Ovariectomy and timing of impaired maxillary alveolar bone regeneration: An experimental study in rats.

Abstract:

BACKGROUND:The aim of this study was to seek the critical time for impairment of alveolar bone regeneration after ovariectomy (OVX) in rats. METHODS:A total of 32 female rats were used. Test group rats were divided into a 2M group (n = 8), a 3M group (n = 8) and a 4M group (n = 8) according to the duration from OVX to defect creation. Bilateral OVX was performed in all test groups, and a sham operation was performed in the control group (n = 8). Drill-hole defects (1.5 mm diameter, 2 mm length) were created on both sides of the maxilla. All rats were euthanized 2 and 4 weeks after the surgery. Microcomputed tomographic (micro-CT), histological, and histomorphometric analyses and in vitro experiments were performed. RESULTS:The 4M group showed significantly less new bone formation and a lower bone mineral density than the other groups in the micro-CT analysis. The histomorphometric analysis also revealed that the 4M group showed significantly less new bone formation than the control and 2M groups. The rats in the 4M group showed significantly higher alkaline phosphatase expression levels and a larger number of calcified nodules than rats in the other groups, whereas osteoclastic activity was significantly lower in the 4M group than in the other groups. CONCLUSIONS:The critical time for impairment of alveolar bone regeneration was 4 months after OVX in rats.

journal_name

J Periodontol

authors

Kim HJ,Kim KH,Lee YM,Ku Y,Heo SJ,Rhyu IC,Seol YJ

doi

10.1002/JPER.19-0537

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1357-1366

issue

10

eissn

0022-3492

issn

1943-3670

journal_volume

91

pub_type

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