Effect of intensive oral hygiene regimen during pregnancy on periodontal health, cytokine levels, and pregnancy outcomes: a pilot study.

Abstract:

BACKGROUND:Data are limited on the potential effect of intensive oral hygiene regimens and periodontal therapy during pregnancy on periodontal health, gingival crevicular fluid (GCF) and serum cytokines, and pregnancy outcomes. METHODS:A clinical trial was conducted on 120 community-dwelling, 16- to 35-year-old pregnant women at 16 to 24 weeks of gestation. Each participant presented with clinical evidence of generalized, moderate-to-severe gingivitis. Oral hygiene products were provided, together with instructions for an intensive daily regimen of hygiene practices. Non-surgical therapy was provided at baseline. Oral examinations were completed at baseline and again at 4 and 8 weeks. In addition, samples of blood and GCF were collected at baseline and week 8. Mean changes in clinical variables and GCF and serum cytokine levels (interleukin [IL]-1β, IL-6, tumor necrosis factor [TNF]-α) between baseline and week 8 were calculated using paired t test. Pregnancy outcomes were recorded at parturition. RESULTS:RESULTS indicated a statistically significant reduction in all clinical variables (P <0.0001) and decreased levels of TNF-α (P = 0.0076) and IL-1β (P = 0.0098) in GCF during the study period. The rate of preterm births (<37 weeks of gestation) was 6.7% (P = 0.113) and low birth weight (<2,500 g) was 10.2% (P = 1.00). CONCLUSIONS:Among the population studied, intensive instructions and non-surgical periodontal therapy provided during 8 weeks at early pregnancy resulted in decreased gingival inflammation and a generalized improvement in periodontal health. Large-scale, randomized, controlled studies are needed to substantiate these findings.

journal_name

J Periodontol

authors

Kaur M,Geisinger ML,Geurs NC,Griffin R,Vassilopoulos PJ,Vermeulen L,Haigh S,Reddy MS

doi

10.1902/jop.2014.140248

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1684-92

issue

12

eissn

0022-3492

issn

1943-3670

journal_volume

85

pub_type

临床试验,杂志文章
  • Clinical evaluation of calcium sulfate in combination with demineralized freeze-dried bone allograft for the treatment of human intraosseous defects.

    abstract:BACKGROUND:Medical-grade calcium sulfate (CS) is a biocompatible, bioabsorbable, and clinically versatile ceramic for use in bone repair. This study compared the clinical efficacy of a combination of calcium sulfate dihydrate, as a binder and barrier, and demineralized freeze-dried bone allograft (DFDBA) to polytetrafl...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2004.75.3.340

    authors: Aichelmann-Reidy ME,Heath CD,Reynolds MA

    更新日期:2004-03-01 00:00:00

  • Association between periodontitis and gestational diabetes mellitus: a case-control study.

    abstract:BACKGROUND:Some studies have reported an association between gestational diabetes mellitus (GDM) and periodontitis. The aim of the present study is to analyze this potential association and the influence of risk variables associated with GDM. METHODS:This case-control study includes 360 women, 90 with GDM and 270 cont...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.120350

    authors: Esteves Lima RP,Miranda Cota LO,Costa FO

    更新日期:2013-09-01 00:00:00

  • Understanding and managing periodontal diseases: a notable past, a promising future.

    abstract::Throughout the 20th century, an understanding of the role of causative bacteria and the susceptible host in the initiation and progression of periodontal disease(s) has emerged from the research efforts of scientists and clinicians worldwide. Over time, specific bacterial types, such as Porphyromonas gingivalis, were ...

    journal_title:Journal of periodontology

    pub_type: 历史文章,杂志文章

    doi:10.1902/jop.2008.080182

    authors: Williams RC

    更新日期:2008-08-01 00:00:00

  • Salivary and plasma levels of Toll-like receptor 2 and Toll-like receptor 4 in chronic periodontitis.

    abstract:BACKGROUND:This cross-sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll-like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy. METHODS:Whole saliva and plasma samples were obtained and full-mouth c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100467

    authors: Buduneli N,Özçaka Ö,Nalbantsoy A

    更新日期:2011-06-01 00:00:00

  • Special Feature: Journal of Periodontology 75th Anniversary.

    abstract::This is a posthumous interview with Dr. Maynard K. Hine (MKH), the second editor of the Journal of Periodontology (from 1950 to 1970), as prepared by Dr. David C. Vandersall (DCV). Dr. Vandersall was a colleague of Dr. Hine while serving as associate clinical professor of periodontics at the Indiana University School ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2004.75.6.781

    authors:

    更新日期:2004-06-01 00:00:00

  • Periodontal parameters around implants anchoring orthodontic appliances: a series of case reports.

    abstract:BACKGROUND:Implants replacing missing teeth provide advantages over clinical orthodontic treatment as compensation for reaction forces is no longer necessary and the lack of teeth is immediately resolved. METHODS:A total of 38 two-stage implants were inserted (16 in maxilla, 22 in mandible) in 10 partially edentulous ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2004.75.1.176

    authors: Molly L,Willems G,van Steenberghe D,Quirynen M

    更新日期:2004-01-01 00:00:00

  • Analysis of daytime variations in gingival crevicular fluid: a circadian periodicity?

    abstract:BACKGROUND:Volumetric alterations in gingival crevicular fluid (GCF) are widely accepted to be associated with periodontal health/disease. The volume/flow of GCF was shown to be affected by an array of methodological factors. However, relatively limited information is available on whether GCF is subject to circadian rh...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.130367

    authors: Günday S,Topcu AO,Ercan E,Yamalik N

    更新日期:2014-03-01 00:00:00

  • Fibrin linkage: a precursor for new attachment.

    abstract::Previous studies indicated that connective tissue attachment to the root surface appeared to be dependent upon a chronologic healing sequence related to fibrin and collagen interactions. It was the purpose of the present study to try and substantiate this hypothesis by using histologic techniques designed to different...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1983.54.3.141

    authors: Polson AM,Proye MP

    更新日期:1983-03-01 00:00:00

  • Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans.

    abstract:BACKGROUND:To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools. METHODS:Gingival biopsy samples collected from 14 subjects during a 28-day stent-induce...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.080645

    authors: Offenbacher S,Barros SP,Paquette DW,Winston JL,Biesbrock AR,Thomason RG,Gibb RD,Fulmer AW,Tiesman JP,Juhlin KD,Wang SL,Reichling TD,Chen KS,Ho B

    更新日期:2009-12-01 00:00:00

  • The influence of interleukin gene polymorphism on expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid.

    abstract:BACKGROUND:A specific composite genotype of the polymorphic interleukin-1 (IL-1) gene cluster has recently been associated with severe periodontitis. One polymorphism of the composite periodontitis-associated genotype (PAG) has been functionally linked with expression of high levels of IL-1. The purpose of this study w...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.6.567

    authors: Engebretson SP,Lamster IB,Herrera-Abreu M,Celenti RS,Timms JM,Chaudhary AG,di Giovine FS,Kornman KS

    更新日期:1999-06-01 00:00:00

  • Periodontitis and three health-enhancing behaviors: maintaining normal weight, engaging in recommended level of exercise, and consuming a high-quality diet.

    abstract:BACKGROUND:Maintaining normal weight, engaging in the recommended level of exercise, and eating healthy food are known to improve general health. The impact of these behaviors on periodontal health is not well documented. This study is aimed at examining whether the increased number of these behaviors is associated wit...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.8.1362

    authors: Al-Zahrani MS,Borawski EA,Bissada NF

    更新日期:2005-08-01 00:00:00

  • Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis.

    abstract:BACKGROUND:Bacterial constituents, such as Gram-negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host-derived inflammatory cytokines. The aim of this study was to establish a model of aggressive inflammatory alveolar bone loss in rats using LPS derived from the periodo...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060321

    authors: Rogers JE,Li F,Coatney DD,Rossa C,Bronson P,Krieder JM,Giannobile WV,Kirkwood KL

    更新日期:2007-03-01 00:00:00

  • Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis.

    abstract:BACKGROUND:Periodontitis is an infection with an episodic pattern of tissue-support destruction. During the generation of a primary CD4(+) T helper 1 (Th1) response, interferon-gamma (IFN-gamma) acts as a positive regulator by selectively inducing Th1 differentiation through increased transcription of T-bet. The aims o...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.080287

    authors: Dutzan N,Vernal R,Hernandez M,Dezerega A,Rivera O,Silva N,Aguillon JC,Puente J,Pozo P,Gamonal J

    更新日期:2009-02-01 00:00:00

  • A 10-year prospective study of tobacco smoking and periodontal health.

    abstract:BACKGROUND:To date only a few studies have evaluated the long-term influence of smoking and smoking cessation on periodontal health. The present study, therefore, was undertaken with the aim to prospectively investigate the influence of smoking exposure over time on the periodontal health condition in a targeted popula...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.8.1338

    authors: Bergström J,Eliasson S,Dock J

    更新日期:2000-08-01 00:00:00

  • Validation of antibiotic efficacy on in vitro subgingival biofilms.

    abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.130167

    authors: Belibasakis GN,Thurnheer T

    更新日期:2014-02-01 00:00:00

  • Periodontal surgery for a patient with paroxysmal nocturnal hemoglobinuria.

    abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon blood stem cell disorder. The acquired defect is in the cell membrane of the precursor of the affected clone, which renders erythrocytes, platelets and granulocytes unusually sensitive to the hemolytic effects of complement. It is characterized by chronic hemoly...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.2.115

    authors: Cohen CI,Zimmerman DR

    更新日期:1988-02-01 00:00:00

  • Effects of endogenous and exogenous prostaglandin E2 on the proliferation and differentiation of a mouse cementoblast cell line (OCCM-30).

    abstract:BACKGROUND:Cementum formation is considered to be a critical event for successful regeneration of periodontal tissues. Cementoblasts share many characteristics with osteoblasts. Prostaglandin E(2) (PGE(2)) is an important local factor in bone metabolism. Although the effects of PGE(2) on osteoblasts are well known, its...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.060148

    authors: Mada Y,Miyauchi M,Oka H,Kitagawa M,Sakamoto K,Iizuka S,Sato S,Noguchi K,Somerman MJ,Takata T

    更新日期:2006-12-01 00:00:00

  • Microstructural volumetric analysis of the jaw following dental implantation under systemic bisphosphonate delivery: An in vivo and ex vivo rat study.

    abstract:BACKGROUND:Because of bisphosphonate medication, dental implantation with a subsequent infection poses a relevant risk factor to suffer from medication-related osteonecrosis of the jaw. This rat study evaluated different implant materials under systemic bisphosphonate delivery using micro-computed tomography (μCT) imag...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0547

    authors: Kniha K,Bock A,Peters F,Magnuska ZA,Gremse F,Möhlhenrich SC,Hölzle F,Modabber A

    更新日期:2020-11-30 00:00:00

  • The effect of chlorhexidine irrigation on tensile wound strength.

    abstract::Chlorhexidine in an alcohol vehicle with flavoring agents has been used as a mouthrinse to reduce plaque accumulation in periodontal surgery patients. The purpose of this study was to evaluate the effects of a chlorhexidine-containing mouthrinse on the early tensile wound strength of healing surgical wounds in the rat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1993.64.8.719

    authors: Shahan MH,Chuang AH,Brennan WA,Dirksen TR,Van Dyke TE,McPherson JC

    更新日期:1993-08-01 00:00:00

  • A bone regenerative approach to alveolar ridge maintenance following tooth extraction. Report of 10 cases.

    abstract::TEN PATIENTS WHO REQUIRED two or more anterior teeth extractions were utilized in this study. Extraction procedures were carried out with a full thickness surgical flap approach. After flap reflection, teeth were removed with a minimum of trauma to the surrounding bone. Following extraction silicone-based impression t...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1997.68.6.563

    authors: Lekovic V,Kenney EB,Weinlaender M,Han T,Klokkevold P,Nedic M,Orsini M

    更新日期:1997-06-01 00:00:00

  • Ovariectomy and timing of impaired maxillary alveolar bone regeneration: An experimental study in rats.

    abstract:BACKGROUND:The aim of this study was to seek the critical time for impairment of alveolar bone regeneration after ovariectomy (OVX) in rats. METHODS:A total of 32 female rats were used. Test group rats were divided into a 2M group (n = 8), a 3M group (n = 8) and a 4M group (n = 8) according to the duration from OVX to...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.19-0537

    authors: Kim HJ,Kim KH,Lee YM,Ku Y,Heo SJ,Rhyu IC,Seol YJ

    更新日期:2020-10-01 00:00:00

  • Using a Delphi panel to survey criteria for successful periodontal therapy in anterior teeth.

    abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.9.1508

    authors: Lightfoot WS,Hefti A,Mariotti A

    更新日期:2005-09-01 00:00:00

  • The use of blade implants in a selected population of partially edentulous adults. A five-year report.

    abstract::Based on the findings observed after the insertion of 33 blade implants in 23 patients, ages 31 to 74, for periods up to 60 months, the following conclusions can be made: (1) The blade implant is a technically feasible procedure which can be maintained in the mouth for period up to 5 years, although some degree of bon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1976.47.1.19

    authors: Smithloff M,Fritz ME

    更新日期:1976-01-01 00:00:00

  • Degradation of basement membrane collagen by proteinases from human gingiva, leukocytes and bacterial plaque.

    abstract::Basement membranes in human gingiva are found in dento-epithelial junction, epithelial-connective tissue junction and endothelium-connective-tissue junction where they have important attachment and filtering functions. The ability of plaque and gingiva-derived proteinases to degrade Type IV collagen, the major protein...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1983.54.12.740

    authors: Uitto VJ

    更新日期:1983-12-01 00:00:00

  • Subgingival microflora of advanced periodontitis in the Dominican Republic.

    abstract::A study of the predominant subgingival microflora was carried out in 24 periodontitis patients, 18 to 60 years of age, in Santo Domingo, Dominican Republic. Paper point sampling, transport in VMGA III, and conventional microbiological techniques were utilized. Direct microscopic examination revealed that cocci and non...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1991.62.9.543

    authors: Slots J,Rams TE,Feik D,Taveras HD,Gillespie GM

    更新日期:1991-09-01 00:00:00

  • Effect of section thickness on cone beam computed tomography-based measurements of intrabony defects compared with clinical measurements.

    abstract:BACKGROUND:It is unknown whether cone beam computed tomography (CBCT) image reconstruction characteristics, including section thickness, may affect linear bone measurements of periodontal intrabony defects. The aim of this study was to compare intrasurgical and CBCT-based linear measurements of intrabony defects focusi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0338

    authors: Nikolic-Jakoba N,Barac M,Jankovic S,Aleksic Z,Spin-Neto R,Wenzel A

    更新日期:2020-08-21 00:00:00

  • Ossifying fibromyxoid tumor in the mandibular gingiva: case report and review of the literature.

    abstract:BACKGROUND:Ossifying fibromyxoid tumors (OFTs) are uncommon soft tissue neoplasms. Only one case arising in the gingiva has been described. METHODS:A 21-year-old woman presented with a painless exophytic mass located in the right posterior mandibular gingiva, which was identified 6 months earlier. Radiographs showed i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2009.080535

    authors: Nonaka CF,Pacheco DF,Nunes RP,Freitas Rde A,Miguel MC

    更新日期:2009-04-01 00:00:00

  • Osteopromotion: a soft-tissue exclusion principle using a membrane for bone healing and bone neogenesis.

    abstract::The research reviewed in this paper constitutes a series of investigations intended to develop and evaluate a new membrane technique, which provides improved conditions for osteogenesis during healing of bone defects and restitution of earlier existing bone. The technique has also been shown to aid in bone grafting as...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1993.64.11s.1116

    authors: Linde A,Alberius P,Dahlin C,Bjurstam K,Sundin Y

    更新日期:1993-11-01 00:00:00

  • Analysis of consecutively placed loaded root-form and plate-form implants in adult Macaca mulatta monkeys.

    abstract::The present paper describes 36 consecutively treated non-human primates (Macaca mulatta) as part of a balanced block design study to examine osseointegration in root- and plate-form implants prepared by atraumatic preparation of bone. Clinical measurements around selected teeth and digital radiology were utilized to m...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.12.1322

    authors: Fritz ME,Braswell LD,Koth D,Jeffcoat M,Reddy M,Brogan D,Cotsonis G,Winter M,Lemons JE

    更新日期:1996-12-01 00:00:00

  • Increased Interleukin-1β Concentration in Gingival Crevicular Fluid as a Characteristic of Periodontitis.

    abstract:BACKGROUND:The levels of interleukin-1β (IL-1β) have been reported to be higher in sites with periodontitis than in healthy controls. This may be the result of a more severe inflammation and/or constitutional differences in IL-1β production. Our aim was to test the hypothesis that the level of IL-1β in gingival crevicu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.12.1457

    authors: Figueredo CMS,Ribeiro MSM,Fischer RG,Gustafsson A

    更新日期:1999-12-01 00:00:00