Abstract:
BACKGROUND:Subantimicrobial-dose doxycycline (SDD) is widely used as an adjunctive treatment to scaling and root planing (SRP), but its long-term effectiveness remains controversial. The purpose of this systematic review was to assess the actual evidence of the effectiveness of SRP + SDD compared to SRP + placebo in the treatment of chronic periodontitis. METHODS:A literature search of electronic databases was performed for articles published through November 1, 2010. Several dental journals were screened during the manual search, and authors were contacted for missing information. The systematic review and meta-analysis were conducted according to the Quality of Reporting of Meta-Analyses statement and recommendations of the Cochrane Collaboration. The methodologic quality of the studies was determined via a Consolidated Standards of Reporting Trials-based assessment. Clinical attachment levels, probing depths, plaque and gingival indices, and gingival crevicular fluid levels were compared between baseline and the end of follow-up. Data were extracted and pooled using a random-effect model. The weighted mean difference was reported with the 95% confidence interval. Heterogeneity was assessed using the χ(2)-based Q-statistic method and I(2) measurement. P <0.05 was considered statistically significant. RESULTS:After applying inclusion and exclusion criteria, three randomized placebo-controlled clinical trials were entered into the meta-analysis. These studies had similar treatment designs, SDD dosage regimens (20 mg twice daily for 3 months), and post-treatment follow-up lengths (9 months). Significant differences were observed for all investigated clinical parameters in favor of the SRP + SDD group. CONCLUSION:The meta-analysis results seemed to support the long-term effectiveness of adjunctive SDD therapy; however, future studies are needed to confirm these findings.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Sgolastra F,Petrucci A,Gatto R,Giannoni M,Monaco Adoi
10.1902/jop.2011.110026subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1570-81issue
11eissn
0022-3492issn
1943-3670journal_volume
82pub_type
杂志文章,meta分析,评审abstract::One hundred and two extracted permanent molars were debrided in 3% H2O2, sealed at the apex, and placed in a vacuum chamber. Safranin dye was introduced into the teeth that were placed in a vacuum of 525 mm of Hg. Observations were made of the external root surface to determine any staining due to patent accessory can...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.1.21
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:A 43-year-old African American male initially presented for a dental evaluation of a recurrent swelling on the buccal aspect of tooth #12. His medical history was unremarkable except for a 20-pack year history of smoking. He was eventually diagnosed as having a necrotic pulp #12, and received root canal trea...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090418
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Evidence is accumulating to support poor oral health as a risk factor for systemic conditions, including cardiovascular diseases, diabetes control, adverse pregnancy outcomes, and pneumonia. Prohibitive costs for clinical assessment of periodontal disease limit information to assess the prevalence and trends...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060481
更新日期:2007-07-01 00:00:00
abstract::Healing of extraction sockets where the buccal plate of bone has been destroyed often results in localized ridge deformities. This is most likely due to the ingrowth of extraskeletal connective tissue into the space originally occupied by the tooth which then fills with a combination of bone and soft tissue. Technique...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.1.17
更新日期:1994-01-01 00:00:00
abstract::The purpose of this investigation was to evaluate calcium hydroxide and potassium nitrate individually as densensitizing agents for hypersensitive root surfaces. The apparatus used in the experiment to measure hypersensitivity was (a) a thermo-electric stimulating device to measure hot and cold stimulation quantitativ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.10.667
更新日期:1977-10-01 00:00:00
abstract::Based on the findings observed after the insertion of 33 blade implants in 23 patients, ages 31 to 74, for periods up to 60 months, the following conclusions can be made: (1) The blade implant is a technically feasible procedure which can be maintained in the mouth for period up to 5 years, although some degree of bon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.1.19
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:There is a large amount of data on surgical root coverage procedures for the treatment of gingival recessions but no controlled clinical trials on the behavior of marginal gingiva following non-surgical therapy. The aim of our study was to compare in terms of root coverage two different modalities of root su...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.2.256
更新日期:2005-02-01 00:00:00
abstract::Periodontal data typically have a hierarchical structure, with sites grouped within individuals, and individuals grouped within communities. Also, the occasion may be regarded as another level since the acquired knowledge indicates that periodontal disease activity may vary over time. Conventional statistical tests ar...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.8.690
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Some reports suggest that the prevalence and severity of gingival overgrowth (GO) is lower in patients taking tacrolimus (Tcr) than in those taking cyclosporin A (CsA). The present study was conducted to determine the prevalence and severity of GO in a group of renal transplant recipients treated with Tcr in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050327
更新日期:2006-06-01 00:00:00
abstract::Standard wounds of simple incision and partial excision of the dentogingival junction were made in miniature swine. The healing from the 1st to the 14th day were described clinically and histologically, and the standardization of the wounds permitted quantitative and statistical analysis. In wounds that are closely ad...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.6.318
更新日期:1980-06-01 00:00:00
abstract::Thirty-four areas of gingival recession in ten patients were treated by a coronally repositioned flap procedure. All but four of these areas had received a free gingiva graft previously. The postoperative evaluations of the wound healing were made at 2 weeks and at 1, 2, 4, 6 and 12 months after the final surgery. In ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.12.686
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:The Nd:YAG laser has recently been used in the treatment of periodontal disease. However, although a clinical reduction of probing depth and gingival inflammation to this new approach has been reported, it has not been fully evaluated. Interleukin-1 beta (IL- 1beta), a potent stimulator of bone resorption, h...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1999.70.11.1276
更新日期:1999-11-01 00:00:00
abstract::Throughout the 20th century, an understanding of the role of causative bacteria and the susceptible host in the initiation and progression of periodontal disease(s) has emerged from the research efforts of scientists and clinicians worldwide. Over time, specific bacterial types, such as Porphyromonas gingivalis, were ...
journal_title:Journal of periodontology
pub_type: 历史文章,杂志文章
doi:10.1902/jop.2008.080182
更新日期:2008-08-01 00:00:00
abstract::Examiner diagnostic accuracy and response times were compared using subtraction and conventional radiography in a dog model. Osseous lesions were induced interproximally and through the mandibular buccal bone interradicularly and radicularly. Standardized preoperative and postoperative conventional radiographs of the ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.6.324
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:This review addresses the ability of a commercially available genetic susceptibility test to determine the risk of developing severe chronic periodontitis. The test is used to detect the simultaneous occurrence of allele 2 at the IL-1A+4845 and IL-1B+3954 loci. If both of these polymorphisms are present, pat...
journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析
doi:10.1902/jop.2002.73.2.231
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:The effect of supragingival plaque control on clinical signs of periodontitis is controversial, particularly when smoking habits are considered. This study evaluated the clinical effects of supragingival plaque control on clinical signs of periodontitis in smokers and never-smokers. METHODS:The following da...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2007.060462
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:An experimental periodontal sensor probe (SP) equipped with an optical fiber for recording function was developed. The aim was to test the intraexaminer reproducibility of probing using the SP and to assess the consistency with the manual probe (MP). METHODS:The SP was assembled with an external sheath cove...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2011.110047
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Procedures to improve peri-implant soft-tissue outcomes of single, immediately placed implants are a topic of interest. This systematic review investigates the effect of various surgical and restorative interventions on implant mid-buccal mucosal level. METHODS:An electronic search of five databases (Januar...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2013.130064
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:It has been established previously that infrared spectroscopy (IRS) can be used to identify periodontitis-specific molecular signatures in gingival crevicular fluid (GCF) and to confirm clinical diagnoses. This follow-up study is designed to assess whether this novel technique is also able to differentiate d...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.120665
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the correlation and accuracy of ultrasound in measuring periodontal dimensions, compared to ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0342
更新日期:2020-07-01 00:00:00
abstract::The greatest challenge in treatment planning is to assign an accurate prognosis and develop a predictable protocol. In the era of evidence-based dentistry, outcome studies have forced us to reexamine our treatment approaches and decide if superior treatment options should be pursued. As endosseous dental implants gain...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070551
更新日期:2008-06-01 00:00:00
abstract::Focal dermal hypoplasia syndrome (FDH) is a congenital disorder of mesodermal derivation with some ectodermal participation. The disorder, first described in 1962, is characterized by tenacious defects consisting of thinning of the skin; herniations of adipose tissue; abnormal skin pigmentation and other skeletal, den...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.6.330
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Compliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0721
更新日期:2020-12-17 00:00:00
abstract:BACKGROUND:There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM:To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary disease (COPD), pneum...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.1340020
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Non-surgical periodontal treatment with an Er:YAG laser has been shown to result in significant clinical attachment level gain; however, clinical results have not been established on a long-term basis following Er:YAG laser treatment. Therefore, the aim of the present study was to present the 2-year results ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2003.74.5.590
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:There is evidence of reduced antioxidant (AO) defense in periodontitis and pregnancy and adverse interactions between periodontitis and pregnancy. METHODS:In this study, serum and gingival crevicular fluid (GCF) total AO capacity (TAOC) and superoxide dismutase (SOD) enzyme concentrations in pregnant patien...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080218
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Periodontitis is a multifactorial and infectious disease that may result in significant debilitation. The aim of this study is to exploit two optical coherence tomography (OCT) systems operating in the Fourier domain at different wavelengths, 930 and 1,325 nm, for structural analysis of periodontal tissue in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.150047
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Chemically modified non-antimicrobial tetracyclines (CMTs) have been shown to inhibit pathologically elevated collagenase (and other matrix metalloproteinase, MMP) activity and bone resorption in vivo and in vitro. METHODS:In the current study, suboptimal doses of CMT-8 (a non-antimicrobial chemically modif...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.8.1069
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Recently, brain-derived neurotrophic factor (BDNF)/high molecular weight hyaluronic acid (HMW-HA) complex with flap surgery has been shown to promote periodontal tissue regeneration. The objective of this study was to evaluate the effects of local subgingival application of BDNF/HMW-HA complex adjunctive to ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0070
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II Type 1 (AT1) receptor axis. It is known that periodontal pathogens elici...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160354
更新日期:2017-01-01 00:00:00