Abstract:
BACKGROUND:MicroRNAs (miRNAs) are a group of small non-coding RNAs that play an important role in the regulation of gene expression. miRNA-146a (miR-146a), a member of the miR-146 family, is involved in the control of inflammation. Periodontitis is a set of chronic inflammatory disorders of the tissues surrounding the teeth that lead to the breakdown of alveolar bone and tooth loss. In this study, expression levels of miR-146a and its targets, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, are evaluated in human patients with chronic periodontitis (CP). METHODS:The study population consisted of 10 healthy controls and 20 individuals with CP. For each participant, clinical parameters including probing depth and clinical attachment level were measured, and a gingival tissue sample was collected. Levels of miR-146a, TNF-α, IL-1β, and IL-6 were quantified using real-time polymerase chain reaction. RESULTS:Levels of miR-146a were significantly higher in patients with CP (P <0.001). There was a positive correlation between levels of miR-146a and clinical parameters (P <0.05). Elevated miR-146a was accompanied by a significant reduction in TNF-α and IL-6 (P <0.001). CONCLUSIONS:Patients with CP had higher levels of miR-146a than healthy individuals, accompanied by reduced levels of TNF-α and IL-6. A positive relationship between miR-146a levels and clinical parameters suggests a pathophysiologic role of miR-146a in CP.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Motedayyen H,Ghotloo S,Saffari M,Sattari M,Amid Rdoi
10.1902/jop.2015.150319subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1380-5issue
12eissn
0022-3492issn
1943-3670journal_volume
86pub_type
杂志文章abstract:BACKGROUND:Contradictory results exist regarding influence of apico-coronal implant placement on crestal bone levels. METHODS:Complete charts of patients ≥18 years old with one or more dental implants were included. Demographic, medical, surgical, and prosthetic information was recorded. Implant bone levels were evalu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160802
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The comparative treatment response of children and young adults with localized aggressive periodontitis treatment (LAgP) affecting primary and permanent dentition is unknown. The objective of this study is to evaluate the influence of non-surgical periodontal therapy with adjunctive systemic antibiotics on t...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2014.140171
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The role played by the internal basal lamina (IBL) and hemidesmosomes between an implant and the peri-implant epithelium (PIE) in the adherence of the epithelium to the implant is controversial. This study used rat maxilla implantation models to clarify the ultrastructure of the PIE-implant interface. METHO...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.6.961
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. To the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known micr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160273
更新日期:2017-02-01 00:00:00
abstract::Clinical and laboratory data were compared in 72 patients with localized periodontitis (LP) and 103 patients with generalized periodontitis (GP). Significantly more LP than GP cases had decreased neutrophil chemotaxis (CTX), and were seropositive for Actinobacillus actinomycetemcomitans (Aa). Significantly, more GP ca...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.10.557
更新日期:1989-10-01 00:00:00
abstract::Intraoral transmission radiographs have been the primary diagnostic method for the assessment of bone support as well as for the detection and measurement of osseous changes due to periodontitis. The purpose of the present paper is three-fold. The first is to review radiographic techniques for the assessment of period...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1992.63.4s.367
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Cyclosporin A (CsA) induces gingival overgrowth (GO) in patients who seem to be prone to this disorder. It is still impossible to determine which patients will develop GO. Patients treated with the new immunosuppressive drug tacrolimus seem not to have GO. The aims of this study were to investigate transform...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050086
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:A specific labeler of the human gingival fibroblast (HGF) does not exist. Anionic maghemite nanoparticles allow labeling of a wide cell variety and their recognition in cellular, organotypical, and animal models. METHODS:We studied internalization effects of nanoparticles on an HGF phenotype in vitro, evalu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050064
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Collagen barrier membranes are commonly applied in periodontal and bone-regenerative procedures. Membranes differ in their resorption pattern following implantation, thus influencing clinical outcome. The purpose of this study was to quantitatively evaluate the biodegradation of three different commercially ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070361
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Patients with Kostmann syndrome (severe congenital neutropenia [SCN]) typically normalize their absolute neutrophil count (ANC) upon granulocyte colony-stimulating factor (G-CSF) therapy. However, although they no longer experience life-threatening bacterial infections, they frequently still have recurrent g...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050191
更新日期:2006-04-01 00:00:00
abstract::Ultrasonic scalers may be operated at different power settings which may influence the final therapeutic result. The displacement amplitude of the scaling tip may affect scaling efficiency or the degree of root surface damage. This investigation aimed to determine whether there was any difference in periodontal healin...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1995.66.9.756
更新日期:1995-09-01 00:00:00
abstract::The present study demonstrated that hyperglycemic diabetic rats fed a low-protein (8%) diet maintained an alveolar bone height similar to controls; in contrast, those fed a standard protein diet (24%) had reduced alveolar bone height (P less than 0.05). Euglycemic diabetic and untreated control rats fed low-protein di...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.5.264
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. In the present study, we investigated whether a mouse cementoblast cell line, OCCM-30 cells,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060257
更新日期:2007-01-01 00:00:00
abstract::During the acute phase of periodontal disease, as many as 60% of the cells of the junctional epithelium may be accounted for by polymorphonuclear cells (PMNs). It is generally accepted that these cells play a dominant role in the destruction of connective tissue by virtue of the proteinases they release and the free o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.7.422
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:The pathogenesis of epithelial thickening in gingival overgrowth remains obscure. Apoptosis plays an important role in maintaining tissue hemostasis. The aim of the present study was to investigate apoptosis via immunohistochemical analyses in cyclosporin A-induced gingival overgrowth tissue samples to deter...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070226
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Microbial internal contamination of oral implants has been suggested as being responsible for inflammatory infiltration of peri-implant tissues at the fixture-abutment interface of 2-stage and 2-component implant systems; it is also considered as a potential source of pathogens. The present in vivo study eva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.12.1652
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Despite previous studies addressing the link between preterm or low birth weight infants and maternal periodontitis, extreme preterm births have received far less attention. This study is designed to address the possible association between maternal periodontal disease and preterm or extreme preterm birth. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090527
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Data are limited on the potential effect of intensive oral hygiene regimens and periodontal therapy during pregnancy on periodontal health, gingival crevicular fluid (GCF) and serum cytokines, and pregnancy outcomes. METHODS:A clinical trial was conducted on 120 community-dwelling, 16- to 35-year-old pregna...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2014.140248
更新日期:2014-12-01 00:00:00
abstract::The form of periodontitis with onset at puberty and affecting predominantly the first molars and incisors is called juvenile periodontitis (JP). The disease has been the object of intense study because from its analysis may come insights into understanding other, more common, forms of periodontitis. We recently had th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.10.602
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Peripheral giant cell granuloma (PGCG) is a reactive lesion that occurs on the gingiva or alveolar mucosa and contains numerous giant cells. Its recurrence rate is 10%. Only five cases associated with dental implants have been reported. This case report describes three additional cases with clinical courses ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090081
更新日期:2009-07-01 00:00:00
abstract::The clinical, histopathologic and functional consequences of the genetic deficiency of leukocyte Mac-1, LFA-1 and p150,95 were assessed among three affected patients, heterozygotes and unaffected individuals among two generations of a single kindred. Longitudinal assessments of this family afforded the unique opportun...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.6.400
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:This study examined conditions under which gingival crevicular blood (GCB) could be used to obtain a useful glucose reading to screen for undiagnosed diabetes during routine dental visits. METHODS:GCB and capillary finger-stick blood (CFB) glucose readings obtained with a glucometer were compared for 46 pat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080542
更新日期:2009-06-01 00:00:00
abstract::Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the focus of intensive research endeavors over the past 2 decades. Over the years, however, numerous reports have inaccurately reported relative centrifugal force (RCF) values, which has caused considerable confusion in the field. Furthermo...
journal_title:Journal of periodontology
pub_type: 社论
doi:10.1002/JPER.18-0553
更新日期:2019-08-01 00:00:00
abstract::Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that bacterial pneumonia will assume increasing importance in the coming ye...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1996.67.10s.1114
更新日期:1996-10-01 00:00:00
abstract::The purpose of this study was to compare extraction socket healing in 8 patients after implantation with either xenogenic bovine bone (n=5 sites), demineralized freeze-dried bone (DFDBA) (n=3 sites), autologous bone (n=3 sites), or human bone morphogenetic proteins in an osteocalcein/osteonectin carrier (hBMP/NCP) (n=...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1998.69.4.414
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is an inflammatory granulomatous systemic disease that rarely affects the oral cavity. Gingival involvement has been reported in only a very limited number of cases, occasionally as the first manifestation of the disease. This article reports a case of sarcoidosis affecting the gingiva and alveol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070139
更新日期:2008-03-01 00:00:00
abstract::Histiocytosis X, a reticuloendothelial disorder, includes the three clinical syndromes: Letterer-Siwe and Hand-Schuller-Christian diseases and eosinophilic granuloma of the bone. Twenty-eight cases of adult onset of histiocytosis X involving the head and neck region were found in the literature during the past 20 year...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1989.60.1.57
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Periodontists have found the gingival autograft to be an effective and predictable technique to increase the amount of attached gingiva around teeth, but this technique requires the surgeon to harvest donor tissue from a remote surgical site. The present study seeks to evaluate the safety and effectiveness o...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.6.867
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Mechanical periodontal therapy consists of a non-surgical course, followed by surgical treatment to eliminate or reduce remaining pathological pockets. Only if diligent mechanical therapy fails are additional measures considered. It has been documented that smoking interferes with the host defense mechanisms...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.10.1166
更新日期:1999-10-01 00:00:00
abstract::Smoker's melanosis is a benign pigmentation of the oral mucosa, predominantly observed on the attached anterior mandibular gingiva and interdental papillae. These macular lesions are independent of genetic factors, therapeutic medication usage, and various systemic disorders. As a group they are often seen after the t...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1991.62.8.524
更新日期:1991-08-01 00:00:00