Abstract:
BACKGROUND:The role played by the internal basal lamina (IBL) and hemidesmosomes between an implant and the peri-implant epithelium (PIE) in the adherence of the epithelium to the implant is controversial. This study used rat maxilla implantation models to clarify the ultrastructure of the PIE-implant interface. METHODS:Ti-6Al-4V implants were inserted either immediately or 2 weeks after the extraction of the upper left first molar of 6- or 4-week-old rats, respectively. The junctional epithelium (JE) of the upper right molars in the same animals was used as a control. Four weeks after implantation, the animals were sacrificed to prepare specimens for light and immunoelectron microscopy. RESULTS:Under light microscopy, the PIE appeared to attach to the implant surface. Ultrastructurally, IBL, consisting of the lamina densa and lamina lucida, and hemidesmosomes were formed only in the lower region, and rarely in the middle region, of the PIE-implant interface. In control teeth, the IBL and hemidesmosomes formed throughout the dento-JE interface. Laminin-1 was found in the IBL and also in the vesicles and vacuoles of the PIE and JE cells. Statistical analysis showed that there was also a significant difference in the amount of IBL between the PIE-implant and dento-JE interfaces. CONCLUSIONS:PIE attached to the implant via hemidesmosomes and IBL in the lower region of the PIE-implant interface. Although PIE cells may secrete laminin-1, which contributes to epidermal cell adhesion, the PIE which attaches to implants only in the lower region of the interface is considered to be the poorly adhered epithelium.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Ikeda H,Yamaza T,Yoshinari M,Ohsaki Y,Ayukawa Y,Kido MA,Inoue T,Shimono M,Koyano K,Tanaka Tdoi
10.1902/jop.2000.71.6.961subject
Has Abstractpub_date
2000-06-01 00:00:00pages
961-73issue
6eissn
0022-3492issn
1943-3670journal_volume
71pub_type
杂志文章abstract:BACKGROUND:Metformin (MF), a second-generation biguanide, is a commonly used oral antidiabetic drug that has been shown recently to stimulate osteoblasts and reduce alveolar bone loss. The present study aims to explore the efficacy of 0.5%, 1%, and 1.5% MF gel as a local drug delivery system in adjunct to scaling and r...
journal_title:Journal of periodontology
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更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Previous studies demonstrated significant variability in the histologic biologic width in periodontal health and mild periodontitis. The purpose of this study was to determine whether the previously established dimensions of the biologic width applied to subjects with severe, generalized, chronic periodontit...
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.5.249
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doi:10.1902/jop.2003.74.7.1060
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.7.626
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of periodontology
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doi:10.1902/jop.2002.73.10.1133
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1995.66.5.321
更新日期:1995-05-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-03-01 00:00:00
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更新日期:2006-08-01 00:00:00
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更新日期:1986-05-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,实务指引
doi:10.1902/jop.2008.080266
更新日期:2008-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:2020-08-21 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.10.1004
更新日期:1996-10-01 00:00:00