Abstract:
BACKGROUND:Cannabis sativa (marijuana) can interfere with bone physiopathology because of its effect on osteoblast and osteoclast activity. However, its impact on periodontal tissues is still controversial. The present study evaluates whether marijuana smoke affects bone loss (BL) on ligature-induced periodontitis in rats. METHODS:Thirty male Wistar rats were used in the study. A ligature was placed around one of the mandible first molars (ligated teeth) of each animal, and they were then randomly assigned to one of two groups: control (n = 15) or marijuana smoke inhalation ([MSI] for 8 minutes per day; n = 15). Urine samples were obtained to detect the presence of tetrahydrocannabinol. After 30 days, the animals were sacrificed and decalcified sections of the furcation area were obtained and evaluated according to the following histometric parameters: bone area (BA), bone density (BD), and BL. RESULTS:Tetrahydrocannabinol was positive in urine samples only for the rats of the MSI group. Non-significant differences were observed for unligated teeth from both groups regarding BL, BA, and BD (P >0.05). However, intragroup analysis showed that all ligated teeth presented BL and a lower BA and BD compared to unligated teeth (P <0.05). The intergroup evaluation of the ligated teeth showed that the MSI group presented higher BL and lower BD (P <0.05) compared to ligated teeth from the control group. CONCLUSION:Considering the limitations of this animal study, cannabis smoke may impact alveolar bone by increasing BL resulting from ligature-induced periodontitis.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Nogueira-Filho GR,Todescan S,Shah A,Rosa BT,Tunes Uda R,Cesar Neto JBdoi
10.1902/jop.2011.100362subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1602-7issue
11eissn
0022-3492issn
1943-3670journal_volume
82pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
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journal_title:Journal of periodontology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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