Abstract:
BACKGROUND:This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including multiple antigen-specific ACPA. METHODS:This multicenter case-control study includes 617 patients diagnosed with RA (n = 287) or OA (n = 330). Panoramic radiographs were taken; patients were categorized into low, moderate, or high tertiles based on mean percentage ABL. Serum ACPA was measured using second-generation anticyclic citrullinated peptide enzyme-linked immunosorbent assay and a multiplex platform to assess distinct antigen-specific ACPA. A generalized linear mixed model for binary data was used to compare stratified ABL in RA versus OA patients. Associations of moderate and high ABL (versus low) with RA disease activity and severity measures were examined using multivariate regression. Antigen-specific ACPA responses were compared among ABL tertiles using significance analysis of microarrays. RESULTS:ACPA-positive patients with RA had a significantly higher mean percentage of sites with ABL >20% compared with patients with OA (P = 0.03). After multivariate adjustment, greater ABL was significantly associated with higher serum ACPA concentration (P = 0.004), 28-joint Disease Activity Score (P = 0.023), health assessment questionnaire disability (P = 0.05), tender joint count (P = 0.02) and joint space narrowing scores (P = 0.05) among patients with RA. ACPAs targeting citrullinated vimentin and histone were significantly higher in moderate and high ABL groups versus low, regardless of smoking status (q <0.1%). CONCLUSIONS:Greater ABL was associated with higher ACPA, consistent with findings at articular sites. ACPA targeting could provide novel insight into important linkages between RA and periodontitis.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Gonzalez SM,Payne JB,Yu F,Thiele GM,Erickson AR,Johnson PG,Schmid MJ,Cannon GW,Kerr GS,Reimold AM,Sokolove J,Robinson WH,Mikuls TRdoi
10.1902/jop.2014.140425subject
Has Abstractpub_date
2015-02-01 00:00:00pages
222-31issue
2eissn
0022-3492issn
1943-3670journal_volume
86pub_type
杂志文章,多中心研究abstract:BACKGROUND:Application of cone-beam computed tomography (CBCT) has grown exponentially across dentistry with a clear impact in implant dentistry. This review aims at providing the scientific context to understand if CBCT imaging should become the standard of care for patients requiring dental implants. METHODS:A liter...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2017.160548
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Previous studies have shown an association between a specific genotype for the inflammatory cytokine interleukin (IL)-1 and the severity of periodontal disease. The purpose of this study was to evaluate the effect of the IL-1 genotype on the outcomes of periodontal surgical regenerative treatment with bone r...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.10.1335
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Some reports suggest that the prevalence and severity of gingival overgrowth (GO) is lower in patients taking tacrolimus (Tcr) than in those taking cyclosporin A (CsA). The present study was conducted to determine the prevalence and severity of GO in a group of renal transplant recipients treated with Tcr in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050327
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Different surgical approaches have been proposed to treat peri-implantitis defects with limited effectiveness and predictability. Laser has been proposed as an effective tool to assist in bacterial decontamination and modulating peri-implant tissue inflammation. The aim of this pilot clinical trial was to ev...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0040
更新日期:2020-08-06 00:00:00
abstract:BACKGROUND:Previous studies showed that host modulation therapy (HMT) or topical antimicrobial therapy (TAT) provided significant adjunctive benefits to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). The purpose of this study was to evaluate a combination therapy involving SRP, HMT, and ...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2008.070237
更新日期:2008-01-01 00:00:00
abstract::This report is an example of tumor metastasis to the temporomandibular joint and its effect on pain, restriction of jaw movement, and the subsequent inability of the patient to function normally. Neoplasm is not the usual etiology of myofascial pain dysfunctionsyndrome and the muscle sparm component of this patient's ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.5.309
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Cyclosporin A (CsA) is a potent immunosuppressant used to prevent organ transplant rejection and to treat various autoimmune diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of this study was to identif...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.11.1273
更新日期:2002-11-01 00:00:00
abstract::Intraoral transmission radiographs have been the primary diagnostic method for the assessment of bone support as well as for the detection and measurement of osseous changes due to periodontitis. The purpose of the present paper is three-fold. The first is to review radiographic techniques for the assessment of period...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1992.63.4s.367
更新日期:1992-04-01 00:00:00
abstract::Formation of the junctional epithelium was studied by routine light microscopy in the molar teeth of commercially slaughtered pigs. It was found that the process whereby the reduced enamel epithelium (REE) contributed to the junctional epithelium formation corresponded largely with changes in man previously described ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.3.164
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:This study was conducted to assess the clinical, immunological, and patient-centered outcomes of microcurrent electrotherapy on palatal wound healing. METHODS:This was a parallel, double-masked randomized clinical trial, in which 53 patients with ridge preservation indications were selected and randomly ass...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0122
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:It is estimated that approximately 85% of all halitosis cases have their origin within the mouth; of these, 50% are caused by tongue residues. Previous studies have established that hydrogen sulfide and mercaptans are the primary components of halitosis. Thus, tongue cleaning gains importance as a means of h...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2004.75.7.1009
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Dendritic cells are characterized by shape, structure, and membrane molecule expression; they contact T lymphocytes to present antigens and stimulate plasma cell differentiation in vitro. Dendritic cells are known to be present in healthy human gingiva and to be altered in HIV-associated periodontitis. Here,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.1.45
更新日期:2002-01-01 00:00:00
abstract::The present study demonstrated that hyperglycemic diabetic rats fed a low-protein (8%) diet maintained an alveolar bone height similar to controls; in contrast, those fed a standard protein diet (24%) had reduced alveolar bone height (P less than 0.05). Euglycemic diabetic and untreated control rats fed low-protein di...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.5.264
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Collinin is a secondary plant metabolite belonging to the class of geranyloxycoumarins. We explored the potential beneficial impact of collinin on periodontal health by investigating its effect on Porphyromonas gingivalis (P. gingivalis), lipopolysaccharide (LPS)-induced inflammatory response of macrophages,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120118
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The analgesic and anti-inflammatory efficacy of tenoxicam and meloxicam were evaluated in this double-masked, randomized, prospective study by analyzing pain scores and the need for rescue-analgesic agents following dental implant surgery. METHODS:One hundred patients, in whom 241 dental implants were place...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2007.070192
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Recombinant human bone morphogenetic protein-2 (rhBMP-2) in a proper carrier has been shown to induce clinically relevant bone formation for several oral/maxillofacial and periodontal indications and to stimulate regeneration of the periodontal attachment. The objective of this study is to evaluate regenerat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.12.1494
更新日期:2002-12-01 00:00:00
abstract::The purpose of this study was to examine the effect of inflammatory cytokines on IFN-γ-induced HLA-DR expression on cultured human gingival fibroblasts by flow cytometry. Natural human IFN-γ, recombinant human interleukin-1β (rhIL-1β), and rh tumor necrosis factor-α (rhTNF-α) were used. IFN-γ-induced upregulation of H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.4.336
更新日期:1994-04-01 00:00:00
abstract::This investigation was conducted on seven individuals referred for treatment of moderate adult periodontitis. Twenty-eight sites with an average probing depth of 5.6 +/- 0.9 mm were evaluated. One tooth per jaw quadrant was randomly assigned to receive one of the following treatments: (I) no treatment, i.e., control; ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1988.59.5.301
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Pentraxins are classic mediators of inflammation and markers of acute-phase reactions. Pentraxin-3 (PTX3) is the first-identified long pentraxin and is believed to be a true independent indicator of disease activity. Although a classic pentraxin, C-reactive protein, and its association with various systemic ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100526
更新日期:2011-05-01 00:00:00
abstract::The sensitivity to tetracycline of 345 bacterial isolates from periodontal lesions was determined. Most species of bacteria, including those thought to be involved in the initiation and progress of destructive periodontal disease, were inhibited in vitro by tetracycline concentrations of 4 to 8 micrograms/ml. This con...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.10.613
更新日期:1981-10-01 00:00:00
abstract::A review of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Disease) is presented. Special emphasis is placed on the oral manifestations which include hemorrhagic vesicles, nodules, papules and ulcers that involve the gingiva and other areas of the mucosa. Two cases are included which were seen in a periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.163
更新日期:1982-03-01 00:00:00
abstract::The American Academy of Periodontology has developed the following parameter on the treatment of chronic periodontitis with slight to moderate loss of periodontal supporting tissues. Patients should be informed of the disease process, therapeutic alternatives, potential complications, expected results, and their respo...
journal_title:Journal of periodontology
pub_type: 指南,杂志文章,实务指引
doi:10.1902/jop.2000.71.5-S.853
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) have inability to maintain the normal levels of protein metabolism products, blood pressure and hematocrit. Periodontal disease involves an inflammatory destructive process. Identification of opportunistic viruses is extremely important as they are associated with c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0583
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Prevalence of peri-implantitis is directly proportional to the time of functional loading. The aim of this retrospective study was to assess the survival and success rates as well as the incidence of peri-implantitis among patients with a history of periodontitis and among implants with 1 to 10 years of func...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0715
更新日期:2019-12-20 00:00:00
abstract::Wounds were prepared in the oral cavity of 15 rabbits and five dogs, and an enzyme-solubilized calfskin collagen was placed over the surgery sites on one side. The contralateral sides acted as controls. Results indicated that the membrane was biologically acceptable to the oral mucosa of rabbits and dogs. Th collagen ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.5.250
更新日期:1979-05-01 00:00:00
abstract::Proposing to place endosseous implants is an integral facet of dental treatment plans. Their insertion is usually associated with a low incidence of untoward events. However, despite careful planning, surgical complications can arise: infection, intraoral hemorrhage, wound dehiscence, postoperative pain, lack of prima...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2008.070067
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Gingival thickness, keratinized tissue width, and bone morphotype are three important parameters used to categorize periodontal phenotypes. These elements all play an important role in the maintenance of periodontal health. The aim of this review is to explore the importance of converting thin phenotype into...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1002/JPER.19-0337
更新日期:2020-03-01 00:00:00
abstract::The research reviewed in this paper constitutes a series of investigations intended to develop and evaluate a new membrane technique, which provides improved conditions for osteogenesis during healing of bone defects and restitution of earlier existing bone. The technique has also been shown to aid in bone grafting as...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1993.64.11s.1116
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the long-term success and survival rates of implants replacing a single molar between two natural teeth and to evaluate the influence of implant characteristics on implant success. METHODS:The study was based on a consecutive cohort of 81 patients who received implants to...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060005
更新日期:2006-09-01 00:00:00
abstract::The purpose of this investigation was to evaluate calcium hydroxide and potassium nitrate individually as densensitizing agents for hypersensitive root surfaces. The apparatus used in the experiment to measure hypersensitivity was (a) a thermo-electric stimulating device to measure hot and cold stimulation quantitativ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.10.667
更新日期:1977-10-01 00:00:00