Effect of selected beta-blockers on supragingival calculus formation.

Abstract:

:Supragingival plaque and calculus indices, salivary flow rates, pH, ionic and total calcium concentrations, total phosphate concentration, and the number of cervical restorations and caries lesions were measured in 29 subjects using systemic beta-(beta) blockers and in 28 subjects who were not taking any systemic medication. After 8 weeks of normal oral hygiene following an oral prophylaxis, a second comparison of each of the above quantities was made. With the exception of the calculus indices and the incidence of cervical restorations, no significant differences were found for any of the measured quantities between the medicated and non-medicated groups at either examination. The medicated group showed significantly lower mean calculus values than the non-medicated group at both examinations and a higher incidence of cervical restorations at the baseline examination, suggesting that beta-blockers decrease the rate of mineralization in the oral cavity. Since beta-blockers did not appear to alter stimulated salivary pH, flow rate, phosphate, ionic calcium or total calcium concentrations, their effect on the mineralization processes must be attributed to other mechanisms. Two hypotheses appear plausible: changes in salivary mineralization rates caused by either direct physico-chemical effects of the secreted beta-blockers in the saliva, or by alterations in the salivary protein/glycoprotein composition, enzymes and oral bacterial flora owing to systemic pharmacological effects of beta-blockers.

journal_name

J Periodontol

authors

Breuer MM,Mboya SA,Moroi H,Turesky SS

doi

10.1902/jop.1996.67.4.428

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

428-32

issue

4

eissn

0022-3492

issn

1943-3670

journal_volume

67

pub_type

临床试验,杂志文章
  • The relationship of transforming growth factor-beta1 gene polymorphism, its plasma level, and gingival overgrowth in renal transplant recipients receiving different immunosuppressive regimens.

    abstract:BACKGROUND:Cyclosporin A (CsA) induces gingival overgrowth (GO) in patients who seem to be prone to this disorder. It is still impossible to determine which patients will develop GO. Patients treated with the new immunosuppressive drug tacrolimus seem not to have GO. The aims of this study were to investigate transform...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050086

    authors: Radwan-Oczko M,Boratyńska M,Zietek M,Zołedziewska M,Jonkisz A

    更新日期:2006-05-01 00:00:00

  • Comparative study of ultrasonic instrumentation for the non-surgical treatment of interproximal and non-interproximal furcation involvements.

    abstract:BACKGROUND:The aim of this clinical trial was to compare the outcome of non-surgical treatment of interproximal and non-interproximal Class II furcation involvements. METHODS:Thirty-eight patients presenting at least one Class II furcation involvement that bled on probing with a probing depth (PD) > or = 5 mm were rec...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2007.060312

    authors: Del Peloso Ribeiro E,Bittencourt S,Nociti FH Jr,Sallum EA,Sallum AW,Casati MZ

    更新日期:2007-02-01 00:00:00

  • The rotation flap for covering denuded root surfaces - a closed wound technique.

    abstract::A rotation flap for covering denuded single root surfaces with attached gingiva has been described and illustrated. This was performed utilizing a closed wound technique. The single flap provided attached gingiva coverage for a moderate area while a double flap provided coverage for a larger area. Although more attach...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1977.48.1.41

    authors: Patur B

    更新日期:1977-01-01 00:00:00

  • Tetracycline: levels of achievable in gingival crevice fluid and in vitro effect on subgingival organisms. Part II. Susceptibilities of periodontal bacteria.

    abstract::The sensitivity to tetracycline of 345 bacterial isolates from periodontal lesions was determined. Most species of bacteria, including those thought to be involved in the initiation and progress of destructive periodontal disease, were inhibited in vitro by tetracycline concentrations of 4 to 8 micrograms/ml. This con...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1981.52.10.613

    authors: Walker CB,Gordon JM,McQuilkin SJ,Niebloom TA,Socransky SS

    更新日期:1981-10-01 00:00:00

  • Effects of endogenous and exogenous prostaglandin E2 on the proliferation and differentiation of a mouse cementoblast cell line (OCCM-30).

    abstract:BACKGROUND:Cementum formation is considered to be a critical event for successful regeneration of periodontal tissues. Cementoblasts share many characteristics with osteoblasts. Prostaglandin E(2) (PGE(2)) is an important local factor in bone metabolism. Although the effects of PGE(2) on osteoblasts are well known, its...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.060148

    authors: Mada Y,Miyauchi M,Oka H,Kitagawa M,Sakamoto K,Iizuka S,Sato S,Noguchi K,Somerman MJ,Takata T

    更新日期:2006-12-01 00:00:00

  • Risk indicators for future clinical attachment loss in adult periodontitis. Tooth and site variables.

    abstract::In an earlier report, we examined the relationship of patient-derived clinical and epidemiological variables to the risk for future clinical attachment loss (CAL) in chronic adult periodontitis. We determined that the extent of the patient's existing periodontal disease as measured by mean attachment loss (MAL) and th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1992.63.4.262

    authors: Grbic JT,Lamster IB

    更新日期:1992-04-01 00:00:00

  • Treatment of localized gingival recessions using gingival unit grafts: a randomized controlled clinical trial.

    abstract:BACKGROUND:One of the success factors in periodontal plastic surgery is the synergistic relationship between involved tissues and vascular supply. Gingiva as a functional unit is unique with a specific vascular configuration and contains the supracrestal portion naturally created to survive over avascular root surfaces...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2012.110685

    authors: Kuru B,Yıldırım S

    更新日期:2013-01-01 00:00:00

  • Morphotypes of the subgingival microflora in diabetic adolescents in Finland.

    abstract::The morphotypes of the subgingival microflora from 85 12 to 18-year-old Finnish adolescents with insulin-dependent diabetes mellitus (IDDM) were studied in Gram- and Rhodes-stained smears. A comparison was made with subgingival plaque samples from paired age- and sex-matched healthy controls. Significant differences w...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1989.60.9.526

    authors: Sandholm L,Swanljung O,Rytömaa I,Kaprio EA,Mäenpää J

    更新日期:1989-09-01 00:00:00

  • Aggregatibacter actinomycetemcomitans-induced bone loss and antibody response in three rat strains.

    abstract:BACKGROUND:The aim of this study is to compare the colonization, immunoglobulin (Ig) G response, and alveolar bone loss in Aggregatibacter actinomycetemcomitans (Aa)-inoculated Fawn Hooded Hypertensive (FHH), Dahl Salt-Sensitive (DSS), and Brown Norway (BN) rats. METHODS:Each rat strain was divided into wild-type Aa-i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100250

    authors: Schreiner H,Markowitz K,Miryalkar M,Moore D,Diehl S,Fine DH

    更新日期:2011-01-01 00:00:00

  • High Glucose Concentrations Suppress the Proliferation of Human Periodontal Ligament Stem Cells and Their Differentiation Into Osteoblasts.

    abstract:BACKGROUND:Diabetes mellitus (DM) is a major risk factor for periodontal disease and affects various cellular functions. Periodontal ligament stem cells (PDLSCs) play an important role in periodontal tissue regeneration; however, the effect of hyperglycemia on PDLSCs is unclear. The aim of this study is to investigate ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.150474

    authors: Kato H,Taguchi Y,Tominaga K,Kimura D,Yamawaki I,Noguchi M,Yamauchi N,Tamura I,Tanaka A,Umeda M

    更新日期:2016-04-01 00:00:00

  • Enhancing effects of areca nut extracts on the production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells.

    abstract:BACKGROUND:The habit of chewing areca quid (AQ) has been implicated in oral pathogenesis, including periodontal disease. Little is understood about the roles of AQ in the cytokine secretion by immune cells. The study examined the effects of areca nut, the major ingredient of AQ, on the production of interleukin (IL)-6 ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.060039

    authors: Chang LY,Wan HC,Lai YL,Liu TY,Hung SL

    更新日期:2006-12-01 00:00:00

  • Laterally moved, coronally advanced flap: a modified surgical approach for isolated recession-type defects.

    abstract:BACKGROUND:Various modifications of the laterally sliding flap have been proposed to reduce the risk of gingival recession at the donor tooth site, but the reported root coverage predictability was quite low. The goal of the present study was to evaluate the effectiveness with respect to root coverage of a modified sur...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2004.75.12.1734

    authors: Zucchelli G,Cesari C,Amore C,Montebugnoli L,De Sanctis M

    更新日期:2004-12-01 00:00:00

  • Validation of antibiotic efficacy on in vitro subgingival biofilms.

    abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.130167

    authors: Belibasakis GN,Thurnheer T

    更新日期:2014-02-01 00:00:00

  • Association of periodontitis with rheumatoid arthritis: a pilot study.

    abstract:BACKGROUND:Similarities exist in the epidemiology and immunopathogenesis of periodontitis and rheumatoid arthritis (RA), but the associations between their respective disease activities and severities are less well documented. We evaluated the prevalence and severity of periodontitis in United States (U.S.) veterans wi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究

    doi:10.1902/jop.2009.090309

    authors: Dissick A,Redman RS,Jones M,Rangan BV,Reimold A,Griffiths GR,Mikuls TR,Amdur RL,Richards JS,Kerr GS

    更新日期:2010-02-01 00:00:00

  • Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women.

    abstract:BACKGROUND:We recently demonstrated that a 2-year subantimicrobial-dose doxycycline (SDD) regimen (double-masked, placebo-controlled clinical trial) in postmenopausal (PM) women exhibiting mild systemic bone loss (osteopenia) and local bone loss (periodontitis) reduced the progression of periodontal attachment loss (in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2008.070623

    authors: Golub LM,Lee HM,Stoner JA,Sorsa T,Reinhardt RA,Wolff MS,Ryan ME,Nummikoski PV,Payne JB

    更新日期:2008-08-01 00:00:00

  • Repigmentation of the gingiva following surgical injury.

    abstract::Oral melanin pigmentation is not uncommon in some races and ethnic groups. Repigmentation of depigmented oral mucosa has been described after chemical, thermal, surgical, pharmacologic or idiopathic factors. Information on the repigmentation of oral tissues after surgical procedures is extremely limited. The communica...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1986.57.1.48

    authors: Perlmutter S,Tal H

    更新日期:1986-01-01 00:00:00

  • A spartate Aminotransferase Activity in Crevicular Fluid From Dental Impiants.

    abstract:BACKGROUND:Aspartate aminotransferase (AST) is an enzyme normally confined to the cytoplasm of cells, but released to the exracellular environment upon cell death. Its levels are associated with the severity of experimental gingivitis and the loss of periodontal attachement. The aim of the present study was to investig...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.7.1151

    authors: Paolantonio M,Di Placido G,Tumini V,Di Stilio M,Contento A,Spoto G

    更新日期:2000-07-01 00:00:00

  • Smoker's melanosis. A case report.

    abstract::Smoker's melanosis is a benign pigmentation of the oral mucosa, predominantly observed on the attached anterior mandibular gingiva and interdental papillae. These macular lesions are independent of genetic factors, therapeutic medication usage, and various systemic disorders. As a group they are often seen after the t...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1991.62.8.524

    authors: Brown FH,Houston GD

    更新日期:1991-08-01 00:00:00

  • The healing of gingival wounds in miniature swine.

    abstract::Standard wounds of simple incision and partial excision of the dentogingival junction were made in miniature swine. The healing from the 1st to the 14th day were described clinically and histologically, and the standardization of the wounds permitted quantitative and statistical analysis. In wounds that are closely ad...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1980.51.6.318

    authors: Wirthlin MR,Yeager JE,Hancock EB,Gaugler RW

    更新日期:1980-06-01 00:00:00

  • The association between palatal grooves in upper incisors and periodontal complications.

    abstract::Palatal groove is a rare morphological defect of upper incisors, frequently associated with localized destruction of periodontal tissue with endodontic complications. In this study, a sample of 1,081 male, young adult subjects, aged 20 to 22, palatal grooving was recorded in 11 (1.01%) subjects, affecting 15 incisors....

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1990.61.3.197

    authors: Bacić M,Karakas Z,Kaić Z,Sutalo J

    更新日期:1990-03-01 00:00:00

  • Human lymphoproliferative reaction to food products. Possible role in periodontal inflammation.

    abstract::Extracts of corn and some nuts were found to ubiquitously stimulate both adult and newborn cord blood lymphocytes to transform and produce a factor chemotactic for monocytes. This indicates that corn and nuts contain a mitogen and are potential stimulators of the cellular immune response. The exposure of lymphocytes t...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1975.46.9.562

    authors: Radentz WH,Baker J,Altman LC,Oppenheim JJ

    更新日期:1975-09-01 00:00:00

  • A Major Human Oral Lysophosphatidic Acid Species, LPA 18:1, Regulates Novel Genes in Human Gingival Fibroblasts.

    abstract:BACKGROUND:The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both normal physiology and inflammation in many systems. However, its actions are just beginning to be defined in oral biology and pathophysiology. METHODS:Microarray analysis was used to test the hypothesis that human gingival fi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.140592

    authors: Cerutis DR,Weston MD,Alnouti Y,Bathena SP,Nunn ME,Ogunleye AO,McVaney TP,Headen KV,Miyamoto T

    更新日期:2015-05-01 00:00:00

  • Prevalence, location, and patency of accessory canals in the furcation region of permanent molars.

    abstract::One hundred and two extracted permanent molars were debrided in 3% H2O2, sealed at the apex, and placed in a vacuum chamber. Safranin dye was introduced into the teeth that were placed in a vacuum of 525 mm of Hg. Observations were made of the external root surface to determine any staining due to patent accessory can...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.1.21

    authors: Gutmann JL

    更新日期:1978-01-01 00:00:00

  • Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis.

    abstract:BACKGROUND:The analysis of samplings from periodontal pockets is important in the diagnosis and therapy of periodontitis. In this study, three different sampling techniques were compared to determine whether one method yielded samples suitable for the reproducible and simultaneous determination of bacterial load, cytok...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2011.100565

    authors: Guentsch A,Kramesberger M,Sroka A,Pfister W,Potempa J,Eick S

    更新日期:2011-07-01 00:00:00

  • The prevention of localized ridge deformities using guided tissue regeneration.

    abstract::Healing of extraction sockets where the buccal plate of bone has been destroyed often results in localized ridge deformities. This is most likely due to the ingrowth of extraskeletal connective tissue into the space originally occupied by the tooth which then fills with a combination of bone and soft tissue. Technique...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1994.65.1.17

    authors: O'Brien TP,Hinrichs JE,Schaffer EM

    更新日期:1994-01-01 00:00:00

  • Aggregatibacter actinomycetemcomitans-Induced AIM2 Inflammasome Activation Is Suppressed by Xylitol in Differentiated THP-1 Macrophages.

    abstract:BACKGROUND:Aggressive periodontitis is characterized by rapid destruction of periodontal tissue caused by Aggregatibacter actinomycetemcomitans. Interleukin (IL)-1β is a proinflammatory cytokine, and its production is tightly regulated by inflammasome activation. Xylitol, an anticaries agent, is anti-inflammatory, but ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.150477

    authors: Kim S,Park MH,Song YR,Na HS,Chung J

    更新日期:2016-06-01 00:00:00

  • Genetic dependence of the specific T-cell cytokine response to Porphyromonas gingivalis in mice.

    abstract:BACKGROUND:Susceptibility to periodontal infections may, in part, be genetically determined. Porphyromonas gingivalis is a major periodontopathogen, and the immune response to this organism requires T-cell help. The aim of the present study was to examine the specific T-cell cytokine responses to P. gingivalis outer me...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2002.73.6.591

    authors: Gemmell E,Carter CL,Bird PS,Seymour GJ

    更新日期:2002-06-01 00:00:00

  • Dose-dependent effects of platelet gel releasate on activities of human osteoblasts.

    abstract:BACKGROUND:Platelet-rich plasma is used in oral and maxillofacial surgery; however, its real efficacy is debated. Also, the in vitro effects on bone-specific functions are contradictory. Understanding the mechanisms of action of platelet-derived factors could be the basis for their proper use in clinical applications. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.070116

    authors: Uggeri J,Belletti S,Guizzardi S,Poli T,Cantarelli S,Scandroglio R,Gatti R

    更新日期:2007-10-01 00:00:00

  • Alveolar bone loss in patients with long-term supportive care.

    abstract::Radiographic record audits were conducted on 63 patients diagnosed as having periodontitis who had been treated and maintained for 10 years or longer in dental school clinics. Acceptable bite-wing radiographs were available for 50 of these patients. Bite-wing radiographs taken 8 to 34 years apart (mean 14.9 years) wer...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1990.61.7.434

    authors: Layport CA,Greco GW,McFall WT Jr

    更新日期:1990-07-01 00:00:00

  • Oral food consumption and subgingival microorganisms: subgingival microbiota of gastrostomy tube-fed children and healthy controls.

    abstract::This study examined the effect of oral food consumption on the prevalence and levels of subgingival bacteria and yeasts in 20 gastrostomy tube-fed children and 24 healthy controls. Microbial identification was carried out using anaerobic culture and 16S rRNA-based PCR identification methods. Streptococcal and Actinomy...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1997.68.12.1163

    authors: Chen C,Ashimoto A,Sangsurasak S,Flynn MJ,Slots J

    更新日期:1997-12-01 00:00:00