Levels of pentraxin-3 in gingival crevicular fluid and plasma in periodontal health and disease.

Abstract:

BACKGROUND:Pentraxins are classic mediators of inflammation and markers of acute-phase reactions. Pentraxin-3 (PTX3) is the first-identified long pentraxin and is believed to be a true independent indicator of disease activity. Although a classic pentraxin, C-reactive protein, and its association with various systemic diseases is well documented in the periodontal literature, there is no data on PTX3 to our knowledge. METHODS:Forty participants (20 males and 20 females; age range: 23 to 50 years) were involved in the study. Participants were divided into three groups based on gingival index, probing depth, and clinical attachment level: the healthy group (group 1; n = 10), gingivitis group (group 2; n = 15), and periodontitis group (group 3; n = 15). Gingival crevicular fluid (GCF) and plasma samples collected from each subject were quantified for PTX3 levels using an enzyme-linked immunosorbent assay. RESULTS:In tandem with the disease progression from healthy to gingivitis to periodontitis, the mean PTX3 concentrations increased in GCF and plasma. However, GCF values were higher than plasma values. It was found that PTX3 concentration was highest in group 3 and lowest in group 1. PTX3 concentrations also correlated positively with periodontal parameters. CONCLUSIONS:GCF and plasma PTX3 concentrations correlated positively in all groups. However, within the limits of the present study, the differences in plasma PTX3 levels were not found to be statistically significant. Hence, GCF PTX3 values were considered a marker of inflammatory activity in periodontal disease. However, PTX3 deserves further consideration as a therapeutic target. Additional large-scale studies should be carried out to confirm positive correlations.

journal_name

J Periodontol

authors

Pradeep AR,Kathariya R,Raghavendra NM,Sharma A

doi

10.1902/jop.2010.100526

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

734-41

issue

5

eissn

0022-3492

issn

1943-3670

journal_volume

82

pub_type

杂志文章
  • A laboratory model biofilm fermenter: design and initial trial on a single species biofilm.

    abstract:BACKGROUND:The minimum inhibitory concentration (MIC) does not provide information on the efficacy of antimicrobial agents against infections involving biofilms, which are many times more resistant than planktonic forms of bacteria. This report is on the design and initial trial of a device for growing standard biofilm...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.9.1443

    authors: Wirthlin MR,Chen PK,Hoover CI

    更新日期:2005-09-01 00:00:00

  • Risk Indicators for Periodontitis in US Adults: NHANES 2009 to 2012.

    abstract:BACKGROUND:Through the use of optimal surveillance measures and standard case definitions, it is now possible to more accurately determine population-average risk profiles for severe (SP) and non-severe periodontitis (NSP) in adults (aged 30 years and older) in the United States. METHODS:Data from the 2009 to 2012 Nat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.160013

    authors: Eke PI,Wei L,Thornton-Evans GO,Borrell LN,Borgnakke WS,Dye B,Genco RJ

    更新日期:2016-10-01 00:00:00

  • The Influence of Glycated Hemoglobin on the Cross Susceptibility Between Type 1 Diabetes Mellitus and Periodontal Disease.

    abstract:BACKGROUND:Periodontal disease is a major complication of type 1 diabetes mellitus (T1DM). The aim of the present study is to investigate the relationship between glycated hemoglobin and circulating levels of interleukin (IL)-6, IL-8, and C-X-C motif chemokine ligand 5 (CXCL5) in non-smoking patients suffering from T1D...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.150149

    authors: Lappin DF,Robertson D,Hodge P,Treagus D,Awang RA,Ramage G,Nile CJ

    更新日期:2015-11-01 00:00:00

  • Effects of cigarette smoke condensate and nicotine on human gingival fibroblast-mediated collagen degradation.

    abstract:BACKGROUND:Members of the matrix metalloproteinase (MMP) family have been shown to be involved in periodontal disease. Risk factors for periodontal disease include tobacco smoking. Cigarette smoke condensate (CSC) is comprised of thousands of chemicals. Nicotine is one of the active components in tobacco. This study co...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100540

    authors: Zhang W,Fang M,Song F,Windsor LJ

    更新日期:2011-07-01 00:00:00

  • A method for determining patient oral care skills: The University of Mississippi Oral Hygiene Index.

    abstract::The plaque control record (O'Leary index) appears to be a commonly used oral hygiene index for assessing oral health skills. This index provides sufficient information for patient education; however, the time involved in data collection reduces its value. Most other indices limit the number of teeth and surfaces and f...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1998.69.10.1176

    authors: Silberman SL,Le Jeune RC,Serio FG,Devidas M,Davidson L,Vernon K

    更新日期:1998-10-01 00:00:00

  • Biofilm Lysine Decarboxylase, a New Therapeutic Target for Periodontal Inflammation.

    abstract:BACKGROUND:Lysine, a nutritionally essential amino acid, enters the oral cavity in gingival crevicular fluid (GCF). During oral hygiene restriction (OHR), lysine decarboxylase (LDC) in dento-gingival biofilms converts lysine to cadaverine. Lysine depletion impairs the dental epithelial barrier to bacterial proinflammat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.140490

    authors: Lohinai Z,Keremi B,Szöko E,Tábi T,Szabo C,Tulassay Z,DiCesare JC,Davis CA,Collins LM,Levine M

    更新日期:2015-10-01 00:00:00

  • Sarcoidosis affecting the periodontium: a long-term follow-up case.

    abstract:BACKGROUND:Clinical manifestations of sarcoidosis affecting the periodontium could mimic aggressive periodontitis. This case report documents the occurrence of sarcoidosis affecting the periodontium, including its clinical features, diagnosis, treatment, and 6-year follow-up. METHODS:An individual with a history of pu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.070117

    authors: Moretti AJ,Fiocchi MF,Flaitz CM

    更新日期:2007-11-01 00:00:00

  • Distribution and readability of periodontal health education literature.

    abstract::THIS INVESTIGATION was undertaken to determine the distribution pattern and readability level of 20 widely distributed printed items containing periodontal health education literature. Average annual distribution was obtained from distributors of the material. The Minnesota Interactive Readability Approximation Progra...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1983.54.9.538

    authors: Bakdash MB,Odman PA,Lange AL

    更新日期:1983-09-01 00:00:00

  • Level of neopterin, a marker of immune cell activation in gingival crevicular fluid, saliva, and urine in patients with aggressive periodontitis.

    abstract:BACKGROUND:Neopterin, a marker of cellular immune activation, is produced by human macrophages after induction by interferon gamma that is secreted by T lymphocytes. Neopterin concentrations in diverse body fluids have been reported to increase in parallel with bacteria in the clinical course of infections. Therefore, ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2002.73.7.720

    authors: Ozmeriç N,Baydar T,Bodur A,Engin AB,Uraz A,Eren K,Sahin G

    更新日期:2002-07-01 00:00:00

  • Journal of Periodontology 75th Anniversary.

    abstract::This tribute was written by Dr. E. Brady Hancock, who was a student of and who succeeded Dr. Timothy J. O'Leary as chair of the Department of Periodontics at Indiana University. Dr. O'Leary served as co-editor of the Journal of Periodontologyfrom 1970 until 1988. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2004.75.9.1175

    authors:

    更新日期:2004-09-01 00:00:00

  • A chlorhexidine-containing methacrylic gel as a periodontal dressing.

    abstract::The modification of a methacrylic gel for use as a periodontal dressing was attempted. The increased adhesion and rigidity of the resultant material appeared consistent with the clinical findings. Satisfactory retention of the dressing was found in 85% of those placed on a group of patients attending for periodontal s...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1975.46.8.465

    authors: Addy M,Douglas WH

    更新日期:1975-08-01 00:00:00

  • Effects of currently available surgical and restorative interventions on reducing midfacial mucosal recession of immediately placed single-tooth implants: a systematic review.

    abstract:BACKGROUND:Procedures to improve peri-implant soft-tissue outcomes of single, immediately placed implants are a topic of interest. This systematic review investigates the effect of various surgical and restorative interventions on implant mid-buccal mucosal level. METHODS:An electronic search of five databases (Januar...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2013.130064

    authors: Lin GH,Chan HL,Wang HL

    更新日期:2014-01-01 00:00:00

  • Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation.

    abstract::Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. The rationale for use of DFDBA includes the fact that proteins capable of inducing new bone; i.e., bone morphogenetic proteins, can be isolated from bone grafts. Commercial bone banks have provided DFDBA to the dental p...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.9.918

    authors: Schwartz Z,Mellonig JT,Carnes DL Jr,de la Fontaine J,Cochran DL,Dean DD,Boyan BD

    更新日期:1996-09-01 00:00:00

  • Effect of Porphyromonas gingivalis lipopolysaccharide on bone marrow mesenchymal stem cell osteogenesis on a titanium nanosurface.

    abstract:BACKGROUND:Titanium (Ti) dental implants have been widely used for prosthetic reconstruction of dentition. Unfortunately, peri-implantitis can result in failure of dental implant osseointegration. Lipopolysaccharide (LPS) acts as a chronic inflammatory stimulus and maintains peri-implant inflammation, worsening the pro...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.140386

    authors: Xing H,Taguchi Y,Komasa S,Yamawaki I,Sekino T,Umeda M,Okazaki J

    更新日期:2015-03-01 00:00:00

  • Histologic and histomorphometric findings from retrieved, immediately occlusally loaded implants in humans.

    abstract:BACKGROUND:The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reco...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.11.1823

    authors: Romanos GE,Testori T,Degidi M,Piattelli A

    更新日期:2005-11-01 00:00:00

  • Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis.

    abstract:BACKGROUND:Hyaluronic acid (HA) has shown anti-inflammatory effects in gingivitis therapy. The potential benefits of local subgingival application of HA adjunctive to scaling and root planing (SRP) were evaluated in this study. METHODS:Twenty patients with chronic periodontitis were included in this split-mouth study....

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2004.75.8.1114

    authors: Xu Y,Höfling K,Fimmers R,Frentzen M,Jervøe-Storm PM

    更新日期:2004-08-01 00:00:00

  • Calcium hydroxide and potassium nitrate as desensitizing agents for hypersensitive root surfaces.

    abstract::The purpose of this investigation was to evaluate calcium hydroxide and potassium nitrate individually as densensitizing agents for hypersensitive root surfaces. The apparatus used in the experiment to measure hypersensitivity was (a) a thermo-electric stimulating device to measure hot and cold stimulation quantitativ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1977.48.10.667

    authors: Green BL,Green ML,McFall WT Jr

    更新日期:1977-10-01 00:00:00

  • Clinical application of spiral tomography in anterior implant placement: case report.

    abstract:BACKGROUND:Placement of endosseous dental implants in edentulous areas of the anterior maxilla poses a unique challenge due to variations in the amount of residual alveolar bone. Implant position becomes crucial in cases demanding high esthetic results but possessing minimal ridge width or in cases requiring augmentati...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2002.73.10.1202

    authors: Dixon DR,Morgan R,Hollender LG,Roberts FA,O'Neal RB

    更新日期:2002-10-01 00:00:00

  • The Use of Cone-Beam Computed Tomography in Management of Patients Requiring Dental Implants: An American Academy of Periodontology Best Evidence Review.

    abstract:BACKGROUND:Application of cone-beam computed tomography (CBCT) has grown exponentially across dentistry with a clear impact in implant dentistry. This review aims at providing the scientific context to understand if CBCT imaging should become the standard of care for patients requiring dental implants. METHODS:A liter...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2017.160548

    authors: Rios HF,Borgnakke WS,Benavides E

    更新日期:2017-10-01 00:00:00

  • Self-Reported Periodontal Disease: Validation in an Epidemiological Survey.

    abstract:BACKGROUND:Evidence is accumulating to support poor oral health as a risk factor for systemic conditions, including cardiovascular diseases, diabetes control, adverse pregnancy outcomes, and pneumonia. Prohibitive costs for clinical assessment of periodontal disease limit information to assess the prevalence and trends...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060481

    authors: Taylor GW,Borgnakke WS

    更新日期:2007-07-01 00:00:00

  • Repair of Class II furcation defects after a reparative tissue graft obtained from extraction sockets treated with growth factors: a histologic and histometric study in dogs.

    abstract:BACKGROUND:Reparative tissue of extraction sockets was proposed as grafting material in the treatment of periodontal defects. Our hypothesis was that the addition of growth factors to extraction sockets improves the regenerative potential of this tissue when used as a graft. The objective of the present study was to an...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.10.1681

    authors: Soares FP,Hayashi F,Yorioka CW,Pannuti CM,Gioso MA,de Lima LA,Romito GA,Pustiglioni FE

    更新日期:2005-10-01 00:00:00

  • Puberty gingivitis in insulin-dependent diabetic children. I. Cross-sectional observations.

    abstract::This cross-sectional study examined the gingivitis occurring at puberty in a population of insulin-dependent juvenile diabetics. Seventy-seven children between the ages of 6 and 15 years were examined for gingivitis levels, stages of pubertal maturation and blood levels of glucose and glycosylated hemoglobin. Bacteria...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1983.54.12.714

    authors: Gusberti FA,Syed SA,Bacon G,Grossman N,Loesche WJ

    更新日期:1983-12-01 00:00:00

  • Sex differences in inflammatory and apoptotic signaling molecules in normal and diseased human gingiva.

    abstract:BACKGROUND:The purpose of this study is to determine whether sex dimorphism exists in the expression of inflammatory and apoptotic mediators in gingiva obtained from normal and diseased sites of periodontal disease. METHODS:Gingival papillae were obtained from individuals (56 males and 62 females) who required extract...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.130718

    authors: Johnson RB,Wikle JC

    更新日期:2014-11-01 00:00:00

  • Clinical outcomes of peri-implant peripheral giant cell granuloma: a report of three cases.

    abstract:BACKGROUND:Peripheral giant cell granuloma (PGCG) is a reactive lesion that occurs on the gingiva or alveolar mucosa and contains numerous giant cells. Its recurrence rate is 10%. Only five cases associated with dental implants have been reported. This case report describes three additional cases with clinical courses ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.090081

    authors: Hernandez G,Lopez-Pintor RM,Torres J,de Vicente JC

    更新日期:2009-07-01 00:00:00

  • Histologic evaluation of the effects of intrasulcular toothbrushing on human sulcular epithelium.

    abstract::Nineteen young adult Caucasian males had an average Gingival Index Score of 0.47. Each was asked to demonstrate his present method of toothbrushing: thirteen used the scrub method, and six combined the scrub and roll methods. Control gingival tissue specimens were taken from the mandibular left first bicuspid or first...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.4.163

    authors: Fry HR,App GR

    更新日期:1978-04-01 00:00:00

  • Treatment of periodontal disease in diabetics reduces glycated hemoglobin.

    abstract::Periodontal disease is a common infection-induced inflammatory disease among individuals suffering from diabetes mellitus. The purpose of this study was to assess the effects of treatment of periodontal disease on the level of metabolic control of diabetes. A total of 113 Native Americans (81 females and 32 males) suf...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1997.68.8.713

    authors: Grossi SG,Skrepcinski FB,DeCaro T,Robertson DC,Ho AW,Dunford RG,Genco RJ

    更新日期:1997-08-01 00:00:00

  • The prevalence and distribution of intrabony defects in dry mandibles.

    abstract::One hundred mandibles of South African Negroes were examined for the presence of intrabony defects, and the distance between the cemento-enamel junction and alveolar bone crest was measured along the buccal and lingual surface of roots associated with interdental craters. Two-hundred thirty-one intrabony defects were ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.3.149

    authors: Tal H

    更新日期:1984-03-01 00:00:00

  • Subgingival microflora in Turkish patients with periodontitis.

    abstract:BACKGROUND:No information exists on periodontitis-associated subgingival microbiota from Turkey. We determined the occurrence, interspecies relationships, and clonal characteristics for a group of periodontal bacteria in a Turkish study population. METHODS:Subgingival microbial samples were obtained from patients with...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2003.74.6.803

    authors: Doğan B,Antinheimo J,Cetiner D,Bodur A,Emingil G,Buduneli E,Uygur C,Firatli E,Lakio L,Asikainen S

    更新日期:2003-06-01 00:00:00

  • Clinical and laboratory characterization of early onset periodontitis.

    abstract::Clinical and laboratory data were compared in 72 patients with localized periodontitis (LP) and 103 patients with generalized periodontitis (GP). Significantly more LP than GP cases had decreased neutrophil chemotaxis (CTX), and were seropositive for Actinobacillus actinomycetemcomitans (Aa). Significantly, more GP ca...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1989.60.10.557

    authors: Astemborski JA,Boughman JA,Myrick PO,Goodman SB,Wooten RK,Agarwal S,Vincent JW,Suzuki JB

    更新日期:1989-10-01 00:00:00

  • Effect of periodontal therapy on patients maintained for 15 years or longer. A retrospective study.

    abstract::A retrospective study of tooth loss in 211 patients who were treated for periodontal disease in private practice and maintained for 15 to 34 years on 3- to 6-month recall schedules is reported. The average age of the patients was 42 years, and the average length of time in maintenance was 22 years. On the basis of res...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1986.57.6.347

    authors: Goldman MJ,Ross IF,Goteiner D

    更新日期:1986-06-01 00:00:00