Abstract:
BACKGROUND:Data are limited on the potential effect of intensive oral hygiene regimens and periodontal therapy during pregnancy on periodontal health, gingival crevicular fluid (GCF) and serum cytokines, and pregnancy outcomes. METHODS:A clinical trial was conducted on 120 community-dwelling, 16- to 35-year-old pregnant women at 16 to 24 weeks of gestation. Each participant presented with clinical evidence of generalized, moderate-to-severe gingivitis. Oral hygiene products were provided, together with instructions for an intensive daily regimen of hygiene practices. Non-surgical therapy was provided at baseline. Oral examinations were completed at baseline and again at 4 and 8 weeks. In addition, samples of blood and GCF were collected at baseline and week 8. Mean changes in clinical variables and GCF and serum cytokine levels (interleukin [IL]-1β, IL-6, tumor necrosis factor [TNF]-α) between baseline and week 8 were calculated using paired t test. Pregnancy outcomes were recorded at parturition. RESULTS:RESULTS indicated a statistically significant reduction in all clinical variables (P <0.0001) and decreased levels of TNF-α (P = 0.0076) and IL-1β (P = 0.0098) in GCF during the study period. The rate of preterm births (<37 weeks of gestation) was 6.7% (P = 0.113) and low birth weight (<2,500 g) was 10.2% (P = 1.00). CONCLUSIONS:Among the population studied, intensive instructions and non-surgical periodontal therapy provided during 8 weeks at early pregnancy resulted in decreased gingival inflammation and a generalized improvement in periodontal health. Large-scale, randomized, controlled studies are needed to substantiate these findings.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Kaur M,Geisinger ML,Geurs NC,Griffin R,Vassilopoulos PJ,Vermeulen L,Haigh S,Reddy MSdoi
10.1902/jop.2014.140248subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1684-92issue
12eissn
0022-3492issn
1943-3670journal_volume
85pub_type
临床试验,杂志文章abstract:BACKGROUND:Medical-grade calcium sulfate (CS) is a biocompatible, bioabsorbable, and clinically versatile ceramic for use in bone repair. This study compared the clinical efficacy of a combination of calcium sulfate dihydrate, as a binder and barrier, and demineralized freeze-dried bone allograft (DFDBA) to polytetrafl...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:BACKGROUND:Some studies have reported an association between gestational diabetes mellitus (GDM) and periodontitis. The aim of the present study is to analyze this potential association and the influence of risk variables associated with GDM. METHODS:This case-control study includes 360 women, 90 with GDM and 270 cont...
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更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:This cross-sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll-like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy. METHODS:Whole saliva and plasma samples were obtained and full-mouth c...
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更新日期:2004-06-01 00:00:00
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doi:10.1902/jop.2004.75.1.176
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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doi:10.1902/jop.2007.060321
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doi:10.1902/jop.2000.71.8.1338
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pub_type: 杂志文章
doi:10.1902/jop.1988.59.2.115
更新日期:1988-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.12.740
更新日期:1983-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-08-21 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.12.1322
更新日期:1996-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1457
更新日期:1999-12-01 00:00:00