Abstract:
:Defects in neutrophil or polymorphonuclear leukocyte (PMNL) chemotaxis have been observed in a number of clinical conditions, including Down's syndrome and insulin-dependent diabetes mellitus (IDDM), which tend to be associated with severe forms of periodontal disease. In addition, impaired PMNL chemotaxis is frequently detected in individuals with localized juvenile periodontitis (LJP). The ability to monitor PMNL function in vivo at the gingival sulcus should therefore be useful as a diagnostic test. In this regard, we developed a technique which measures the response of PMNLs to a chemotactic agent, e.g., casein and N-formylmethionylleucylphenylalanine (N-FMLP) placed directly into gingival crevices. The development of the technique and its relationship to in vitro assays of chemotaxis are discussed, and data obtained from tests of the assay on control and streptozotocin-induced diabetic rats and human subjects with various periodontal diseases and IDDM are presented. As compared with healthy subjects and control animals, atypical (double peak) and reduced crevicular PMNL response patterns were observed during oral and systemic diseases. This suggests that the in vivo assay with appropriate modifications can be used diagnostically to assess PMNL migratory dysfunction and to identify individuals who may be susceptible to severe forms of periodontal disease.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Iacono VJ,Singh S,Golub LM,Ramamurthy NS,Kaslick Rdoi
10.1902/jop.1985.56.11s.56subject
Has Abstractpub_date
1985-11-01 00:00:00pages
56-62issue
11 Suppleissn
0022-3492issn
1943-3670journal_volume
56pub_type
杂志文章,评审abstract:BACKGROUND:Low-calorie diets are commonplace for reducing body weight. However, no information is available on the effects of a reduced-calorie diet on periodontal inflammation and disease. The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070629
更新日期:2008-07-01 00:00:00
abstract::The relationship between diabetes mellitus and oral health status was determined in Pima Indians from the Gila River Indian Community in Arizona. This tribe of native Americans has the world's highest reported incidence and prevalence of non-insulin-dependent (type 2) diabetes mellitus. The probing attachment level, a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.2.123
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the effects of adjunctive meloxicam on the matrix metalloproteinase-8 (MMP-8) levels of gingival crevicular fluid (GCF) in chronic periodontitis patients following the initial phase of periodontal therapy. METHODS:Twelve chronic periodontitis patients received ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.1.103
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Periodontitis is a multifactorial and infectious disease that may result in significant debilitation. The aim of this study is to exploit two optical coherence tomography (OCT) systems operating in the Fourier domain at different wavelengths, 930 and 1,325 nm, for structural analysis of periodontal tissue in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.150047
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Surface modifications to dental implants have been used in an attempt to accelerate the osseointegration process. The objective of this study was to biomechanically/histomorphometrically evaluate a bioceramic grit-blasted and acid-etched surface (BGB/AA; test) versus a dual acid-etched implant surface (contr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080106
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Considering the role of growth factors in periodontal regeneration, the aim of this study was to evaluate the influence of platelet-derived growth factor (PDGF)-BB, insulin-like growth factor (IGF)-1, and transforming growth factor-beta 1(TGF-β1), alone or in combination, on the rate of proliferation and adh...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070119
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The clinical use of an enamel matrix derivative (EMD) has been shown to promote formation of new cementum, periodontal ligament (PDL), and bone and to significantly enhance the clinical outcomes after regenerative periodontal surgery. It is currently unknown to what extent the bleeding during periodontal sur...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110404
更新日期:2012-07-01 00:00:00
abstract::Periodontal diseases are thought to result from inflammatory responses to bacterial challenges in the gingival crevicular area. Antibodies are a major host-protective mechanism in many bacterial infections. Consequently, the antibody responses to suspected periodontal pathogenic bacteria have been extensively measured...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1993.64.8s.807
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis (Pg) is a major etiologic agent of periodontitis, whose virulence has been attributed to different factors, including lipopolysaccharide (LPS). Vascular ectopic calcification as a well-known major risk factor for adverse cardiovascular diseases is a highly prevalent vascular pathophe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.150602
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:This prospective and controlled study elucidates the impact of smoking on the salivary microbiome and its further influence on marginal bone loss (MBL) around an implant during a 3-month bone-healing period. METHODS:Saliva samples were collected preoperatively from 20 periodontally healthy patients with sin...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160808
更新日期:2017-12-01 00:00:00
abstract::A study was undertaken to evaluate the antigenic potential of allogeneic freeze-dried skin (FDS) when used as a grafting material and to examine the clinical results when FDS is used for the correction of mucogingival problems in humans. FDS was obtained from an HLA-tissue-type donor according to Navy Tissue Bank prot...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.10.571
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:Implant failures are rare but do occur. Mechanical factors are certainly important in implant failures; so are biologic, iatrogenic, and functional factors. Mobility is the cardinal sign of implant failure. Three major etiologic factors have been suggested for implant failures: infection, impaired healing, a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.3.385
更新日期:2003-03-01 00:00:00
abstract::Periodontal regeneration requires formation of periodontal tissues lost due to periodontal disease. To better understand the formation of new periodontal tissues during periodontal repair and regeneration, immunohistochemical expression of extracellular matrix components of normal as well as healing periodontal tissue...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.7.579
更新日期:1995-07-01 00:00:00
abstract::A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximate...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1986.57.8.472
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:It has been suggested that cyclosporine A (CsA) induces gingival enlargement by promoting an increase in the gingival extracellular matrix (ECM). Nonetheless, the variable occurrence of CsA-induced gingival enlargement in patients receiving this medication indicates a multifactorial pathogenesis. Clinical ob...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120224
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Smoking is the most important environmental risk factor for periodontal disease. Elevated levels of serum-soluble CD44 (sCD44) have been detected in smokers and also have been recognized as a diagnostic marker in some smoking-induced diseases. The present study investigates the salivary sCD44 profiles of smo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090630
更新日期:2010-05-01 00:00:00
abstract::Fourteen intrabony periodontal defects and six furcation defects (Class II) were treated by a flap procedure which included the use of a polytetrafluoroethylene membrane to allow guided tissue regeneration. After 4 to 6 weeks of healing, the membranes were retrieved and examined by scanning electron microscopy for the...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.8.515
更新日期:1990-08-01 00:00:00
abstract::TEN PATIENTS WHO REQUIRED two or more anterior teeth extractions were utilized in this study. Extraction procedures were carried out with a full thickness surgical flap approach. After flap reflection, teeth were removed with a minimum of trauma to the surrounding bone. Following extraction silicone-based impression t...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1997.68.6.563
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that enamel matrix derivative (EMD) has the ability to improve clinical parameters when used to treat intraosseous defects. The purpose of the present study was to compare at 12 months postsurgery sites treated with open flap debridement (OFD) alone to those treated with OF...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2001.72.1.25
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Gingival recession (GR) defects can be treated by various methods, including acellular dermal matrix (ADM) or coronally advanced flaps (CAFs). The aim of this histomorphometric experiment is to compare the efficacy of ADM and CAF for treating GR defects in dogs. METHODS:In eight beagle dogs, a critical-size...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120380
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Lingual plate perforation at the time of implant placement in posterior mandible is a potential surgical complication, and presence of a lingual concavity is considered a risk factor. Little is known about the spatial relationship between implant and lingual plate. The role of lingual concavity in the risk o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100313
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:There is evidence of reduced antioxidant (AO) defense in periodontitis and pregnancy and adverse interactions between periodontitis and pregnancy. METHODS:In this study, serum and gingival crevicular fluid (GCF) total AO capacity (TAOC) and superoxide dismutase (SOD) enzyme concentrations in pregnant patien...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080218
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:This study explored which factors affected patients' decisions to pursue either surgical or non-surgical periodontal treatment. METHODS:Data were collected from 74 patients at a regularly scheduled periodontal appointment, at which each patient was told that periodontal treatment was needed, and 2 weeks fol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050206
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Periopathogens and cariogenic species survive more than 48 hours on toothbrushes even under dry storage. This study examined a decontamination of toothbrushes by means of the bactericidal effect of different toothpastes or a special coating of the tufts. METHODS:Eight untreated periodontitis patients were p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.3.312
更新日期:2003-03-01 00:00:00
abstract::This study was a first stage evaluation of the plaque inhibitory properties of an experimental cetylpyridinium chloride (CPC)/essential oil mouthrinse. The study was a formulation, not ingredient, evaluation and comparisons were made with established mouthrinse products. The 5 rinses tested were: the experimental form...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1994.65.10.904
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Through the use of optimal surveillance measures and standard case definitions, it is now possible to more accurately determine population-average risk profiles for severe (SP) and non-severe periodontitis (NSP) in adults (aged 30 years and older) in the United States. METHODS:Data from the 2009 to 2012 Nat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160013
更新日期:2016-10-01 00:00:00
abstract::This report describes the case of a 21-year-old female who presented with localized gingival ulceration that over a period of 4 weeks became generalized, affecting all the buccal gingiva as well as the lower lip. A detailed medical history suggested that the patient was generating the lesions herself. She was monitore...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.5.442
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The number of immunocompromised patients is increasing as a consequence of successful organ transplantation. Placing dental implants in these patients has been questioned because of their increased risk for infections. The 10-year follow-up data of a 71-year-old liver transplant recipient with long-term immu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.6.909
更新日期:2004-06-01 00:00:00
abstract::The effects of twice weekly topical applications of hydrogen peroxide on the buccal epithelium of Syrian hamsters were studied. Animals were treated either with hydrogen peroxide alone, with hydrogen peroxide and the carcinogen 9, 10-dimethyl-1,2-benzanthracene (DMBA), or with DMBA alone. In animals treated with 30% H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.11.685
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Mounting evidence supports a connection between periodontal disease and coronary heart disease, ischemic stroke, and diabetes. This theoretically grounded study examines the knowledge, attitudes, and screening and referral behaviors of primary care nurse practitioners (NPs) in relation to the periodontal dis...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100259
更新日期:2010-12-01 00:00:00