The role of obesity as a modifying factor in patients undergoing non-surgical periodontal therapy.

Abstract:

BACKGROUND:Earlier studies have shown an association between obesity and periodontitis, which is mediated by cytokine production. The aim of this study is to assess the role of obesity as a modifying factor on periodontal clinical parameters and on circulating proinflammatory cytokine levels in subjects undergoing non-surgical periodontal treatment. METHODS:Twenty-seven obese subjects and 25 normal-weight subjects were enrolled in this study. Subjects in both groups had generalized chronic periodontitis. The periodontal parameters measured before and 3 months after non-surgical periodontal therapy were: visible plaque index, bleeding gingival index, bleeding on probing, probing depth, and clinical attachment level. In addition, subjects underwent anthropometric measurements and serum analyses of fasting glucose, glycated hemoglobin, interleukin-1β, interleukin-6, tumor necrosis factor-α, and interferon-γ. RESULTS:Periodontal therapy significantly decreased visible plaque index, bleeding gingival index, bleeding on probing, probing depth of 4 to 6 mm, probing depth ≥7 mm, clinical attachment level of 4 to 6 mm, and clinical attachment level ≥7 mm in both groups (P ≤0.05). Circulating proinflammatory cytokines significantly decreased in obese and normal-weight subjects after periodontal treatment (P ≤0.05). However, interleukin-6 and tumor necrosis factor-α levels remained higher in obese subjects 3 months after treatment (P ≤0.05). CONCLUSION:Obesity does not seem to play a negative role by interfering in the improvement of the periodontal clinical response or decreasing circulating proinflammatory cytokine levels after periodontal treatment.

journal_name

J Periodontol

authors

Zuza EP,Barroso EM,Carrareto AL,Pires JR,Carlos IZ,Theodoro LH,Toledo BE

doi

10.1902/jop.2010.100545

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

676-82

issue

5

eissn

0022-3492

issn

1943-3670

journal_volume

82

pub_type

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