Abstract:
BACKGROUND:Hyaluronic acid (HA) has shown anti-inflammatory effects in gingivitis therapy. The potential benefits of local subgingival application of HA adjunctive to scaling and root planing (SRP) were evaluated in this study. METHODS:Twenty patients with chronic periodontitis were included in this split-mouth study. Sulcus fluid flow rate (SFFR) and sulcus bleeding index were monitored at baseline and after 1, 2, 3, 4, 5, 6, and 12 weeks; probing depth and clinical attachment level were monitored at baseline and 6 and 12 weeks. Subgingival plaque samples were also taken at these same three appointments to determine the presence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, and Treponema denticola. All patients were treated with full-mouth scaling and root planing (SRP); in addition, an HA gel was administered subgingivally in the test sites every week for 6 weeks. RESULTS:An improvement of all clinical variables was observed (P < 0.05) in both groups. Clinically, no difference between test and control sites could be found. No difference between test and control sites was seen in the tested microorganisms. CONCLUSIONS:No clinical or microbiological improvement was achieved by the adjunctive use of HA gel compared to SRP alone. Only SFFR was affected by the use of HA in terms of a more rapid reduction of SFFR in the test sites.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Xu Y,Höfling K,Fimmers R,Frentzen M,Jervøe-Storm PMdoi
10.1902/jop.2004.75.8.1114subject
Has Abstractpub_date
2004-08-01 00:00:00pages
1114-8issue
8eissn
0022-3492issn
1943-3670journal_volume
75pub_type
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journal_title:Journal of periodontology
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更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...
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journal_title:Journal of periodontology
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更新日期:2005-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.6.328
更新日期:1990-06-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.2.287
更新日期:2000-02-01 00:00:00
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pub_type: 评论,杂志文章
doi:10.1902/jop.1994.65.12.1169
更新日期:1994-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1995.66.10.870
更新日期:1995-10-01 00:00:00
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pub_type: 指南,杂志文章,实务指引
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更新日期:2003-11-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.1.41
更新日期:1977-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.140706
更新日期:2015-08-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.12.1231
更新日期:1997-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:1986-06-01 00:00:00
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journal_title:Journal of periodontology
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.7.469
更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1998.69.10.1119
更新日期:1998-10-01 00:00:00