Abstract：
BACKGROUND:Matrix metalloproteinases (MMPs) are a family of host-derived proteinases reported to mediate multiple functions associated with periodontal destruction and inflammation. Most of the existing data have been gathered from adults with chronic periodontitis. The purpose of this study was to determine the MMP levels in a cohort of African American children with and without aggressive periodontitis. METHODS:Gingival crevicular fluid (GCF) was collected in a cohort of 44 African American children, 7 to 19 years of age, with and without aggressive periodontitis (AgP) and compared to healthy unrelated children and to adults with chronic periodontitis (CP). GCF volume was determined with a calibrated gingival fluid meter. The samples were assayed for MMP-1, -2, -3, -8, -9, -12, and -13 using fluorimetric substrates. RESULTS:The MMP levels from diseased sites in the subjects with AgP were statistically higher (P <0.05) in almost all instances than those associated with the unrelated controls or with the subjects with CP. MMP-8 was significantly elevated in the diseased sites of the children with AgP relative to non-diseased sites in the same children (P = 0.002), as well as the siblings, non-diseased controls, and subjects with CP (P < or =0.0001). There was no positive correlation between probing depth and any MMP level. CONCLUSIONS:MMP levels were elevated in AgP sites relative to non-diseased sites in the same subjects, in siblings, and in unrelated controls. MMPs associated with the AgP sites in children were generally elevated compared to an adult cohort with a history of CP.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Alfant B,Shaddox LM,Tobler J,Magnusson I,Aukhil I,Walker Cdoi
10.1902/jop.2008.070513subject
Has Abstractpub_date
2008-05-01 00:00:00pages
819-26issue
5eissn
0022-3492issn
1943-3670journal_volume
79pub_type
杂志文章abstract：BACKGROUND:Recombinant human bone morphogenetic protein (rhBMP)-2 in a bioabsorbable collagen sponge (ACS) carrier supports significant bone formation. However, histomorphometric data on the augmentation of bone formation beyond the skeletal envelope are insufficient. Our objective was to evaluate the short-term effect...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2008.070305
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Chronic exposure to occupational noise is reported to cause a wide range of health problems. But, there are no reports on studies investigating the association between noise exposure and periodontitis. The purpose of this study was to examine the relationship between occupational noise exposure and periodont...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1002/JPER.17-0484
更新日期：2018-04-01 00:00:00
abstract：:The correlation between downgrowth of subgingival plaque and loss of attachment was evaluated on 27 teeth which had to be extracted because of advanced bone loss in 16 patients between ages 12 and 22. The diagnostic criteria were those used for periodontosis. The teeth were stained and examined under the stereomicrosc...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1977.48.3.125
更新日期：1977-03-01 00:00:00
abstract：BACKGROUND:The specific advantage of administering systemic antibiotics during initial, non-surgical therapy or in the context of periodontal surgery is unclear. This study assesses the differential outcomes of periodontal therapy supplemented with amoxicillin-metronidazole during either the non-surgical or the surgica...
journal_title：Journal of periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1902/jop.2014.140478
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Gingiva is composed of attached and marginal (free) gingiva and interdental papilla. Increasing esthetic demands in dentistry have created a need to restore all parts of the gingiva. However, the interdental papilla has limited regeneration potential compared to other parts of the gingiva. It also is more su...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2007.060165
更新日期：2007-02-01 00:00:00
abstract：:The assessment of new attachment after periodontal treatment has been the focus of continuous research. An approach to longitudinally examine the deposition of cementum was devised by using fluorescence microscopy (FL), contact microradiography (CMR), and toluidine blue staining (TBS) after the injection of three labe...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1991.62.4.284
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:The aim of this 9-month reentry study was to compare the regenerative healing using porous (P) and non-porous (NP) teflon barrier membranes plus demineralized freeze dried bone allografts (DFDBA) in Class II buccal/lingual furcation defects. METHODS:Twenty-four patients, 13 males and 11 females, ages 38 to ...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1902/jop.2001.72.11.1580
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:The interproximal dental papilla is considered an essential component of the anterior and posterior regions of the maxilla and mandible. The absence of this structure has esthetic and phonetical consequences and lateral food impaction problems occur with the implant-supported prosthesis. The aims of the pres...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2004.75.9.1242
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Periodontitis is a multifactorial and infectious disease that may result in significant debilitation. The aim of this study is to exploit two optical coherence tomography (OCT) systems operating in the Fourier domain at different wavelengths, 930 and 1,325 nm, for structural analysis of periodontal tissue in...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2015.150047
更新日期：2015-09-01 00:00:00
abstract：:The authors review patient-reported outcome (PRO) metrics for dentistry, and in particular, periodontics. The PRO commentary for periodontics includes a review of split-mouth, randomized, controlled clinical trial results that specifically tracked pain at different sites over time after intervention and provided guide...
journal_title：Journal of periodontology
pub_type： 杂志文章,评审
doi：10.1902/jop.2014.130693
更新日期：2014-10-01 00:00:00
abstract：:Ultrasonic scalers may be operated at different power settings which may influence the final therapeutic result. The displacement amplitude of the scaling tip may affect scaling efficiency or the degree of root surface damage. This investigation aimed to determine whether there was any difference in periodontal healin...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1902/jop.1995.66.9.756
更新日期：1995-09-01 00:00:00
abstract：:The purpose of this single blind clinical study was to determine the effects of two commerical mouthwashes (one containing cetylpyridinium chloride and domiphen bromide and the other containing only cetlypridinium chloride) on existing plaque accumulations. A second purpose was to determine if a residual effect could ...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章
doi：10.1902/jop.1976.47.7.419
更新日期：1976-07-01 00:00:00
abstract：:Twelve gingival samples removed from 6 human volunteers were sectioned in small pieces, parts of which served as uncultured pieces. The remaining pieces were organ cultured for 5 hours in control, compound 48/80, and antihuman IgE media. Uncultured tissues, cultured tissues, and cultured spent media were analyzed spec...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1975.46.3.171
更新日期：1975-03-01 00:00:00
abstract：BACKGROUND:This study compared 6-month and 3-year outcomes for root coverage (RC) by coronally advanced flap (CAF) procedures in localized gingival recessions. METHODS:Two centers, that had participated in a 6-month multinational multicenter randomized clinical trial (RCT), followed up 18 patients with 36 Miller Class...
journal_title：Journal of periodontology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1902/jop.2017.160767
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:A 43-year-old African American male initially presented for a dental evaluation of a recurrent swelling on the buccal aspect of tooth #12. His medical history was unremarkable except for a 20-pack year history of smoking. He was eventually diagnosed as having a necrotic pulp #12, and received root canal trea...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2010.090418
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:The role of keratinized tissue (KT) for maintenance of periodontal health has been debated for many years. This study assesses the long-term "biologic remodeling" of periodontal dimensions of teeth treated with free gingival grafts (FGGs) compared with adjacent/untreated teeth. METHODS:Seventy-four patients...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2017.170010
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the correlation and accuracy of ultrasound in measuring periodontal dimensions, compared to ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1002/JPER.19-0342
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Contradictory results exist regarding influence of apico-coronal implant placement on crestal bone levels. METHODS:Complete charts of patients ≥18 years old with one or more dental implants were included. Demographic, medical, surgical, and prosthetic information was recorded. Implant bone levels were evalu...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2017.160802
更新日期：2017-08-01 00:00:00
abstract：:Public health surveillance has been defined as the ongoing systematic collection, analysis, interpretation, and dissemination of data regarding a health-related event for use in public health action to reduce morbidity and mortality and to improve health. Surveillance is an essential element of public health program i...
journal_title：Journal of periodontology
pub_type： 杂志文章,评审
doi：10.1902/jop.2007.060340
更新日期：2007-07-01 00:00:00
abstract：:This longitudinal study of randomly selected Norwegian students and academicians has shown that 50% of the 17-year olds have lost no periodontal support, and the other 50% exhibited slight localized loss of attachment primarily on buccal surfaces of first molars and first bicuspids of both jaws. At 21 all students sho...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1978.49.12.607
更新日期：1978-12-01 00:00:00
abstract：BACKGROUND:Pain generated by needle sticks (Ns) for the delivery of local anesthetic and/or scaling and root planing (SRP) instrumentation is commonly addressed by the use of topical anesthetics, such as a benzocaine-gel preparation (BGP). Pain suppression following such use has been highly variable. Development of med...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1902/jop.2001.72.4.479
更新日期：2001-04-01 00:00:00
abstract：:In order to provide longitudinal data for endosteal bladevent implants, a continuing study is being conducted from an original group of 49 implants in 32 patients placed 15 years ago. The present work evaluated 26 of these bladevent implants in 18 patients. Three basic patterns were observed 15 years postoperatively: ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1987.58.9.589
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND:It has been shown that different implant designs and different vertical implant positions have an influence on crestal bone levels. The aim of the present study was to evaluate radiographic crestal bone changes around experimental dental implants with non-matching implant-abutment diameters placed submucosal...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2008.070132
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Smoking is the most important environmental risk factor for periodontal disease. Elevated levels of serum-soluble CD44 (sCD44) have been detected in smokers and also have been recognized as a diagnostic marker in some smoking-induced diseases. The present study investigates the salivary sCD44 profiles of smo...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2010.090630
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:This cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. METHODS:Samples from 97 implants/teeth (58 implants [19 hea...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2017.160751
更新日期：2017-08-01 00:00:00
abstract：:This study investigates the effects of the placement of a bioresorbable Type I collagen barrier on clinically healthy sites. Ten human subjects, with at least one pair of matched periodontal defects included in a previous study, were investigated for the effect of guided tissue regeneration (GTR) membrane placement on...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1993.64.1.57
更新日期：1993-01-01 00:00:00
abstract：:Plasma cells are widely distributed in inflamed periodontal tissues, the adjacent periodontal ligament and nearby alveolar bone spaces, of old rats (20 and 27 months) raised on a conventional diet in a normal laboratory environment. Electron microscopy revealed three morphologic types (or perhaps stages) of these cell...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1983.54.4.227
更新日期：1983-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to seek the critical time for impairment of alveolar bone regeneration after ovariectomy (OVX) in rats. METHODS:A total of 32 female rats were used. Test group rats were divided into a 2M group (n = 8), a 3M group (n = 8) and a 4M group (n = 8) according to the duration from OVX to...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1002/JPER.19-0537
更新日期：2020-10-01 00:00:00
abstract：:The purpose of this study was to determine which treatment of a large osseous defect adjacent to an endosseous dental implant would produce the greatest regeneration of bone and degree of osseointegration: barrier membrane therapy plus demineralized freeze-dried bone allograft (DFDBA), membrane therapy alone, or no tr...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1997.68.10.933
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Epidemiological studies have suggested that there is a genetic component to susceptibility to chronic periodontitis. Studies in humans and in animal models have suggested that some of the important components may be polymorphisms in key immunological genes. METHODS:This paper summarizes previously published...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2005.76.11-S.2042
更新日期：2005-11-01 00:00:00
