Abstract:
BACKGROUND:Regenerative periodontal treatment aims to restore the attachment of the periodontal ligament and gingival collagen fibers to both the cementum of the root surface and alveolar bone. Fibroblasts are the predominant cells of the periodontal ligament and gingiva and have important roles in the function and regeneration of the tooth-supporting apparatus. This study investigated whether a putative collagen-based cell-binding peptide (P-15) increases gingival fibroblast attachment to root shavings and bone replacement graft (BRG) materials. METHODS:Gingival and dermal fibroblast attachment to root shavings and BRG materials, and cell proliferation on root shavings and sections were measured fluorometrically. Root shavings and root sections obtained from periodontally healthy teeth were treated with P-15 at 2 concentrations (200 ng/g or 400 ng/g). Citric acid (CA)-treated root materials were also compared to untreated root shavings and root sections that served as negative control groups. RESULTS:Attachment of all cells to bone fragments (whether freeze-dried or demineralized) was significantly greater than to hydroxyapatite (HA)-based BRG materials. The addition of P-15 to HA did not significantly increase gingival or dermal fibroblast attachment. At a concentration of 400 ng/g, P-15 significantly increased gingival and dermal fibroblast attachment to root shavings as compared to untreated shavings. Bone fragments, HA-based BRG materials, and untreated root shavings inhibited gingival fibroblast proliferation. Treatment of root sections with P-15 did not have any effect on gingival fibroblast proliferation. CONCLUSIONS:P-15 is a potential alternative to CA for promoting fibroblast attachment to root surfaces. However, P-15 did not enhance fibroblast proliferation on root sections.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Lallier TE,Palaiologou AA,Yukna RA,Layman DLdoi
10.1902/jop.2003.74.4.458subject
Has Abstractpub_date
2003-04-01 00:00:00pages
458-67issue
4eissn
0022-3492issn
1943-3670journal_volume
74pub_type
杂志文章abstract::Specific risk indicators associated with either susceptibility or resistance to severe forms of periodontal disease were evaluated in a cross-section of 1,426 subjects, 25 to 74 years of age, mostly metropolitan dwellers, residing in Erie County, New York, and surrounding areas. The study sample exhibited a wide range...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.3.260
更新日期:1994-03-01 00:00:00
abstract::The relation between utilization of dental services from community dentists and the extent and severity of alveolar bone loss is reported for a panel of men followed for over 6 years. Oral health data were collected by the Department of Veterans Affairs, Dental Longitudinal Study, which began in 1969 and still continu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.5s.551
更新日期:1994-05-01 00:00:00
abstract::A small laser doppler probe with an outside diameter comparable to a conventional periodontal probe (0.5 mm) was developed. The objectives of this investigation were to determine if intrasulcular laser doppler readings (LDR): 1) are reproducible; 2) can detect vascular changes associated with trauma from probe placeme...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1995.66.3.171
更新日期:1995-03-01 00:00:00
abstract::The modification of a methacrylic gel for use as a periodontal dressing was attempted. The increased adhesion and rigidity of the resultant material appeared consistent with the clinical findings. Satisfactory retention of the dressing was found in 85% of those placed on a group of patients attending for periodontal s...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.8.465
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130167
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Guided bone regeneration (GBR) using a non-absorbable barrier has provided clinicians the ability to place implants in sites compromised by insufficient bone, including immediate extraction sites. Recent evidence suggests that successful GBR outcomes may be possible using bioabsorbable polymer barriers. MET...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.2.250
更新日期:2001-02-01 00:00:00
abstract::THE MAXILLARY anterior region presents a difficult and unique therapeutic challenge to both the periodontist and restorative dentist. Although access for surgical and prosthetic procedures is certainly easiest in this part of the mouth, the problem of esthetics, in terms of increased tooth length and loss of interdent...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.4.208
更新日期:1981-04-01 00:00:00
abstract::Gingival incisions were performed distal to each of the two lower incisors on 25 adult male guinea pigs. For every animal, electrosection with an electrosurgical scalpel was used on one side, and a conventional scalpel was used on the other. The surgical instruments in all cases were brought into direct contact with p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.1.40
更新日期:1975-01-01 00:00:00
abstract::Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that bacterial pneumonia will assume increasing importance in the coming ye...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1996.67.10s.1114
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to seek the critical time for impairment of alveolar bone regeneration after ovariectomy (OVX) in rats. METHODS:A total of 32 female rats were used. Test group rats were divided into a 2M group (n = 8), a 3M group (n = 8) and a 4M group (n = 8) according to the duration from OVX to...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0537
更新日期:2020-10-01 00:00:00
abstract::Computer-based thermal imaging techniques were used to compare the rewarming rates of normal and inflamed human gingiva following cooling. A Modified Gingival Index (MGI) score, gingival crevicular fluid (GCF) measurement, and clinical photograph were obtained from a maxillary or mandibular anterior facial region in 2...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.11.628
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:In the attempt to limit the post-surgery increase in buccal gingival recession (bREC), effect of a connective tissue graft (CTG) when combined with a buccal single flap approach (SFA) in the regenerative treatment of intraosseous defects is evaluated. METHODS:Data related to 30 patients with an intraosseous...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究
doi:10.1902/jop.2016.160471
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:To improve regenerative therapies, it is important to understand the cells and factors modulating periodontal tissues. Our group has focused on bone sialoprotein (BSP), a mineralized tissue-selective protein considered to be involved in the initiation of cementogenesis and osteogenesis. In this study, we exa...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050057
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Several recent studies have indicated that total antioxidant capacity (TAOC) of plasma seems to be compromised in chronic periodontitis (ChP). The aim of this study is to investigate plasma TAOC in patients with ChP and to assess the effects of vitamin C as an adjunct to non-surgical periodontal treatment. ...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2010.100173
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Clinical and radiographic measures are gold standards for diagnosing periodontitis but offer little information regarding the pathogenesis of the disease. We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080139
更新日期:2008-11-01 00:00:00
abstract::Intraoral transmission radiographs have been the primary diagnostic method for the assessment of bone support as well as for the detection and measurement of osseous changes due to periodontitis. The purpose of the present paper is three-fold. The first is to review radiographic techniques for the assessment of period...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1992.63.4s.367
更新日期:1992-04-01 00:00:00
abstract::Demineralized bone matrix (DBM) is widely used in the repair of pathologies associated with skeletal defects and periodontal diseases. The present study was directed at establishing in vivo and in vitro models for a quantitative assessment of the osteoinductivity of DBM before clinical use. Athymic mice were used in a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.11.1076
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:This study compared 6-month and 3-year outcomes for root coverage (RC) by coronally advanced flap (CAF) procedures in localized gingival recessions. METHODS:Two centers, that had participated in a 6-month multinational multicenter randomized clinical trial (RCT), followed up 18 patients with 36 Miller Class...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2017.160767
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The use of nanoparticles of graft materials may lead to breakthrough applications for periodontal regeneration. However, due to their small particle size, nanoparticles may be eliminated from periodontal defects by phagocytosis. In an attempt to improve nanoparticle retention in periodontal defects, the pres...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2013.120701
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a worldwide health problem with increasing prevalence and poor outcomes, including severe cardiovascular disease and renal osteodystrophy. With advances in medical treatment, patients with CKD are living longer and require oral care. The aim of this study is to determine the e...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090379
更新日期:2010-02-01 00:00:00
abstract::Palatal groove is a rare morphological defect of upper incisors, frequently associated with localized destruction of periodontal tissue with endodontic complications. In this study, a sample of 1,081 male, young adult subjects, aged 20 to 22, palatal grooving was recorded in 11 (1.01%) subjects, affecting 15 incisors....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.3.197
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Peri-implantitis treatments are mainly based on protocols for teeth but have not shown favorable outcomes for implants. The potential role of titanium dissolution products in peri-implantitis necessitate the consideration of material properties in devising treatment protocols. We assessed implant cleaning in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0186
更新日期:2020-08-26 00:00:00
abstract::This report is an example of tumor metastasis to the temporomandibular joint and its effect on pain, restriction of jaw movement, and the subsequent inability of the patient to function normally. Neoplasm is not the usual etiology of myofascial pain dysfunctionsyndrome and the muscle sparm component of this patient's ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.5.309
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:The comparative treatment response of children and young adults with localized aggressive periodontitis treatment (LAgP) affecting primary and permanent dentition is unknown. The objective of this study is to evaluate the influence of non-surgical periodontal therapy with adjunctive systemic antibiotics on t...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2014.140171
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:A hypothesis of an increased risk for destructive periodontal diseases due to psychological stress has long been promoted. However, the research on stress and periodontal disease is still in its infancy. One of the reasons is thought to be that there is no suitable animal model for investigating the relation...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.2.306
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Neutrophils (PMNs) are critical components of the innate immune system and help to maintain oral health in the face of a constant bacterial challenge. However, along with protecting the periodontium from microbial invasion, these cells release potent lysosomal enzymes and oxygen radicals that can be destruct...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070107
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:With declining general health, the maintenance of oral health becomes increasingly difficult. Unfortunately, health care resources are limited. An assessment tool for detecting a patient's need for oral health care assistance would promote its adequate distribution. The aim of this study is to evaluate if th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.150349
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to quantify glycosaminoglycans (GAG) released into the gingival crevicular fluid (GCF) during health, gingivitis, and adult periodontitis. The investigation tested the hypothesis that increased amounts of GAG can be measured in GCF associated with gingivitis and adult periodontitis as com...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.3.186
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Previous studies have shown an association between a specific genotype for the inflammatory cytokine interleukin (IL)-1 and the severity of periodontal disease. The purpose of this study was to evaluate the effect of the IL-1 genotype on the outcomes of periodontal surgical regenerative treatment with bone r...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.10.1335
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:The peri-implant soft tissue phenotype (PSP) encompasses the keratinized mucosa width (KMW), mucosal thickness (MT), and supracrestal tissue height (STH). Numerous approaches to augment soft tissue volume around endosseous dental implants have been investigated. To what extent PSP modification is beneficial ...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1002/JPER.19-0716
更新日期:2021-01-01 00:00:00