Abstract:
BACKGROUND:The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II Type 1 (AT1) receptor axis. It is known that periodontal pathogens elicit host-derived immune response due to release of cytokines such as interleukin (IL)-1β, and fibroblasts are among the most numerous sentinel cells that contribute to this production. The aim of this study is to determine whether AT1 receptor (AT1R) contributes to production of inflammatory cytokines that are important for periodontal pathogenesis using primary human gingival fibroblasts (HGFs) and human periodontal ligament fibroblasts (HPLFs) stimulated with IL-1β. METHODS:Through RNA interference or pharmacologic inhibition using AT1R antagonist losartan, HGF and HPLF were stimulated by IL-1β for 3 (messenger RNA [mRNA]) or 24 (protein) hours. RESULTS:IL-1β upregulated mRNA expression of AT1R, IL-1β, IL-6, IL-8, tumor necrosis factor-alpha, and osteoprotegerin (OPG) in HGF and HPLF. AT1R knockdown impaired IL-1β-induced IL-6 and IL-8 secretion in cultured HGF and HPLF. AT1R silencing also increased OPG gene expression in HGF only. Pharmacologic inhibition of AT1R through losartan modulated mRNA transcription of IL-6 and IL-8 in HPLF but not in HGF. In contrast, IL-1β-induced secretion of IL-6 and IL-8 was not influenced by losartan in HGF or HPLF. CONCLUSION:These results suggest that AT1R knockdown and AT1R pharmacologic blockade by losartan may differently control balance of inflammatory cytokines, such as IL-6 and IL-8, in primary human periodontal fibroblasts.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Gabriele LG,Morandini AC,Dionísio TJ,Santos CFdoi
10.1902/jop.2016.160354subject
Has Abstractpub_date
2017-01-01 00:00:00pages
e1-e11issue
1eissn
0022-3492issn
1943-3670journal_volume
88pub_type
杂志文章abstract:BACKGROUND:Gingival augmentation procedures around natural teeth and dental implants are performed to facilitate plaque control, to improve patient comfort, to prevent future recession, and in conjunction with restorative, orthodontic, or prosthetic dentistry. The aim of this study is to answer the most common question...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2015.130684
更新日期:2015-02-01 00:00:00
abstract::Focal dermal hypoplasia syndrome (FDH) is a congenital disorder of mesodermal derivation with some ectodermal participation. The disorder, first described in 1962, is characterized by tenacious defects consisting of thinning of the skin; herniations of adipose tissue; abnormal skin pigmentation and other skeletal, den...
journal_title:Journal of periodontology
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doi:10.1902/jop.1989.60.6.330
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Sodium alendronate (ALN) is an aminobisphosphonate and potent inhibitor of bone resorption. It has been suggested that ALN might be a promising carrier of biomolecules for periodontal bone repair. The aim of this randomized split-mouth clinical trial was to evaluate the effects of the topical application of ...
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doi:10.1002/JPER.19-0160
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Peri-implantitis treatments are mainly based on protocols for teeth but have not shown favorable outcomes for implants. The potential role of titanium dissolution products in peri-implantitis necessitate the consideration of material properties in devising treatment protocols. We assessed implant cleaning in...
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pub_type: 杂志文章
doi:10.1002/JPER.20-0186
更新日期:2020-08-26 00:00:00
abstract::Mycoplasma have been identified in one case of juvenile periodontitis by size, morphology, hemadsorption and cultural techniques. These microorganisms were found on the surface of the tooth, on the surface of pocket epithelium and invading the gingival epithelium and adjacent connective tissue. These observations sugg...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.10.574
更新日期:1984-10-01 00:00:00
abstract::Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the focus of intensive research endeavors over the past 2 decades. Over the years, however, numerous reports have inaccurately reported relative centrifugal force (RCF) values, which has caused considerable confusion in the field. Furthermo...
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pub_type: 社论
doi:10.1002/JPER.18-0553
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:The aim of this study is to compare the colonization, immunoglobulin (Ig) G response, and alveolar bone loss in Aggregatibacter actinomycetemcomitans (Aa)-inoculated Fawn Hooded Hypertensive (FHH), Dahl Salt-Sensitive (DSS), and Brown Norway (BN) rats. METHODS:Each rat strain was divided into wild-type Aa-i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100250
更新日期:2011-01-01 00:00:00
abstract::Interproximal bony defects were treated with either porous hydroxyapatite (PHA) or decalcified freeze-dried bone allograft (DFDB) implants at two different clinical centers. Twelve paired defects in 12 patients were treated at each center. Six months post-surgically the defects were measured to assess changes from the...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1990.61.7.399
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:The aerosol generated by an ultrasonic scaler contains microorganisms that can penetrate into the body through the respiratory system of dental surgeons and patients. The aim of this pilot study is to evaluate and compare the efficacy of commercially available preprocedural mouthrinses containing 0.2% chlorh...
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pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2013.120616
更新日期:2014-04-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090703
更新日期:2010-06-01 00:00:00
abstract::This report describes the case of a 21-year-old female who presented with localized gingival ulceration that over a period of 4 weeks became generalized, affecting all the buccal gingiva as well as the lower lip. A detailed medical history suggested that the patient was generating the lesions herself. She was monitore...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.5.442
更新日期:1994-05-01 00:00:00
abstract::The assessment of new attachment after periodontal treatment has been the focus of continuous research. An approach to longitudinally examine the deposition of cementum was devised by using fluorescence microscopy (FL), contact microradiography (CMR), and toluidine blue staining (TBS) after the injection of three labe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.4.284
更新日期:1991-04-01 00:00:00
abstract::Chlorhexidine mouthrinse is a widely used adjunct in periodontal therapy due to its bactericidal effects. The effect of this agent on chronic gingivitis and wound healing following surgical therapy in animals and humans has been favorable. The re-establishment of lost connective tissue attachment to the root surface f...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.7.434
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Little is known about systemic, environmental, and periodontal risk factors of gingival recessions. This study identifies variables related to buccal gingival recessions in an adult French population; this study uses data collected in the First National Periodontal and Systemic Examination Survey. METHODS:T...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100102
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Crohn's disease is a chronic inflammatory bowel disease characterized by uncertainty in etiology and pathogenesis occasionally with manifestations in oral mucous membranes. This report reviews the literature on Crohn's disease and presents a patient with Crohn's disease on continuous anti-inflammatory and im...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.4.537
更新日期:2003-04-01 00:00:00
abstract::The levels of serum antibody reactive to selected periodontopathogens were determined in 182 clinically characterized patients: 35 healthy control, 50 juvenile periodontitis, 42 adult periodontitis and 55 rapidly progressive periodontitis. Reactive antibody levels were determined using an enzyme-linked immunosorbent a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.8.464
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:It is hypothesized that levels of advanced glycation end products (AGEs) are higher in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with type-2 diabetes mellitus (type-2 DM) than controls (systemically healthy individuals without CP. The aim was to assess the levels of AGEs in t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0209
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Evaluation of clinical long-term results 20 years after connective tissue grafting (CTG) or guided tissue regeneration (GTR) using bioabsorbable barriers for root coverage therapy. METHODS:Initially, 15 patients with 38 Miller Class I and II recession defects underwent CTG or GTR according to random assignm...
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pub_type: 杂志文章
doi:10.1002/JPER.19-0203
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Some studies have reported an association between gestational diabetes mellitus (GDM) and periodontitis. The aim of the present study is to analyze this potential association and the influence of risk variables associated with GDM. METHODS:This case-control study includes 360 women, 90 with GDM and 270 cont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120350
更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2003.74.11.1634
更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2017.170210
更新日期:2017-12-05 00:00:00
abstract::Growth factors and cytokines are currently under investigation as potential therapeutics for the site-specific regeneration of alveolar bone. Many of these factors, including TGF-beta, PDGF, IGF-I, IGF-II, and FGF influence bone growth and resorption, and as such may be useful in the regeneration process. However, the...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
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更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate effects of strontium ranelate (SR) on alveolar bone loss (ABL) in rats with experimental periodontitis. METHODS:Forty Wistar rats were randomly divided into five groups: 1) control (n = 8); 2) ligated (n = 8); 3) 300 mg/kg SR (SR300, n = 8); 4) 625 mg/kg SR (SR625, n ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160227
更新日期:2017-02-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070361
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Low-calorie diets are commonplace for reducing body weight. However, no information is available on the effects of a reduced-calorie diet on periodontal inflammation and disease. The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070629
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:A subcategory of chronic neutropenia is chronic benign neutropenia, which is characterized by a prolonged non-cyclic neutropenia as the sole abnormality, with no underlying disease to which the neutropenia can be attributed. Chronic neutropenia is defined as a low absolute neutrophil count for >6 months. In ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060076
更新日期:2006-11-01 00:00:00
abstract::One hundred mandibles of South African Negroes were examined for the presence of intrabony defects, and the distance between the cemento-enamel junction and alveolar bone crest was measured along the buccal and lingual surface of roots associated with interdental craters. Two-hundred thirty-one intrabony defects were ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.3.149
更新日期:1984-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100189
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The root coverage esthetic score (RES) was published in 2009 as an esthetic scoring system to measure visible final outcomes of root coverage procedures performed on Miller I and II recession defects. The aim of this study was to evaluate the intra-examiner, intra-group, and inter-examiner reliability of the...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.17-0556
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Lingual plate perforation at the time of implant placement in posterior mandible is a potential surgical complication, and presence of a lingual concavity is considered a risk factor. Little is known about the spatial relationship between implant and lingual plate. The role of lingual concavity in the risk o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100313
更新日期:2011-01-01 00:00:00