Abstract:
:Supragingival plaque and calculus indices, salivary flow rates, pH, ionic and total calcium concentrations, total phosphate concentration, and the number of cervical restorations and caries lesions were measured in 29 subjects using systemic beta-(beta) blockers and in 28 subjects who were not taking any systemic medication. After 8 weeks of normal oral hygiene following an oral prophylaxis, a second comparison of each of the above quantities was made. With the exception of the calculus indices and the incidence of cervical restorations, no significant differences were found for any of the measured quantities between the medicated and non-medicated groups at either examination. The medicated group showed significantly lower mean calculus values than the non-medicated group at both examinations and a higher incidence of cervical restorations at the baseline examination, suggesting that beta-blockers decrease the rate of mineralization in the oral cavity. Since beta-blockers did not appear to alter stimulated salivary pH, flow rate, phosphate, ionic calcium or total calcium concentrations, their effect on the mineralization processes must be attributed to other mechanisms. Two hypotheses appear plausible: changes in salivary mineralization rates caused by either direct physico-chemical effects of the secreted beta-blockers in the saliva, or by alterations in the salivary protein/glycoprotein composition, enzymes and oral bacterial flora owing to systemic pharmacological effects of beta-blockers.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Breuer MM,Mboya SA,Moroi H,Turesky SSdoi
10.1902/jop.1996.67.4.428subject
Has Abstractpub_date
1996-04-01 00:00:00pages
428-32issue
4eissn
0022-3492issn
1943-3670journal_volume
67pub_type
临床试验,杂志文章abstract:BACKGROUND:Cyclosporin A (CsA) induces gingival overgrowth (GO) in patients who seem to be prone to this disorder. It is still impossible to determine which patients will develop GO. Patients treated with the new immunosuppressive drug tacrolimus seem not to have GO. The aims of this study were to investigate transform...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050086
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:The aim of this clinical trial was to compare the outcome of non-surgical treatment of interproximal and non-interproximal Class II furcation involvements. METHODS:Thirty-eight patients presenting at least one Class II furcation involvement that bled on probing with a probing depth (PD) > or = 5 mm were rec...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2007.060312
更新日期:2007-02-01 00:00:00
abstract::A rotation flap for covering denuded single root surfaces with attached gingiva has been described and illustrated. This was performed utilizing a closed wound technique. The single flap provided attached gingiva coverage for a moderate area while a double flap provided coverage for a larger area. Although more attach...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.1.41
更新日期:1977-01-01 00:00:00
abstract::The sensitivity to tetracycline of 345 bacterial isolates from periodontal lesions was determined. Most species of bacteria, including those thought to be involved in the initiation and progress of destructive periodontal disease, were inhibited in vitro by tetracycline concentrations of 4 to 8 micrograms/ml. This con...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.10.613
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Cementum formation is considered to be a critical event for successful regeneration of periodontal tissues. Cementoblasts share many characteristics with osteoblasts. Prostaglandin E(2) (PGE(2)) is an important local factor in bone metabolism. Although the effects of PGE(2) on osteoblasts are well known, its...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060148
更新日期:2006-12-01 00:00:00
abstract::In an earlier report, we examined the relationship of patient-derived clinical and epidemiological variables to the risk for future clinical attachment loss (CAL) in chronic adult periodontitis. We determined that the extent of the patient's existing periodontal disease as measured by mean attachment loss (MAL) and th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.4.262
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:One of the success factors in periodontal plastic surgery is the synergistic relationship between involved tissues and vascular supply. Gingiva as a functional unit is unique with a specific vascular configuration and contains the supracrestal portion naturally created to survive over avascular root surfaces...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.110685
更新日期:2013-01-01 00:00:00
abstract::The morphotypes of the subgingival microflora from 85 12 to 18-year-old Finnish adolescents with insulin-dependent diabetes mellitus (IDDM) were studied in Gram- and Rhodes-stained smears. A comparison was made with subgingival plaque samples from paired age- and sex-matched healthy controls. Significant differences w...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.9.526
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:The aim of this study is to compare the colonization, immunoglobulin (Ig) G response, and alveolar bone loss in Aggregatibacter actinomycetemcomitans (Aa)-inoculated Fawn Hooded Hypertensive (FHH), Dahl Salt-Sensitive (DSS), and Brown Norway (BN) rats. METHODS:Each rat strain was divided into wild-type Aa-i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100250
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is a major risk factor for periodontal disease and affects various cellular functions. Periodontal ligament stem cells (PDLSCs) play an important role in periodontal tissue regeneration; however, the effect of hyperglycemia on PDLSCs is unclear. The aim of this study is to investigate ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.150474
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The habit of chewing areca quid (AQ) has been implicated in oral pathogenesis, including periodontal disease. Little is understood about the roles of AQ in the cytokine secretion by immune cells. The study examined the effects of areca nut, the major ingredient of AQ, on the production of interleukin (IL)-6 ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060039
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Various modifications of the laterally sliding flap have been proposed to reduce the risk of gingival recession at the donor tooth site, but the reported root coverage predictability was quite low. The goal of the present study was to evaluate the effectiveness with respect to root coverage of a modified sur...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.12.1734
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130167
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Similarities exist in the epidemiology and immunopathogenesis of periodontitis and rheumatoid arthritis (RA), but the associations between their respective disease activities and severities are less well documented. We evaluated the prevalence and severity of periodontitis in United States (U.S.) veterans wi...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究
doi:10.1902/jop.2009.090309
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:We recently demonstrated that a 2-year subantimicrobial-dose doxycycline (SDD) regimen (double-masked, placebo-controlled clinical trial) in postmenopausal (PM) women exhibiting mild systemic bone loss (osteopenia) and local bone loss (periodontitis) reduced the progression of periodontal attachment loss (in...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2008.070623
更新日期:2008-08-01 00:00:00
abstract::Oral melanin pigmentation is not uncommon in some races and ethnic groups. Repigmentation of depigmented oral mucosa has been described after chemical, thermal, surgical, pharmacologic or idiopathic factors. Information on the repigmentation of oral tissues after surgical procedures is extremely limited. The communica...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.1.48
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Aspartate aminotransferase (AST) is an enzyme normally confined to the cytoplasm of cells, but released to the exracellular environment upon cell death. Its levels are associated with the severity of experimental gingivitis and the loss of periodontal attachement. The aim of the present study was to investig...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.7.1151
更新日期:2000-07-01 00:00:00
abstract::Smoker's melanosis is a benign pigmentation of the oral mucosa, predominantly observed on the attached anterior mandibular gingiva and interdental papillae. These macular lesions are independent of genetic factors, therapeutic medication usage, and various systemic disorders. As a group they are often seen after the t...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1991.62.8.524
更新日期:1991-08-01 00:00:00
abstract::Standard wounds of simple incision and partial excision of the dentogingival junction were made in miniature swine. The healing from the 1st to the 14th day were described clinically and histologically, and the standardization of the wounds permitted quantitative and statistical analysis. In wounds that are closely ad...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.6.318
更新日期:1980-06-01 00:00:00
abstract::Palatal groove is a rare morphological defect of upper incisors, frequently associated with localized destruction of periodontal tissue with endodontic complications. In this study, a sample of 1,081 male, young adult subjects, aged 20 to 22, palatal grooving was recorded in 11 (1.01%) subjects, affecting 15 incisors....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.3.197
更新日期:1990-03-01 00:00:00
abstract::Extracts of corn and some nuts were found to ubiquitously stimulate both adult and newborn cord blood lymphocytes to transform and produce a factor chemotactic for monocytes. This indicates that corn and nuts contain a mitogen and are potential stimulators of the cellular immune response. The exposure of lymphocytes t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.9.562
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both normal physiology and inflammation in many systems. However, its actions are just beginning to be defined in oral biology and pathophysiology. METHODS:Microarray analysis was used to test the hypothesis that human gingival fi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.140592
更新日期:2015-05-01 00:00:00
abstract::One hundred and two extracted permanent molars were debrided in 3% H2O2, sealed at the apex, and placed in a vacuum chamber. Safranin dye was introduced into the teeth that were placed in a vacuum of 525 mm of Hg. Observations were made of the external root surface to determine any staining due to patent accessory can...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.1.21
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:The analysis of samplings from periodontal pockets is important in the diagnosis and therapy of periodontitis. In this study, three different sampling techniques were compared to determine whether one method yielded samples suitable for the reproducible and simultaneous determination of bacterial load, cytok...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2011.100565
更新日期:2011-07-01 00:00:00
abstract::Healing of extraction sockets where the buccal plate of bone has been destroyed often results in localized ridge deformities. This is most likely due to the ingrowth of extraskeletal connective tissue into the space originally occupied by the tooth which then fills with a combination of bone and soft tissue. Technique...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.1.17
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Aggressive periodontitis is characterized by rapid destruction of periodontal tissue caused by Aggregatibacter actinomycetemcomitans. Interleukin (IL)-1β is a proinflammatory cytokine, and its production is tightly regulated by inflammasome activation. Xylitol, an anticaries agent, is anti-inflammatory, but ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.150477
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Susceptibility to periodontal infections may, in part, be genetically determined. Porphyromonas gingivalis is a major periodontopathogen, and the immune response to this organism requires T-cell help. The aim of the present study was to examine the specific T-cell cytokine responses to P. gingivalis outer me...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.6.591
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is used in oral and maxillofacial surgery; however, its real efficacy is debated. Also, the in vitro effects on bone-specific functions are contradictory. Understanding the mechanisms of action of platelet-derived factors could be the basis for their proper use in clinical applications. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070116
更新日期:2007-10-01 00:00:00
abstract::Radiographic record audits were conducted on 63 patients diagnosed as having periodontitis who had been treated and maintained for 10 years or longer in dental school clinics. Acceptable bite-wing radiographs were available for 50 of these patients. Bite-wing radiographs taken 8 to 34 years apart (mean 14.9 years) wer...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.7.434
更新日期:1990-07-01 00:00:00
abstract::This study examined the effect of oral food consumption on the prevalence and levels of subgingival bacteria and yeasts in 20 gastrostomy tube-fed children and 24 healthy controls. Microbial identification was carried out using anaerobic culture and 16S rRNA-based PCR identification methods. Streptococcal and Actinomy...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.12.1163
更新日期:1997-12-01 00:00:00