Abstract:
:The clinical efficacy of minocycline in a subgingival local delivery system was evaluated alone (M) or as an adjunct to scaling and root planing (M + SRP), in comparison to scaling and root planing (SRP) or to no subgingival treatment (NoTx) in adult periodontitis. Fifty-one adult patients with > or = 7 mm periodontal pockets demonstrating the presence by culture of Porphyromonas gingivalis (Pg), Prevotella intermedia (P(i)), or Actinobacillus actinomycetemcomitans (Aa) were randomized into one of the above 4 treatment groups. All sites > or = 5 mm in the most diseased quadrant in each patient received the therapy. Other quadrants were not treated. All patients received standardized oral hygiene instructions at the beginning of the study. At 0, 1, 3 and 6 months following therapy the 7 mm experimental sites were evaluated for selected periodontal pathogens by DNA probe analysis. At these same time points, the plaque index, gingival index, and bleeding on probing were evaluated as well as probing depth and relative clinical attachment level which were assessed by means of an automated probe. Probing depth reduction with M + SRP was significantly greater than all other groups at one month and significantly greater than NoTx and SRP at 3 months. There were no differences in probing depth reduction among groups at 6 months. At 6 months the gain in clinical attachment level was significantly greater for SRP than for either the NoTx or M groups. The prevalence of Pg decreased significantly in the M and M + SRP groups at one month.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Jones AA,Kornman KS,Newbold DA,Manwell MAdoi
10.1902/jop.1994.65.11.1058subject
Has Abstractpub_date
1994-11-01 00:00:00pages
1058-66issue
11eissn
0022-3492issn
1943-3670journal_volume
65pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Macrophages account for 5% to 30% of the inflammatory infiltrate in periodontitis and are activated by the classic and alternative pathways. These pathways are identified by indirect markers, among which interferon (IFN)-γ and interleukin-6 (IL)-6 of the classic pathway and IL-4 of the alternative pathway ha...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130078
更新日期:2014-05-01 00:00:00
abstract::Subtraction radiography requires radiographs made with identical projection geometry. Recently a new radiographic aiming device and an x-ray beam manipulator made it possible to repeat radiographic exposures in vivo with small angular errors and to measure the angular errors occurring. The purpose of the present inves...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.4.278
更新日期:1993-04-01 00:00:00
abstract::Subtraction radiography requires radiographs made with identical projection geometry. The purpose of the present investigation was to develop and evaluate a new in vivo method to measure angular radiographic projection error. This included the development of a system for accurate control of the x-ray beam angulation r...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.11.674
更新日期:1991-11-01 00:00:00
abstract::The oral hygiene, the gingival condition, pocket depth, and the incidence of caries on crowned teeth were studied during a period of 5 years in a group of patients (114) who had been treated with fixed dental prostheses. Prior to the prosthetic treatment, the patients received periodontal treatment. During the study, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.4.221
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Neopterin, a marker of cellular immune activation, is produced by human macrophages after induction by interferon gamma that is secreted by T lymphocytes. Neopterin concentrations in diverse body fluids have been reported to increase in parallel with bacteria in the clinical course of infections. Therefore, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.7.720
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Through the use of optimal surveillance measures and standard case definitions, it is now possible to more accurately determine population-average risk profiles for severe (SP) and non-severe periodontitis (NSP) in adults (aged 30 years and older) in the United States. METHODS:Data from the 2009 to 2012 Nat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160013
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) have inability to maintain the normal levels of protein metabolism products, blood pressure and hematocrit. Periodontal disease involves an inflammatory destructive process. Identification of opportunistic viruses is extremely important as they are associated with c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0583
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:It has been shown that lowering the concentration of chlorhexidine (CHX) in mouthrinses from 0.2% to 0.12% does not adversely affect inhibition of plaque accumulation. The aim of this study was to evaluate the inhibition of plaque growth by 2 commercially available mouthrinses used according to the manufactu...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2003.74.2.214
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the adjunctive effect of the local application of a hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis. METHODS:Twelve patients with chronic periodontitis were recruited to participate in a study with a split-mouth design and pro...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2009.090128
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:This cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. METHODS:Samples from 97 implants/teeth (58 implants [19 hea...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160751
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The purpose of these clinical guidelines, commissioned by the Italian Society of Periodontology and compiled with the tools and instructions of the Appraisal of Guidelines for Research and Evaluation (AGREE) collaboration, was to determine, in terms of efficacy, complications, and patient opinions, the most ...
journal_title:Journal of periodontology
pub_type: 杂志文章,实务指引
doi:10.1902/jop.2008.080266
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:To validate the concept of early implant placement for use in the esthetically sensitive anterior maxilla, clinical trials should ideally include objective esthetic criteria when assessing outcome parameters. METHODS:In this cross-sectional, retrospective 2- to 4-year study involving 45 patients treated wit...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080435
更新日期:2009-01-01 00:00:00
abstract::The purpose of the present study was to use a novel intracrevicular lavage technique to evaluate short-term effects of phase I therapy on crevicular cell populations. Nineteen patients with untreated advanced adult periodontitis were selected for phase I therapy. One side of the dentition was treated with ultrasonic c...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1995.66.3.235
更新日期:1995-03-01 00:00:00
abstract::Classification by origin and structure of the many different coatings which occur on the surfaces of teeth and artificial surfaces exposed to the oral environment necessitate a revision of the terminology used to describe these coatings. Numerous gaps still exist in our understanding of the origin, morphological struc...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1976.47.3.139
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:This study explored which factors affected patients' decisions to pursue either surgical or non-surgical periodontal treatment. METHODS:Data were collected from 74 patients at a regularly scheduled periodontal appointment, at which each patient was told that periodontal treatment was needed, and 2 weeks fol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050206
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:This commentary compares the abilities of full-mouth disinfection (FDIS), full-mouth root planing (FRP), and partial-mouth disinfection (PDIS) to improve periodontal health. FDIS consists of 4 quadrants of root planing completed within 24 hours with adjunctive chlorhexidine therapies (e.g., rinsing, subgingi...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2002.73.7.797
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis (Pg) is a major etiologic agent of periodontitis, whose virulence has been attributed to different factors, including lipopolysaccharide (LPS). Vascular ectopic calcification as a well-known major risk factor for adverse cardiovascular diseases is a highly prevalent vascular pathophe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.150602
更新日期:2016-07-01 00:00:00
abstract::Three block sections of treated human intraosseous lesions within one individual are presented. These lesions were debrided, filled with autogenous grafts and at two sites the root was treated with citric acid. The treated sites were lightly root planed once a month and the blocks were removed 6 months after surgery. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.2.67
更新日期:1983-02-01 00:00:00
abstract::Throughout the 20th century, an understanding of the role of causative bacteria and the susceptible host in the initiation and progression of periodontal disease(s) has emerged from the research efforts of scientists and clinicians worldwide. Over time, specific bacterial types, such as Porphyromonas gingivalis, were ...
journal_title:Journal of periodontology
pub_type: 历史文章,杂志文章
doi:10.1902/jop.2008.080182
更新日期:2008-08-01 00:00:00
abstract::A surgical and suturing method is described for the subgingival placement of Gore-tex periodontal material during new attachment procedures. The periodontal material isolates the root surface from epithelium and gingival connective tissue. Three cases were treated. Clinical new attachment was evident from clinical pro...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.12.819
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:As patient demand increases for more natural restorations in the esthetic zone, clinicians must have the highest level of skill and knowledge to maintain or reform the interdental papilla between teeth, between implants and teeth, and between adjacent implants. To date, there are no reports that have measure...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.12.1785
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Epidermolysis bullosa acquisita (EBA) is an uncommon, acquired, chronic subepidermal bullous disease. This report describes a case of EBA with gingival involvement. A 43-year-old woman with EBA was referred to our clinic for periodontal therapy because of gingival tenderness and bleeding. She has been on cyc...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.4.550
更新日期:2001-04-01 00:00:00
abstract::An investigation into periodontal disease in the Syrian Golden hamster was conducted over a period of six months. With the periodontitis-producing Diet 2000 only mild destruction of the periodontium was observed. The interproximal area between M1 and M2 may be a better area for analysis of early periodontal disease in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.6.368
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:This article reports a rare case of metastasis of salivary duct carcinoma of the parotid gland to the gingiva and reviews the occurrence of metastatic processes to the oral mucosa. METHODS:A 67-year-old white male presented with a chief complaint of a painless nodular tissue growth on the gingiva with repor...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070283
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis is one of the major microbial pathogens associated with chronic periodontitis. To eradicate such pathogens by periodontal therapy, it is essential to clarify the source of infection. Recent findings suggest that the genotype of the fimbriae is one of the important factors in infectio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.9.1355
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Alanine aminopeptidase (ALAP) and dipeptidyl peptidase IV (DPPIV) are ectopeptidases that play a role in collagen degradation and are thought to be involved in the destruction of periodontal tissue. This study compared the activities of salivary ALAP and DPPIV in patients with periodontitis and periodontally...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090233
更新日期:2009-11-01 00:00:00
abstract::This investigation was conducted on seven individuals referred for treatment of moderate adult periodontitis. Twenty-eight sites with an average probing depth of 5.6 +/- 0.9 mm were evaluated. One tooth per jaw quadrant was randomly assigned to receive one of the following treatments: (I) no treatment, i.e., control; ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1988.59.5.301
更新日期:1988-05-01 00:00:00
abstract::Dipeptidyl peptidase (DPP) II and IV activities were demonstrated in unfixed cryostat sections of gingival tissue from chronic periodontitis patients using histochemistry with 2-methoxy-4-naphthylamine (MNA) substrates. In the case of DPP IV, enzyme localization was confirmed by immunocytochemistry with mouse monoclon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.9.846
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:The objective of this study was to histologically evaluate periodontal healing following flap surgery in intrabony periodontal defects to determine the influence of the number of bone walls on periodontal regeneration. METHODS:One-, 2-, and 3-wall intrabony periodontal defects were surgically produced at th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.2.229
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-alpha (TNF-alpha) may play an important role in insulin resistance. In this study, we hypothesized that TNF-alpha produced due to periodontal inflammation synergistically affects insulin resistance as well as TNF-alpha produced from adipose tissues in insulin-resistant type 2 diabetes p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.6.774
更新日期:2001-06-01 00:00:00