Abstract:
BACKGROUND:Susceptibility to periodontal infections may, in part, be genetically determined. Porphyromonas gingivalis is a major periodontopathogen, and the immune response to this organism requires T-cell help. The aim of the present study was to examine the specific T-cell cytokine responses to P. gingivalis outer membrane antigens in a mouse model and their relationship with H-2 haplotype. METHODS:BALB/c and DBA/2J (H-2d), CBACaH (H-2k), and C57BL6 (H-2b) mice were immunized with P. gingivalis outer membrane antigens weekly for 3 weeks. One week after the final injection, the spleens were removed, and 6 T-cell lines specific for P. gingivalis were established for each mouse strain. The percentage of CD4 and CD8 cells in the P. gingivalis-specific T-cell lines staining positive for intracytoplasmic interleukin (IL)-4, interferon (IFN)-gamma, and IL-10 was determined by 2-color flow cytometry. RESULTS:The cytokine profiles of T-cell lines from BALB/c and DBA/2J mice showed no significant differences. Significantly fewer IL-4+, IFN-gamma+, and IL-10+ CD4 cells than IL-4+, IFN-gamma+, and IL-10+ CD8 cells, respectively, were demonstrated for both strains. P. gingivalis-specific T-cell lines generated from CBACaH mice were similar to those generated from BALB/c and DBA/2J mice; however, the mean percentage of IL-4+ CD4 cells in CBACaH mice was lower than the percentage of IFN-gamma+ CD4 cells. Also, the mean percentage of IFN-gamma+ CD4 cells in CBACaH mice was significantly increased compared to DBA/2J mice. Unlike the other 3 strains, T-cell lines established from C57BL6 mice contained similar percentages of cytokine-positive cells, although the percentage of IL-4+ CD4 cells was reduced in comparison to the percentage of CD8 cells. However, comparisons with the other 3 strains demonstrated a higher percentage of IL-4+ CD4 cells than in lines established from the spleens of DBA/2J mice, IFN-gamma+ CD4 cells than in lines established from BALB/c and CBACaH mice, and IL-10+ CD4 cells than in lines established from all 3 other strains. No significant differences in the percentage of positive CD8 cells were demonstrated between lines in the 4 strains of mice. CONCLUSION:The specific T-cell response to P. gingivalis in mice may, in the case of the CD4 response, depend on MHC genes. These findings are consistent with the concept that patient susceptibility is important to the outcome of periodontal infection and may, in part, be genetically determined.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Gemmell E,Carter CL,Bird PS,Seymour GJdoi
10.1902/jop.2002.73.6.591subject
Has Abstractpub_date
2002-06-01 00:00:00pages
591-6issue
6eissn
0022-3492issn
1943-3670journal_volume
73pub_type
杂志文章abstract::THE MAXILLARY anterior region presents a difficult and unique therapeutic challenge to both the periodontist and restorative dentist. Although access for surgical and prosthetic procedures is certainly easiest in this part of the mouth, the problem of esthetics, in terms of increased tooth length and loss of interdent...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.4.208
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND:Patients with Kostmann syndrome (severe congenital neutropenia [SCN]) typically normalize their absolute neutrophil count (ANC) upon granulocyte colony-stimulating factor (G-CSF) therapy. However, although they no longer experience life-threatening bacterial infections, they frequently still have recurrent g...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050191
更新日期:2006-04-01 00:00:00
abstract::The literature related to smoking and periodontal disease is reviewed. The effects of smoking on oral hygiene, gingivitis, necrotizing gingivitis, periodontitis, bacteria and the host's response are presented. From this review it is apparent that while the relationship between smoking and periodontal disease needs fur...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1986.57.10.617
更新日期:1986-10-01 00:00:00
abstract::A review of the experimental evidence evidence on marrow inhibition by implanted roots has shown that an inhibitory factor is present in all root surfaces. It is most marked in periodontally diseased roots and least in periodontally healthy roots. It is hypothesized that a "marked" amount would inhibit periodontal cel...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.1.49
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Successful periodontal treatment requires a commitment to regular lifelong maintenance and may be perceived by patients to be costly. This study calculates the total lifetime cost of periodontal treatment in the setting of a specialist periodontal practice and investigates the cost implications of choosing n...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110689
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Procedures to improve peri-implant soft-tissue outcomes of single, immediately placed implants are a topic of interest. This systematic review investigates the effect of various surgical and restorative interventions on implant mid-buccal mucosal level. METHODS:An electronic search of five databases (Januar...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2013.130064
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. To the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known micr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160273
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Various surgical techniques have been proposed for treating gingival recession. This randomized clinical trial compared the coronally positioned flap (CPF) alone or in conjunction with a subepithelial connective tissue graft (SCTG) in the treatment of gingival recession. METHODS:Eleven non-smoking subjects ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2004.75.3.413
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Periodontitis and osteoporosis are characterized by the loss of bone mass. Osteocalcin levels have been postulated as a marker of inhibition of bone formation. The aim of the present study was to assess plasma, saliva, and gingival crevicular fluid (GCF) levels of osteocalcin and correlate them with periodon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.4.513
更新日期:2005-04-01 00:00:00
abstract::A study was done in an attempt to develop a simple test for the severity of periodontal disease. Gingival fluid collected on filter paper was tested for protein content, and the resulting color was compared to standard color filters. Tissue was excised and prepared for histologic examination. The inflammatory cell inf...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.8.391
更新日期:1978-08-01 00:00:00
abstract::This cross-sectional study examined the gingivitis occurring at puberty in a population of insulin-dependent juvenile diabetics. Seventy-seven children between the ages of 6 and 15 years were examined for gingivitis levels, stages of pubertal maturation and blood levels of glucose and glycosylated hemoglobin. Bacteria...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.12.714
更新日期:1983-12-01 00:00:00
abstract::The purpose of this investigation was to determine the prevalence of the palato-gingival groove in maxillary incisor teeth and the health status of the lingual periodontal tissues adjacent to maxillary incisor teeth with and without the grooves. A total of 531 individuals aged 17 to 35 years were examined for the pres...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.1.41
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Previous studies have focused on antibiotic resistance of Gram-negative bacteria before and after periodontal therapy. The purpose of this analysis is to assess changes in resistance patterns of the commensal Gram-positive microbiota. The viridans group streptococci (VGS) have been suggested to serve as rese...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2015.150494
更新日期:2016-05-01 00:00:00
abstract::A review of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Disease) is presented. Special emphasis is placed on the oral manifestations which include hemorrhagic vesicles, nodules, papules and ulcers that involve the gingiva and other areas of the mucosa. Two cases are included which were seen in a periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.163
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Cementum formation is considered to be a critical event for successful regeneration of periodontal tissues. Cementoblasts share many characteristics with osteoblasts. Prostaglandin E(2) (PGE(2)) is an important local factor in bone metabolism. Although the effects of PGE(2) on osteoblasts are well known, its...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060148
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:The crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the correlation and accuracy of ultrasound in measuring periodontal dimensions, compared to ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0342
更新日期:2020-07-01 00:00:00
abstract::This report is an example of tumor metastasis to the temporomandibular joint and its effect on pain, restriction of jaw movement, and the subsequent inability of the patient to function normally. Neoplasm is not the usual etiology of myofascial pain dysfunctionsyndrome and the muscle sparm component of this patient's ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.5.309
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Coronally advanced flap (CAF) has been shown to effectively treat gingival recession. Platelet-rich plasma (PRP), containing autologous growth factors, has been shown to promote soft tissue healing. Therefore, the purpose of this study was to evaluate the effects of PRP in combination with CAF. METHODS:Twen...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2005.76.10.1768
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:There is a large amount of data on surgical root coverage procedures for the treatment of gingival recessions but no controlled clinical trials on the behavior of marginal gingiva following non-surgical therapy. The aim of our study was to compare in terms of root coverage two different modalities of root su...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.2.256
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II Type 1 (AT1) receptor axis. It is known that periodontal pathogens elici...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160354
更新日期:2017-01-01 00:00:00
abstract::Few scientific investigations have addressed the ability of mouthrinses to reduce oral malodor for periods longer than 3 hours. In the present report, we have employed simple, recently described techniques to assess the day-long reduction in oral malodor of a novel 2-phase oil:water mouthrinse (TPM), as compared to a ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1992.63.1.39
更新日期:1992-01-01 00:00:00
abstract::This is a posthumous interview with Dr. Maynard K. Hine (MKH), the second editor of the Journal of Periodontology (from 1950 to 1970), as prepared by Dr. David C. Vandersall (DCV). Dr. Vandersall was a colleague of Dr. Hine while serving as associate clinical professor of periodontics at the Indiana University School ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.6.781
更新日期:2004-06-01 00:00:00
abstract::The aim of this investigation was to induce alveolar bone defects experimentally in dogs and to study the effects of mechanical tooth cleaning on their subsequent development. Thirty premolars from four beagle dogs were used. Bone defects were created by surgically exposing the adjacent alveolar bone and applying stee...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.3.135
更新日期:1978-03-01 00:00:00
abstract::Mycoplasma have been identified in one case of juvenile periodontitis by size, morphology, hemadsorption and cultural techniques. These microorganisms were found on the surface of the tooth, on the surface of pocket epithelium and invading the gingival epithelium and adjacent connective tissue. These observations sugg...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.10.574
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:The pathogenesis of epithelial thickening in gingival overgrowth remains obscure. Apoptosis plays an important role in maintaining tissue hemostasis. The aim of the present study was to investigate apoptosis via immunohistochemical analyses in cyclosporin A-induced gingival overgrowth tissue samples to deter...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070226
更新日期:2007-12-01 00:00:00
abstract::In an earlier report, we examined the relationship of patient-derived clinical and epidemiological variables to the risk for future clinical attachment loss (CAL) in chronic adult periodontitis. We determined that the extent of the patient's existing periodontal disease as measured by mean attachment loss (MAL) and th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.4.262
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a worldwide health problem with increasing prevalence and poor outcomes, including severe cardiovascular disease and renal osteodystrophy. With advances in medical treatment, patients with CKD are living longer and require oral care. The aim of this study is to determine the e...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090379
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Today, implants are placed using both non-submerged and submerged approaches, and in 1- and 2-piece configurations. Previous work has demonstrated that peri-implant crestal bone reactions differ radiographically under such conditions and are dependent on a rough/smooth implant border in 1-piece implants and ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.9.1412
更新日期:2000-09-01 00:00:00
abstract::A study was undertaken to evaluate the antigenic potential of allogeneic freeze-dried skin (FDS) when used as a grafting material and to examine the clinical results when FDS is used for the correction of mucogingival problems in humans. FDS was obtained from an HLA-tissue-type donor according to Navy Tissue Bank prot...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.10.571
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:Epidemiologic and randomized controlled studies have shown that periodontal diseases may be associated with preterm labor and delivery of infants with low birth weights. The purpose of the present study was to determine the presence of microbial invasion of the amniotic cavity by periodontopathic bacteria in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060368
更新日期:2007-07-01 00:00:00