The effect of diabetes on tooth loss caused by periodontal disease: A nationwide population-based cohort study in South Korea.


BACKGROUND:Our purpose was to compare the risk of tooth loss caused by periodontal disease between diabetic and nondiabetic individuals and to estimate the relative risk of tooth loss according to the severity and control of diabetes. METHODS:We selected 10,215 individuals who were diagnosed as diabetics in the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) database in 2003 and the same number of individuals who had never been diagnosed with diabetes during the period covered by the NHIS-NSC (2002-2013) with propensity score matching. Diabetic individuals were divided into two groups according to the treatment modality. We counted the number of teeth lost in each group to determine the difference in the risk of tooth loss among groups and used the Cox proportional hazards model to calculate hazard ratios (HRs) of tooth loss caused by periodontitis. RESULTS:Diabetic individuals had a higher risk of tooth loss than nondiabetic individuals (HR = 1.298, 95% confidence interval [CI]: 1.233 ≤ HR ≤ 1.366; P < 0.01). The severer the degree of diabetes, the higher the risk of tooth loss. As the number of dental visits increased, the risk of tooth loss declined (HR = 0.998, 95% CI: 0.996 ≤ HR ≤ 0.999; P < 0.01). CONCLUSIONS:Within the limits of this retrospective cohort study, the risk of tooth loss among diabetic individuals was higher than that among nondiabetic individuals. The risk of tooth loss declined with increasing numbers of dental visits and increased with the severity of diabetes.


J Periodontol


Yoo JJ,Kim DW,Kim MY,Kim YT,Yoon JH




Has Abstract


2019-06-01 00:00:00












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    abstract:BACKGROUND:This preliminary in vitro study, presented at the General Session of the International and American Association for Dental Research in 2010 (Barcelona, Spain), evaluates whether three-dimensional (3D) optical scanning and subsequent superimposing procedures could be used for reproducible volumetric evaluatio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Lehmann KM,Kasaj A,Ross A,Kämmerer PW,Wagner W,Scheller H

    更新日期:2012-01-01 00:00:00

  • Effects of tetracycline-containing gel and a mixture of tetracycline and citric acid-containing gel on non-surgical periodontal therapy.

    abstract::The purpose of this study was to assess the clinical and microbiological effects of a newly developed root conditioning gel system containing tetracycline or a mixture of tetracycline and citric acid on non-surgical periodontal therapy. Sixty-four (64) single-rooted teeth with a probing depth of 4 to 6 mm were randoml...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jeong SN,Han SB,Lee SW,Magnusson I

    更新日期:1994-09-01 00:00:00

  • Effect of a Connective Tissue Graft in Combination With a Single Flap Approach in the Regenerative Treatment of Intraosseous Defects.

    abstract:BACKGROUND:In the attempt to limit the post-surgery increase in buccal gingival recession (bREC), effect of a connective tissue graft (CTG) when combined with a buccal single flap approach (SFA) in the regenerative treatment of intraosseous defects is evaluated. METHODS:Data related to 30 patients with an intraosseous...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究


    authors: Trombelli L,Simonelli A,Minenna L,Rasperini G,Farina R

    更新日期:2017-04-01 00:00:00

  • Periodontal wound healing with and without platelet-rich plasma: histologic observations and assessment of flap tensile strength.

    abstract:BACKGROUND:Platelet-rich plasma (PRP) has been promoted as a surgical adjunct to enhance hard and soft tissue wound healing. Although anecdotally reported to be of value, the results of controlled studies examining the added effects of PRP on surgical procedures have been mixed. The purpose of this study was to test th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Powell CA,Bannister SR,Mackey SA,Maller SC,McDonnell HT,Deas DE

    更新日期:2009-06-01 00:00:00

  • Forty-eight-month periodontal attachment loss incidence in a population-based cohort study: role of baseline status, incident tooth loss, and specific behavioral factors.

    abstract:BACKGROUND:The objectives of this study were to: 1) test hypotheses that behavioral factors, baseline clinical status, and incident tooth loss are significantly associated with attachment loss incidence (ALI) and 2) quantify the effect of incident tooth loss on conclusions made about ALI. METHODS:The Florida Dental Ca...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Gilbert GH,Shelton BJ,Fisher MA

    更新日期:2005-07-01 00:00:00

  • Inhibition of superoxide generation by human polymorphonuclear leukocytes with chlorhexidine. Its possible relation to periodontal disease.

    abstract::During the acute phase of periodontal disease, as many as 60% of the cells of the junctional epithelium may be accounted for by polymorphonuclear cells (PMNs). It is generally accepted that these cells play a dominant role in the destruction of connective tissue by virtue of the proteinases they release and the free o...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Goultschin J,Levy H

    更新日期:1986-07-01 00:00:00

  • Gingival crevicular fluid concentration and side effects of minocycline: a comparison of two dose regimens.

    abstract::The purpose of this study was to conduct a direct comparison of two dose regimens of minocycline to determine 1) whether they achieved crevicular fluid concentrations in a therapeutic range; and 2) the frequency of side effects. In a double-blind design, 30 patients divided into 2 groups were given either 100 mg minoc...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Freeman E,Ellen RP,Thompson G,Weinberg SE,Song M,Lazarus RH

    更新日期:1992-01-01 00:00:00

  • Detection of eight periodontal microorganisms and distribution of Porphyromonas gingivalis fimA genotypes in Chinese patients with aggressive periodontitis.

    abstract:BACKGROUND:The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP. METHODS:...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Feng X,Zhang L,Xu L,Meng H,Lu R,Chen Z,Shi D,Wang X

    更新日期:2014-01-01 00:00:00

  • Genetic Control of the Immune Response in Pathogenesis.

    abstract:BACKGROUND:Epidemiological studies have suggested that there is a genetic component to susceptibility to chronic periodontitis. Studies in humans and in animal models have suggested that some of the important components may be polymorphisms in key immunological genes. METHODS:This paper summarizes previously published...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Baker PJ

    更新日期:2005-11-01 00:00:00

  • Palatal tubercles, palatal tori, and mandibular tori: prevalence and anatomical features in a U.S. population.

    abstract::The prevalence and features of 3 types of exostoses commonly encountered during periodontal surgery were studied in a sample of 328 modern American skulls drawn from the collection at the American Museum of Natural History. Measurements were made of the height, width, and breadth of exostoses. The relationship to teet...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Sonnier KE,Horning GM,Cohen ME

    更新日期:1999-03-01 00:00:00

  • Tetracycline and its derivatives strongly bind to and are released from the tooth surface in active form.

    abstract::Several antibiotics were found to adsorb to saliva-coated enamel and to inhibit in vitro plaque formation by pure cultures of oral bacteria: Actinomyces viscosus, Actinomyces naeslundii and Streptococcus mutans. Tetracycline, minocycline and oxytetracycline adsorbed to the greatest degree, showing 100-fold higher adso...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Baker PJ,Evans RT,Coburn RA,Genco RJ

    更新日期:1983-10-01 00:00:00

  • Ultrastructural and immunoelectron microscopic studies of the peri-implant epithelium-implant (Ti-6Al-4V) interface of rat maxilla.

    abstract:BACKGROUND:The role played by the internal basal lamina (IBL) and hemidesmosomes between an implant and the peri-implant epithelium (PIE) in the adherence of the epithelium to the implant is controversial. This study used rat maxilla implantation models to clarify the ultrastructure of the PIE-implant interface. METHO...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Ikeda H,Yamaza T,Yoshinari M,Ohsaki Y,Ayukawa Y,Kido MA,Inoue T,Shimono M,Koyano K,Tanaka T

    更新日期:2000-06-01 00:00:00

  • The management of drug induced gingival hyperplasia in mentally retarded patients with hemophilia: a report of two cases.

    abstract::Two cases of hemophilia in severely mentally retarded patients with drug-induced gingival hyperplasia are presented. The method of management in each case is described. A conservative approach is recommended in which tissue removals and only selected extractions are performed. It is also suggested that the sequela of ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Murphy JB,Nersasian R,Clark A

    更新日期:1978-01-01 00:00:00

  • In Vivo Inhibition of Porphyromonas gingivalis Growth and Prevention of Periodontitis With Quorum-Sensing Inhibitors.

    abstract:BACKGROUND:Autoinducer (AI)-2 has an important role in biofilm formation in the oral environment. Mature biofilms formed as a result of the cell-to-cell communication make it difficult to overcome periodontitis with the use of antibiotics. Previous in vitro studies suggest that quorum-sensing inhibitors (QSIs) interfer...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Cho YJ,Song HY,Ben Amara H,Choi BK,Eunju R,Cho YA,Seol Y,Lee Y,Ku Y,Rhyu IC,Koo KT

    更新日期:2016-09-01 00:00:00

  • Immediate loading of implants placed with the osteotome technique: one-year prospective case series.

    abstract:BACKGROUND:There is limited information regarding marginal bone-level changes around immediately loaded implants placed with the osteotome technique. The aim of this case series is to prospectively evaluate the clinical and radiographic outcome of immediately loaded implants placed with the osteotome technique over a 1...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章


    authors: Koutouzis T,Koutouzis G,Tomasi C,Lundgren T

    更新日期:2011-11-01 00:00:00

  • Reliability of partial-mouth recording systems to determine periodontal status: a pilot study in an adult Portuguese population.

    abstract:BACKGROUND:The efficacy of various partial-mouth recording (PMR) systems is analyzed in the evaluation of periodontal status, using index teeth and different combinations of quadrants. METHODS:The study group was formed of 108 adults aged 25 to 65 years old. A full-mouth examination (FME) was performed in all particip...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Relvas M,Tomás I,Salazar F,Velazco C,Blanco J,Diz P

    更新日期:2014-06-01 00:00:00

  • Risk indicators for future clinical attachment loss in adult periodontitis. Tooth and site variables.

    abstract::In an earlier report, we examined the relationship of patient-derived clinical and epidemiological variables to the risk for future clinical attachment loss (CAL) in chronic adult periodontitis. We determined that the extent of the patient's existing periodontal disease as measured by mean attachment loss (MAL) and th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Grbic JT,Lamster IB

    更新日期:1992-04-01 00:00:00

  • Ultrasonography for chairside evaluation of periodontal structures: A pilot study.

    abstract:BACKGROUND:The crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the correlation and accuracy of ultrasound in measuring periodontal dimensions, compared to ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Tattan M,Sinjab K,Lee E,Arnett M,Oh TJ,Wang HL,Chan HL,Kripfgans OD

    更新日期:2020-07-01 00:00:00

  • Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration. A review.

    abstract::The use of antibiotics in periodontal therapy has received increasing attention in recent years. Although generally safe, certain antibiotics, including tetracycline and ampicillin, have been shown to interact indirectly with oral contraceptives, with a resultant decrease in oral contraceptive efficacy. This paper rev...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审


    authors: Barnett ML

    更新日期:1985-01-01 00:00:00

  • The effect of a supragingival plaque-control regimen on the subgingival microbiota in smokers and never-smokers: evaluation by real-time polymerase chain reaction.

    abstract:BACKGROUND:The aim of the present study was to evaluate the effect of strict supragingival plaque control on the subgingival microbiota in smokers and never-smokers. Research into the impact of supragingival plaque control on the number of subgingival bacteria has resulted in contradictory findings. Real-time polymeras...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章


    authors: Gomes SC,Nonnenmacher C,Susin C,Oppermann RV,Mutters R,Marcantonio RA

    更新日期:2008-12-01 00:00:00

  • The effect of verapamil on the prevalence and severity of cyclosporine-induced gingival overgrowth in renal allograft recipients.

    abstract::Cyclosporine A (CsA) and verapamil are two agents used in renal transplantation, both of which are suspected of inducing gingival overgrowth. This study was conducted to investigate the effect of verapamil on the severity and prevalence of CsA-induced gingival overgrowth. Fifty-one (51) renal transplant recipients (to...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Cebeci I,Kantarci A,Firatli E,Carin M,Tuncer O

    更新日期:1996-11-01 00:00:00

  • Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women.

    abstract:BACKGROUND:We recently demonstrated that a 2-year subantimicrobial-dose doxycycline (SDD) regimen (double-masked, placebo-controlled clinical trial) in postmenopausal (PM) women exhibiting mild systemic bone loss (osteopenia) and local bone loss (periodontitis) reduced the progression of periodontal attachment loss (in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Golub LM,Lee HM,Stoner JA,Sorsa T,Reinhardt RA,Wolff MS,Ryan ME,Nummikoski PV,Payne JB

    更新日期:2008-08-01 00:00:00

  • Microbiota of successful osseointegrated dental implants.

    abstract:BACKGROUND:The long-term survival of dental implants depends, in part, on control of bacterial infection in the peri-implant region. Periodontal pathogens colonized implants symptomatic through infection, whereas the microbiota of successful implants was similar to that of periodontal health. This study examined the im...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Lee KH,Maiden MF,Tanner AC,Weber HP

    更新日期:1999-02-01 00:00:00

  • Angiotensin II Type 1 Receptor Knockdown Impairs Interleukin-1β-Induced Cytokines in Human Periodontal Fibroblasts.

    abstract:BACKGROUND:The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II Type 1 (AT1) receptor axis. It is known that periodontal pathogens elici...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Gabriele LG,Morandini AC,Dionísio TJ,Santos CF

    更新日期:2017-01-01 00:00:00

  • Upregulation of heme oxygenase-1 expression in gingiva after cyclosporin A treatment.

    abstract:BACKGROUND:Heme oxygenase (HO)-1 is a stress-inducible protein that confers cytoprotection, but its role in gingiva during cyclosporin A (CsA) therapy is unknown. We used in vivo and in vitro models to investigate the expression of mRNA and protein for HO-1 in gingiva upon CsA treatment. METHODS:Twenty-six male Spragu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Chiu HC,Lan GL,Chiang CY,Chin YT,Tu HP,Ming-Jen Fu M,Shin N,Fu E

    更新日期:2008-11-01 00:00:00

  • The Inhibition of Interferon-γ-Induced Upregulation of HLA-DR Expression on Cultured Human Gingival Fibroblasts by Interleukin-1β or Tumor Necrosis Factor-α.

    abstract::The purpose of this study was to examine the effect of inflammatory cytokines on IFN-γ-induced HLA-DR expression on cultured human gingival fibroblasts by flow cytometry. Natural human IFN-γ, recombinant human interleukin-1β (rhIL-1β), and rh tumor necrosis factor-α (rhTNF-α) were used. IFN-γ-induced upregulation of H...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Takahashi K,Takigawa M,Ami H,Kurihara H,Murayama Y

    更新日期:1994-04-01 00:00:00

  • Platelet-rich plasma derived from bone marrow aspirate promotes new cementum formation.

    abstract:BACKGROUND:This study evaluates the influence of platelet-rich plasma derived from bone marrow aspirate (PRP-BMA) on the healing of periodontal fenestration defects in rats. METHODS:Periodontal fenestration defects were surgically created in the mandibles of 40 rats. The animals were randomly divided into two groups, ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Nagata MJ,de Campos N,Messora MR,Santinoni CS,Bomfim SR,Fucini SE,Pola NM,Neves AP,de Almeida JM,Theodoro LH,Ervolino E

    更新日期:2014-12-01 00:00:00

  • The role of CD4+ cells in vivo on the induction of the immune response to Porphyromonas gingivalis in mice.

    abstract:BACKGROUND:It has previously been suggested that CD4+ T cells play a pivotal role in regulating the immune response to periodontal pathogens. The aim of the present study therefore was to determine delayed type hypersensitivity (DTH), spleen cell proliferation, serum and splenic anti-Porphyromonas gingivalis antibody l...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Sosroseno W,Bird PS,Gemmell E,Seymour GJ

    更新日期:2002-10-01 00:00:00

  • Rationale for stabilization.

    abstract::1. The subjective separation of the normal and the diseased periodontium for splinting purposes is artificial. With the exception of cases of secondary trauma from occlusion, the diseased periodontium should be treated in the same manner as the normal periodontium with regards to splinting. 2. Retionales for stabiliza...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审


    authors: Lemmerman K

    更新日期:1976-07-01 00:00:00

  • Association between periodontitis and blood lipid levels in a Korean population.

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    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Lee S,Im A,Burm E,Ha M

    更新日期:2018-01-01 00:00:00