Abstract:
BACKGROUND:Collinin is a secondary plant metabolite belonging to the class of geranyloxycoumarins. We explored the potential beneficial impact of collinin on periodontal health by investigating its effect on Porphyromonas gingivalis (P. gingivalis), lipopolysaccharide (LPS)-induced inflammatory response of macrophages, and osteoclastogenesis. METHODS:Collinin was synthesized from pyrogallol and propiolic acid. A microdilution assay was used to determine antibacterial activity of collinin. The effect of collinin on collagenase activity of P. gingivalis was determined using fluorescent collagen. Macrophages were treated with collinin before being stimulated with LPS. The secretion of interleukin-6, chemokine (C-C motif) ligand 5, and prostaglandin E2 was assessed by enzyme-linked immunosorbent assays (ELISA). The inhibitory effect of collinin on differentiation of human preosteoclastic cells was assessed by tartrate-resistant acid phosphatase staining, whereas the secretion of matrix metalloproteinase-9 (MMP-9) was measured by ELISA. Bone resorption activity was investigated by using a human bone plate coupled with an immunoassay that detected the release of collagen fragments. RESULTS:Collinin inhibited the growth of P. gingivalis. The effect was more pronounced under iron-restricted conditions. Collinin dose dependently inhibited the degradation of type I collagen by P. gingivalis. It was also a potent inhibitor of the LPS-induced inflammatory response in macrophages and completely inhibited receptor activator of nuclear factor κB ligand-dependent osteoclast differentiation and MMP-9 secretion. Last, collinin affected bone degradation mediated by mature osteoclasts by significantly decreasing the release of collagen helical peptides. CONCLUSION:Although clinical trials are required, data from these in vitro analyses support the potential of collinin as a therapeutic agent for treating inflammatory periodontitis associated with bone breakdown.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Santos J,Marquis A,Epifano F,Genovese S,Curini M,Grenier Ddoi
10.1902/jop.2012.120118subject
Has Abstractpub_date
2013-05-01 00:00:00pages
704-11issue
5eissn
0022-3492issn
1943-3670journal_volume
84pub_type
杂志文章abstract:BACKGROUND:Platelet-derived growth factor (PDGF-BB) has been shown to enhance periodontal regeneration. Principles of guided tissue regeneration dictate that one of the goals of therapy is to modulate the wound healing processes to favor repopulation of the wound with cells derived from the periodontal ligament rather ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.3.331
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Metastasis of a malignant tumor to the oral cavity is rare, but it can be the first manifestation of a primary tumor. METHODS:The clinicopathologic features of a gingival metastasis originating from lung adenocarcinoma in a female patient are described. A 57-year-old woman showed a rapidly growing, painless...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070246
更新日期:2008-01-01 00:00:00
abstract::Primary socket closure in immediate implantation may be difficult, due to the opening left by the extracted tooth. The absolute need for bone augmentation and primary flap closure for implants placed into fresh extraction sites has never been proven. The hypothesis of the present study was that immediate implants can ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.7.743
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:It is hypothesized that levels of advanced glycation end products (AGEs) are higher in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with type-2 diabetes mellitus (type-2 DM) than controls (systemically healthy individuals without CP. The aim was to assess the levels of AGEs in t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0209
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Platelet-rich fibrin (PRF) is an autologous preparation that has encouraging effects in healing and regeneration. The aim of this trial is to evaluate the effectiveness of coronally advanced flap (CAF) + connective tissue graft (CTG) + PRF in Miller Class I and II recession treatment compared to CAF + CTG. ...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2015.150015
更新日期:2015-11-01 00:00:00
abstract::Dipeptidyl peptidase (DPP) II and IV activities were demonstrated in unfixed cryostat sections of gingival tissue from chronic periodontitis patients using histochemistry with 2-methoxy-4-naphthylamine (MNA) substrates. In the case of DPP IV, enzyme localization was confirmed by immunocytochemistry with mouse monoclon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.9.846
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the effect of smoking on the periodontal status and the salivary composition in subjects with established periodontitis before and after periodontal therapy. METHODS:Our study group included 26 healthy subjects, 12 smokers and 14 non-smokers with established periodo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.10.1240
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:This cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. METHODS:Samples from 97 implants/teeth (58 implants [19 hea...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160751
更新日期:2017-08-01 00:00:00
abstract::The cross-sectional relationship between severe loss of periodontal attachment (LPA) and worsening immune status due to HIV infection was evaluated in 474 HIV-infected subjects (416 men, 58 women) aged 18 to 49 years who had been classified at stages 1 through 6 of the Walter Reed Army Institute of Research (WR) Stagi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.6.421
更新日期:1995-06-01 00:00:00
abstract::Enormous advances have been made over the past decade concerning the proper use of statistical techniques in reporting periodontal research. However, numerous articles still appear which use inappropriate or less than optimal statistical methods. This paper describes the most common problems encountered in a recent re...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.4.206
更新日期:1990-04-01 00:00:00
abstract::1. The subjective separation of the normal and the diseased periodontium for splinting purposes is artificial. With the exception of cases of secondary trauma from occlusion, the diseased periodontium should be treated in the same manner as the normal periodontium with regards to splinting. 2. Retionales for stabiliza...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1976.47.7.405
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Guided bone regeneration (GBR) has been widely utilized for the promotion of bone augmentation in bone loss areas. However, little information has been available regarding chronological changes in newly formed bone and alterations in the nature of newly formed bone after removal of a barrier membrane. The pr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.3.341
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Peripheral giant cell granuloma (PGCG) is a reactive lesion that occurs on the gingiva or alveolar mucosa and contains numerous giant cells. Its recurrence rate is 10%. Only five cases associated with dental implants have been reported. This case report describes three additional cases with clinical courses ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090081
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Neutrophils (PMNs) are critical components of the innate immune system and help to maintain oral health in the face of a constant bacterial challenge. However, along with protecting the periodontium from microbial invasion, these cells release potent lysosomal enzymes and oxygen radicals that can be destruct...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070107
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Several studies seek to prove the relationship between bruxism and periodontal status although it remains unclear and debatable. We aimed to assess the association between self-reported (SR) bruxism with the periodontal status in a large scale survey. MATERIAL AND METHODS:A total of 1064 individuals from th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0364
更新日期:2019-12-18 00:00:00
abstract::The report is a review of the literature related to hepatitis B and its implications for dental practitioners. Hepatitis B represents a serious health risk among dentists and simple preventive measures can greatly reduce the risk of transmission or contraction of the disease. Certain positive findings in a healthy his...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1980.51.3.162
更新日期:1980-03-01 00:00:00
abstract::In order to provide longitudinal data for endosteal bladevent implants, a continuing study is being conducted from an original group of 49 implants in 32 patients placed 15 years ago. The present work evaluated 26 of these bladevent implants in 18 patients. Three basic patterns were observed 15 years postoperatively: ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.9.589
更新日期:1987-09-01 00:00:00
abstract::The purpose of this study was to determine the levels of calprotectin and lactoferrin, 2 microbiostatic proteins, in the gingival crevicular fluid (GCF) of normal children. The children represented a population, primarily underprivileged, seeking care at a regional dental health care center. GCF was collected from Ram...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.8.879
更新日期:1998-08-01 00:00:00
abstract::Standard wounds of simple incision and partial excision of the dentogingival junction were made in miniature swine. The healing from the 1st to the 14th day were described clinically and histologically, and the standardization of the wounds permitted quantitative and statistical analysis. In wounds that are closely ad...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.6.318
更新日期:1980-06-01 00:00:00
abstract:BACKGROUND:The crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the correlation and accuracy of ultrasound in measuring periodontal dimensions, compared to ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0342
更新日期:2020-07-01 00:00:00
abstract::The clinical, histopathologic and functional consequences of the genetic deficiency of leukocyte Mac-1, LFA-1 and p150,95 were assessed among three affected patients, heterozygotes and unaffected individuals among two generations of a single kindred. Longitudinal assessments of this family afforded the unique opportun...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.6.400
更新日期:1987-06-01 00:00:00
abstract::Plasma cells are widely distributed in inflamed periodontal tissues, the adjacent periodontal ligament and nearby alveolar bone spaces, of old rats (20 and 27 months) raised on a conventional diet in a normal laboratory environment. Electron microscopy revealed three morphologic types (or perhaps stages) of these cell...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.4.227
更新日期:1983-04-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of the Nd:YAG laser on in vitro fibroblast attachment to endotoxin-treated root surfaces and to describe any laser-induced cementum surface alterations. Thirty 4 mm x 4 mm cementum segments were obtained from unerupted third molars. The treatment groups were as fol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.7.626
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Leucine-rich alpha-2 glycoprotein (LRG) is a novel acute phase protein involved in inflammation-associated diseases and that considered to be induced by multiple proinflammatory cytokines. This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor ne...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0358
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The pathobiology of systemic lupus erythematosus (SLE) is similar to that of periodontitis in that the immunoglobulin G Fc receptor (FcgammaR) and proinflammatory cytokines play an important role. Genetic variations of FcgammaR and interleukin (IL)-1 are associated with susceptibility to both diseases. There...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060194
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis is one of the major microbial pathogens associated with chronic periodontitis. To eradicate such pathogens by periodontal therapy, it is essential to clarify the source of infection. Recent findings suggest that the genotype of the fimbriae is one of the important factors in infectio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.9.1355
更新日期:2003-09-01 00:00:00
abstract::The levels of serum antibody reactive to selected periodontopathogens were determined in 182 clinically characterized patients: 35 healthy control, 50 juvenile periodontitis, 42 adult periodontitis and 55 rapidly progressive periodontitis. Reactive antibody levels were determined using an enzyme-linked immunosorbent a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.8.464
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140077
更新日期:2014-09-01 00:00:00
abstract::Greater cell attachment to demineralized dentin has been associated with subsequent development of a fiber attachment system. The purpose of this study was to evaluate tissue interactions to dentin demineralized with different concentrations of tetracycline solution. Dentin specimens were obtained from beneath root su...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.11.714
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:In Alabama, low birth weight (LBW) infants are about 20 times more likely to die before their first birthday compared to normal birth weight infants. While the rate of LBW has been consistently higher among African Americans compared to whites, there has been a gradual increase in LBW for both African Americ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.11.1491
更新日期:2001-11-01 00:00:00