Abstract:
BACKGROUND:This cross-sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll-like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy. METHODS:Whole saliva and plasma samples were obtained and full-mouth clinical periodontal measurements were recorded from 22 otherwise healthy patients with chronic periodontitis and 21 systemically and periodontally healthy control subjects. Salivary and plasma TLR2 and TLR4 levels were determined by enzyme-linked immunoassays. Data were tested statistically using Mann-Whitney U test. RESULTS:The healthy group exhibited significantly lower values in all clinical measurements (P <0.001). The salivary TLR2 levels were similar in the two study groups (P >0.05). The patients with chronic periodontitis exhibited significantly higher salivary TLR4 (P <0.01) and plasma TLR2 and TLR4 levels (P <0.05). CONCLUSION:The present findings support a hypothesis that inflammation increases expression of TLRs which leads to an increased detection of TLRs in saliva and plasma, which could be useful as a diagnostic test for periodontal diseases.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Buduneli N,Özçaka Ö,Nalbantsoy Adoi
10.1902/jop.2010.100467subject
Has Abstractpub_date
2011-06-01 00:00:00pages
878-84issue
6eissn
0022-3492issn
1943-3670journal_volume
82pub_type
杂志文章abstract:BACKGROUND:Enhanced neutrophil responses play a critical role in the activation of the innate immune system and causation of aggressive periodontitis (AgP). The hypothesis that comprehensive periodontal treatment expedites resolution of amplified leukocyte activity and facilitates the reconstitution of periodontal heal...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.9.995
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to longitudinally evaluate, over a 3-year period, the reduction of gingival recession through use of a subepithelial free connective tissue graft placed under a coronally advanced partial-thickness pedicle flap. METHODS:Twenty-one buccal recession defects (mean 3.67 mm; range 3...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2002.73.12.1412
更新日期:2002-12-01 00:00:00
abstract::The purposes of this study were to determine if: 1) an association exists between cigarette smoking and signs of periodontal disease after controlling for the confounding variables of age, sex, plaque, and calculus; 2) the prevalence of 5 bacteria commonly associated with periodontal disease differs between smokers an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.12.1225
更新日期:1993-12-01 00:00:00
abstract::Intraoral transmission radiographs have been the primary diagnostic method for the assessment of bone support as well as for the detection and measurement of osseous changes due to periodontitis. The purpose of the present paper is three-fold. The first is to review radiographic techniques for the assessment of period...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1992.63.4s.367
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Our purpose was to compare the risk of tooth loss caused by periodontal disease between diabetic and nondiabetic individuals and to estimate the relative risk of tooth loss according to the severity and control of diabetes. METHODS:We selected 10,215 individuals who were diagnosed as diabetics in the Korean...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0480
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Alanine aminopeptidase (ALAP) and dipeptidyl peptidase IV (DPPIV) are ectopeptidases that play a role in collagen degradation and are thought to be involved in the destruction of periodontal tissue. This study compared the activities of salivary ALAP and DPPIV in patients with periodontitis and periodontally...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090233
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Hyaluronic acid (HA) has shown anti-inflammatory effects in gingivitis therapy. The potential benefits of local subgingival application of HA adjunctive to scaling and root planing (SRP) were evaluated in this study. METHODS:Twenty patients with chronic periodontitis were included in this split-mouth study....
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2004.75.8.1114
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma (PRP) harbors growth factors identified in bone. It has been suggested that these factors enhance osteogenesis. The objective of this study was to conduct a radiographic evaluation on local bone formation following surgical implantation of a PRP preparation using a critical-size rat calv...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.8.1287
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Amelogenin is a major component of developing extracellular enamel matrix proteins and plays a crucial role during the formation of tooth enamel. In addition, amelogenins are suggested to exert biologic functions as signaling molecules through cell-surface receptors. The purpose of this study is to examine t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110408
更新日期:2012-05-01 00:00:00
abstract::The present study aimed to establish a titanium implantation model using rat maxillae as well as demonstrate the chronological tissue responses to implantation. Pure titanium implants were inserted in the upper first molar extraction sites of Wistar rats 1 month after tooth extraction. The animals were sacrificed at 1...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.4.485
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:A 43-year-old African American male initially presented for a dental evaluation of a recurrent swelling on the buccal aspect of tooth #12. His medical history was unremarkable except for a 20-pack year history of smoking. He was eventually diagnosed as having a necrotic pulp #12, and received root canal trea...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090418
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Distraction of the periosteum results in the formation of new bone in the gap between the periosteum and the original bone. We postulate that the use of a barrier membrane would be beneficial for new bone formation in periosteal distraction. METHODS:To selectively influence the contribution of the periosteu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110418
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Tobacco and some of its volatile and non-volatile components have been found to affect many types of cells including gingival fibroblasts. Since normal gingival fibroblast functioning is fundamental to the maintenance of the periodontal connective tissue, as well as to wound healing, we examined the effect o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.3.425
更新日期:2000-03-01 00:00:00
abstract::Unique hydroxyl ion-modulating compounds based on the amino acid glycine have been developed that possess both antimicrobial and pro-healing properties. The purpose of the present study was to determine the effects of one of these compounds, 8.5% (w/v) sodium N, N-bis-2 (hydroxylethyl) aminoacetate (SBHA) with 0.3% (w...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.5.448
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Some studies have advocated marrow penetration in guided bone augmentation (GBA), whereas others have shown that bone can be generated without marrow penetration. This study examined the effect of marrow penetration and the optimal rate of penetration. METHODS:In 10 rabbits, the calvarium was exposed, and c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070086
更新日期:2007-10-01 00:00:00
abstract::The American Academy of Periodontology has developed the following parameter on the treatment of "refractory" periodontitis. Patients should be informed of the disease process, therapeutic alternatives, potential complications, expected results, and their responsibility in treatment. Consequences of no treatment shoul...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.5-S.859
更新日期:2000-05-01 00:00:00
abstract::Repeated measurements of attachment level appear to be important assessments in periodontal clinical trials, yet the lack of reliability for this assessment creates measurement error which in turn demands increased sample sizes or reduces the power of the test. A plastic occlusal stent has been developed as a fixed re...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.2.115
更新日期:1987-02-01 00:00:00
abstract::Gingival crevicular fluid (GCF) levels of the polymorphonuclear leukocyte (PMN) lysosomal enzyme beta-glucuronidase (beta G), the pro-inflammatory cytokine interleukin 1 beta (IL-1 beta), and immunoglobulins (IgA, IgG, and IgM) were examined in 16 HIV seropositive (HIV+) and 10 HIV seronegative (HIV-) injecting drug u...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.3.249
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Previous studies showed that host modulation therapy (HMT) or topical antimicrobial therapy (TAT) provided significant adjunctive benefits to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). The purpose of this study was to evaluate a combination therapy involving SRP, HMT, and ...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2008.070237
更新日期:2008-01-01 00:00:00
abstract::Demineralized bone matrix (DBM) is widely used in the repair of pathologies associated with skeletal defects and periodontal diseases. The present study was directed at establishing in vivo and in vitro models for a quantitative assessment of the osteoinductivity of DBM before clinical use. Athymic mice were used in a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.11.1076
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:The comparative treatment response of children and young adults with localized aggressive periodontitis treatment (LAgP) affecting primary and permanent dentition is unknown. The objective of this study is to evaluate the influence of non-surgical periodontal therapy with adjunctive systemic antibiotics on t...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2014.140171
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The baseline periodontal examination is reported to be a painful dental procedure, but currently there are limited practical techniques to reduce this pain. The objective of this study is to evaluate the efficacy of an intrapocket anesthetic gel in the reduction of pain on periodontal probing in a group of u...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.110106
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Lingual plate perforation at the time of implant placement in posterior mandible is a potential surgical complication, and presence of a lingual concavity is considered a risk factor. Little is known about the spatial relationship between implant and lingual plate. The role of lingual concavity in the risk o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100313
更新日期:2011-01-01 00:00:00
abstract::In order to increase our understanding of the immunologic aspects of periodontal disease, three groups of extracted human teeth were evaluated for the presence of antibody on the cementum surface. Antibody was demonstrated by direct immunofluorescence using monospecific antibody with human alpha , gamma and upsilon ch...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.168
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is an inflammatory granulomatous systemic disease that rarely affects the oral cavity. Gingival involvement has been reported in only a very limited number of cases, occasionally as the first manifestation of the disease. This article reports a case of sarcoidosis affecting the gingiva and alveol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070139
更新日期:2008-03-01 00:00:00
abstract::Periodontitis and rheumatoid arthritis (RA) appear to share many pathologic features. In this review, the common pathologic mechanisms of these two common chronic conditions are explored. Emerging evidence now suggests a strong relationship between the extent and severity of periodontal disease and RA. While this rela...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.11-S.2066
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:This study systematically evaluates the effect of occlusal overload (OV) on peri-implant tissue health in animal studies. METHODS:MEDLINE, EMBASE, and LILACS databases were searched for articles published up to and including January 2010. Studies that reported outcomes of non-splinted titanium dental implan...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2010.100176
更新日期:2010-10-01 00:00:00
abstract::Histologic sections from six autopsy cases which from a clinical point of view fitted into the criteria of periodontosis were examined with the aim at evaluating the role of subgingival plaque in the etiology of the loss of attachment in this condition. The following pertinent observations were made: 1. The subgingiva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.11.636
更新日期:1976-11-01 00:00:00
abstract::The dynamics of bone turnover in the furcations of teeth treated with expanded polytetrafluoroethylene (ePTFE) membranes were evaluated using multiple fluorochrome labels in 6 male beagle dogs. Loss of attachment involving the furcation area was induced in the second, third, and fourth premolar teeth using silk ligatu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.1.84
更新日期:1994-01-01 00:00:00
abstract::Periodontitis is an inflammatory disease caused by microbial infection in the subgingival region. Risk factors associated with the development and progression of this disease are numerous, multifactorial, complex, and often not well defined across individuals and population groups. The focus of this paper is to provid...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1994.65.5s.539
更新日期:1994-05-01 00:00:00