Abstract:
BACKGROUND:Several studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to investigate the association between the circulating proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, prostaglandin E(2), serotonin, rheumatoid factor, and periodontitis in patients with rheumatoid arthritis. METHODS:Nineteen patients, 17 women and two men, with rheumatoid arthritis were included. These patients had been examined repeatedly (average of three times) with regard to inflammatory markers and mediators from blood samples. Their teeth, excluding third molars, were examined with regard to number, clinical attachment level (CAL), probing depth (PD), and gingival bleeding on probing (BOP). Assessment of furcation involvement and increased tooth mobility was also made. All patients were non-smokers. Thirty healthy individuals, 20 women and 10 men, were included as a reference regarding TNF-alpha. RESULTS:Patients with high levels of time-averaged TNF-alpha from repeated plasma samples had a higher frequency of BOP as well as increased CAL and PD compared to those with low levels. CONCLUSION:Gingivitis and periodontitis are related to high levels of circulating TNF-alpha in patients with rheumatoid arthritis.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Nilsson M,Kopp Sdoi
10.1902/jop.2008.070599subject
Has Abstractpub_date
2008-09-01 00:00:00pages
1689-96issue
9eissn
0022-3492issn
1943-3670journal_volume
79pub_type
杂志文章abstract:BACKGROUND:Some studies have advocated marrow penetration in guided bone augmentation (GBA), whereas others have shown that bone can be generated without marrow penetration. This study examined the effect of marrow penetration and the optimal rate of penetration. METHODS:In 10 rabbits, the calvarium was exposed, and c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070086
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:This study explored which factors affected patients' decisions to pursue either surgical or non-surgical periodontal treatment. METHODS:Data were collected from 74 patients at a regularly scheduled periodontal appointment, at which each patient was told that periodontal treatment was needed, and 2 weeks fol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050206
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Osseointegrated dental implants are currently recognized as a standard treatment method in dentistry. Titanium (Ti) and its alloys are the metals of choice for endosseous parts of currently available dental implants. Ti-6Al-4V is the most used Ti alloy, however; an improved version, Ti-6Al-7Nb, has been rece...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.8.900
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Periodontitis patients harboring Actinobacillus actinmycetemcomitans (Aa) are prime candidates for systemic antibiotic therapy. Besides tetracycline and the combination of metronidazole and amoxicillin the fluoroquinolones are also believed to have antibacterial activity against Aa. The aim of the present st...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2000.71.2.202
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Increasing age is associated with systemic diseases as well as with periodontal diseases. We wondered whether a biological age score constructed exclusively from systemic biomarkers would reflect periodontal risk factors at baseline and tooth loss as well as periodontal outcome during 10 years follow-up. ME...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0591
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:A 5-year-old Japanese boy presented with persistent gingival inflammation and severe mobility of the right lower primary incisors. Due to severe alveolar bone loss and a deep periodontal pocket (5 mm), the incisors were extracted at the second visit. METHODS:Clinical, radiographic, histological, and microbi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.7.1060
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Enhanced neutrophil responses play a critical role in the activation of the innate immune system and causation of aggressive periodontitis (AgP). The hypothesis that comprehensive periodontal treatment expedites resolution of amplified leukocyte activity and facilitates the reconstitution of periodontal heal...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.9.995
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:In chronic periodontitis (CP), the gene polymorphism of interleukin-6 (IL-6) to 174C/G has been associated with the altered production of this cytokine. The aim of this pilot study is to compare the allelic and genotypic frequencies in patients with CP with control individuals without periodontitis (NP) and ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120230
更新日期:2013-05-01 00:00:00
abstract::Dipeptidyl peptidase (DPP) II and IV activities were demonstrated in unfixed cryostat sections of gingival tissue from chronic periodontitis patients using histochemistry with 2-methoxy-4-naphthylamine (MNA) substrates. In the case of DPP IV, enzyme localization was confirmed by immunocytochemistry with mouse monoclon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.9.846
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Autologous bone can be harvested from the flutes of a conventional drill or from a bone scraper; here we compared whether autologous bone chips generated by a new slow-speed instrument were more osteogenic than the bone chips generated by conventional drills or bone scrapers. Additionally, we tested whether ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0524
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL) and osteoprotegerin (OPG) are critical for homeostatic control of osteoclast activity, suggesting their vital roles in the progression of bone loss in periodontitis. In this study, the expression of RANKL and OPG mRNA and the relationshi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060398
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Multiple factors that influence the precision of periodontal probing measurements have been identified. These factors can be categorized as being dependent upon host-related, probe-related, or examiner-related variables. However, the potential influence of examiner handedness (right or left) on the measureme...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050185
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:An immunohistochemical study was conducted to compare distributions of mast cell subpopulations in normal human gingiva and in gingival overgrowth induced by nifedipine and immunosuppressive medication. METHODS:Gingival samples were collected from 12 triple-medicated organ transplant recipients (immunosuppr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.7.933
更新日期:2004-07-01 00:00:00
abstract::Increasingly, patients referred to periodontists have undergone some form of non-surgical periodontal treatment prior to their referral. As a result of this, there is an increased need to treat isolated, rather than generalized, periodontal defects. A surgical technique that utilizes small incisions and a limited acce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1547
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Alanine aminopeptidase (ALAP) and dipeptidyl peptidase IV (DPPIV) are ectopeptidases that play a role in collagen degradation and are thought to be involved in the destruction of periodontal tissue. This study compared the activities of salivary ALAP and DPPIV in patients with periodontitis and periodontally...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090233
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Recent research indicated that periodontal infection may worsen systemic diseases, including pulmonary disease. Respiratory infections, such as pneumonia and the exacerbation of chronic obstructive pulmonary disease, involve the aspiration of bacteria from the oropharynx into the lower respiratory tract. ME...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100582
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Neopterin, a marker of cellular immune activation, is produced by human macrophages after induction by interferon gamma that is secreted by T lymphocytes. Neopterin concentrations in diverse body fluids have been reported to increase in parallel with bacteria in the clinical course of infections. Therefore, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.7.720
更新日期:2002-07-01 00:00:00
abstract::Twelve gingival samples removed from 6 human volunteers were sectioned in small pieces, parts of which served as uncultured pieces. The remaining pieces were organ cultured for 5 hours in control, compound 48/80, and antihuman IgE media. Uncultured tissues, cultured tissues, and cultured spent media were analyzed spec...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.3.171
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal i...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2016.160015
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Behçet's disease is a multisystem disorder of unknown etiology, affecting predominantly the oral mucosa, skin, and eyes. Recurrent and painful episodes of oral ulcerations interfere with regular oral hygiene leading to rapid bacterial plaque accumulation. The aims of this study were to evaluate the periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1449
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been found to promote the osteoblastic differentiation of human periodontal ligament cells. Its effect depends on the delivery system used. In this study we examined the effect of rhBMP-2 on the proliferation and osteoblastic differentiation of hum...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.7.982
更新日期:2003-07-01 00:00:00
abstract::Plasma cells are widely distributed in inflamed periodontal tissues, the adjacent periodontal ligament and nearby alveolar bone spaces, of old rats (20 and 27 months) raised on a conventional diet in a normal laboratory environment. Electron microscopy revealed three morphologic types (or perhaps stages) of these cell...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.4.227
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is used in oral and maxillofacial surgery; however, its real efficacy is debated. Also, the in vitro effects on bone-specific functions are contradictory. Understanding the mechanisms of action of platelet-derived factors could be the basis for their proper use in clinical applications. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070116
更新日期:2007-10-01 00:00:00
abstract::The present paper describes 36 consecutively treated non-human primates (Macaca mulatta) as part of a balanced block design study to examine osseointegration in root- and plate-form implants prepared by atraumatic preparation of bone. Clinical measurements around selected teeth and digital radiology were utilized to m...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.12.1322
更新日期:1996-12-01 00:00:00
abstract::A new flap design for placement of implants into osseous defects has been described. The flap design can be used in anterior and posterior areas of human subjects. Photographs of representative cases are presented. Wound healing always occurred by primary intention and without evidence of immediate graft exfoliation. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.4.204
更新日期:1985-04-01 00:00:00
abstract::The capacity of collagen membranes to support guided regeneration of periodontal tissues in the dog was assessed. The mesiolabial, labial and distolabial aspects of the mesial root of the second and third mandibular premolar were surgically exposed in three beagle dogs. Collagen membranes, 0.5 to 0.7 mm thick, prepare...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.6.380
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia (previously T. forsythensis), which are regarded as the principal periodontopathogenic bacteria, exist as a consortium in subgingival biofilms. We aimed to examine quantitative relationships between P. gingivalis, T. denticola, and T. fo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070398
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Periodontitis is a multifactorial and infectious disease that may result in significant debilitation. The aim of this study is to exploit two optical coherence tomography (OCT) systems operating in the Fourier domain at different wavelengths, 930 and 1,325 nm, for structural analysis of periodontal tissue in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.150047
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Lysine, a nutritionally essential amino acid, enters the oral cavity in gingival crevicular fluid (GCF). During oral hygiene restriction (OHR), lysine decarboxylase (LDC) in dento-gingival biofilms converts lysine to cadaverine. Lysine depletion impairs the dental epithelial barrier to bacterial proinflammat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.140490
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Only a few studies have examined the association between periodontitis and glycated hemoglobin (HbA1c) levels in individuals without diabetes. The aim of this study is to compare HbA1c levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130661
更新日期:2014-12-01 00:00:00