Abstract:
BACKGROUND:Xenografts to augment the maxillary sinus have been used extensively. The aim of the present study was to evaluate, qualitatively and quantitatively, two different HA derivatives of natural and synthetic sources on newly formed bone in the augmented sinus. METHODS:A bilateral sinus augmentation procedure with simultaneous (16 out of 20 sites) or subsequent implant placement was performed in 10 patients. The antrum was randomly filled with a deproteinized, bovine hydroxyapatite mineral (B-HA) on one side and a non-ceramic resorbable hydroxyapatite (NC-HA) on the other. Cylindrical specimens were harvested from the augmented core at 12 months. Decalcified specimens were sectioned at a cross-horizontal plane and stained with hematoxylin and eosin for histopathologic and histomorphometric examinations. Tissue area fractions of bone, marrow, and the grafted particles were calculated for each specimen from the lateral to the deep region, and changes in values were compared within each material and between them. RESULTS:New bone formation was evident. B-HA and NC-HA particles were observed in all specimens surrounded by newly formed bone in direct connection or by soft tissue marrow. Morphometrically in the B-HA sites, from the lateral to deeper area, bone area fraction increased from 29.8% to 54.2% (average 42.1%) and marrow area fraction decreased from 37.9% to 26.7% (average 33.3%). The mineral area fraction decreased from 32.3% to 19.1% (average 24.7%). All increasing/decreasing patterns were statistically significant (P < 0.001). In the NC-HA sites, from the lateral to deeper area, bone area fraction increased from 25% to 36.5% (average 32.3%) and marrow area fraction decreased from 51.6% to 41.9% (average 43.2%) (P <0.001). The mineral area fraction decreased from 29% to 21.7% (average 24.6%) (P = 0.038). Comparison between the two HA derivative groups showed a significant difference between the bone area fraction averages (P = 0.0053) and between the increasing patterns along the core depth (P = 0.0006). There was also a significant difference between the decreasing marrow patterns (P = 0.003), but not between their averages. Comparison between the mineral area fractions showed no differences. CONCLUSIONS:B-HA and NC-HA were proven to be biocompatible materials. Although the B-HA-augmented sites showed a higher percentage of bone formation at 12 months, both are suitable bone derivatives in sinus augmentation procedures and can accommodate osseointegrated implants.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Artzi Z,Nemcovsky CE,Tal H,Dayan Ddoi
10.1902/jop.2001.72.7.911subject
Has Abstractpub_date
2001-07-01 00:00:00pages
911-20issue
7eissn
0022-3492issn
1943-3670journal_volume
72pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:The aim of this 9-month reentry study was to compare the regenerative healing using porous (P) and non-porous (NP) teflon barrier membranes plus demineralized freeze dried bone allografts (DFDBA) in Class II buccal/lingual furcation defects. METHODS:Twenty-four patients, 13 males and 11 females, ages 38 to ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2001.72.11.1580
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Cyclosporin A (CsA) is a potent immunosuppressant used to prevent organ transplant rejection and to treat various autoimmune diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of this study was to identif...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.11.1273
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Titanium (Ti) dental implants have been widely used for prosthetic reconstruction of dentition. Unfortunately, peri-implantitis can result in failure of dental implant osseointegration. Lipopolysaccharide (LPS) acts as a chronic inflammatory stimulus and maintains peri-implant inflammation, worsening the pro...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140386
更新日期:2015-03-01 00:00:00
abstract::This study examined for 3 years the changes in periodontal status and the possible correlations with selected subgingival microbiota and diabetic conditions in a group of 16 insulin-dependent diabetes mellitus (IDDM, JD) patients as compared with their 16 healthy cohabiting siblings (HS). JD patients were monitored ev...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.2.120
更新日期:1998-02-01 00:00:00
abstract::In recent years there has been a dramatic increase in the use of nonprecious alloy and porcelain crowns in clinical dentistry. The alloy in these restorations frequently contains a high percentage (greater than 70%) of nickel. Most cases of metal hypersensitivity are related to nickel, and clinical manifestations of t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.7.486
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:The adjunctive use of enamel matrix derivative (EMD) in the surgical therapy of intrabony defects results in improved outcomes compared to surgical debridement alone. However, the role of EDTA root conditioning in EMD therapy has not been investigated. The purpose of this study was to compare the 12-month ou...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.77.1.103
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The goal of guided tissue regeneration-based root coverage (GTRC) is to repair gingival recession via new attachment formation. Numerous clinical trials have been conducted utilizing the concept of GTR to promote root coverage. Most GTRC studies have had relatively small sample sizes and have not utilized po...
journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析,评审
doi:10.1902/jop.2003.74.10.1520
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the results after guided tissue regeneration (GTR) using a bioabsorbable membrane in Class II furcation defects in mandibular molars over a 24-month period. METHODS:Nine patients with 2 comparable Class II furcation defects were included. The defects in each patient...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2003.74.1.3
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The aim of this study is to compare the colonization, immunoglobulin (Ig) G response, and alveolar bone loss in Aggregatibacter actinomycetemcomitans (Aa)-inoculated Fawn Hooded Hypertensive (FHH), Dahl Salt-Sensitive (DSS), and Brown Norway (BN) rats. METHODS:Each rat strain was divided into wild-type Aa-i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100250
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Periodontal root coverage procedures to treat recession areas are indicated for unesthetic, exposed, and/or painful root surfaces. Many methods, most using autogenous soft tissue grafts, have been utilized, but with associated morbidity at the donor sites. An alternative donor material would reduce the morbi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2001.72.8.998
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Only a few studies have examined the association between periodontitis and glycated hemoglobin (HbA1c) levels in individuals without diabetes. The aim of this study is to compare HbA1c levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130661
更新日期:2014-12-01 00:00:00
abstract::This tribute was written by Dr. E. Brady Hancock, who was a student of and who succeeded Dr. Timothy J. O'Leary as chair of the Department of Periodontics at Indiana University. Dr. O'Leary served as co-editor of the Journal of Periodontologyfrom 1970 until 1988. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.9.1175
更新日期:2004-09-01 00:00:00
abstract::Ten mouse monoclonal antibodies were prepared against cultured bovine periodontal ligament cells to be used as reagents for the study of periodontal disease and wound healing. Using standard immunohistochemical methods, these antibodies were found to recognize cell surface antigens in formalin-fixed bovine periodontiu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.3.190
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Clinical and radiographic measures are gold standards for diagnosing periodontitis but offer little information regarding the pathogenesis of the disease. We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080139
更新日期:2008-11-01 00:00:00
abstract::THIS INVESTIGATION was undertaken to determine the distribution pattern and readability level of 20 widely distributed printed items containing periodontal health education literature. Average annual distribution was obtained from distributors of the material. The Minnesota Interactive Readability Approximation Progra...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.9.538
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Recent studies showed the clinical benefits of a one stage full-mouth disinfection, when compared to the worldwide standard treatment strategy of consecutive root planings per quadrant without proper disinfection of the remaining intraoral niches. The purpose of this study was to investigate the microbiologi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1999.70.6.646
更新日期:1999-06-01 00:00:00
abstract::Gingival incisions were performed distal to each of the two lower incisors on 25 adult male guinea pigs. For every animal, electrosection with an electrosurgical scalpel was used on one side, and a conventional scalpel was used on the other. The surgical instruments in all cases were brought into direct contact with p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.1.40
更新日期:1975-01-01 00:00:00
abstract::This study clinically analyzed the efficacy of a connective tissue graft including the periosteum used as a barrier to enhance new attachment and osseous regeneration. Fifteen patients, with no systemic diseases, and adult periodontitis including 2 Class II furcation involvements in lower molars comprised the study gr...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1991.62.12.775
更新日期:1991-12-01 00:00:00
abstract::Accurate diagnosis of periodontal destruction in the furcation region of multi-rooted teeth is a critical component of treatment planning, with different therapeutic approaches chosen based upon clinical determination of the severity of involvement. The current study assessed both vertical and horizontal depths of 274...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.7.649
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:The analgesic and anti-inflammatory efficacy of tenoxicam and meloxicam were evaluated in this double-masked, randomized, prospective study by analyzing pain scores and the need for rescue-analgesic agents following dental implant surgery. METHODS:One hundred patients, in whom 241 dental implants were place...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2007.070192
更新日期:2007-12-01 00:00:00
abstract::The present study aimed to establish a titanium implantation model using rat maxillae as well as demonstrate the chronological tissue responses to implantation. Pure titanium implants were inserted in the upper first molar extraction sites of Wistar rats 1 month after tooth extraction. The animals were sacrificed at 1...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.4.485
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:One endpoint of periodontal therapy is to regenerate the structure lost due to periodontal disease. In the periodontium, gingival epithelium is regenerated by oral epithelium. Underlying connective tissue, periodontal ligament, bone, and cementum are derived from connective tissue. Primitive connective tissu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.12.2194
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Chronic periodontitis (CP) exhibits inflammation and alveolar bone loss, and severe forms of periodontitis are suggested to have a genetic basis. Vitamin D receptor (VDR) regulates bone metabolism and inflammation-related genes, and single nucleotide polymorphisms (SNPs) in the VDR gene may affect the functi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080465
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Low-calorie diets are commonplace for reducing body weight. However, no information is available on the effects of a reduced-calorie diet on periodontal inflammation and disease. The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070629
更新日期:2008-07-01 00:00:00
abstract::Oral polymorphonuclear leukocytes (pmn) were obtained from 10 adult donors in good oral health using a method employing repeated mouth rinse collection. Interleukin-1β (IL-1β) mRNA was detected in freshly obtained cells by blot hybridization of total cellular RNA with a biotin labeled cDNA probe. Supernates from oral ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.9.761
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Osseointegrated dental implants are currently recognized as a standard treatment method in dentistry. Titanium (Ti) and its alloys are the metals of choice for endosseous parts of currently available dental implants. Ti-6Al-4V is the most used Ti alloy, however; an improved version, Ti-6Al-7Nb, has been rece...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.8.900
更新日期:2002-08-01 00:00:00
abstract::During the acute phase of periodontal disease, as many as 60% of the cells of the junctional epithelium may be accounted for by polymorphonuclear cells (PMNs). It is generally accepted that these cells play a dominant role in the destruction of connective tissue by virtue of the proteinases they release and the free o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.7.422
更新日期:1986-07-01 00:00:00
abstract::The purposes of this study were to determine if: 1) an association exists between cigarette smoking and signs of periodontal disease after controlling for the confounding variables of age, sex, plaque, and calculus; 2) the prevalence of 5 bacteria commonly associated with periodontal disease differs between smokers an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.12.1225
更新日期:1993-12-01 00:00:00
abstract::The present paper describes 36 consecutively treated non-human primates (Macaca mulatta) as part of a balanced block design study to examine osseointegration in root- and plate-form implants prepared by atraumatic preparation of bone. Clinical measurements around selected teeth and digital radiology were utilized to m...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.12.1322
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Alveolar ridge augmentation procedures are often needed prior to implant placement or prosthetic rehabilitation. The purpose of this study was to develop a quantitative method to assess the clinical outcome of such procedures. METHODS:Two volumetric methods, based on the volume difference between the pre- a...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.3.302
更新日期:2002-03-01 00:00:00