Effect of restraint stress on the progression of experimental periodontitis in rats.

Abstract:

BACKGROUND:A hypothesis of an increased risk for destructive periodontal diseases due to psychological stress has long been promoted. However, the research on stress and periodontal disease is still in its infancy. One of the reasons is thought to be that there is no suitable animal model for investigating the relationship. METHODS:One hundred male Wistar rats were included. A nylon ligature was placed around the second right maxillary molars. The animals were then divided into group S, exposed to a restraint stress for 12 hours/day for up to 10 days, and group N, controls. Ten animals were sacrificed on days 2, 4, 6, 8, and 10. Blood samples were taken, and the blood glucose level and the concentrations of adrenocorticotropic hormone, corticosterone, and adrenaline were measured as the markers of stress. The atrophies of the thymus and the spleen were measured. The furcation area of the second maxillary molars was examined histologically and histometrically. RESULTS:In group S, all values of stress markers were increased, and the thymus and the spleen were atrophied. Whereas group N showed only slight alveolar bone resorption, a marked alveolar bone resorption occurred in group S between days 8 and 10. An increase in beaded nerve terminals occurred around the vessels in the furcation area of group S. CONCLUSION:The results of the present study suggest that the restraint stress modulates the progression of periodontal inflammation and that this rat model is suitable for investigating the association between stress and periodontal disease.

journal_name

J Periodontol

authors

Takada T,Yoshinari N,Sugiishi S,Kawase H,Yamane T,Noguchi T

doi

10.1902/jop.2004.75.2.306

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

306-15

issue

2

eissn

0022-3492

issn

1943-3670

journal_volume

75

pub_type

杂志文章
  • Ultrastructural and immunoelectron microscopic studies of the peri-implant epithelium-implant (Ti-6Al-4V) interface of rat maxilla.

    abstract:BACKGROUND:The role played by the internal basal lamina (IBL) and hemidesmosomes between an implant and the peri-implant epithelium (PIE) in the adherence of the epithelium to the implant is controversial. This study used rat maxilla implantation models to clarify the ultrastructure of the PIE-implant interface. METHO...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.6.961

    authors: Ikeda H,Yamaza T,Yoshinari M,Ohsaki Y,Ayukawa Y,Kido MA,Inoue T,Shimono M,Koyano K,Tanaka T

    更新日期:2000-06-01 00:00:00

  • The long-term effectiveness of periodontal therapy in a clinical practice.

    abstract::A retrospective study was conducted of 620 patients in a periodontal practice over the years 1960 to 1982. Various periodontal therapies were assessed by using careful office protocols, meticulous record-keeping and well-defined outcome criteria. Four treatment outcome categories were used: two representing satisfacto...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.5.253

    authors: Meador HL,Lane JJ,Suddick RP

    更新日期:1985-05-01 00:00:00

  • Fusobacterium nucleatum T18 aggregates human mononuclear cells and inhibits their PHA-stimulated proliferation.

    abstract::In previous studies Fusobacterium nucleatum has been shown to induce either stimulatory or inhibitory effects on human mononuclear cells. We examined the interaction of human mononuclear cells with human and cynomolgus monkey strains of F. nucleatum. Peripheral blood mononuclear cells (PBMCs) isolated from normal dono...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1997.68.1.39

    authors: Kinder Haake S,Lindemann RA

    更新日期:1997-01-01 00:00:00

  • Cervical enamel projections and associated pouch-like opening in mandibular furcations.

    abstract:BACKGROUND:Cervical enamel projections (CEPs) have been listed among the tooth-associated risk factors that could lead to isolated furcation defects around molar teeth. This is more likely when Grade III CEPs are present. However, the histologic aspects of the CEP interface with regard to the presence or absence of cem...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.110088

    authors: Blanchard SB,Derderian GM,Averitt TR,John V,Newell DH

    更新日期:2012-02-01 00:00:00

  • Centric relation determinations: clinical and radiographic comparisons.

    abstract::This study investigated variations in occlusal prematurities and condylar positions using different methods of determining centric relation. Thirty patients were randomly placed into three groups of 10. In Group I a clinical analysis of occlusal patterns using bilateral mandibular manipulation (BMM) was compared to re...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1981.52.7.347

    authors: Carwell ML,McFall WT Jr

    更新日期:1981-07-01 00:00:00

  • Removal torque and histomorphometric evaluation of bioceramic grit-blasted/acid-etched and dual acid-etched implant surfaces: an experimental study in dogs.

    abstract:BACKGROUND:Surface modifications to dental implants have been used in an attempt to accelerate the osseointegration process. The objective of this study was to biomechanically/histomorphometrically evaluate a bioceramic grit-blasted and acid-etched surface (BGB/AA; test) versus a dual acid-etched implant surface (contr...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.080106

    authors: Marin C,Granato R,Suzuki M,Gil JN,Piattelli A,Coelho PG

    更新日期:2008-10-01 00:00:00

  • Functional polymorphisms in the matrix metalloproteinase-9 gene in relation to severity of chronic periodontitis.

    abstract:BACKGROUND:Members of the matrix metalloproteinase (MMP) family are implicated in the chronic remodeling in periodontal diseases. Therefore, we performed a case-control study to investigate a plausible association between susceptibility to chronic periodontitis (CP) and the polymorphisms in the MMP-9 (gelatinase B) gen...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050347

    authors: Holla LI,Fassmann A,Muzík J,Vanek J,Vasku A

    更新日期:2006-11-01 00:00:00

  • Impact of cannabis sativa (marijuana) smoke on alveolar bone loss: a histometric study in rats.

    abstract:BACKGROUND:Cannabis sativa (marijuana) can interfere with bone physiopathology because of its effect on osteoblast and osteoclast activity. However, its impact on periodontal tissues is still controversial. The present study evaluates whether marijuana smoke affects bone loss (BL) on ligature-induced periodontitis in r...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100362

    authors: Nogueira-Filho GR,Todescan S,Shah A,Rosa BT,Tunes Uda R,Cesar Neto JB

    更新日期:2011-11-01 00:00:00

  • Changes of subgingival total colony forming units and black pigmented bacteroides after a single irrigation of periodontal pockets with 1.64% SnF2.

    abstract::Periodontal pockets of 11 subjects were irrigated once with either 1.64% SnF2 or saline applied by syringe. Changes on the total anaerobic colony forming units (CFU) and black pigmented bacteroides (BPBs) of the irrigated pockets were assessed for 31 days. The results showed little change of the CFUs by either single ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.6.330

    authors: Schmid E,Kornman KS,Tinanoff N

    更新日期:1985-06-01 00:00:00

  • Botryoid odontogenic cyst: analysis of 33 cases.

    abstract::The botryoid odontogenic cyst is considered to be a multiloculated variant of the lateral periodontal cyst. Fewer than 40 of these lesions have been described, many of which have recurred. This paper describes the demographic, clinical, microscopic, and radiographic features of 33 unreported cases from the files of th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1995.66.12.1069

    authors: Gurol M,Burkes EJ Jr,Jacoway J

    更新日期:1995-12-01 00:00:00

  • Redefining the biologic width in severe, generalized, chronic periodontitis: implications for therapy.

    abstract:BACKGROUND:Previous studies demonstrated significant variability in the histologic biologic width in periodontal health and mild periodontitis. The purpose of this study was to determine whether the previously established dimensions of the biologic width applied to subjects with severe, generalized, chronic periodontit...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.080066

    authors: Novak MJ,Albather HM,Close JM

    更新日期:2008-10-01 00:00:00

  • Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.

    abstract:BACKGROUND:There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM:To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary disease (COPD), pneum...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.1340020

    authors: Linden GJ,Herzberg MC,working group 4 of the joint EFP\/AAP workshop.

    更新日期:2013-04-01 00:00:00

  • Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women.

    abstract:BACKGROUND:We recently demonstrated that a 2-year subantimicrobial-dose doxycycline (SDD) regimen (double-masked, placebo-controlled clinical trial) in postmenopausal (PM) women exhibiting mild systemic bone loss (osteopenia) and local bone loss (periodontitis) reduced the progression of periodontal attachment loss (in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2008.070623

    authors: Golub LM,Lee HM,Stoner JA,Sorsa T,Reinhardt RA,Wolff MS,Ryan ME,Nummikoski PV,Payne JB

    更新日期:2008-08-01 00:00:00

  • Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone.

    abstract:BACKGROUND:Purified recombinant human platelet-derived growth factor BB (rhPDGF-BB) is a potent wound healing growth factor and stimulator of the proliferation and recruitment of both periodontal ligament (PDL) and bone cells. The hypothesis tested in this study was that application of rhPDGF-BB incorporated in bone al...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2003.74.9.1282

    authors: Nevins M,Camelo M,Nevins ML,Schenk RK,Lynch SE

    更新日期:2003-09-01 00:00:00

  • Association between periodontitis and chronic obstructive pulmonary disease in a Chinese population.

    abstract:BACKGROUND:A relationship between periodontitis and chronic respiratory disease has been suggested by recent studies. The aim of this study is to explore the association between periodontitis and chronic obstructive pulmonary disease (COPD) in a Chinese population. METHODS:We conducted a case-control study of 581 COPD...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.110472

    authors: Si Y,Fan H,Song Y,Zhou X,Zhang J,Wang Z

    更新日期:2012-10-01 00:00:00

  • Whole mouth microbiota effects following subgingival delivery of sanguinarium.

    abstract::An increased incidence of antibiotic-resistant bacteria and yeast overgrowth has been reported following various periodontal treatments. The objective of this study was to detect possible overgrowth of opportunistic bacteria and fungi as well as changes in normal microbiota after application of a biodegradable deliver...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1995.66.10.870

    authors: Godowski KC,Wolff ED,Thompson DM,Housley CJ,Polson AM,Dunn RL,Duke SP,Stoller NH,Southard GL

    更新日期:1995-10-01 00:00:00

  • Citric acid demineralization and subepithelial connective tissue grafts.

    abstract:BACKGROUND:The present study was designed to evaluate the effect, if any, of citric acid root demineralization in the outcome of subepithelial connective tissue grafts performed to cover localized gingival recessions. METHODS:Thirty-six patients participated, each providing one gingival recession; 19 received citric a...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2000.71.4.568

    authors: Caffesse RG,De LaRosa M,Garza M,Munne-Travers A,Mondragon JC,Weltman R

    更新日期:2000-04-01 00:00:00

  • Bacterial penetration of gingiva in the adult beagle dog with periodontitis.

    abstract::Invasion of gingival tissues by bacteria is thought to be a major factor in development of periodontal lesions. Morphologic studies have revealed bacteria within the pocket epithelium, gingival connective tissues, alveolar bone, and oral epithelium. The current studies are intended to determine whether they are presen...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1990.61.1.35

    authors: Silverstein LH,Schuster GS,Garnick JJ,Singh B

    更新日期:1990-01-01 00:00:00

  • Is platelet concentrate advantageous for the surgical treatment of periodontal diseases? A systematic review and meta-analysis.

    abstract:BACKGROUND:The aim of the present review is to systematically evaluate the effects of autogenous platelet concentrates on clinical outcomes of the surgical treatment of periodontal diseases. METHODS:MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched using a combination of specific se...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1902/jop.2010.100605

    authors: Del Fabbro M,Bortolin M,Taschieri S,Weinstein R

    更新日期:2011-08-01 00:00:00

  • Comparative clinical study of porous hydroxyapatite and decalcified freeze-dried bone in human periodontal defects.

    abstract::Interproximal bony defects were treated with either porous hydroxyapatite (PHA) or decalcified freeze-dried bone allograft (DFDB) implants at two different clinical centers. Twelve paired defects in 12 patients were treated at each center. Six months post-surgically the defects were measured to assess changes from the...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1990.61.7.399

    authors: Oreamuno S,Lekovic V,Kenney EB,Carranza FA Jr,Takei HH,Prokic B

    更新日期:1990-07-01 00:00:00

  • Comparison of two differently processed acellular dermal matrix products for root coverage procedures: a prospective, randomized multicenter study.

    abstract:BACKGROUND:The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession defects. METHODS:Eig...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1902/jop.2014.140198

    authors: Wang HL,Romanos GE,Geurs NC,Sullivan A,Suárez-López Del Amo F,Eber RM

    更新日期:2014-12-01 00:00:00

  • Effect of citric acid treatment on the migration of epithelium on root surfaces in vitro.

    abstract::Explants of bovine gingival mucosa were cultured for four days on scaled and citric acid-conditioned root surfaces. Demineralization of the hard tissue with citric acid exposed the collagenous matrix of the root. Undemineralized islands were frequently seen among the collagen fibers of the treated roots. When cultured...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.2.95

    authors: Larjava H,Salonen J,Häkkinen L,Närhi T

    更新日期:1988-02-01 00:00:00

  • Resveratrol Inhibits Periodontitis-Related Bone Loss in Rats Subjected to Cigarette Smoke Inhalation.

    abstract:BACKGROUND:Alternative therapeutic approaches have been explored to modulate host response to periodontal disease. Knowledge of new strategies to treat periodontitis is particularly relevant in patients presenting augmented risk to periodontitis, such as smokers. The aim of this study is to investigate the impact of re...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2017.170025

    authors: Ribeiro FV,Pino DS,Franck FC,Benatti BB,Tenenbaum H,Davies JE,Pimentel SP,Casarin RC,Cirano FR,Casati MZ

    更新日期:2017-08-01 00:00:00

  • Cytokines and bone-related factors in systemically healthy patients with chronic periodontitis and patients with type 2 diabetes and chronic periodontitis.

    abstract:BACKGROUND:This study compares the levels of cytokines and bone-related factors in the gingival crevicular fluid (GCF) of systemically healthy patients with chronic periodontitis (CP); and better-controlled, and poorly controlled patients with type 2 diabetes and CP. METHODS:Thirty-seven patients with type 2 diabetes ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100643

    authors: Ribeiro FV,de Mendonça AC,Santos VR,Bastos MF,Figueiredo LC,Duarte PM

    更新日期:2011-08-01 00:00:00

  • Periodontitis and gestational diabetes mellitus in non-smoking females.

    abstract:BACKGROUND:Chronic inflammation has been implicated in the pathogenesis of gestational diabetes mellitus (GDM). Periodontal disease is associated with increased levels of inflammatory mediators and may be a risk factor for GDM. The authors aimed to examine the association between periodontitis and GDM among non-smoking...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.120344

    authors: Chokwiriyachit A,Dasanayake AP,Suwannarong W,Hormdee D,Sumanonta G,Prasertchareonsuk W,Wara-Aswapati N,Combellick J,Pitiphat W

    更新日期:2013-07-01 00:00:00

  • Collinin reduces Porphyromonas gingivalis growth and collagenase activity and inhibits the lipopolysaccharide-induced macrophage inflammatory response and osteoclast differentiation and function.

    abstract:BACKGROUND:Collinin is a secondary plant metabolite belonging to the class of geranyloxycoumarins. We explored the potential beneficial impact of collinin on periodontal health by investigating its effect on Porphyromonas gingivalis (P. gingivalis), lipopolysaccharide (LPS)-induced inflammatory response of macrophages,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.120118

    authors: Santos J,Marquis A,Epifano F,Genovese S,Curini M,Grenier D

    更新日期:2013-05-01 00:00:00

  • Role of matrix metalloproteinases in human periodontal diseases.

    abstract::Matrix metalloproteinases (MMP) are a family of proteolytic enzymes that mediate the degradation of extracellular matrix macromolecules, including interstitial and basement membrane collagens, fibronectin, laminin, and proteoglycan core protein. The enzymes are secreted or released in latent form and become activated ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1993.64.5s.474

    authors: Birkedal-Hansen H

    更新日期:1993-05-01 00:00:00

  • Increased Interleukin-1β Concentration in Gingival Crevicular Fluid as a Characteristic of Periodontitis.

    abstract:BACKGROUND:The levels of interleukin-1β (IL-1β) have been reported to be higher in sites with periodontitis than in healthy controls. This may be the result of a more severe inflammation and/or constitutional differences in IL-1β production. Our aim was to test the hypothesis that the level of IL-1β in gingival crevicu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.12.1457

    authors: Figueredo CMS,Ribeiro MSM,Fischer RG,Gustafsson A

    更新日期:1999-12-01 00:00:00

  • The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease.

    abstract:BACKGROUND:Caspases are key mediators of apoptosis. Caspase-8 mediates extrinsic, and caspase-9 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase-independent process. Because apoptosis is involved in periodontal disease,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.17-0716

    authors: Aral K,Aral CA,Kapila Y

    更新日期:2019-03-01 00:00:00

  • Treatment of localized gingival recessions using gingival unit grafts: a randomized controlled clinical trial.

    abstract:BACKGROUND:One of the success factors in periodontal plastic surgery is the synergistic relationship between involved tissues and vascular supply. Gingiva as a functional unit is unique with a specific vascular configuration and contains the supracrestal portion naturally created to survive over avascular root surfaces...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2012.110685

    authors: Kuru B,Yıldırım S

    更新日期:2013-01-01 00:00:00