whether cone beam computed tomography (CBCT) image reconstruction characteristics, including section thickness, may affect linear bone measurements of periodontal intrabony defects. The aim of this study was to compare intrasurgical and CBCT-based linear measurements of intrabony defects focusi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0338
更新日期:2020-08-21 00:00:00
abstract:BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal i...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2016.160015
更新日期:2016-12-01 00:00:00
abstract::Radiographic record audits were conducted on 63 patients diagnosed as having periodontitis who had been treated and maintained for 10 years or longer in dental school clinics. Acceptable bite-wing radiographs were available for 50 of these patients. Bite-wing radiographs taken 8 to 34 years apart (mean 14.9 years) wer...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.7.434
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Most studies comparing prevalence of periodontal disease and risk factors by using partial protocols were performed in adult populations, with several studies being conducted in clinical settings. The aim of this study is to assess the accuracy of partial protocols in estimating the prevalence of periodontal...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110250
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:This prospective and controlled histologic study evaluates the impact of smoking on bone-to-implant contact, the bone density in the threaded area, and the bone density outside the threaded area around microimplants with anodized surface retrieved from human jaws. METHODS:A total of 24 subjects (mean age 51...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090493
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Longitudinal clinical studies show smoking is a risk factor for periodontal disease progression. It has also been documented that smoking impairs healing after periodontal therapy. However, the longitudinal effect of smoking on treatment results in patients who undergo long-term maintenance therapy has not b...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.6.839
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:This study was conducted to assess the clinical, immunological, and patient-centered outcomes of microcurrent electrotherapy on palatal wound healing. METHODS:This was a parallel, double-masked randomized clinical trial, in which 53 patients with ridge preservation indications were selected and randomly ass...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0122
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:Alanine aminopeptidase (ALAP) and dipeptidyl peptidase IV (DPPIV) are ectopeptidases that play a role in collagen degradation and are thought to be involved in the destruction of periodontal tissue. This study compared the activities of salivary ALAP and DPPIV in patients with periodontitis and periodontally...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090233
更新日期:2009-11-01 00:00:00
abstract::Human gingival fibroblasts were cultured in vitro using as substrates an extracellular matrix (matrix) and polytetrafluoride (PTFE) membranes, which are used in guided tissue regeneration. To test the degree of biocompatibility of these membranes, the cellular proliferation and the accumulation of extracellular matrix...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.9.857
更新日期:1997-09-01 00:00:00
abstract::The oral hygiene, the gingival condition, pocket depth, and the incidence of caries on crowned teeth were studied during a period of 5 years in a group of patients (114) who had been treated with fixed dental prostheses. Prior to the prosthetic treatment, the patients received periodontal treatment. During the study, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.4.221
更新日期:1977-04-01 00:00:00
abstract::The literature related to smoking and periodontal disease is reviewed. The effects of smoking on oral hygiene, gingivitis, necrotizing gingivitis, periodontitis, bacteria and the host's response are presented. From this review it is apparent that while the relationship between smoking and periodontal disease needs fur...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1986.57.10.617
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Recent research indicated that periodontal infection may worsen systemic diseases, including pulmonary disease. Respiratory infections, such as pneumonia and the exacerbation of chronic obstructive pulmonary disease, involve the aspiration of bacteria from the oropharynx into the lower respiratory tract. ME...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100582
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:This commentary compares the abilities of full-mouth disinfection (FDIS), full-mouth root planing (FRP), and partial-mouth disinfection (PDIS) to improve periodontal health. FDIS consists of 4 quadrants of root planing completed within 24 hours with adjunctive chlorhexidine therapies (e.g., rinsing, subgingi...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2002.73.7.797
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:There is limited information about two-part implants placed in subcrestal positions. The aim of this study is to retrospectively evaluate the 1-year outcome of implants placed non-submerged and in a subcrestal position. METHODS:Records of 50 consecutive partially edentulous patients restored with dental imp...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090317
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) are a family of host-derived proteinases reported to mediate multiple functions associated with periodontal destruction and inflammation. Most of the existing data have been gathered from adults with chronic periodontitis. The purpose of this study was to determine the MMP le...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070513
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Patients with juvenile idiopathic arthritis (JIA) have been shown to have incipient attachment loss (AL) more frequently than systemically healthy individuals. This study investigated neutrophil activity and proinflammatory cytokines in these patients and aged-matched controls. METHODS:Elastase activity, me...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.1.75
更新日期:2005-01-01 00:00:00
abstract::The use of antibiotics in periodontal therapy has received increasing attention in recent years. Although generally safe, certain antibiotics, including tetracycline and ampicillin, have been shown to interact indirectly with oral contraceptives, with a resultant decrease in oral contraceptive efficacy. This paper rev...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1985.56.1.18
更新日期:1985-01-01 00:00:00
abstract::1. The grafted material appears extremely compatible with the animals tested for the observed time periods. 2. The procedures used led to the obliteration of surgically created one-wall infrabony periodontal pockets with fibrous connective tissue and/or bone. 3. The ready access, ease of placement and flexibility of t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.8.453
更新日期:1975-08-01 00:00:00
abstract::The relation between utilization of dental services from community dentists and the extent and severity of alveolar bone loss is reported for a panel of men followed for over 6 years. Oral health data were collected by the Department of Veterans Affairs, Dental Longitudinal Study, which began in 1969 and still continu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.5s.551
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. In the present study, we investigated whether a mouse cementoblast cell line, OCCM-30 cells,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060257
更新日期:2007-01-01 00:00:00
abstract::Proposing to place endosseous implants is an integral facet of dental treatment plans. Their insertion is usually associated with a low incidence of untoward events. However, despite careful planning, surgical complications can arise: infection, intraoral hemorrhage, wound dehiscence, postoperative pain, lack of prima...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2008.070067
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP. METHODS:...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.120677
更新日期:2014-01-01 00:00:00
abstract::Extracts of corn and some nuts were found to ubiquitously stimulate both adult and newborn cord blood lymphocytes to transform and produce a factor chemotactic for monocytes. This indicates that corn and nuts contain a mitogen and are potential stimulators of the cellular immune response. The exposure of lymphocytes t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.9.562
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:A hypothesis of an increased risk for destructive periodontal diseases due to psychological stress has long been promoted. However, the research on stress and periodontal disease is still in its infancy. One of the reasons is thought to be that there is no suitable animal model for investigating the relation...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.2.306
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Many studies have shown that periodontal disease can be successfully treated. However, there is limited documentation as to what happens when periodontal disease is left untreated. This study examined patients in a private practice who were diagnosed with periodontal disease and did not complete any treatmen...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.5.672
更新日期:2003-05-01 00:00:00
abstract::Ultrasonic and sonic scalers appear to attain similar results as hand instruments for removing plaque, calculus, and endotoxin. Ultrasonic scalers used at medium power seem to produce less root surface damage than hand or sonic scalers. Due to instrument width, furcations may be more accessible using ultrasonic or son...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2000.71.11.1792
更新日期:2000-11-01 00:00:00
abstract::This study compared demineralized-unicortical-ilium-strips (DUIS) and an expanded polytetrafluoroethylene (ePTFE) physical barrier in combination with decalcified freeze-dried bone allograft (DFDBA) for treatment of Class II mandibular furcations. Twenty patients with adult periodontitis and at least 2 furcation invas...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.8.803
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Human periodontal ligament stem cells (hPDLSCs) are readily accessible and represent a promising source of mesenchymal stem cells (MSCs) for therapies. For expected clinical applications of stem cell therapies, prolonged maintenance of stemness of hPDLSCs after storage is crucial. Likewise, optimization of c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.150693
更新日期:2016-07-01 00:00:00