Exophytic mass of the gingiva as the first manifestation of metastatic pulmonary adenocarcinoma.

Abstract:

BACKGROUND:Metastasis of a malignant tumor to the oral cavity is rare, but it can be the first manifestation of a primary tumor. METHODS:The clinicopathologic features of a gingival metastasis originating from lung adenocarcinoma in a female patient are described. A 57-year-old woman showed a rapidly growing, painless, exophytic mass in the left mandibular gingiva. The whole lesion was excised, and histologic and immunohistochemical analyses were performed. RESULTS:The histopathologic sections showed a proliferation of poorly differentiated spindle and pleomorphic cells. Because the differentiation between carcinoma and sarcoma of spindle cell tumors was difficult, additional immunohistochemical evaluation was performed. The intraoral healing after tumor removal was uneventful. The discrepancy between the histopathologic results and the clinical findings led to a thorough examination by the patient's physician. Finally, a biopsy of the lungs confirmed a poorly differentiated adenocarcinoma with multiple metastases, including the oral cavity. CONCLUSIONS:An exophytic lesion on the gingiva can be the first sign of metastatic adenocarcinoma to the oral mucosa. This case emphasizes that even apparently benign-looking gingival lesions in anamnestically healthy patients need to be examined histopathologically.

journal_name

J Periodontol

authors

Pozzi EC,Altermatt HJ,Rees TD,Bornstein MM

doi

10.1902/jop.2008.070246

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

187-91

issue

1

eissn

0022-3492

issn

1943-3670

journal_volume

79

pub_type

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