The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

Abstract:

:A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximately twice the recommended daily allowances. Results indicate that although the group receiving ascorbate supplementation demonstrated a significant increase in plasma levels of the vitamin as compared to a placebo group, no significant differences with respect to PMN chemotaxis or responses to experimental gingivitis were found between the groups.

journal_name

J Periodontol

authors

Vogel RI,Lamster IB,Wechsler SA,Macedo B,Hartley LJ,Macedo JA

doi

10.1902/jop.1986.57.8.472

subject

Has Abstract

pub_date

1986-08-01 00:00:00

pages

472-9

issue

8

eissn

0022-3492

issn

1943-3670

journal_volume

57

pub_type

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