The potential role of bone morphogenetic proteins in periodontal reconstruction.

Abstract:

:Growth factors and cytokines are currently under investigation as potential therapeutics for the site-specific regeneration of alveolar bone. Many of these factors, including TGF-beta, PDGF, IGF-I, IGF-II, and FGF influence bone growth and resorption, and as such may be useful in the regeneration process. However, these molecules have effects on many other tissue and cell types. In contrast, the bone morphogenetic proteins (BMPs) represent a unique set of differentiation factors that induce new bone formation at the site of implantation instead of changing the growth rate of pre-existing bone. Recombinant human BMP-2 (rhBMP-2), for example, has been shown to induce ectopic bone formation in an in vivo setting. Cell culture studies indicate that rhBMP-2 can cause mesenchymal precursor cells to differentiate into cartilage- and bone-forming cells. Additional animal studies have shown that rhBMP-2 is capable of replacing large (2.5 cm) defects in canine mandibles, healing a variety of long bone defects in orthopedic animal models, and repairing bony defects in animal models of bone lost due to periodontal disease. These results suggest that rhBMP-2 has broad therapeutic potential for dental and cranio/maxillofacial reconstruction.

journal_name

J Periodontol

authors

Wozney JM

doi

10.1902/jop.1995.66.6.506

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

506-10

issue

6

eissn

0022-3492

issn

1943-3670

journal_volume

66

pub_type

杂志文章,评审
  • Apoptosis and expression of caspase-3 in cyclosporin-induced gingival overgrowth.

    abstract:BACKGROUND:The pathogenesis of epithelial thickening in gingival overgrowth remains obscure. Apoptosis plays an important role in maintaining tissue hemostasis. The aim of the present study was to investigate apoptosis via immunohistochemical analyses in cyclosporin A-induced gingival overgrowth tissue samples to deter...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.070226

    authors: Bulut S,Ozdemir BH

    更新日期:2007-12-01 00:00:00

  • Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects.

    abstract:BACKGROUND:Simvastatin has been shown to stimulate new bone growth on rat mandibles, but much of the bone is lost over time. The purpose of this study is to evaluate the impact of a locally or systemically applied antiresorptive agent (alendronate) on simvastatin-induced bone formation in and adjacent to a rat periodon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.110683

    authors: Killeen AC,Rakes PA,Schmid MJ,Zhang Y,Narayana N,Marx DB,Payne JB,Wang D,Reinhardt RA

    更新日期:2012-12-01 00:00:00

  • Tongue-cleaning methods: a comparative clinical trial employing a toothbrush and a tongue scraper.

    abstract:BACKGROUND:It is estimated that approximately 85% of all halitosis cases have their origin within the mouth; of these, 50% are caused by tongue residues. Previous studies have established that hydrogen sulfide and mercaptans are the primary components of halitosis. Thus, tongue cleaning gains importance as a means of h...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2004.75.7.1009

    authors: Pedrazzi V,Sato S,de Mattos Mda G,Lara EH,Panzeri H

    更新日期:2004-07-01 00:00:00

  • The Inhibition of Interferon-γ-Induced Upregulation of HLA-DR Expression on Cultured Human Gingival Fibroblasts by Interleukin-1β or Tumor Necrosis Factor-α.

    abstract::The purpose of this study was to examine the effect of inflammatory cytokines on IFN-γ-induced HLA-DR expression on cultured human gingival fibroblasts by flow cytometry. Natural human IFN-γ, recombinant human interleukin-1β (rhIL-1β), and rh tumor necrosis factor-α (rhTNF-α) were used. IFN-γ-induced upregulation of H...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1994.65.4.336

    authors: Takahashi K,Takigawa M,Ami H,Kurihara H,Murayama Y

    更新日期:1994-04-01 00:00:00

  • A 10-year prospective study of tobacco smoking and periodontal health.

    abstract:BACKGROUND:To date only a few studies have evaluated the long-term influence of smoking and smoking cessation on periodontal health. The present study, therefore, was undertaken with the aim to prospectively investigate the influence of smoking exposure over time on the periodontal health condition in a targeted popula...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.8.1338

    authors: Bergström J,Eliasson S,Dock J

    更新日期:2000-08-01 00:00:00

  • The putative collagen-binding peptide P-15 promotes fibroblast attachment to root shavings but not hydroxyapatite.

    abstract:BACKGROUND:Regenerative periodontal treatment aims to restore the attachment of the periodontal ligament and gingival collagen fibers to both the cementum of the root surface and alveolar bone. Fibroblasts are the predominant cells of the periodontal ligament and gingiva and have important roles in the function and reg...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2003.74.4.458

    authors: Lallier TE,Palaiologou AA,Yukna RA,Layman DL

    更新日期:2003-04-01 00:00:00

  • Level of neopterin, a marker of immune cell activation in gingival crevicular fluid, saliva, and urine in patients with aggressive periodontitis.

    abstract:BACKGROUND:Neopterin, a marker of cellular immune activation, is produced by human macrophages after induction by interferon gamma that is secreted by T lymphocytes. Neopterin concentrations in diverse body fluids have been reported to increase in parallel with bacteria in the clinical course of infections. Therefore, ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2002.73.7.720

    authors: Ozmeriç N,Baydar T,Bodur A,Engin AB,Uraz A,Eren K,Sahin G

    更新日期:2002-07-01 00:00:00

  • Alternative anesthetic technique for maxillary periodontal surgery.

    abstract:BACKGROUND:Maxillary periodontal surgery typically requires multiple injections and may inadvertently affect facial structures such as the upper lip, lateral aspect of the nose, and lower eyelid. To minimize these sequelae and reduce the number of total injections, a relatively new injection technique has been proposed...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.070621

    authors: Holtzclaw D,Toscano N

    更新日期:2008-09-01 00:00:00

  • Periodontal status and subgingival microbiota of insulin-dependent juvenile diabetics: a 3-year longitudinal study.

    abstract::This study examined for 3 years the changes in periodontal status and the possible correlations with selected subgingival microbiota and diabetic conditions in a group of 16 insulin-dependent diabetes mellitus (IDDM, JD) patients as compared with their 16 healthy cohabiting siblings (HS). JD patients were monitored ev...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1998.69.2.120

    authors: Sbordone L,Ramaglia L,Barone A,Ciaglia RN,Iacono VJ

    更新日期:1998-02-01 00:00:00

  • Enhancing effects of areca nut extracts on the production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells.

    abstract:BACKGROUND:The habit of chewing areca quid (AQ) has been implicated in oral pathogenesis, including periodontal disease. Little is understood about the roles of AQ in the cytokine secretion by immune cells. The study examined the effects of areca nut, the major ingredient of AQ, on the production of interleukin (IL)-6 ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.060039

    authors: Chang LY,Wan HC,Lai YL,Liu TY,Hung SL

    更新日期:2006-12-01 00:00:00

  • Position paper: sonic and ultrasonic scalers in periodontics. Research, Science and Therapy Committee of the American Academy of Periodontology.

    abstract::Ultrasonic and sonic scalers appear to attain similar results as hand instruments for removing plaque, calculus, and endotoxin. Ultrasonic scalers used at medium power seem to produce less root surface damage than hand or sonic scalers. Due to instrument width, furcations may be more accessible using ultrasonic or son...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2000.71.11.1792

    authors: Drisko CL,Cochran DL,Blieden T,Bouwsma OJ,Cohen RE,Damoulis P,Fine JB,Greenstein G,Hinrichs J,Somerman MJ,Iacono V,Genco RJ,Research, Science and Therapy Committee of the American Accademy of Periodontology.

    更新日期:2000-11-01 00:00:00

  • Adjunctive effects of laser therapy on somatosensory function and vasomotor regulation of periodontal tissues in patients with periodontitis: A randomized controlled clinical trial.

    abstract:BACKGROUND:The purpose of this prospective study was to compare the changes in periodontal somatosensory function and microcirculation in patients with periodontitis following initial treatment with scaling and root planing (SRP) with or without adjuvant laser therapy. METHODS:Twenty-four patients suffering from perio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/JPER.19-0562

    authors: Gou H,Fan R,Chen X,Li L,Wang X,Xu Y,Svensson P,Wang K

    更新日期:2020-10-01 00:00:00

  • Association between cigarette smoking, bacterial pathogens, and periodontal status.

    abstract::The purposes of this study were to determine if: 1) an association exists between cigarette smoking and signs of periodontal disease after controlling for the confounding variables of age, sex, plaque, and calculus; 2) the prevalence of 5 bacteria commonly associated with periodontal disease differs between smokers an...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1993.64.12.1225

    authors: Stoltenberg JL,Osborn JB,Pihlstrom BL,Herzberg MC,Aeppli DM,Wolff LF,Fischer GE

    更新日期:1993-12-01 00:00:00

  • Oral conditions in individuals with selective immunoglobulin A deficiency and common variable immunodeficiency.

    abstract::Saliva and serum samples were collected from 36 individuals with selective immunoglobulin A deficiency (IgAd) and 23 patients with common variable immunodeficiency (CVI). The oral examination included registration of the teeth, Russell's periodontal index (PI), pocket formation, and salivary flow rate in both unstimul...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1992.63.12.984

    authors: Engström GN,Engström PE,Hammarström L,Smith CI

    更新日期:1992-12-01 00:00:00

  • Periodontal soft tissue non-root coverage procedures: a systematic review from the AAP Regeneration Workshop.

    abstract:BACKGROUND:Gingival augmentation procedures around natural teeth and dental implants are performed to facilitate plaque control, to improve patient comfort, to prevent future recession, and in conjunction with restorative, orthodontic, or prosthetic dentistry. The aim of this study is to answer the most common question...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2015.130684

    authors: Kim DM,Neiva R

    更新日期:2015-02-01 00:00:00

  • Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis.

    abstract:BACKGROUND:Porphyromonas gingivalis has been implicated as an etiologic agent of rheumatoid arthritis (RA) because of the expression of peptidylarginine deiminase. The present study evaluates whether periodontal treatment may affect serum antibodies to P. gingivalis and citrulline levels in relation to disease activity...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2013.130079

    authors: Okada M,Kobayashi T,Ito S,Yokoyama T,Abe A,Murasawa A,Yoshie H

    更新日期:2013-12-01 00:00:00

  • Effects of currently available surgical and restorative interventions on reducing midfacial mucosal recession of immediately placed single-tooth implants: a systematic review.

    abstract:BACKGROUND:Procedures to improve peri-implant soft-tissue outcomes of single, immediately placed implants are a topic of interest. This systematic review investigates the effect of various surgical and restorative interventions on implant mid-buccal mucosal level. METHODS:An electronic search of five databases (Januar...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2013.130064

    authors: Lin GH,Chan HL,Wang HL

    更新日期:2014-01-01 00:00:00

  • Clinical and volumetric analysis of three-wall intrabony defects following open flap debridement.

    abstract::Fourteen defects were treated with flap debridement procedures using the Prichard principle of epithelial exclusion. Six defects were considered to be medium in width (3-4 mm), seven defects were wide (greater than 4 mm), and one defect was narrow (1-2 mm). The parameters studied were changes in gingival and plaque sc...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1986.57.5.277

    authors: Becker W,Becker BE,Berg L,Samsam C

    更新日期:1986-05-01 00:00:00

  • Prospective study of the impact of peri-implant soft tissue properties on patient-reported and clinically assessed outcomes.

    abstract:BACKGROUND:It has been proposed that the presence of a zone of keratinized mucosa (KM) around implants is associated with less discomfort during brushing and improved esthetic outcomes. Therefore, mucogingival procedures have been recommended for patients with discomfort during brushing, and to enhance esthetic results...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.18-0031

    authors: Bonino F,Steffensen B,Natto Z,Hur Y,Holtzman LP,Weber HP

    更新日期:2018-09-01 00:00:00

  • Untreated periodontal disease: a follow-up on 30 cases.

    abstract:BACKGROUND:Many studies have shown that periodontal disease can be successfully treated. However, there is limited documentation as to what happens when periodontal disease is left untreated. This study examined patients in a private practice who were diagnosed with periodontal disease and did not complete any treatmen...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2003.74.5.672

    authors: Harris RJ

    更新日期:2003-05-01 00:00:00

  • Interleukin-18 concentrations and the pathogenesis of periodontal disease.

    abstract:BACKGROUND:Interleukin-18 (IL-18) is reported as an important regulatory cytokine in non-oral inflammation. Our objective was to compare the concentrations of IL-18 within diseased and healthy human gingiva with concentrations of other T(H)1 and T(H)2 cytokines to determine possible effects of IL-18 on gingival inflamm...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.5.785

    authors: Johnson RB,Serio FG

    更新日期:2005-05-01 00:00:00

  • Alveolar bone loss is associated with circulating anti-citrullinated protein antibody (ACPA) in patients with rheumatoid arthritis.

    abstract:BACKGROUND:This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究

    doi:10.1902/jop.2014.140425

    authors: Gonzalez SM,Payne JB,Yu F,Thiele GM,Erickson AR,Johnson PG,Schmid MJ,Cannon GW,Kerr GS,Reimold AM,Sokolove J,Robinson WH,Mikuls TR

    更新日期:2015-02-01 00:00:00

  • Prevalence, location, and patency of accessory canals in the furcation region of permanent molars.

    abstract::One hundred and two extracted permanent molars were debrided in 3% H2O2, sealed at the apex, and placed in a vacuum chamber. Safranin dye was introduced into the teeth that were placed in a vacuum of 525 mm of Hg. Observations were made of the external root surface to determine any staining due to patent accessory can...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.1.21

    authors: Gutmann JL

    更新日期:1978-01-01 00:00:00

  • Preliminary Results of Non-Surgical Periodontal Treatment in Patients With Breast Cancer Undergoing Chemotherapy.

    abstract:BACKGROUND:Although priority is often given to treat the cancer itself, focus should also be directed to prevention and improvement of oral complications that may occur as a result of cancer and/or its treatment. This study compares periodontal treatment results in healthy patients and patients with breast cancer under...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.160101

    authors: Vargas-Villafuerte KR,Dantas FT,Messora MR,Novaes AB Jr,Grisi MF,Taba M Jr,Souza SL,Candido Dos Reis FJ,Carrara HH,Palioto DB

    更新日期:2016-11-01 00:00:00

  • Histologic findings after implantation and evaluation of different grafting materials and titanium micro screws into extraction sockets: case reports.

    abstract::The purpose of this study was to compare extraction socket healing in 8 patients after implantation with either xenogenic bovine bone (n=5 sites), demineralized freeze-dried bone (DFDBA) (n=3 sites), autologous bone (n=3 sites), or human bone morphogenetic proteins in an osteocalcein/osteonectin carrier (hBMP/NCP) (n=...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1998.69.4.414

    authors: Becker W,Clokie C,Sennerby L,Urist MR,Becker BE

    更新日期:1998-04-01 00:00:00

  • The effect of periodontal bone loss on bite force discrimination.

    abstract::This study compared bite force discrimination between 14 treated periodontal patients with significant bone resorption and 14 control subjects who were free of periodontal disease. Bite force was measured using a strain gauge scale which permitted subjects to visually monitor when their bite force equaled a preset res...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.4.236

    authors: Williams WN,Low SB,Cooper WR,Cornell CE

    更新日期:1987-04-01 00:00:00

  • New attachment achieved by guided tissue regeneration in beagle dogs.

    abstract::This study tested the effects of using a Gore-Tex periodontal material on new connective tissue attachment in beagle dogs with natural periodontitis. Seven female beagle dogs with advanced periodontitis were selected and given thorough root debridement. Under general anesthesia four weeks later, mucoperiosteal flaps w...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.9.589

    authors: Caffesse RG,Smith BA,Castelli WA,Nasjleti CE

    更新日期:1988-09-01 00:00:00

  • The effect of a supragingival plaque-control regimen on the subgingival microbiota in smokers and never-smokers: evaluation by real-time polymerase chain reaction.

    abstract:BACKGROUND:The aim of the present study was to evaluate the effect of strict supragingival plaque control on the subgingival microbiota in smokers and never-smokers. Research into the impact of supragingival plaque control on the number of subgingival bacteria has resulted in contradictory findings. Real-time polymeras...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2008.070558

    authors: Gomes SC,Nonnenmacher C,Susin C,Oppermann RV,Mutters R,Marcantonio RA

    更新日期:2008-12-01 00:00:00

  • Sex differences in inflammatory and apoptotic signaling molecules in normal and diseased human gingiva.

    abstract:BACKGROUND:The purpose of this study is to determine whether sex dimorphism exists in the expression of inflammatory and apoptotic mediators in gingiva obtained from normal and diseased sites of periodontal disease. METHODS:Gingival papillae were obtained from individuals (56 males and 62 females) who required extract...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.130718

    authors: Johnson RB,Wikle JC

    更新日期:2014-11-01 00:00:00

  • Oral aspects of Gaucher's disease: a literature review and case report.

    abstract:BACKGROUND:Gaucher's disease (GD) is a lysosomal storage disease with a high incidence in Ashkenazi Jews. The disease is caused by an autosomally recessive inherited deficiency of the lysosomal enzyme glucocerebrosidase, leading to the accumulation of glucocerebroside in macrophages. The lipid-laden macrophages, called...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2007.060341

    authors: Horwitz J,Hirsh I,Machtei EE

    更新日期:2007-04-01 00:00:00