Abstract:
BACKGROUND:Chronic kidney disease (CKD) is a worldwide health problem with increasing prevalence and poor outcomes, including severe cardiovascular disease and renal osteodystrophy. With advances in medical treatment, patients with CKD are living longer and require oral care. The aim of this study is to determine the effects of CKD and dietary phosphate on mandibular bone structure using a uremic mouse model. METHODS:Uremia (U) was induced in female dilute brown agouti/2 mice by partial renal ablation. Uremic mice received a normal-phosphate (NP) or a high-phosphate (HP) diet. sham surgeries were performed in a control group of mice; half received an NP diet, and the other half was fed an HP diet. At termination, animals were sacrificed, and mandibles were collected for microcomputed tomography (micro-CT) and histologic analysis. RESULTS:Sera levels of blood urea nitrogen, parathyroid hormone, and alkaline phosphatase were significantly increased in U/NP and U/HP mice versus sham controls, whereas serum calcium was increased in the U/HP group, and no differences were noted in serum phosphate levels among groups. Micro-CT analyses revealed a significant reduction in cortical bone thickness and an increase in trabecular thickness and trabecular bone volume/tissue volume in U/NP and U/HP groups compared to the sham/NP group. A significant reduction in cortical bone thickness was also found in the sham/HP group versus the sham/NP group. Histologic evaluation confirmed increased trabeculation in the U groups. CONCLUSION:CKD in mice, especially under conditions of HP feeding, results in marked effects on alveolar bone homeostasis.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Lee MM,Chu EY,El-Abbadi MM,Foster BL,Tompkins KA,Giachelli CM,Somerman MJdoi
10.1902/jop.2009.090379subject
Has Abstractpub_date
2010-02-01 00:00:00pages
300-9issue
2eissn
0022-3492issn
1943-3670journal_volume
81pub_type
杂志文章abstract:BACKGROUND:This research explored how patients with surgical versus non-surgical periodontal treatment differ in trait anxiety, depression, perceived stress, and well-being on the day of surgery and in their reported pain and use of pain medication 2 and 4 weeks after treatment. In addition, it was investigated how psy...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050302
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Placement of endosseous dental implants in edentulous areas of the anterior maxilla poses a unique challenge due to variations in the amount of residual alveolar bone. Implant position becomes crucial in cases demanding high esthetic results but possessing minimal ridge width or in cases requiring augmentati...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.10.1202
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:The aim of this study is to make a longitudinal evaluation of the incidence and severity of gingival overgrowth (GO) induced by immunosuppressive agents, such as tacrolimus (Tcr) and cyclosporin A (CsA), in the absence of calcium channel blockers in patients undergoing renal transplantation (RT). METHODS:Th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100368
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Chronic periodontitis (CP) exhibits inflammation and alveolar bone loss, and severe forms of periodontitis are suggested to have a genetic basis. Vitamin D receptor (VDR) regulates bone metabolism and inflammation-related genes, and single nucleotide polymorphisms (SNPs) in the VDR gene may affect the functi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080465
更新日期:2009-04-01 00:00:00
abstract::To date, there are no ultrastructural studies that have examined untreated chronic periodontal pockets immediately following dental debridement with an oral irrigation device. This study used both scanning electron microscopic and transmission electron microscopic methodology to examine previously untreated human peri...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.3.155
更新日期:1988-03-01 00:00:00
abstract::This study tested the hypothesis that severe periodontitis in persons with non-insulin-dependent diabetes mellitus (NIDDM) increases the risk of poor glycemic control. Data from the longitudinal study of residents of the Gila River Indian Community were analyzed for dentate subjects aged 18 to 67, comprising all those...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.10s.1085
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Little attention has been given to understanding the variation in biomechanical behavior of oral soft tissues, and this represents an obstacle for the development of biomaterials that perform with appropriate biomechanical characteristics. With this as our motivation, a uniaxial mechanical analysis was perfo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100573
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140077
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The specific advantage of administering systemic antibiotics during initial, non-surgical therapy or in the context of periodontal surgery is unclear. This study assesses the differential outcomes of periodontal therapy supplemented with amoxicillin-metronidazole during either the non-surgical or the surgica...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2014.140478
更新日期:2015-03-01 00:00:00
abstract::Fourteen intrabony periodontal defects and six furcation defects (Class II) were treated by a flap procedure which included the use of a polytetrafluoroethylene membrane to allow guided tissue regeneration. After 4 to 6 weeks of healing, the membranes were retrieved and examined by scanning electron microscopy for the...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.8.515
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Contradictory results exist regarding influence of apico-coronal implant placement on crestal bone levels. METHODS:Complete charts of patients ≥18 years old with one or more dental implants were included. Demographic, medical, surgical, and prosthetic information was recorded. Implant bone levels were evalu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160802
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Gingival melanin depigmentation procedures are commonly associated with recurrence of pigmentation, which starts with migration of melanocytes from the adjacent free gingiva. The extent and rate of recurrence varies according to the treatment modalities used and duration of follow-up. The aim of this study i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120094
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The aim of this split-mouth study is to compare long-term (18 to 35 years) periodontal conditions of sites treated with gingival augmentation procedures (GAPs) and untreated homologous contralateral sites. METHODS:Forty-seven patients with 64 sites (test group), with lack of attached gingiva associated with...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160284
更新日期:2016-12-01 00:00:00
abstract::The clinical, histopathologic and functional consequences of the genetic deficiency of leukocyte Mac-1, LFA-1 and p150,95 were assessed among three affected patients, heterozygotes and unaffected individuals among two generations of a single kindred. Longitudinal assessments of this family afforded the unique opportun...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.6.400
更新日期:1987-06-01 00:00:00
abstract::Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that bacterial pneumonia will assume increasing importance in the coming ye...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1996.67.10s.1114
更新日期:1996-10-01 00:00:00
abstract::Probing pain threshold (PPT) assessments were conducted in the facial and oral sulci of maxillary central incisors and first molars of 10 periodontally healthy adults. All subjects were systemically healthy, free of pain, and reported no current medication usage. A computer-linked electronic probe, modified to deliver...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.7.812
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the effects of adjunctive meloxicam on the matrix metalloproteinase-8 (MMP-8) levels of gingival crevicular fluid (GCF) in chronic periodontitis patients following the initial phase of periodontal therapy. METHODS:Twelve chronic periodontitis patients received ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.1.103
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Most dental implants are positioned using a drilling surgery technique. However, dentistry recently experienced the implementation of piezoelectric surgery. This technique was introduced to overcome some of the limitations involving rotating instruments in bone surgery. This study used biomolecular and histo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060285
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Subantimicrobial-dose doxycycline (SDD) is widely used as an adjunctive treatment to scaling and root planing (SRP), but its long-term effectiveness remains controversial. The purpose of this systematic review was to assess the actual evidence of the effectiveness of SRP + SDD compared to SRP + placebo in th...
journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析,评审
doi:10.1902/jop.2011.110026
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Generalized aggressive periodontitis is described as a clinical entity affecting both deciduous and permanent dentition with extensive alveolar bone loss, mobility, and exfoliation of all or many teeth. Controversy exists on dental implant use to restore missing dentition in younger patients. METHODS:This c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.3.411
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Bleeding indices are used as a screen for periodontal disease activity, a measure of disease prevalence, and a measure of effectiveness in clinical trials. Bleeding on probing (BOP) is widely interpreted as a sign of disease activity whereas its absence is interpreted as both a sign and predictor of health. ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2004.75.5.679
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Several studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to investigate the association between the circulating proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, prostaglandin E(2), serotonin, rheumatoid ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070599
更新日期:2008-09-01 00:00:00
abstract::The interpretation of dental radiographs for the diagnosis of periodontal disease conditions poses several difficulties. These include the inability to adequately reproduce the projection geometry and optical density of the exposures. In order to improve the ability to extract accurate quantitative information from a ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.7.435
更新日期:1983-07-01 00:00:00
abstract::This study was conducted to determine the possible influence of diabetes on the pathogenesis of periodontal disease. A total of 148 patients, 120 females and 28 males, were surveyed. Their ages ranged between 9 and 50 years, with an average age of 30. The experimental group consisted of 83 diabetics and there was a co...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.9.445
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Various modifications of the laterally sliding flap have been proposed to reduce the risk of gingival recession at the donor tooth site, but the reported root coverage predictability was quite low. The goal of the present study was to evaluate the effectiveness with respect to root coverage of a modified sur...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.12.1734
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Through the use of optimal surveillance measures and standard case definitions, it is now possible to more accurately determine population-average risk profiles for severe (SP) and non-severe periodontitis (NSP) in adults (aged 30 years and older) in the United States. METHODS:Data from the 2009 to 2012 Nat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160013
更新日期:2016-10-01 00:00:00
abstract::Three wall intrabony defects were produced in 11 dogs using a round bur followed by curettes and hoes. A copper band was fixed to the tooth with stainless steel ligature wire. Six weeks later, the copper band was removed and the defect was treated with an enriched collagen solution (ECS) prepared from acid-extracted d...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.11.623
更新日期:1984-11-01 00:00:00
abstract::Strict control of dental plaque accumulation remains the cornerstone of successful maintenance of the treated patient. However, some recurrences of periodontitis appear to take place despite good oral hygiene habits. A proportion of these are likely due to qualitative features of the periodontal microbiota rather than...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1988.59.7.439
更新日期:1988-07-01 00:00:00
abstract::The aim of the present study was to clinically and radiographically compare guided tissue regeneration (GTR) therapy with bioabsorbable polyglactin 910 barriers and conventional periodontal surgery in intrabony defects. In 26 patients with advanced periodontitis, 29 teeth exhibiting interproximal intrabony defects wer...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1998.69.11.1210
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:A 5-year-old Japanese boy presented with persistent gingival inflammation and severe mobility of the right lower primary incisors. Due to severe alveolar bone loss and a deep periodontal pocket (5 mm), the incisors were extracted at the second visit. METHODS:Clinical, radiographic, histological, and microbi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.7.1060
更新日期:2003-07-01 00:00:00