Abstract:
BACKGROUND:Porphyromonas gingivalis has been implicated as an etiologic agent of rheumatoid arthritis (RA) because of the expression of peptidylarginine deiminase. The present study evaluates whether periodontal treatment may affect serum antibodies to P. gingivalis and citrulline levels in relation to disease activity of RA. METHODS:Fifty-five patients with RA were randomly assigned to receive oral hygiene instruction and supragingival scaling (treatment group, n = 26) or no periodontal treatment (control group, n = 29). Periodontal and rheumatologic parameters and serum levels of cytokine and inflammatory markers citrulline and immunoglobulin (Ig)G to P. gingivalis were examined at baseline and 8 weeks later. RESULTS:Both groups did not differ statistically in any parameters except percentage of sites with probing depth and clinical attachment level ≥ 4 mm at baseline. The treatment group exhibited a significantly greater decrease in disease activity score including 28 joints using C-reactive protein (DAS28-CRP) (P = 0.02), serum levels of IgG to P. gingivalis hemin binding protein (HBP)35 (P = 0.04), and citrulline (P = 0.02) than the control group. Serum levels of IgG to P. gingivalis HBP35 were significantly correlated positively with those of anti-cyclic citrullinated peptide antibodies (P = 0.0002). The same correlation was obtained between serum levels of IgG to P. gingivalis-sonicated extracts and those of rheumatoid factor (P = 0.02). CONCLUSIONS:These results suggest that supragingival scaling decreases DAS28-CRP and serum levels of IgG to P. gingivalis HBP35 and citrulline in patients with RA. These observations may reflect a role of P. gingivalis in the protein citrullination, which is related to the pathogenesis of RA.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Okada M,Kobayashi T,Ito S,Yokoyama T,Abe A,Murasawa A,Yoshie Hdoi
10.1902/jop.2013.130079subject
Has Abstractpub_date
2013-12-01 00:00:00pages
e74-84issue
12eissn
0022-3492issn
1943-3670journal_volume
84pub_type
杂志文章,随机对照试验abstract:BACKGROUND:This study evaluated patients who had been treated with recombinant human bone morphogenetic protein-2 (rhBMP-2) loaded in an absorbable collagen sponge (ACS) in human extraction sites or in sites that required alveolar ridge augmentation. An earlier report on the same patients revealed that after 4 months, ...
journal_title:Journal of periodontology
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abstract:BACKGROUND:Patients with Kostmann syndrome (severe congenital neutropenia [SCN]) typically normalize their absolute neutrophil count (ANC) upon granulocyte colony-stimulating factor (G-CSF) therapy. However, although they no longer experience life-threatening bacterial infections, they frequently still have recurrent g...
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doi:10.1902/jop.2006.050191
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doi:10.1902/jop.2000.71.10.1575
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doi:10.1902/jop.2002.73.1.45
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abstract::This report describes a case of rapidly progressive periodontal tissue breakdown and bone loss in an HIV-infected markedly immunosuppressed homosexual male. Within 6 months of initial presentation with a necrotizing ulcerative gingivitis, the lesion extended to a necrotizing ulcerative stomatitis involving the surroun...
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pub_type: 杂志文章
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journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:1975-08-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.120219
更新日期:2013-05-01 00:00:00
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doi:10.1902/jop.1998.69.7.743
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070305
更新日期:2008-02-01 00:00:00
abstract::In order to compare the effect of partial demineralization with root planing and partial demineralization of cementum with that of dentin on healing, the ultrastructural morphology of the interface between the layer of human periodontal ligament-derived, fibroblast-like cells (HPF) and the treated root surface was stu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.4.267
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1985.56.11s.81
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pub_type: 杂志文章
doi:10.1902/jop.2001.72.3.331
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1902/jop.1990.61.1.35
更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-05-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160273
更新日期:2017-02-01 00:00:00
abstract::A 1% carrageenan solution was injected into the palatal mucosa of male guinea pigs between the two first molars. Biopsy specimens were taken 1, 3, 6, 12 and 24 hours after the injection. Control specimens with healthy mucosa and tyrode injected mucosa were used in order to evaluate the carrageenan-induced inflammation...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.3.114
更新日期:1979-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1443
更新日期:2005-09-01 00:00:00